• metabolism
  • These data indicate that pharmacokinetic models for arsenic metabolism and disposition need to include mechanisms for organ-specific accumulation of some arsenicals and that urinary metabolite profiles are not necessarily reflective of target tissue dosimetry. (biomedsearch.com)
  • Expression
  • Tissue-specific expression of P450aromA and P450aromB mRNA was studied in adult sea bass. (csic.es)
  • The expression of CD97 on macrophage and the abundant presence of its ligand CD55 on fibroblast-like synovial cells suggest that the CD97-CD55 interaction is involved in the recruitment and/or retention of macrophages into the synovial tissue in rheumatoid arthritis. (wikipedia.org)
  • In brain tissue, CD97 is undetectable in normal white matter, and expression of CD55 is fairly restricted to the endothelium. (wikipedia.org)
  • dendritic cells
  • Because dendritic cells were discovered amongst "adherent" accessory cells (i.e. those that attach to tissue culture surfaces), they had to be distinguished from macrophages, whose hallmarks were persistent phagocytosis and adherence to tissue culture surfaces. (wikipedia.org)
  • Some general features of T cell responses that are initiated by dendritic cells: - adaptive immunity develops in two stages: DCs present antigens and initiate the afferent limb, while the other APC mediate the effectors to eliminate the antigen or infection - in tissue cultures, immunity develops in clusters of DC and lymphocytes. (wikipedia.org)
  • Mice
  • To test this hypothesis an interspecies comparison of the tissue distribution of $sup 35$S-labeled WR-2721 was carried out in normal mice, rats, rabbits, and dogs at 15 and 30 minutes after intravenous administration. (unt.edu)
  • lymphocytes
  • The tissue-homing of all lymphocytes involves their interactions with endothelial cells (ECs) and with various tissue accessory cells. (nih.gov)
  • rats
  • After a single dose of [ 14 C]dasatinib to pregnant Sprague-Dawley rats at gestation day 18, radioactivity was extensively distributed in maternal tissues. (aspetjournals.org)
  • The objectives of the current study were to investigate the lacteal secretion and maternal/fetal distribution of [ 14 C]dasatinib in rats after p.o. administration. (aspetjournals.org)
  • accessory cells
  • A similar importance for alpha 4 beta 1/VCAM-1 was established for the interaction between HCs and relevant tissue accessory cells. (nih.gov)
  • found
  • They are often found within tissues where they can be activated by antigen-presenting cells upon infection. (wikipedia.org)
  • TRAAK is only expressed in neuronal tissue, and can be found in the brain, spinal cord, and retina, which suggests that it has a function beyond mechanotransduction in terms of neuronal excitability. (wikipedia.org)
  • dose
  • Data originally obtained in studies using the mouse and rat indicated that the tissue distribution of WR-2721 was possibly more closely related to dose per unit surface area than to dose per unit weight. (unt.edu)
  • This document provides guidance on circumstances when repeated dose tissue distribution studies should be considered. (europa.eu)
  • responses
  • In animal models and human tissues, they act through TP to promote platelet responses and stimulate blood vessel contraction. (wikipedia.org)
  • animal
  • The rate of flipping is sufficiently rapid to suggest that this AE1-catalyzed process is physiologically important in red blood cells and possibly in other animal tissues as well. (wikipedia.org)
  • effects
  • The different duration of the cardiac and central effects of digitalis preparations may be caused by different élimination rates of both tissue compartments. (springer.com)
  • drug
  • Pre-irradiation intravenous administration of the radioprotective drug S- 2-[3-aminopropylamino]ethylphosphorothioic acid (WR-2721) has potential value in radiotherapy because it doubles the radiation resistance of normal mouse tissues while affording only minimal protection to tumors. (unt.edu)
  • study
  • The present study explores the mechanisms that underlie these tissue reactions. (nih.gov)
  • brain
  • In summary, dasatinib was extensively distributed in maternal tissues and secreted into milk, but its penetration into the adult brain was limited. (aspetjournals.org)
  • cells
  • Endothelial interactions of hairy cells: the importance of alpha 4 beta 1 in the unusual tissue distribution of the disorder. (nih.gov)
  • Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan. (wikipedia.org)