• The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear (PMN) cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. (who.int)
  • At therapeutic doses of metronidazole (4.98-24.86 μg/mL) significant inhibition of the production of reactive oxygen species was noted in both methods. (who.int)
  • The data suggest a scavenging mechanism of metronidazole on reactive oxygen species generated by PMN. (who.int)
  • 10- 14 These cardiovascular effects can potentially contribute to the worse outcomes observed with high flow oxygen therapy in myocardial infarction, 15 stroke, 16 neonatal resuscitation 17 and fulminant sepsis, 18 although the enhanced production of reactive oxygen species causing reperfusion injury may also play a role. (bmj.com)
  • Several physiological stresses including nutrient starvation, hypoxia, reactive oxygen species (ROS) production, pathogenic infections, and chemotherapy can trigger phagophore formation. (hindawi.com)
  • Provided in the diet, antioxidants neutralize reactive oxygen species (ROS, which are produced in the system during physiological processes). (aprifel.com)
  • We recently proposed that the aggregation of RB molecules (monomers) lowers the quantum yield of reactive oxygen species (ROS) molecules. (aiche.org)
  • While factors such as nitric oxide modulate HPV, reactive oxygen species (ROS) have been suggested to act as essential mediators in HPV. (ersjournals.com)
  • With intact cells, the to radiation killing compared with well formation of oxygen reactive intermediates oxygenated healthy cells [ 2,3,7-9 ]. (who.int)
  • Many mechanisms of genotoxicity/carcinogenicity for PCBs appear to involve issue of reactive oxygen species/oxidative stress , including the appearance of oxidative DNA damage. (cdc.gov)
  • For a single vessel model, the MRO 2 can be estimated in terms of the mean flow velocity, vessel crosssectional area, total concentration of hemoglobin (CHB), and the difference between the oxygen saturation (sO 2 ) of blood flowing into and out of the tissue region. (spie.org)
  • 1 We proposed that a different alignment may be preferable for clinicians in demonstrating its beneficial characteristics, enhancing both the "pick up" of oxygen despite cardiorespiratory disease and the "drop off" of oxygen to the tissues despite falling oxygen saturation (fig 1). (bmj.com)
  • Right: Oxyhaemoglobin dissociation curve realigned to demonstrate its two key characteristics: (a) haemoglobin maintains high levels of saturation despite marked reductions in oxygen tension, and (b) oxygen tension remains relatively stable as oxyhaemoglobin saturation declines. (bmj.com)
  • These characteristics result in (a) the pick up of oxygen by haemoglobin being maintained despite reduced oxygen tension, and (b) delivery of oxygen to the tissues being maintained despite progressively falling oxyhaemoglobin saturation. (bmj.com)
  • The OxiplexTS, a non-invasive tissue oximeter for the measurement of oxy- and deoxy-hemoglobin concentration in tissues, total blood volume and oxygen saturation. (iss.com)
  • By combining near-infrared spectroscopy (NIRS) monitoring of regional tissue oxygen saturation (StO(2)) with an ischemic provocation test, the vascular occlusion test (VOT), local tissue oxygen consumption and vascular reactivity at the microcirculatory level can be assessed. (rug.nl)
  • The functional biomarkers and tissue parameters deoxygenated hemoglobin, oxygenated hemoglobin, total hemoglobin, saturation of hemoglobin, fat content, and water content were analyzed in thyroid lobes affected by Graves' disease ( n = 6), thyroid lobes with healthy tissue ( n = 8), benign thyroid nodules ( n = 13), and malignant thyroid nodules ( n = 3). (snmjournals.org)
  • Tissue oxygen saturation (StO2) is the average blood oxygen saturation in a given section of tissue. (lu.se)
  • A pulse oximeter measures arterial oxygen saturation (SaO2). (lu.se)
  • In-vivo monitoring of tissue oxygen saturation using diffuse reflectance spectroscopy (DRS). Figure: Reistad 2016. (lu.se)
  • In-vivo monitoring of tissue oxygen saturation and distribution using photoacoustic imaging (PAI). (lu.se)
  • OBJECTIVES: To quantify how incremental capillary perfusion loss, such as that seen in experimental models of sepsis, affects tissue oxygenation using a computation model of oxygen transport. (uwo.ca)
  • We have used different optical techniques to study tissue oxygenation in healthy volunteers. (lu.se)
  • 3 The oxygen consumption of the mammalian retina (per gram of tissue) is nearly 50% greater than that of the kidney, three times greater than the cerebral cortex and six times that of cardiac muscle. (arn.org)
  • 4 Moreover, because most of the metabolic activity of the retina is concentrated in the photoreceptor layer 5 --comprising less than half of the total mass of the retina--it is clear that the oxygen demands (per gram of tissue) of the photoreceptors are comparatively greater than such whole retinal estimates imply. (arn.org)
  • Regardless, the impaired oxygen delivery at the tissue level results in depressed cellular respiration and potential organ dysfunction. (bmj.com)
  • CONCLUSIONS: These results suggest a substantial increase in total SR is required in order to compensate for impaired oxygen delivery as a result of loss of capillary perfusion and increased oxygen consumption during sepsis. (uwo.ca)
  • There was an increase in the tissue content of neutral mucins in animals treated with curcumin at a concentration of 50 mg/kg/day for four weeks, whereas in the group treated with 200 mg/kg/day there was an increase independent of the time of intervention. (scielo.br)
  • It is believed that a signifi cant effect of blueberry consumption compared with red grapes fruit on plasma TAC increase may be due to the higher concentration of anthocyanin in these fruits. (aprifel.com)
  • Notably, we utilized a fluorescence-based oxygen sensor to monitor the concentration of molecular oxygen in real-time. (aiche.org)
  • It is a rising concentration of carbon dioxide - not a declining concentration of oxygen - that plays the major role in regulating the ventilation of the lungs. (oilsandplants.com)
  • CONCLUSIONS: Our results indicate that an intermediate vascular density region exists where enhanced blood oxygen concentration may be beneficial for radiation response. (lu.se)
  • Functional capillary density (FCD) loss was applied incrementally up to ~40% and combined with high tissue oxygen consumption to simulate severe sepsis. (uwo.ca)
  • The digestive tract begins to break down carbohydrates into glucose, which is used for energy upon consumption. (nih.gov)
  • Any extra glucose in the bloodstream is stored in the liver and muscle tissue until further energy is needed. (nih.gov)
  • Mesenchymal stem cells (MSCs) are the most commonly used cells in tissue engineering and regenerative medicine. (frontiersin.org)
  • Impact of Incremental Perfusion Loss on Oxygen Transport in a Capillary Network Mathematical Model. (uwo.ca)
  • The oxygen sensing and signal transduction machinery is located in the pulmonary arterial smooth muscle cells (PASMCs) of the pre-capillary vessels, albeit the physiological response may be modulated in vivo by the endothelium. (ersjournals.com)
  • The ease with which oxygen and carbon dioxide can pass between air and blood is clear from this electron micrograph of two alveoli (Air) and an adjacent capillary from the lung of a laboratory mouse. (oilsandplants.com)
  • As tissues consume oxygen to produce energy, haemoglobin in the local capillary blood supply is stimulated to release its bound oxygen. (lu.se)
  • They compared the effect on oxygen consumption (VO2) and substrate utilization, estimated by the respiratory-exchange ratio (RER), in 8 healthy young men who performed the same moderate-intensity training session (36 min of cardiovascular training on treadmill at 65% maximum heart rate) in the morning in 2 tests in random sequence: FST test (fasting condition) without any food intake or FED test (feeding condition) after breakfast. (nih.gov)
  • High flow oxygen was shown to result in worsening ventilation-perfusion mismatch due to absorption atelectasis and inhibition of reflex pulmonary vasoconstriction. (bmj.com)
  • The goal of management is early recognition in order to restore tissue perfusion and thereby prevent progression to multisystem organ failure and death. (medscape.com)
  • Impact of Incremental Perfusion Loss on Oxygen Transport in a Capillar" by Graham M Fraser, Michael D Sharpe et al. (uwo.ca)
  • The steady-state oxygen tension field of the tumor was calculated by iteratively employing Green's function method for diffusion and the Michaelis-Menten model for consumption. (lu.se)
  • It was hoped that, through a different perspective of the haemoglobin oxygen dissociation curve, it might be possible to overcome the ingrained practice of doctors, nurses and paramedics to prescribe high flow oxygen to breathless patients who do not necessarily have arterial hypoxaemia. (bmj.com)
  • Paradoxically, high flow oxygen in excess of that required to relieve arterial hypoxaemia may cause a reversible decrease in oxygen consumption. (bmj.com)
  • These adverse effects are not widely known and high flow oxygen is widely prescribed to breathless patients, regardless of the presence of arterial hypoxaemia. (bmj.com)
  • A person with excellent arterial oxygen supply could have a region of poorly perfused tissue that becomes necrotic. (lu.se)
  • However, it does not necessarily relate to local tissue health. (lu.se)
  • The fate of these residues, whether excreted without causing harm, or converted to metabolites that are toxic, or if bound covalently to tissues, is unknown. (cdc.gov)
  • 19 This effect is likely to be due to maldistribution of blood flow, with functional shunting to protect the vital organs from non-physiological effects of high oxygen tension. (bmj.com)
  • Conclusion: EVOO consumption reduced body fat and improved blood pressure. (researchgate.net)
  • Antioxidant compounds provided with the diet improve total antioxidant capacity of human blood and tissues. (aprifel.com)
  • The last one with direct transferrable results for human health is the oxygen radical absorbance capacity (ORAC) technique, which is also an effective method for measuring TAC of human blood plasma 2 . (aprifel.com)
  • Increasing red blood cell supply rate (SR) to baseline levels returned tissue PO2 to within 5% of baseline. (uwo.ca)
  • This is because consumption of alcohol before sleeping tends to relax the throat muscles and negatively affect the brain's breathing center by reducing the oxygen levels in the blood and even causing possible tissue damage. (home-remedies-for-you.com)
  • On the basis of the analysis of mean PaCO2,ETCO2,PjCO2, and core temperature it may be claimed that there is no significant influence of these parameters upon cerebral blood flow and oxygen consumption by cerebral tissue. (medscimonit.com)
  • IHT increases the hypoxic ventilatory response (meaning it helps you get more oxygen when you really need it), increases red blood cell count, and increases your aerobic capacity. (doctorshealthpress.com)
  • Oxygen is taken into the body through the airways, absorbed into the lungs, then transported through the body in the blood. (oilsandplants.com)
  • Since noroviruses attach to carbohydrates of the histo-blood group family, tests using immunohistochemical analysis were performed to evaluate specific binding of virus or viruslike particles to oyster tissues through these ligands. (cdc.gov)
  • Since noroviruses can attach to carbohydrates of the ABH and Lewis histo-blood group family in humans, we also examined the possibility of a similar specific binding to oyster tissues through related carbohydrates ( 17 , 18 ). (cdc.gov)
  • This increase occurs after consumption of larger portions of fruits of at least 200g. (aprifel.com)
  • In either case, reinflation occurs as the air is gradually absorbed by the tissues. (oilsandplants.com)
  • For childhood neoplasms, it is safe to assume that cancer is the product of degeneration in a neoplastic sense of tissues undergoing very rapid proliferation and differentiation, in which proliferative and differentiative programs are being disturbed by increasingly early (maternal-fetal) exposure to a growing number of environmental stressors and pollutants. (frontiersin.org)
  • Even in patients with exacerbations of chronic obstructive pulmonary disease in respiratory failure, the risks of high flow oxygen therapy are often not recognised. (bmj.com)
  • The potential adverse pulmonary effects of high flow oxygen therapy were recognised soon after its widespread use in clinical practice. (bmj.com)
  • Perhaps the least recognised risk with high flow oxygen is that its use may lead to a delay in the ability to recognise and treat a progressive deterioration in pulmonary function. (bmj.com)
  • Products such as paper, tissue, and eco-friendly packing material, are supported by oxygen injection to speed up the delignification of pulp, increases lime kiln capacity and reduces consumption of expensive bleaching chemicals, all to enable efficient and quality production. (atlascopco.com)
  • 7, 8 These effects may contribute to the reduction in lung volumes and decreased transfer factor observed with high flow oxygen. (bmj.com)
  • We will now further study and develop tissue oximetry technology to gain real-time readings of StO2 in localized volumes of tissue. (lu.se)
  • The goal of this study was to explore the regulatory mechanism of trehalose on the autophagy death of SHSY5Y cells induced by oxygen and sugar deprivation from the aspect of glycolysis. (ijpsonline.com)
  • These molecules contain carbon, hydrogen, and oxygen atoms. (nih.gov)
  • Photochemical tissue bonding (PTB) of wounds and surgical incisions relies on the use of photosensitive molecules and light to induce the formation of covalent linkages in collagenous tissue. (aiche.org)
  • Oxygen nanobubbles (ONB) have been implicated in enhancement of oxygen delivery to a variety of tissues. (wku.edu)
  • For each oxygen distribution, the oxygen enhancement ratio (OER) was calculated and the mean absorbed dose at which the tumor control probability (TCP) was 0.99 (D(99)) was determined using the linear-quadratic cell survival model (LQ model). (lu.se)
  • In a recent commentary we argued that the traditional representation of the haemoglobin oxygen dissociation curve developed by physiologists may be disconcerting for clinicians because of the prominence of the steep slope of oxygen desaturation with falling oxygen tension. (bmj.com)
  • Since phosphocreatine resynthesis is largely limited by oxidative ATP production, ONBs may serve as a means to improve oxygen delivery and recovery during anaerobic exercise. (wku.edu)
  • On-site oxygen production is essential for the pulp and paper industry. (atlascopco.com)
  • be it vitality, tissue and hormone manufacturing, antibodies from the immune system production and normalize bodily capabilities. (songsforamerica.net)
  • Air is taken in via the upper airways (the nasal cavity, pharynx and larynx) through the lower airways (trachea, primary bronchi and bronchial tree) and into the small bronchioles and alveoli within the lung tissue. (oilsandplants.com)
  • Shock is a life-threatening condition that results in a mismatch between oxygen supply and demand, leading to end-organ ischemia. (medscape.com)
  • RESULTS: A loss of ~40% FCD loss decreased median tissue PO2 to 22.9 and 20.1 mmHg in NI and NII compared to 28.1 and 27.5 mmHg under resting conditions. (uwo.ca)
  • RESULTS: Decreased pO(2) shifted the oxygen distribution to lower values, whereas decreased vessel density caused the distribution to widen and shift to lower values. (lu.se)
  • In the perioperative phase oxygen delivery and consumption can be influenced by different factors, i.e. type of surgery, anesthetic and cardiovascular drugs, or fluids. (rug.nl)
  • Blockade of transport receptors may alter tissue exposure (eg, diuresis from blockade of adenosine A1 receptors, such as with aminophylline, may decrease exposure). (msdmanuals.com)
  • Cancer, Cirrhosis of the liver, pancreatitis, heart diseases are some of the common long term diseases caused by continuous and excessive consumption of alcohol . (home-remedies-for-you.com)
  • Human exposure to PCB degradation products and metabolites (these compounds are not well studied but are found in human tissues and in the environment). (cdc.gov)
  • Human SH-SY5Y cells were divided into three groups includes control group (control), model group (oxygen and sugar deprivation) and experimental group (oxygen and sugar deprivation+trehalose). (ijpsonline.com)
  • Increased consumption of fruits and vegetables is considered as closely related to protection of human health and wellbeing. (aprifel.com)
  • Human system benefi ts from fruit and vegetables, the intake of which is also related with anti-nutrients such as the consumption of low-molecular antioxidant substances. (aprifel.com)
  • Research suggests that the possibility of human plasma antioxidant defences can be intensively increased in response to the consumption of certain types of fruits. (aprifel.com)
  • 1994. Polychlorinated biphenyls, 1,1,1-trichloro-2,2 bis(p-chlorophenyl)ethane (p,p'-DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) in human plasma related to fish consumption. (cdc.gov)
  • These data show that the oyster can selectively concentrate a human pathogen and that conventional depuration will not eliminate noroviruses from oyster tissue. (cdc.gov)
  • Radiosensitizers are chemical agents that have the potential to increase the lethal effect of radicals induced during irradiation [1-6].The extent of radiation damage to cells is dependent on the amount of oxygen available to the cell [1,2,7,8]. (who.int)
  • Vigorous exercise can increase by 20-25 times the demand of the tissues for oxygen. (oilsandplants.com)
  • It also was shown that consumption of sweet Bing cherries has a clear effect on plasma TAC. (aprifel.com)
  • The most pronounced radiation effect of increased pO(2) occurred with tumor tissue with 50% of the maximum vessel density used in the simulations. (lu.se)
  • Trehalose can reduce the damage of SH-SY5Y cells caused by oxygen and sugar deprivation. (ijpsonline.com)
  • However, consideration of the very high energy demands of the photoreceptor cells in the vertebrate retina suggests that rather than being a challenge to teleology the curious inverted design of the vertebrate retina may in fact represent a unique solution to the problem of providing the highly active photoreceptor cells of higher vertebrates with copious quantities of oxygen and nutrients. (arn.org)
  • Regular consumption of the oxygen in Kaqun water facilitates the ongoing repair and regeneration of your cells. (bodyhealth.com)
  • This pilot study showed the applicability and the potential of hybrid multispectral optoacoustic tomography/ultrasound to semiquantitatively provide tissue characterization and functional parameters in thyroid disorders for improved noninvasive diagnostics of thyroid diseases. (snmjournals.org)
  • The most popular description in scientifi c literature related to antioxidant activity is total antioxidant activity (TAC) which determines the ability of substance, materials, food to neutralize oxygen-free radical specific form, irrespectively to specific antioxidant activity of present antioxidants1. (aprifel.com)
  • median tissue PO2 was recovered to baseline levels by increasing total SR 3 - 4 fold. (uwo.ca)
  • In vivo experiments confirmed mitochondrial abundance and mitochondrial oxygen consumption rates were elevated in host tissues following MSC treatment. (frontiersin.org)
  • 2 This amplification process requires vast quantities of metabolic energy and consequently the photoreceptor layer has one of the highest metabolic rates of any known tissue. (arn.org)
  • We confirmed that the RB/HP-γ-CD host-guest complex yields the fastest photobleaching and oxygen consumption rates. (aiche.org)
  • In the present study, we examine the specific impacts of MSCs on mitochondrial morphology and function in host tissues. (frontiersin.org)
  • The first state is known as Slow wave sleep (SWS) and the second state is known as Rapid Eye Movement sleep (REM).Consumption of alcohol 30 to 60 minutes before sleeping is known to hamper one's sleep patterns, duration of sleep and even sequence of sleep. (home-remedies-for-you.com)
  • People who are not snorers tend to snore after consumption of alcohol just before sleeping. (home-remedies-for-you.com)
  • People who experience sleep problems are often experienced by people may minimize their alcohol consumption. (home-remedies-for-you.com)
  • Consumption of alcohol before sleeping is particularly dangerous for elderly people as it may make them disoriented and unsteady is if they try to walk during the night. (home-remedies-for-you.com)
  • Extreme consumption of alcohol is also known to hamper the functioning of the calcium channels in the thalamus which is that part of the brain that deals with sleep. (home-remedies-for-you.com)
  • There has always been a direct connection between consumption of alcohol and sleep. (home-remedies-for-you.com)
  • 2- 4 However, such a change of long established practice would also require a recognition of the risks of inappropriate high flow oxygen therapy. (bmj.com)
  • as a result, toxic agents are delivered at a rate 50 times that of other tissues and in much higher concentrations. (msdmanuals.com)