Antibodies are the key components of immune system that bind to specific markers on cells or tissues, thereby offering first line of defense against multiple disorders. (digitalshivamsharma.com)
Histopathologic analysis of the immuno-PET-positive lymph nodes revealed the presence of grossly metastasized ovarian cancer cells within the lymphoid tissues. (snmjournals.org)
The magnitude of an antiviral CTL response is thought to be controlled by the initiation of a cell cycle program within lymphoid tissues. (ox.ac.uk)
Cytotoxic3
Cancer-stroma targeting therapy by cytotoxic immunoconjugate bound to the collagen 4 network in the tumor tissue. (ucsd.edu)
A poignant reminder here was the disastrous peripheral nerve damage experienced by women with breast cancer treated with a ricin A chain-based immunotoxin which unexpectedly also targeted nervous tissue.4 The most sensitive in vitro method for determining the selective cytotoxic potency of saporin-based immunotoxins is by measuring their ability to selectively inhibit protein synthesis in antigen-expressing cell lines in a dose-dependent manner. (atsbio.com)
Graft rejection1
It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (lookformedical.com)
Mice2
A single i.v. injection of the radiotracer into tumor-bearing mice revealed a time dependent and specific localization of [(125)I]-SHPP-VG76e to the tumor tissue. (ox.ac.uk)
INTRODUCTION: Our objective was to evaluate the tumor and normal tissue distribution and nuclear importation properties of [(111)In]-mouse IgG (mIgG) conjugated to tat peptides (GRKKRRQRRRPPQGYG) in athymic mice with subcutaneous BT-474 human breast cancer xenografts. (ox.ac.uk)
Monoclonal1
Human tissue/Mouse monoclonal antibody to a Human tissue constituent/anti Mouse Ig isotype-specific immunoconjugate. (nordicmubio.com)
Tumors4
CONCLUSION: [(111)In]-labeled tat immunoconjugates may have potential for imaging intracellular epitopes or localized Auger electron radiotherapy of tumors. (ox.ac.uk)
This invention includes pharmaceutical compositions, methods and kits for the treatment or diagnosis of a malignant tumors, including brain tumors, and diseases or disorders characterized by abnormal brain tissue. (patsnap.com)
The induction of prolonged survival and growth of allografts of either tumors or normal tissues which would ordinarily be rejected. (lookformedical.com)
A potential disadvantage of BCMA is that soluble BCMA can be released or shed from tumors into the the surrounding tissues and into the circulation. (biomedcentral.com)
Antibody1
The absence of the Fc domain in the conjugate ensures minimal interaction with the tissue components and cell surfaces other than the primary antibody activity. (exalpha.com)
Specificity1
Previous studies in our laboratory described the in vitro cytotoxicity and specificity of an immunoconjugate composed of mAb ZME-018 and the plant toxin gelonin. (houstonmethodist.org)
Antigen2
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is a glycoprotein that has limited expression in normal adult tissues, but is overexpressed in carcinomas of the gastrointestinal tract, the genitourinary and respiratory systems, and breast cancer. (nih.gov)
Tolcher AW, Ochoa L, Hammond LA et al (2003) Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study. (springer.com)
Intracellular2
Direct staining of fixed cell and tissue substrates, to demonstrate the intracellular presence of IgG. (exalpha.com)
Desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA and results in either gene transcription or gene repression. (medindex.am)
Vitro1
The development of such therapeutic molecules required robust preclinical investigations to determine their toxicity profiles in animals, the normal tissue-binding specificities, and to demonstrate their selective anti-tumor activity both in vitro and in vivo. (atsbio.com)
Soft tissue5
Eight patients with occult metastatic prostate cancer following radical prostatectomy as evidenced solely by a rising serum PSA and evidence of soft tissue lesions outside the prostatic fossa detected by an [ 111 I]indium capromab pendetide scan received an infusion of 10 mg of capromab pendetide labeled with 9 mCi/m 2 of [ 90 Y]yttrium. (elsevierpure.com)
To determine the objective response rate by RECIST 1.1 criteria among patients with measurable soft tissue by RECIST 1.1 criteria at baseline. (ucsf.edu)
A maxillofacial and brain CT scan revealed bilateral destructive soft tissue masses in the region of the maxillary sinuses. (contemporarypediatrics.com)
Bilateral circumferential soft tissue densities were seen in the extraconal regions of the orbit with severe proptosis. (contemporarypediatrics.com)
The biopsy specimen from the right maxillary sinus showed soft tissue infiltration with myeloid leukemic cells, consistent with a chloroma. (contemporarypediatrics.com)
Therapy1
Tailored immunoconjugate therapy depending on a quantity of tumor stroma. (ucsd.edu)
Normal6
Invasion and metastasis of malignant epithelial cells into normal tissues is accompanied by adaptive changes in the mesenchyme-derived supporting stroma of the target organs. (aacrjournals.org)
This immunoconjugate is not species-specific since inter-species cross-reactivity is a normal feature of antisera to immunoglobulins. (nordicmubio.com)
What sets OXS-1550 (DT2219ARL) apart from other treatments, such as chemotherapy, is that it is designed to specifically target and kill cancer cells while minimizing damage to normal tissues. (gtbiopharma.com)
METHODS: Tumor and normal tissue uptake was compared after intravenous (iv) or intratumoral injection of [(111)In]-mIgG-tat and [(111)In]-mIgG. (ox.ac.uk)
RESULTS: [(111)In]-mIgG-tat was eliminated from the blood and normal tissues two- to threefold more rapidly after iv injection than [(111)In]-mIgG. (ox.ac.uk)
A major challenge in the construction of targeted toxins is reducing the nonspecific binding of the toxin moiety to normal tissues and increasing the cytotoxicity of the treatment. (nih.gov)
Vivo1
Complement activation in vivo implies active disease and may contribute to the elicitation of the pathogenesis and he extent of tissue destruction. (nordicmubio.com)
Therapeutic1
We have performed extensive preclinical studies evaluating the therapeutic potential and optimizing the regimen of dosing photo-immunoconjugates including with cancer stem cells. (nih.gov)
Transplantation1
One attractive strategy to prevent or control allograft rejection is to genetically modify the donor tissue before transplantation. (ox.ac.uk)
Metastasis1
Cell and tissue interactions in carcinogenesis and metastasis and their clinical significance. (ucsd.edu)
Protein1
Large-scale inference of protein tissue origin in gram-positive sepsis plasma using quantitative targeted proteomics. (lu.se)
Donor1
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
Toxicity1
We conclude that radioimmunotherapy for occult metastatic prostate cancer using 90 Y- capromab-pendetide at the dose described does not lower serum PSA, is associated with significant hematologic toxicity, and leads to complexation of the immunoconjugate following subsequent capromab pendetide infusion. (elsevierpure.com)
Demonstrate1
We demonstrate that antiviral CTLs remain in cell cycle while transiting to infected tissues. (ox.ac.uk)
Gene1
Similar gene-based strategies might also be feasible to prevent rejection of other transplanted tissues or organs. (ox.ac.uk)
Cells3
The present invention provides systems, methods, and compositions for targeted delivery of nanoparticles and/or agents to tissues, cells, and/or subcellular locales. (patsnap.com)
Dehio C. Bartonella interactions with en- areas such as shepherds ( 1 ) and farm- may be a natural marine reservoir for dothelial cells and erythrocytes. (cdc.gov)
BCMA is not present in other hematological cells like hematopoietic stem cells or other tissues. (biomedcentral.com)
Patients1
To evaluate the immune-related tissue and blood biomarkers for complete pathological response in patients with stage II-III HER2+ BC receiving neoadjuvant chemotherapy. (ucsd.edu)
Bind1
We could circumvent this background signal by choosing to image body spaces, such as the peritoneum, in which the targeted tissue would bind the agent and fluoresce but the unbound probe would be absorbed rapidly and exit the space, leading to high tumor-to-background ratios. (nih.gov)
Clinical1
We patented NIR-PIT and soon licensed it to the Aspyrian Therapeuctics Inc., a small biotech startup in San Diego, and helped them to start a first-in-human Phase I clinical trial in inoperable head and neck cancer using the photo-immunoconjugate cetuximab-IR700 beginning in mid-2015 (RM-1929). (nih.gov)
Cell1
Riechelmann H, Sauter A, Golze W et al (2008) Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma. (springer.com)
Blood1
OXS-1550 uses a proprietary immunoconjugate platform technology as a treatment for leukemia and other blood-born cancers. (gtbiopharma.com)
Plasma1
Pharmacokinetic studies of 125 I-labeled ZME-018 and ZME-gelonin demonstrated a shorter terminal-phase plasma half-life of the immunoconjugate than native ZME (20.6 h compared to 41.3 h). (houstonmethodist.org)
Components1
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. (lookformedical.com)
Activity1
This agent also exhibits antiproliferative activity in endometrial tissue and may exhibit chemopreventive and antineoplastic activities in endometrial carcinoma. (medindex.am)