Tissues gene expression regulation developmental. Medical search. Frequent questions

Lastly, we used RNA knockdown methods to diminish the expression of connexin proteins, which generate so-called "gap junctions" between cells - channels of communication which calcium and other molecules can traverse. (uib.no)
MS membrane proteins are essential for tissue development, cellular motion, osmotic homeostasis, and sensing external and self-generated mechanical cues like those responsible for touch and proprioception. (stanford.edu)
Molecular and Cellular Oncology researchers work on providing insights into gene expression regulation and its deregulation in cancer, the cellular response to genomic insults, the molecular structure of cancer-relevant proteins, and new signaling transduction processes driving tumor growth. (cancer.gov)
Findings are presented which are consistent with involvement of nuclear structure in gene regulatory mechanisms which support osteoblast differentiation by addressing four principal questions: 1) Does the representation of nuclear matrix proteins reflect the developmental stage-specific requirements for modifications in transcription during osteoblast differentiation? (umassmed.edu)
2) Are developmental stage-specific transcription factors components of nuclear matrix proteins? (umassmed.edu)
4) Are alterations in gene expression and cell phenotypic properties in transformed osteoblasts and osteosarcoma cells reflected by modifications in nuclear matrix proteins? (umassmed.edu)
There is a striking representation of nuclear matrix proteins unique to cells, tissues as well as developmental stages of differentiation, and tissue organization. (umassmed.edu)
It is realistic to consider the utilization of nuclear matrix proteins for targeting regions of cell nuclei and specific genomic domains on the basis of developmental phenotypic properties or tissue pathology. (umassmed.edu)
Proteins: Fluorochrome can detect specific proteins in cells or tissues, allowing researchers to study their distribution and expression levels. (dadangoray.com)
It is widely believed that in mammalian cells the cellular transcription factor (DRTF1/E2F integrates cell-cycle events with the transcription apparatus by interacting with important regulators of the cell cycle, such as the retinoblastoma gene product (pRb) and related proteins, cyclins, and cyclin-dependent kinases. (ox.ac.uk)
Both DP-1 and DP-2 synergistically interact with members of the E2F family of proteins, E2F-1, E2F-2, and E2F-3, to generate DNA binding complexes that specifically recognize the E2F site and functionally interact with E2F-1 in E2F site-dependent transcriptional activation of cellular genes. (ox.ac.uk)
virtually every tissue expresses at least one family member, consistent with a critical role for TEAD proteins in either cell proliferation or differentiation. (embl-heidelberg.de)
There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)

One of the yet unsolved riddles in biology is how cells in the early embryo become organized to generate the different tissues and complex structures of the body. (uib.no)
I graduated from Lomonosov Moscow State University as a Master in Physiology with specialization in developmental biology. (uib.no)
Surveys principles of genetics, and molecular, cellular and developmental biology in relation to human disease processes. (ucr.edu)
The Vision Molecular Biology Laboratory studies regulation of specific gene expression during functional differentiation and development of the vertebrate eye. (uclahealth.org)
The resulting information helps define how genes can be regulated and should enable better predictive biology for farm animals. (usda.gov)
Developmental Biology (3cr. (udel.edu)
Development: For advances in developmental biology and stem cells. (lu.se)

We report an RNA-sequencing (RNA-Seq)-based comprehensive transcriptome atlas of Chia sampled from 13 tissue types covering vegetative and reproductive growth stages. (oregonstate.edu)
We characterized this pattern at different developmental stages, noting that it was always the cells that give rise to the muscle lineage that were the initiators. (uib.no)
With this goal, we have generated extensive data on transcriptomics from different cellular fractions, whole cell proteomics and nine histone modifications in twelve time points along the transdifferentiation from pre-B cells into macrophages, and whole tissue transcriptomics and nine histone modification profiles in four Drosophila tissues (wing, eye, leg and antenna) along three developmental stages (third instar larvae, white pupa and late pupa). (crg.es)
It is essential to have a better understanding on inter-individual variation of gene expression, methylation and genetic effects specific to liver, and on different conditions, e.g. developmental stages. (biomedcentral.com)
While previous studies in chickens, cattle, and pigs have identified lncRNAs in developmental stages or differentially expressed under specific conditions in a limited number of tissues, more comprehensive identification of lncRNAs in these species is needed. (usda.gov)
Northern blot analysis shows that ZNF322 is expressed in every human tissue examined at adult stage and during embryonic developmental stages from 80 days to 24 weeks. (anthropogeny.org)
Production of NO during early developmental stages is required for formation of multi-ciliated cells, ionocytes and small secretory cells by regulation of epidermal specific gene expression. (labgenexp.eu)

Like enhancers, silencers may be located at locations farther up or downstream from the genes they regulate. (wikipedia.org)
Although a small number of 3' regulatory regions have been identified and validated so far, many studies have shown that plant 3' regulatory regions have a higher potential to regulate gene expression in plants compared to widely used 3' regulatory regions, such as NOS and OCS from Agrobacterium tumefaciens and 35S from cauliflower mosaic virus. (frontiersin.org)
Recently, pol III and core components of the pol III complex such as TFIIIC have been demonstrated to establish boundaries between genomic domains, and regulate gene expression within those domains. (yale.edu)
In this submission, the chicken, cattle, and pig genomes were surveyed for what is known as long non-coding RNAs, which help to regulate gene expression. (usda.gov)

Next, the importance of embryonic developmental genes such as homeobox and T-box transcription factors are highlighted in conduction system development and function. (medscape.com)

Her specific aim is to shed light onto the contribution of the cell division patterns and the differentiation path of a cell to the formation of the spiralian cell types and tissues. (uni-goettingen.de)
Cardiac differentiation involves a cascade of coordinated gene expression that regulates cell proliferation and matrix protein formation in a defined temporal-spatial manner. (anthropogeny.org)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)

Her lab has recently worked with gene expression patterns during sexual reproduction and regeneration of syllids. (uni-goettingen.de)
To understand the biological roles of soybean CAMTA (GmCAMTA) family members in response to abiotic stresses, we characterized expression patterns of 15 GmCAMTA genes in response to various abiotic stresses. (bvsalud.org)
The GmCAMTA genes exhibited distinct circadian regulation expression patterns and were differently expressed in response to salt, drought, and cold stresses. (bvsalud.org)
Amazingly, these piRNAs exhibit synchronized expression in the germ line, despite being interspersed among hundreds of coding genes with diverse expression patterns. (yale.edu)
These transcripts match previously known patterns of lncRNA, such as generally lower expression levels than protein-coding genes and higher tissue specificity. (usda.gov)
Finally, through evaluation of co-expression modules, we identified gene sets with unique expression patterns that depended on ELP1 expression. (figshare.com)
Based on these results and prior studies, increased AQP9 expression may lead to increased arsenic transport in the female fetal placenta, which in turn may alter the expression patterns of key developmental genes that we have previously shown to be associated with arsenic exposure. (biomedcentral.com)
Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)

These results indicate that Gli2 and Gli3 possess specific and overlapping functions in Shh signalling during foregut development, and suggest that mutations in GLI genes may be involved in human foregut malformations. (nih.gov)
Inherited causes account for approximately 50% of individuals seen for childhood (prelingual) hearing loss, of which 70% are due to mutations in numerous single genes that impair auditory function alone (nonsyndromic). (medscape.com)
Waardenburg syndrome type IV is autosomal recessive with variable penetrance and is due to SOX10 or endothelin-B receptor ( EDNRB ) gene mutations, which appear to correlate with the intestinal and/or neurological symptoms manifested in patients. (medscape.com)
Mutations in the FOLR1 gene cause cerebral folate transport deficiency. (medlineplus.gov)
FOLR1 gene mutations result in a lack of protein or malfunctioning protein. (medlineplus.gov)
which means both copies of the gene in each cell have mutations. (medlineplus.gov)
Cario H, Bode H, Debatin KM, Opladen T, Schwarz K. Congenital null mutations of the FOLR1 gene: a progressive neurologic disease and its treatment. (medlineplus.gov)
Human genetic studies have identified mutations in the sodium channel SCN5A gene causing tachyarrhythmia disorders, as well as progressive cardiac conduction system diseases, or overlapping syndromes. (medscape.com)

Comparison of the argos genes from Drosophila melanogaster and the housefly, Musca domestica, supports our structure-function analysis. (ox.ac.uk)
Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior. (ox.ac.uk)
Male courtship behavior in Drosophila is in large part regulated by the gene fruitless (fru). (ox.ac.uk)

By analyzing the methylomes and transcriptomes of 14 fetal and 181 adult livers, we identified 657 differentially methylated genes with adult-specific expression, these genes were enriched for transcription factor binding sites of HNF1A and HNF4A. (biomedcentral.com)
Further, gene length analysis of the differentially expressed genes showed that the loss of Elp1 mainly impacts the expression of long genes and that by gradually restoring Elongator their expression is progressively rescued. (figshare.com)

In order to examine whether there are classes of progenitor cells with distinct developmental properties contributing to this developmental progression, we examined antigen expression in progenitor cells during rat retinal development. (nih.gov)
These findings demonstrate that expression of these two markers by progenitors is highly correlated with a bias towards the production of amacrine and horizontal cells. (nih.gov)
An infectious retrovirus vector has been used to transfer a bacterial gene encoding resistance to the neomycin analogue G418 into pluripotent haematopoietic stem cells present in explanted murine bone marrow tissue. (nature.com)
Subsequent transplantation of the cells into lethally irradiated mice results in engraftment of the animals with donor haematopoietic tissue containing the bacterial gene. (nature.com)
How do cells in the early embryo coordinate their development to create the different tissues of the body? (uib.no)
Under ERC funding, we have traced the transcriptomic and epigenetic profiles along dynamic processes, in particular, across human pre-B cells transdifferentiation into macrophages and along fruit fly tissue development. (crg.es)
Ubiquitous but variable expression is seen in brain and other tissues like heart, pancreas and also in human bladder carcinoma cells. (novusbio.com)
Tissue-wise, these studies encompass differentiating ocular lens fiber cells, the retina, the brain and the heart. (uclahealth.org)
Bhat SP, Hale IL, Matsumoto B, Elghanayan D. Ectopic Expression of αB-crystallin in Chinese Hamster Ovary cells suggests a nuclear role for this protein. (uclahealth.org)
We wish to understand how germ cells protect their DNA, while turning different genes on and off at the right times to make functional sperm and eggs. (yale.edu)
We are studying germ cell regulation primarily using the model organism C. elegans, a nematode, because of the large number of germ cells it contains, and because of the many experimental advantages it offers. (yale.edu)
Because the genes in C. elegans are related to those in higher organisms, the results from our studies should help us to understand how germ cells function in humans as well. (yale.edu)
This allows biomolecules to be identified and quantified in cells or tissues, making it an essential tool for many biological studies. (dadangoray.com)
Fluorescence microscopy allows the visualization of fluorescent molecules in cells and tissues under a microscope. (dadangoray.com)
In summary, fluorochrome detection is a powerful technique used to identify and quantify specific biomolecules in cells and tissues. (dadangoray.com)
They can be used to label and identify specific molecules or structures within cells or tissues. (dadangoray.com)
In addition, regenerative medicine - which is based on the ability of stem cells to repair tissue damage - is set to become new prototype of treatment concerning human health. (outlookconferences.com)
A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells. (ox.ac.uk)
Chromatin immunoprecipitation followed by sequencing (ChIP-seq) and microarray expression analysis were used to show that RUNX1 binds approximately 9,000 target sites in erythroid cells and is primarily active in the undifferentiated state. (ox.ac.uk)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)
When a microRNA is present in the cell, it binds to the target sites and downregulates GFP expression, while in cells that do not express the microRNA GFP, it is expressed. (lu.se)

Enhancers promote transcription by providing a binding platform for transcription factors [ 12 ] that can act on (distal) target genes through three-dimensional chromatin looping [ 13 - 15 ]. (biomedcentral.com)
Importantly, we have identified for the first time, by means of the DamID technique, direct Fru transcriptional target genes. (ox.ac.uk)
Fru target genes overwhelmingly represent genes previously reported to be involved in the nervous system development, such as CadN, lola and pdm2. (ox.ac.uk)
Functional analysis shows that a subset of the target genes is suppressed by RUNX1 via the newly identified partner MYEF2. (ox.ac.uk)

The platform was then applied to the analysis of differential splice forms in lung cancer samples compared to matched normal lung tissue. (biomedcentral.com)
These large-scale high-throughput analytical methods have been applied to the identification of differential splicing events in cancer tissues [ 8 ]. (biomedcentral.com)
This study provides a differential gene expression profile between TMJ fibrous and bony ankylosis. (medscimonit.com)
Two interrelated paradigms currently under investigation are: 1) Molecular basis of the differential expression of the gene for the small heat shock protein Alpha B-crystallin, a protein associated with with vision (e.g. in the ocular lens), oncogenesis (e.g. in breast cancer) and neural degeneration (e.g. in Alzheimer's disease). (uclahealth.org)
These data suggest that there is differential expression of the SRIF gene in different regions of the brain and in the stomach during development. (northwestern.edu)
Differential tissue distribution, developmental programming, estrogen regulation and promoter characteristics of cyp19 genes in teleost fish. (egejfas.org)

Together, these results suggest that ZNF322 is a member of the zinc-finger transcription factor family and may act as a positive regulator in gene transcription mediated by the MAPK signaling pathways. (anthropogeny.org)

Regulation of gene expression at the beginning of mammalian development and the TEAD family of transcription factors. (embl-heidelberg.de)

The principal theme of this prospect will be the contribution of nuclear structure to the regulation of gene expression as functionally related to development and maintenance of the osteoblast phenotype during establishment of bone tissue-like organization. (umassmed.edu)
How extensively does genome organization contribute to coordinated expression of functionally related genes? (yale.edu)

In three separate lines of transgenic mice, expression in fetal livers was high, and this level persisted into adulthood. (princeton.edu)
Mice contain at least four, and perhaps five, genes with the same TEA DNA binding domain (mTEAD genes). (embl-heidelberg.de)

Through APA, a single gene containing multiple PAS can generate a considerable number of transcript isoforms, thereby producing a highly diversified transcriptome ( Tian and Manley, 2013 ). (frontiersin.org)
In this study, we aimed to clone brain-derived Cyp19b and ovary-derived Cyp19a the P450 aromatase gene isoforms and to indicate the expression levels of these genes in the hypothalamus and ovary tissues from reproductively arrested ovarian development (RA) and non-arrested ovarian development (RN) Alburnus tarichi from Lake Van, Turkey. (egejfas.org)
Distinct cytochrome P450 aromatase isoforms in the common carp (Cyprinus carpio): Sexual dimorphism and onset of ontogenic expression. (egejfas.org)

We observed that meQTL were more stable between tissues than eQTL and a very strong tissue-specificity for the identified associations between CpG methylation and gene expression. (biomedcentral.com)
2) Are enhancer-promoter interactions tissue-specific, and what are the drivers of this specificity? (ens-lyon.fr)
We address these questions in vivo with unprecedented cell specificity and comprehensiveness, utilizing innovative methods to investigate how genome structure and organization influences gene expression specifically in the C. elegans germ line. (yale.edu)

Chia () Gene Expression Atlas Elucidates Dynamic Spatio-Temporal Changes Associated With Plant Growth and Development. (oregonstate.edu)
Methods that assess the influence of genetic variation on development, compare gene expression and regulation across tissues and time points, or leverage comparative genomics to understand developmental and evolutionary processes and integrate with existing tissue and cell atlas efforts are strongly encouraged. (inomics.com)
Here we found that knockdown of connexin expression, and therefore of gap junction expression, disrupted the coordination of the intercellular calcium wave, and resulted in abnormal development. (uib.no)
We have made some important contributions to the field: the discovery of a role for chromatin structure in the regulation of splicing, that splicing occurs mostly co-transcriptionally, and that genes regulated during development are transcribed in the absence of canonically activating chromatin marks. (crg.es)
Gregor Bucher is interested in the gene regulatory network of head development and the evolution of the brain focusing on the central complex. (uni-goettingen.de)
The Tumor Host Interactions program seeks to understand how the environment of tissues and cancers influences the development of cancers, the aggressiveness of these cancers, their responses to therapies, and outcomes for patients. (cancer.gov)
Developmental Therapeutics focuses on the discovery, development, and delivery of new anticancer therapies. (cancer.gov)
The goal of the Developmental Therapeutics program is to reduce the cancer burden through the integration of the processes of discovery, development, and delivery of new anticancer agents. (cancer.gov)
The calmodulin-binding transcription activators (CAMTAs) mediate transcriptional regulation of development, growth, and responses to various environmental stresses in plants. (bvsalud.org)
Our results suggest that GmCAMTA2 and GmCAMTA8 genes are regulated by circadian rhythms and function as negative regulators in development and drought stress responses. (bvsalud.org)
Phylogenetic analysis reveals that HPX15, AsP-15 and AcP-15 are unique to Anophelines and this may be due to the involvement of this peroxidase in regulation of Plasmodium development. (biomedcentral.com)
Hybridization of a 32 P-labeled rat SRIF cDNA probe to Northern blots of total RNA from the above tissues during development demonstrated a single hybridizing band approximately 670 base pairs in length. (northwestern.edu)
When SRIF mRNA levels from each stage of development were quantified and normalized by the amount of poly (A) + RNA present at that stage of development, a unique pattern of SRIF gene expression was seen in each region. (northwestern.edu)
Results Comprehensive lncRNA annotations for the chicken, cattle, and pig genomes were generated by utilizing RNA-seq from unique tissue samples with the same eight tissues at the same development stage (mature) and two biological replicates in each species. (usda.gov)
The C(2)H(2) zinc finger-containing transcription factors have been implicated as critical regulators of multiple cardiac-expressed genes and are important for human heart development and diseases. (anthropogeny.org)
Given that FD is caused by a reduction, not loss, of ELP1, we generated two new mouse models by introducing different copy numbers of the human FD ELP1 transgene into the Elp1 knockout mouse (Elp1-/-) and observed that human ELP1 expression rescues embryonic development in a dose dependent manner. (figshare.com)
We found that ELP1 is essential for the expression of genes responsible for nervous system development. (figshare.com)
Moreover, we find that the distal NDRs are enriched specifically for binding motifs of the pluripotency and germ cell master regulators such as NANOG, SOX17, AP2γ and OCT4 in human FGCs, indicating the existence of a delicate regulatory balance between pluripotency-related genes and germ cell-specific genes in human FGCs, and the functional significance of these genes for germ cell development in vivo . (nature.com)
2005). Finally, negative revealed that SSEA4 is detectable in the early neuroepi- selection strategies have been also developed as an alter- thelium, and its expression decreases as development native method to enrich for NSCs from both adult proceeds. (lu.se)

Introduction aux principaux concepts en biologie : origine et chimie de la vie, capture et utilisation de l'énergie dans les systèmes biologiques, hérédité et génétique, biodiversité et ses origines, évolution, systématique des principaux groupes d'organismes vivants et interactions biotiques. (uottawa.ca)
Host-induced gene silencing (HIGS) has been effectively applied to study pathogenic gene function during host-microbe interactions and control fungal diseases in various crops. (bvsalud.org)
Overall, the results of this study demonstrate that HIGS is a very effective and efficient biological tool not only to accurately characterize the functions of fungal pathogenic genes during rice-M. oryzae interactions, but also to control fungal disease and ensure a successful rice production. (bvsalud.org)
3) Are all enhancer-promoter interactions functional, and how does the activity of an enhancer relate to the expression of the gene it interacts with? (ens-lyon.fr)
Canonical heat shock element in the αB-crystallin gene shows tissue-specific and developmentally controlled interactions with heat shock factor. (uclahealth.org)
Topics: gamete interactions, establishment of body plans, cell signaling and tissue interactions, morphogenetic pattern formation, developmental regulation of gene expression, molecular control of tissue specification and diversification, and the evolutionary comparison of developmental processes. (udel.edu)

The assembled transcriptome is estimated to have the complete sequence information for ~86% of the genes found in the Chia genome. (oregonstate.edu)
The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. (biomedcentral.com)
How does genome organization stabilize and instruct tissue-specific gene expression? (yale.edu)
While genome assemblies and the identification of coding genes greatly enhanced our ability to connect DNA sequence (genotype) to traits of interest (phenotype), it becoming clear that genomes need to be more comprehensively annotated, especially with respect to regulatory elements. (usda.gov)

As one of the FAANG pilot projects, lncRNAs were identified across eight tissues in two adult male biological replicates from chickens, cattle, and pigs. (usda.gov)
Conclusions LncRNAs have been identified in three important farm animal species using eight tissues from adult individuals. (usda.gov)
In the adult however, the expression of DP-1 and DP-2 is tissue restricted. (ox.ac.uk)
Local expression of CYP19A1 and CYP19A2 in developing and adult killifish (Fundulus heteroclitus). (egejfas.org)

Waardenburg syndrome is a rare disease characterized by deafness in association with pigmentary anomalies and defects of neural crest-derived tissues. (medscape.com)
Morbidity is related to deafness and to defects of neural crest-derived tissues, including mental retardation, seizures, psychiatric disorders, skeletal anomalies, and eye disorders (including cataracts). (medscape.com)
The remainder are associated with other developmental anomalies termed syndromic deafness. (medscape.com)

In eukaryotes, the complex regulation of temporal- and tissue-specific gene expression is controlled by the binding of transcription factors to enhancers, which in turn interact with the promoter of their target gene(s) via the formation of a chromatin loop . (ens-lyon.fr)
The laboratory is interested in (a) elucidating developmental and tissue-specific control of the heat shock promoter of the Alpha B-crystallin gene and (b) understanding the biological function of the Alpha B-crystallin protein. (uclahealth.org)
Developmentally dictated expression of heat shock factors and specific interaction of the αB-crystallin heat shock promoter with HSF4. (uclahealth.org)

The focus will be on the involvement of the nuclear matrix, chromatin structure, and nucleosome organization in transcriptional control of cell growth and bone cell related genes. (umassmed.edu)
An analysis of lncRNA conservation across species identified a set of conserved lncRNA with potential functions associated with chromatin structure and gene regulation. (usda.gov)

His efforts are focused on the identification of the complete set of biomineralizing effector genes in the pulmonate gastropod Lymnaea stagnalis , and on identifying the gene regulatory and cellular communication events that coordinate the initiation of shell formation in the early snail embryo. (uni-goettingen.de)
Here we have identified and characterized a novel zinc-finger gene named ZNF322 using degenerated primers from a human embryo heart cDNA library. (anthropogeny.org)
can be unambiguously characterized and the advantages offered by the early amphibian embryo have made possible the identification of some basic features of their regulation. (silverchair.com)
Chromatin-mediated repression is established after formation of a 2-cell embryo, concurrent with the developmental acquisition of enhancer function. (embl-heidelberg.de)

Given the substantial inter-individual variation seen in metabolism, regulation of nutrients, protein synthesis, and detoxification of xenobiotics. (biomedcentral.com)
at the protein level, investigatiing the physiological function of the gene product. (uclahealth.org)
The gene contains four exons and spans 23.2kb in chromosome 6p22.1 region, and transcribes a 2.7kb mRNA that encodes a protein with 402 amino acid residues. (anthropogeny.org)
Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage. (figshare.com)
Familial dysautonomia (FD), a hereditary sensory and autonomic neuropathy, is caused by a mutation in the Elongator complex protein 1 (ELP1) gene that lead to a tissue-specific reduction of ELP1 protein. (figshare.com)
The FOLR1 gene provides instructions for making a protein called folate receptor alpha. (medlineplus.gov)
Additionally, folate is involved in the production and repair of DNA, regulation of gene activity (expression), and protein production. (medlineplus.gov)

To determine the roles of GmCAMTAs in the regulation of developmental processes and stress responses, we isolated GmCAMTA2 and GmCAMTA8 cDNAs from soybean and generated Arabidopsis overexpressing transgenic plants. (bvsalud.org)
A developmental per- contexts interact with biological processes to affect food spective considers family, school, and community context. (cdc.gov)

Its regulation is multilayered and includes the inherent role of RNA structural arrangement, which will undergo temporal and tissue-specific changes ( 5 ). (frontiersin.org)

About 65,587 of 82,663 transcripts were translated into 99,307 peptides, and we were successful in assigning InterPro annotations to 45,209 peptides and gene ontology (GO) terms to 32,638 peptides. (oregonstate.edu)
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to explore the function of splicing factors (SFs) that were associated with AS events. (frontiersin.org)
DAVID was used to perform the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis for the different expression genes (DEGs). (medscimonit.com)

It helps in deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) and gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (novusbio.com)

This information is embedded at multiple levels - in the regulatory information of individual genes, in the partitioning of that sequence into chromatin domains, and in the spatial segregation of these domains into functionally distinct regions of the nucleus. (yale.edu)

and the regulation of the expression of enzyme-coding genes associated with important metabolic pathways. (oregonstate.edu)
We then conducted a comprehensive transcriptome analysis in mouse embryos to identify genes and pathways whose expression correlates with the amount of ELP1. (figshare.com)

In this context, we have characterized the orphan cytokine receptor CRLF3, which is expressed in various tissues throughout eumetazoan species, as an ancient receptor that is sensitive to erythropoietin-like ligands. (uni-goettingen.de)
Expression of zebra fish Aromatase cyp19a and cyp19b genes in response to the ligands of estrogen receptor and aryl hydrocarbon receptor. (egejfas.org)

Through understanding functional recovery in terms of neuronal subtype and connectivity, the work presented in this thesis aims to bring the prospect of CRT closer to the clinic, I also describe the generation of a very promising alternative cell source that could rival fetal tissue. (lu.se)

HDAC-9 is a histone deacetylase with an important role in the regulation of gene expression and hematopoiesis. (novusbio.com)

not unique for the embryonic system but are shared by other ogenesis regulation must consider different scales of multi-cellular modeling areas. (lu.se)
Anatomical distribution and cellular basis for high levels of Aromatase activity in the brain of teleost fish: Aromatase enzyme and mRNA expression identify glia as source. (egejfas.org)

However, there is substantial inter-individual variation in hepatic gene expression, and although numerous genetic factors have been identified, less is known about the epigenetic factors. (biomedcentral.com)
Our analyses generated a comprehensive resource of factors involved in the regulation of hepatic gene expression, and allowed us to estimate the proportion of variation in gene expression that could be attributed to genetic and epigenetic variation, both crucial to understanding differences in drug response and the etiology of liver diseases. (biomedcentral.com)
More examples on epigenetic regulation of ADME genes have been reviewed by Kacevska et al. (biomedcentral.com)

To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels. (stanford.edu)

Using gene specific primers, tissue-specific and developmental-specific expression as well as its immune role against bacteria, fungus and P. berghei was studied. (biomedcentral.com)

dsRNAi plants, which produce small interfering RNAs targeting fungal genes. (bvsalud.org)

A reduction of 50% in the gene dosage of Gli3 in a Gli2-/- background resulted in oesophageal atresia with tracheo-oesophageal fistula and a severe lung phenotype. (nih.gov)
These studies entail attempts at relating gene activity to the functional phenotype of vision. (uclahealth.org)
The tissue-specific expression of DP family members suggests that the combination of DP/E2F heterodimers that constitute DRTF1/E2F is influenced by the phenotype of the cell. (ox.ac.uk)
The Brachyury gene is named for its phenotype, which was identified 70 years ago as a mutant mouse strain with a short blunted tail. (embl-heidelberg.de)

Use of human fetal tissue raises several ethical issues, but are there alternative cell sources that can substitute effectively? (lu.se)

The tissue-specificities of these associations were analyzed in muscle, subcutaneous adipose tissue and visceral adipose tissue. (biomedcentral.com)
Lipodystrophy, the abnormal distribution of fat, encompasses lipoatrophy, the loss of fat, and other abnormalities of adipose tissue. (medscape.com)
Lipodystrophies are categorized based on etiology (genetic or acquired) and distribution of lost adipose tissue, affecting the entire body (generalized) or only regions (partial). (medscape.com)

In particular, such mechanisms can influence the expression of hepatic ADME genes. (biomedcentral.com)

The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition. (medlineplus.gov)

The unique combinations of either activating or inhibiting transcription factors that bind to enhancer DNA regions determine whether or not the gene that enhancer interacts with is activated for transcription or not. (wikipedia.org)
In contrast, an AFP gene activated by the albumin enhancer was repressed after birth. (princeton.edu)

Using NanoString technology, we further analyzed the fetal placenta samples from the NHBCS for the expression of genes encoding arsenic transporters and metabolic enzymes. (biomedcentral.com)
The resemblance between the metabolic abnormalities of these extreme states of adiposity underscores the importance of fat tissue in energy homeostasis. (medscape.com)

Xenopus embryonic epidermis has become a useful model reflecting human epithelial tissue composition. (labgenexp.eu)

This Notice of Funding Opportunity (NOFO) solicits applications to develop innovative and generalizable statistical methods to enable analysis of data from the human Developmental Genotype-Expression (dGTEx) and non-human primate (NHP dGTEx) projects. (inomics.com)
pendent of those associated with cretory ducts, columnar epithelia the KRAS gene is more frequent- other key mechanistic characteris- lining the gastrointestinal tract and ly mutated in human cancer, which tics of IARC Group 1 carcinogens. (who.int)

Abnormalities in cardiac conduction can occur due to a variety of factors, including developmental and congenital defects, acquired injury or ischemia of portions of the conduction system, or less commonly due to inherited diseases that alter cardiac conduction system function. (medscape.com)

Interestingly, the expression levels of GmCAMTA2, GmCAMTA8, and GmCAMTA12 were higher in stem tissue than in other soybean tissues. (bvsalud.org)

This chapter discusses the relative merits of the basic approaches to assay tissue-specific gene expression. (princeton.edu)

[ 1 ] The impulse is then conducted through the atrium to the atrioventricular junction from where, after a delay, the electrical signal is propagated to the ventricles along bundles of specialized conduction tissue to the distal Purkinje fibers, which ramify among the contractile myocardium. (medscape.com)

Diseases resulting from developmental defects will be discussed. (udel.edu)

Further study of this phenomenon may provide insight into the in vivo control of SRIF gene expression and the role of SRIF in the developing brain. (northwestern.edu)

In this respect, he is using a broad range of methods including immunohistochemical analyses, histological staining procedures and ultrastructural investigations as well as gene expression analyses and phylogenomic approaches. (uni-goettingen.de)

Haploid androgenetic axolotl embryos develop devoid of the 8S DNA-ligase characteristic of control embryos ( Fig. 1A,B ). The paternal gene for DNA-ligase I is in a repressed state. (silverchair.com)

To determine whether developmental regulation results from stage-specific enhancers, the capacity of the AFP enhancers is tested to direct the expression of albumin. (princeton.edu)

Knockdown of Myef2 expression in developing zebrafish results in a reduced number of HSC. (ox.ac.uk)
Two Cyp19 (P450 Aromatase) genes on duplicated Zebrafish chromosomes are expressed in ovary or brain. (egejfas.org)

It has been the albumin and AFP genes contain a number of regulatory sequences important for their expression. (princeton.edu)

Of the 526 unique eQTL associated genes, 293 correlated significantly not only with genetic variation but also with methylation levels. (biomedcentral.com)
DNA: Fluorochrome can detect DNA sequences, making it an essential tool in genetic studies such as gene expression analysis. (dadangoray.com)

We also identified 1,000 genes specific to fetal liver, which were enriched for GATA1, STAT5A, STAT5B and YY1 binding sites. (biomedcentral.com)
It cannot be detected in the unfertilized egg, sperm or differentiated tissues such as liver or muscle. (silverchair.com)
11), altered liver structure and function (12), altered naire data from 8,765 children aged 5 to 7 years, smoking gene expression (13), and possibly type 2 diabetes mel- after pregnancy was not associated with childhood obesity litus (10). (cdc.gov)

Anatomy13

Organisms5

Diseases2

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes63

Disciplines and Occupations3

Information Science6

Health Care2

Proteins13

Biology7

Stages7

Regulate4

Embryonic developmental1

Differentiation3

Patterns8

Mutations8

Drosophila3

Differentially2

Cells21

Target genes4

Differential6

Transcription factor1

Mammalian1

Functionally related2

Mice2

Isoforms3

Specificity3

Development19

Interactions6

Genome4

Adult4

Anomalies3

Promoter3

Chromatin structure2

Embryo4

Protein7

Processes2

Undergo1

Ontology3

Transcriptional regulation1

Distinct1

Pathways2

Receptor2

Neuronal1

Hematopoiesis1

Cellular2

Epigenetic3

Genetics1

Primers1

RNAs1

Phenotype4

Fetal tissue1

Adipose tissue3

Mechanisms1

Autosomal1

Enhancer2

Metabolic2

Epithelial1

Human2

Abnormalities1

Stem1

Specific gene expression1

Distal1

Diseases1

Vivo1

Analyses1

Embryos1

Enhancers1

Zebrafish2

Regulatory sequences1

Genetic2

Liver3