• Dosimetry
  • These data indicate that pharmacokinetic models for arsenic metabolism and disposition need to include mechanisms for organ-specific accumulation of some arsenicals and that urinary metabolite profiles are not necessarily reflective of target tissue dosimetry. (biomedsearch.com)
  • liver
  • This raises the interesting prospect of having differential modes of regulating intercellular channels within a given tissue and, at least in the case of liver, a given cell. (rupress.org)
  • The mRNA expression levels of this gene are highest in the kidney and liver, although mRNA levels have been found in many other tissues. (wikipedia.org)
  • rats
  • To test this hypothesis an interspecies comparison of the tissue distribution of $sup 35$S-labeled WR-2721 was carried out in normal mice, rats, rabbits, and dogs at 15 and 30 minutes after intravenous administration. (unt.edu)
  • After a single dose of [ 14 C]dasatinib to pregnant Sprague-Dawley rats at gestation day 18, radioactivity was extensively distributed in maternal tissues. (aspetjournals.org)
  • The objectives of the current study were to investigate the lacteal secretion and maternal/fetal distribution of [ 14 C]dasatinib in rats after p.o. administration. (aspetjournals.org)
  • In light of this, we investigated the influence of lifetime dietary VK exposure on the tissue distribution of phylloquinone (K 1 ) and menaquinone-4 (MK-4) vitamers in 3-, 12- and 22-month-old male and female rats fed different K 1 diets since weaning or subjected to a 40% calorie restricted diet (CR) since adulthood. (mdpi.com)
  • Despite lifelong higher K 1 intakes per unit body weight, tissue K 1 and MK-4 contents at 20 months were generally lower in CR rats compared to their ad libitum ( AL) counterparts. (mdpi.com)
  • The effect of Walker tumor on sulphacetamide distribution was studied in rats 21 days after tumor implantation in a hind leg. (aspetjournals.org)
  • dendritic cells
  • Because dendritic cells were discovered amongst "adherent" accessory cells (i.e. those that attach to tissue culture surfaces), they had to be distinguished from macrophages, whose hallmarks were persistent phagocytosis and adherence to tissue culture surfaces. (wikipedia.org)
  • Some general features of T cell responses that are initiated by dendritic cells: - adaptive immunity develops in two stages: DCs present antigens and initiate the afferent limb, while the other APC mediate the effectors to eliminate the antigen or infection - in tissue cultures, immunity develops in clusters of DC and lymphocytes. (wikipedia.org)
  • lymphocytes
  • The tissue-homing of all lymphocytes involves their interactions with endothelial cells (ECs) and with various tissue accessory cells. (nih.gov)
  • accessory cells
  • A similar importance for alpha 4 beta 1/VCAM-1 was established for the interaction between HCs and relevant tissue accessory cells. (nih.gov)
  • found
  • They are often found within tissues where they can be activated by antigen-presenting cells upon infection. (wikipedia.org)
  • TRAAK is only expressed in neuronal tissue, and can be found in the brain, spinal cord, and retina, which suggests that it has a function beyond mechanotransduction in terms of neuronal excitability. (wikipedia.org)
  • dose
  • Data originally obtained in studies using the mouse and rat indicated that the tissue distribution of WR-2721 was possibly more closely related to dose per unit surface area than to dose per unit weight. (unt.edu)
  • This document provides guidance on circumstances when repeated dose tissue distribution studies should be considered. (europa.eu)
  • human
  • In animal models and human tissues, they act through TP to promote platelet responses and stimulate blood vessel contraction. (wikipedia.org)
  • animal
  • The rate of flipping is sufficiently rapid to suggest that this AE1-catalyzed process is physiologically important in red blood cells and possibly in other animal tissues as well. (wikipedia.org)
  • drug
  • Pre-irradiation intravenous administration of the radioprotective drug S- 2-[3-aminopropylamino]ethylphosphorothioic acid (WR-2721) has potential value in radiotherapy because it doubles the radiation resistance of normal mouse tissues while affording only minimal protection to tumors. (unt.edu)
  • brain
  • In summary, dasatinib was extensively distributed in maternal tissues and secreted into milk, but its penetration into the adult brain was limited. (aspetjournals.org)
  • study
  • The present study explores the mechanisms that underlie these tissue reactions. (nih.gov)
  • cells
  • Endothelial interactions of hairy cells: the importance of alpha 4 beta 1 in the unusual tissue distribution of the disorder. (nih.gov)
  • Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan. (wikipedia.org)
  • content
  • Whether the lower tissue MK-4 content is the result of lower synthesis from K 1 or greater tissue utilization remains to be determined. (mdpi.com)
  • higher
  • Tissue contents of the K vitamers differed according to organs, were generally higher in females than in males, and increased with K 1 intake. (mdpi.com)