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  • vivo
  • Order versus disorder: in vivo bone formation within osteoconductive scaffolds," Scientific Reports , vol. 2, p. 274, 2012. (hindawi.com)
  • Generally humans, in vivo, can regenerate injured tissues for limited distances of up to 2mm. (wikipedia.org)
  • The use of hECTs in generating tissue engineered heart valves is also being explored to improve current heart valve constructs in in vivo animal studies. (wikipedia.org)
  • As tissue engineering technology advances to overcome current limitations, hECTs are a promising avenue for experimental drug discovery, screening and disease modelling and in vivo repair. (wikipedia.org)
  • The superstructure of a conduit or scaffold is important for simulating in vivo conditions for nerve tissue formation. (wikipedia.org)
  • polymeric
  • Tissue engineering merges the disciplines of study like cell biology, materials science, engineering and surgery to enable growth of new living tissues on scaffolding constructed from implanted polymeric materials. (unt.edu)
  • fibers
  • SHG microscopy visualized the fibers of the cellulose scaffold, together with a small signal obtained from the cytoplasmic myosin of the muscle cells. (spie.org)
  • Melt electrospun fibers were used as part of a "bimodal tissue scaffold", where both micron-scale and nano-scale fibers were deposited simultaneously. (wikipedia.org)
  • Ways of forming artificial superstructure include the use of thermo-responsive hydrogels, longitudinally oriented channels, longitudinally oriented fibers, stretch-grown axons, and nanofibrous scaffolds. (wikipedia.org)
  • patient's
  • Professor Hollander's pioneering work includes the development of a method of creating cartilage cells from stem cells, which helped to make possible the first successful transplant of a tissue-engineered trachea, utilising the patient's own stem cells. (eurekalert.org)
  • By using a 3D printer it allows the user to tailor a scaffold structure to a patient's specific need helping to speed up the recovery of the patient. (umsystem.edu)
  • cells
  • Fed by special nutrients the cells multiply using the fibres as a scaffold to form an organ in a few weeks. (sciencephoto.com)
  • Research led by the Universities of Bristol and Liverpool has shown that it is possible to combine cells with a special scaffold to produce living tissue in the laboratory. (eurekalert.org)
  • Until now, the approach has generally been limited to growing small pieces of tissue, as larger dimensions reduce the oxygen supply to the cells in the centre. (eurekalert.org)
  • By attaching an oxygen-carrying protein, myoglobin, to the stem cells before they are used to engineer cartilage, they ensure that each cell has its own oxygen reservoir that it can access when the oxygen in the scaffold drops to dangerously low levels. (eurekalert.org)
  • The integration of living, human smooth muscle cells in biosynthesized cellulose scaffolds was monitored by nonlinear microscopy toward contractile artificial blood vessels. (spie.org)
  • We followed the cell migration into the three-dimensional structure, illustrating that while the cells submerge into the scaffold they extrude filopodia on top of the surface. (spie.org)
  • In their simplest form, these technologies allow the manufacture of scaffolds upon which cells can grow for later implantation into the body. (sciencemag.org)
  • Cells donated by the patient are expanded in culture and are then transferred to the scaffold. (sciencemag.org)
  • Both the scaffold material composition and its internal architecture (dimensions of the struts, walls, pores, or channels) control the behavior and well-being of the cells seeded inside. (sciencemag.org)
  • Multi-Layer Phase Analysis: Quantifying the Elastic Properties of Soft Tissues and Live Cells with Ultra-High-Frequency Scanning Acoustic Microscopy. (wikipedia.org)
  • It is essentially harnessing the potential of stem cells by constraining their differentiation in vitro toward a specific cell type or tissue of interest. (wikipedia.org)
  • During differentiation, pluripotent cells make a number of developmental decisions to generate first the three germ layers (ectoderm, mesoderm and endoderm) of the embryo and intermediate progenitors, followed by subsequent decisions or check points, giving rise to all the body's mature tissues. (wikipedia.org)
  • This method consists in exposing the cells to specific signaling pathways modulators and manipulating cell culture conditions (environmental or exogenous) to mimick the natural sequence of developmental decisions to produce a given cell type/tissue. (wikipedia.org)
  • To replace live tissue, either the existing cells of the body are stimulated to regrow the tissue native to the area or bioactive substances inserted in the pulp chamber. (wikipedia.org)
  • by default these tissues have new cells available to replace expended cells. (wikipedia.org)
  • More information is now known regarding the passive replacement of tissues in the human body, as well as the mechanics of stem cells. (wikipedia.org)
  • An alternative emerging method involves growing a bladder from cells taken from the patient and allowed to grow on a bladder-shaped scaffold. (wikipedia.org)
  • Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological tissues. (wikipedia.org)
  • Doris Taylor's heart in a jar Tissue-engineered airway Tissue-engineered vessels Artificial skin constructed from human skin cells embedded in a hydrogel, such as in the case of bioprinted constructs for battlefield burn repairs. (wikipedia.org)
  • Artificial bone marrow Artificial bone Laboratory-grown penis Oral mucosa tissue engineering Foreskin Tissue engineering utilizes living cells as engineering materials. (wikipedia.org)
  • Human engineered cardiac tissues (hECTs) are derived by experimental manipulation of pluripotent stem cells, such as human embryonic stem cells (hESCs) and, more recently, human induced pluripotent stem cells (hiPSCs) to differentiate into human cardiomyocytes. (wikipedia.org)
  • These tissues provide a unique in vitro model to study cardiac physiology with a species-specific advantage over cultured animal cells in experimental studies. (wikipedia.org)
  • Hutmacher
  • Hutmacher ( 1 ) gave an early analysis of the topological requirements of a suitable scaffold material and reviewed the manufacturing routes that could be used to achieve the desired structure. (sciencemag.org)
  • blood vessels
  • Play media While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin, muscle etc. (wikipedia.org)
  • He and the researchers in his lab have made advances in tissue engineering, such as the creation of engineered blood vessels and vascularized engineered muscle tissue. (wikipedia.org)
  • Furthermore
  • Furthermore, scaffolds derived from biologic tissues are more challenging to produce and can have issues related to quality control and lot-to-lot variability. (marketresearch.com)
  • Furthermore, the effect of scaffold decomposition due to immersion in simulated body fluid (SBF) on the diffusivity is addressed. (springer.com)
  • differentiation
  • Directed differentiation is a bioengineering methodology at the interface of stem cell biology, developmental biology and tissue engineering. (wikipedia.org)
  • Cell differentiation and tissue organogenesis involve a limited set of developmental signaling pathways. (wikipedia.org)
  • Directed differentiation provides a potentially unlimited and manipulable source of cell and tissues. (wikipedia.org)
  • Neural
  • Due to the limited availability of donor tissue and functional recovery in autologous nerve grafting, neural tissue engineering research has focused on the development of bioartificial nerve guidance conduits as an alternative treatment, especially for large defects. (wikipedia.org)
  • artificial
  • An artificial organ is an engineered device or tissue that is implanted or integrated into a human - interfacing with living tissue - to replace a natural organ, to duplicate or augment a specific function or functions so the patient may return to a normal life as soon as possible. (wikipedia.org)
  • polymers
  • Succinic acid also serves as the bases of certain biodegradable polymers, which are of interest in tissue engineering applications. (wikipedia.org)
  • biological
  • Decellularization is currently done by contacting xenographic tissue with a combination of chemical detergents and biological agents. (sc.edu)
  • The most basic objective of a nerve guidance conduit is to combine physical, chemical, and biological cues under conditions that will foster tissue formation. (wikipedia.org)
  • applications
  • This event will discuss the latest technologies to recreate the 3D tissue environment for medical research and therapeutic applications. (cam.ac.uk)
  • Gellan xanthan gels have been shown to be excellent carriers for growth factors and as matrices for several tissue engineering applications. (dovepress.com)
  • They may hold key applications in the fields of cancer therapy, tissue scaffolding, and protein purification. (wikipedia.org)
  • Not using solvents to process a polymer assists in tissue engineering applications where solvents are often toxic. (wikipedia.org)
  • thesis
  • A second effort in this thesis addressed the potential separation of the scaffold from the tissue (loss of apposition) due to the differences in their low strain responses. (unt.edu)
  • Developmental Biology
  • The continued success of tissue engineering, and the eventual development of true human replacement parts, will grow from the convergence of engineering and basic research advances in tissue, matrix, growth factor, stem cell, and developmental biology, as well as materials science and bio informatics. (wikipedia.org)
  • Additionally
  • Additionally, the integration of computer-assisted design and modern medical imaging allows customized designing of scaffolds. (marketresearch.com)
  • Additionally, keeping in mind the size and shape of the final tissue, the potential of the physical dimensions of the tissue of origin must be considered. (wikipedia.org)
  • grafts
  • As a proof of principle, grafts of engineered heart tissues have been implanted in rats following MI with beneficial effects on left ventricular function. (wikipedia.org)
  • material
  • The use of scaffolds in tissue engineering is associated with various limitations such as material associated infection, mechanical failure of materials, and immunogenic reactions to implanted materials. (marketresearch.com)
  • We are evaluating a novel decellularization method using liquid or supercritical carbon dioxide that will prevent tissue dehydration, remove all nuclear material from the tissue, and maintain its biochemical and mechanical integrity during the treatment process. (sc.edu)
  • To remedy this problem, a denser scaffold providing higher material concentration could be developed. (asme.org)
  • The designed scaffolds are optimized to provide spatial functionality and controlled material concentration under deformed conditions. (asme.org)
  • Scaffold-free cartilage: Cartilage generated without the use of exogenous scaffold material. (wikipedia.org)
  • therapies
  • hECTs provide a valuable resource to reproduce the normal development of human heart tissue, understand the development of human cardiovascular disease (CVD), and may lead to engineered tissue-based therapies for CVD patients. (wikipedia.org)
  • Vascularization
  • Vascularization in bone tissue engineering: physiology, current strategies, major hurdles and future challenges. (springer.com)
  • Among the major challenges now facing tissue engineering is the need for more complex functionality, as well as both functional and biomechanical stability and vascularization in laboratory-grown tissues destined for transplantation. (wikipedia.org)
  • cardiac
  • The team's findings, published today [17 June] in Nature Communications , could really expand the possibilities in tissue engineering, not only in cartilage, but also for other tissue such as cardiac muscle or bone. (eurekalert.org)
  • novel
  • The present study addresses required novel types of bone tissue engineering BG scaffolds that are derived from natural marine sponges. (springer.com)
  • Success with this project will both lead to fundamental understanding of a novel decellularization process and provide a new technology for preparing natural TE scaffolds. (sc.edu)
  • Powerful developments in the multidisciplinary field of tissue engineering have yielded a novel set of tissue replacement parts and implementation strategies. (wikipedia.org)
  • synthetic
  • Whether the conduit is in the form of a biologic tube, synthetic tube or tissue-engineered conduit, it should facilitate neurotropic and neurotrophic communication between the proximal and distal ends of the nerve gap, block external inhibitory factors, and provide a physical guidance for axonal regrowth. (wikipedia.org)