• The two main types of stromal tumors are Leydig cell tumors and Sertoli cell tumors. (medlineplus.gov)
  • Stromal tumors usually occur during childhood. (medlineplus.gov)
  • Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
  • Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
  • Ovarian stromal tumors develop in the ovaries' structural connective tissue cells that produce the female hormones estrogen and progesterone. (moffitt.org)
  • however, stromal tumors represent only about 1% of all ovarian cancers. (moffitt.org)
  • This type of cancer is more prevalent in women over the age of 50, but roughly 5% of ovarian stromal tumors form in young girls. (moffitt.org)
  • Because stromal tumors develop in the ovarian cells that produce female hormones, the tumors often end up producing estrogen, which can result in abnormal vaginal bleeding. (moffitt.org)
  • Sometimes, ovarian stromal tumors can actually produce male hormones, which could cause regular menstruation to stop, or superfluous facial and body hair to grow or enlarge the clitoris. (moffitt.org)
  • Stromal tumors may be benign (noncancerous) or malignant (cancerous). (moffitt.org)
  • Thecomas and fibromas are examples of benign stromal tumors. (moffitt.org)
  • Moffitt's Gynecologic Oncology Program is home to a multispecialty team of surgeons, medical oncologists, reproductive endocrinologists and many other professionals, who specialize in treating all types of ovarian cancer , including stromal tumors. (moffitt.org)
  • But generally speaking, ovarian stromal tumors are frequently discovered early and can be surgically treated. (moffitt.org)
  • To speak with a Moffitt oncologist specializing in the treatment of ovarian stromal tumors, call 1-888-663-3488 or complete our new patient registration form online. (moffitt.org)
  • Finally, elevation of serum AMH above normal male prepubertal levels may be indicative of rare cases of sex-cord stromal tumors or Sertoli cell-limited disturbance in the McCune Albright syndrome. (biomedcentral.com)
  • Testicular germ cell cancers in young adult men derive from a precursor lesion called carcinoma in situ (CIS) of the testis. (ku.dk)
  • The term "ovarian cancer" is often used to describe cancers that begin in the cells in the ovary, fallopian tube, or peritoneum. (cancer.net)
  • These cancers grow from germ cells, the cells that make sperm. (medlineplus.gov)
  • The disease-free survival rate for Stage II and III cancers is slightly lower, depending on the size of the tumor and when treatment is begun. (medlineplus.gov)
  • Most of the testicular cancers arise from germinal cell tumors and spread rapidly. (planetayurveda.net)
  • Greater than 95%of testicular cancers start with germ cells. (planetayurveda.net)
  • These Are the less developed cancers with cells that appear like embryos in their early stages. (planetayurveda.net)
  • Testicular cancers are malignant tumors that form in one or both testes . (osmosis.org)
  • Germ cell testicular cancers come from germ cells that normally develop into sperm . (osmosis.org)
  • Non-germ cell testicular cancers come from the Sertoli cells or the Leydig cells which can secrete excess sex hormones . (osmosis.org)
  • There are also rare testicular cancers from cells that support other roles. (horizonhospital.org)
  • Tumors or cancers of the KIDNEY. (lookformedical.com)
  • Our data are in line with the idea that CIS cells may be gonocytes that survived in the postnatal testis. (ku.dk)
  • We speculate that disturbed development of somatic cells in the fetal testis may play a role in allowing undifferentiated cells to survive in the postnatal testes. (ku.dk)
  • Tumor formation generally start in cells in leydig cells in the testis that normally make male sex hormones. (planetayurveda.net)
  • Sertoli cells are supportive cells that provide nutrients to developing sperm cells, and contribute to the blood-testis barrier by only allowing certain molecules, like testosterone , into the seminiferous tubules . (osmosis.org)
  • Testicular cancer also called Germ Cell Tumour most commonly presents with a painless lump/swelling in the testis. (horizonhospital.org)
  • In the interstitial tissue, Leydig cells synthesize androgens and the insulin-like factor 3 (INSL3) [ 3 ], whereas in the seminiferous tubules, Sertoli cells regulate the nutrients and factors that reach the germ cells by means of the blood-testis barrier. (biomedcentral.com)
  • We determined the expression of components of the ECS in the human fetal testis from 6 to 17 developmental weeks and assessed the direct effects of phytocannabinoids Δ9-trans-tetrahydrocannabinol (THC) and cannabidiol (CBD) on the testis morphology and cell functions ex vivo. (biomedcentral.com)
  • Depending on the molecules and testis age, highly deleterious effects of phytocannabinoid exposure were observed on testis tissue after 14 days, including Sertoli and germ cell death. (biomedcentral.com)
  • The testis was considered to be a thyroid hormone unresponsive tissue [ 3 ]. (hindawi.com)
  • particularly the Sertoli cells, which play a major role in spermatogenesis and are the main cell type in the testis which expresses T 3 receptors [ 16 ]. (hindawi.com)
  • It is well established that the formation of normal numbers of Sertoli cells is a key factor in determining testis size, germ cell numbers per testis, and sperm production rate in adulthood in a range of mammals, including humans [ 17 ]. (hindawi.com)
  • At the termination of experiments the testis were fixed and stained with H&E. There was degeneration of germ cells with increase in capsular wall thickness of testis, and leydig cell depletion and sertoli cell depletion in seminiferous tubules. (ijmhr.org)
  • The immunohistological and ultrastructural features of the human testis with emphasis upon the process of spermatogenesis and the cytology of the Leydig cells were reviewed in this study. (ac.ir)
  • The present study also has its future implications in staging of cancer metastasis in the patients with Seminoma Testis and Leydig Cell Tumors and also in future xenografting of testicular tissue from an infant human donor. (ac.ir)
  • The testis tissue samples from aborted human fetuses of various weeks of gestation were taken and then subjected to immunohistochemistry by Ki-67 antibodies and also to Scanning Electron Microscopy and Transmission Electron Microscopy. (ac.ir)
  • 2. Miething A. Arrested germ cell divisions in the ageing human testis. (ac.ir)
  • 12. Richardson LL, Kleinman HK, Dym M. Altered basement membrane synthesis in the testis after tissue injury. (ac.ir)
  • Cell biology of Leydig cells in the testis. (ac.ir)
  • Additionally, testicular and ovarian tissue may develop on the same side of the pelvis as a separate ovary and testis. (medscape.com)
  • Giant cell formation in the testis, which is usually accompanies germinal celldegeneration/atrophy was observed at the dose of 50 mg/kg and above. (europa.eu)
  • Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)
  • Because the surfaces of the ovaries, the lining of the fallopian tubes, and the covering cells of the peritoneum are made up of the same types of cells, most of these diseases look alike under a microscope. (cancer.net)
  • There are many types of tumors that can start in the ovaries. (news-medical.net)
  • Stage IB - Growth is limited to both ovaries without any tumor on their outer surfaces. (news-medical.net)
  • Ovarian cancer describes cancer in women that begins in the different cells of the ovaries (they produce eggs), fallopian tubes or peritoneum, which determines the type of ovarian cancer. (uchealth.org)
  • A thin, lighted tube through which your doctor can look at your ovaries and other pelvic organs and tissues in the area. (uchealth.org)
  • In stage I of the ovarian carcinoma, the tumour is localised in one or both of the ovaries. (cancertame.com)
  • Germ cell ovarian tumour arises from the germ cells (the cells that give rise to ovaries during the foetal development). (cancertame.com)
  • In stage I, a germ cell ovarian tumour is localised to one or both ovaries. (cancertame.com)
  • The presence of advanced ovarian cancer is often suspected on clinical grounds, but it can be confirmed only pathologically by removal of the ovaries or, when the disease is advanced, by sampling tissue or ascitic fluid. (medscape.com)
  • Primordial follicles of adult ovaries did not contain STAR, whereas antral follicles stained intensely in the thecal layer, with occasional staining of granulosa cells. (elsevierpure.com)
  • Fetal ovaries contained sporadic stromal cells displaying intense StAR staining, particularly in the hilar region. (elsevierpure.com)
  • The ovaries consist of different types of tissue ( epithelial , germ cells, and sex cord tissue), which may give rise to benign or malignant tumors . (amboss.com)
  • Ovarian tumors are cancerous growths that form on a woman's ovaries. (knowcancer.com)
  • Most of the tumors are believed to form on the surface of the ovaries, although there is some evidence indicating that they can also form on the fallopian tubes. (knowcancer.com)
  • Egg cells are stored in small follicles (vesicles) in the ovaries. (brusselsoncofertility.be)
  • If your lower abdomen is irradiated, the ovaries (containing the egg cells) and the womb will also become damaged. (brusselsoncofertility.be)
  • Cancerous tumors from several organ systems, such as gastrointestinal and female genital tract, could spread to the ovaries [2]. (symptoma.com)
  • Lymphatic spread of tumor is faster and more common from the stomach to the ovaries than from the colon while the vascular spread is higher from the colon than from the stomach [2]. (symptoma.com)
  • Krukenberg tumors are associated with bilateral, asymmetrical enlargement of the ovaries without peritoneal adhesions and deposits while metastases from other tumors are embedded within the ovarian capsule or in the peritoneum [1]. (symptoma.com)
  • The National Comprehensive Cancer Network (NCCN) guidelines recommend initial staging for both seminomas and nonseminoma germ cell tumors with contrast-enhanced CT scan of the abdomen and pelvis. (medscape.com)
  • These germ cell tumors are divided into seminomas and nonseminomas. (planetayurveda.net)
  • Their five main subtypes include seminomas, teratomas , yolk sac tumors or endodermal sinus tumors, choriocarcinoma or placental tissue tumors, and embryonal carcinomas. (osmosis.org)
  • These produce the spermatozoa and give rise to two types of tumors: seminomas and non-seminomas. (steptohealth.com)
  • Non-seminomas - There are a few types of non-seminomas: choriocarcinoma, embryonal carcinoma, teratoma and yolk sac tumors. (horizonhospital.org)
  • Seminomas and testicular germ cell tumors were negative. (elsevierpure.com)
  • A seminiferous tubule has a thick wall of epithelial cells that surround a fluid-filled lumen, a bit like a garden hose. (osmosis.org)
  • This intermediate (I)-ProSG subset translocates from the center of seminiferous tubules to the spermatogonial stem cell (SSC) 'niche' in its periphery soon after birth. (biologists.com)
  • In the ultrastructural study, it is shown that the seminiferous epithelium is structurally partitioned by the Sertoli cells into basal and adluminal compartments via the specialized tight junctions between the Sertoli cells. (ac.ir)
  • Degeneration and hyalinization of the seminiferous tubules with poor germ cell development is frequently observed. (medscape.com)
  • In stage II, the tumour spreads to the uterus, fallopian tubes and other tissues within the pelvis. (cancertame.com)
  • By definition, serous tumors are characterized by a proliferation of epithelium resembling that lining the fallopian tubes. (medscape.com)
  • While sperm production has classically been the focus of adult reproductive function, somatic cells are crucial for the maintenance of spermatogenesis and gamete production. (biomedcentral.com)
  • Sertoli cells not only regulate the inflow of external substances, but also produce several substances which are critical to the proper progression of spermatogenesis [ 4 ]. (biomedcentral.com)
  • A complete in vitro spermatogenesis has been obtained from mouse prepubertal testicular tissue, although with low efficiency. (elifesciences.org)
  • In vitro spermatogenesis could indeed be proposed to patients with testicular localization of residual tumor cells, for whom testicular tissue autografting is not indicated (about 30% of patients with acute leukemia). (elifesciences.org)
  • Piperine stimulates pubertal Leydig cell development by increasing Leydig cell number and promoting its maturation while it inhibits spermatogenesis in the rat. (frontiersin.org)
  • A tumor can be cancerous or benign. (cancer.net)
  • A cancerous tumor is malignant, meaning it can grow, invade, and spread to other parts of the body. (cancer.net)
  • Ovarian tumors are named according to the type of cells the tumor started from and whether the tumor is benign or cancerous. (news-medical.net)
  • Cancerous epithelial tumors are carcinomas. (news-medical.net)
  • A benign tumor means the tumor can grow but will not spread. (cancer.net)
  • Some are benign, or noncancerous, and the patient can be cured by surgically removing one ovary or the part of the ovary containing the tumor. (news-medical.net)
  • Most epithelial ovarian tumors are benign. (news-medical.net)
  • There are several types of benign epithelial tumors, including serous adenomas, mucinous adenomas, and Brenner tumors. (news-medical.net)
  • Most tumors originating in these cells are benign. (steptohealth.com)
  • As in the previous case, most tumors are benign, but if they aren't, they do not have a good prognosis. (steptohealth.com)
  • A 2-year interim analysis from the International Ovarian Tumor Analysis Phase 5 (IOTA5) study showed that 80% of ovarian cysts considered benign on ultrasonography either disappeared or required no intervention. (medscape.com)
  • One third of all ovarian tumors are serous, and two thirds of these serous tumors are benign. (medscape.com)
  • Of these tumors, 75% are benign and are found in women aged 30-50 years. (medscape.com)
  • Nephrogenic rests, benign foci of embryonal kidney cells that persist abnormally into postnatal life, are considered to be Wilms tumor precursors. (nih.gov)
  • these are called borderline tumors or tumors of low malignant potential (LMP tumors). (news-medical.net)
  • The remaining 15 per cent of the ovarian tumours are germ cell tumours, stromal tumours and the borderline tumours. (cancertame.com)
  • A systematic review and meta-analysis by Liu et al found that the malignancy rate, including borderline tumors, for simple ovarian cysts in postmenopausal women was approximately 1 in 10,000. (medscape.com)
  • Twaalhoven 1999,Houck 2000, Tempfer 2007, Brun 2008 Accuracy for malignancy of epithelial OvTu 90-94% Accuracy for borderline tumors approx. (symptoma.com)
  • Most affected patients require surgery and chemotherapy because of the aggressive nature of the tumors, but the overall prognosis is excellent. (medscape.com)
  • Grade 1 EOC more closely resembles normal tissue and tends to have a better prognosis than Grade 3 EOC, which looks less like normal tissue and usually implies a worse outlook than Grade 1 EOC. (news-medical.net)
  • Unfortunately the prognosis for those diagnosed with ovarian tumors is generally poor. (knowcancer.com)
  • Tumors with anaplastic histology usually have somatic mutation of TP53 and inferior prognosis compared to tumors with favorable histology [ Ooms et al 2016 , Daw et al 2020 ]. (nih.gov)
  • Testicular cancer is a condition in which the unusual cell grows out of control in the tissue of one or both of the testes. (planetayurveda.net)
  • Fetal testes displayed intense Leydig cell staining. (elsevierpure.com)
  • This study reports useful information on the limits of the organotypic culture of neonatal mouse testes, which has been regarded as an experimental strategy that can be extended to humans in the clinical setting for the conservation and subsequent re-use of testicular tissue. (elifesciences.org)
  • The evidence that the culture of testicular fragments of 6.5-day-old mouse testes does not allow optimal differentiation of steroidogenic cells is compelling and should enable further optimizations in the future. (elifesciences.org)
  • Cisplatin is an organic metal co-ordination complex and is a widely used chemotherapeutic agent against a variety of malignant tumors, like sarcomas and carcinomas. (ijmhr.org)
  • About 85 per cent of the ovarian tumours are carcinomas, which include mucinous cystadenocarcinoma, serous cystadenocarcinoma, clear cell cystadenocarcinoma, endometrioid adenocarcinoma and undifferentiated carcinoma. (cancertame.com)
  • The wall of the tubule is made up of two kinds of cells: at the periphery , there's the germ cells known as spermatogonia, which are the primordial sperm cells that begin dividing over and over in puberty , and give rise to male gametes. (osmosis.org)
  • AMH is secreted in high amounts by Sertoli cells from fetal life until the onset of puberty. (biomedcentral.com)
  • In all documented biopsied cases, there is a significant decline in germ cell development and an increase in tubular sclerosis by puberty. (medscape.com)
  • By the time you reach puberty only 200,000 to 400,000 egg cells are left. (brusselsoncofertility.be)
  • Recent evidence suggests that children withKlinefelter syndrome are born with spermatogonia and lose large numbers of germ cellsduring puberty. (health-abstracts.com)
  • It has many synonyms like endodermal sinus tumor, infantile embryonal carcinoma and orchid blastoma. (planetayurveda.net)
  • It's common for germ cell-associated testicular cancer to begin with a carcinoma in situ . (steptohealth.com)
  • Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
  • The stromal tumours include granulosa cell tumour and Sertoli-Leydig tumour. (cancertame.com)
  • Mucinous epithelial tumors account for approximately 10-15% of all epithelial ovarian neoplasms. (medscape.com)
  • Mucinous tumors are most common in the third to fifth decades of life and are only rarely bilateral. (medscape.com)
  • Rupture of a mucinous cystadenoma or cystadenocarcinoma leading to the spread of tumor cells throughout the peritoneum . (amboss.com)
  • Mucinous cells cause gelatinous ascites and intraabdominal adhesions. (amboss.com)
  • Despite a conserved density of Leydig cells after 30 days of culture (D30), transcript levels of adult Leydig cell and steroidogenic markers were decreased. (elifesciences.org)
  • In conclusion, this study reports the failure of adult Leydig cell development and altered steroid production and signaling in tissue cultures. (elifesciences.org)
  • The development of adult Leydig cell population was also analyzed 65 days postpartum. (frontiersin.org)
  • Yolk sac tumors, which are also known as endodermal sinus tumors, are the most common prepubertal GCTs. (medscape.com)
  • Chemotherapy uses medicines to kill cancer cells. (medlineplus.gov)
  • They generally present in the form of a single tumor but if they spread they do not respond well to chemotherapy. (planetayurveda.net)
  • The normal sertoli cells generally support and nourish the sperm making germ cells and the same like leydig cells do not respond well to chemotherapy or radiation. (planetayurveda.net)
  • These cells grow more quickly and are less responsive to radiation and chemotherapy. (horizonhospital.org)
  • Traditional treatment for ovarian tumors is a combination of chemotherapy and surgery. (knowcancer.com)
  • Pediatric cancer treatments such as chemotherapy have recognized toxicity on germline stem cells, which could lead to infertility at adulthood ( 1 , 2 ). (elifesciences.org)
  • The treatment is aimed at destroying cancer cells: by removing them during a surgical procedure, by destroying them by means of radiation or by stopping there development with the help of chemotherapy. (brusselsoncofertility.be)
  • But a treatment with chemotherapy or radiotherapy is not selective and will also impact on other cells apart from the cancer cells. (brusselsoncofertility.be)
  • The chemotherapy also affects the germ cells. (brusselsoncofertility.be)
  • During chemotherapy a medicine is administered which stops the division of cancer cells. (brusselsoncofertility.be)
  • These types of cancer begin when healthy cells in these areas change and grow out of control, forming a mass called a tumor. (cancer.net)
  • For ovarian cancer, the biopsy is most commonly done by removing the tumor during surgery. (uchealth.org)
  • In rare cases, a suspected ovarian cancer may be biopsied during a laparoscopy procedure or with a needle placed directly into the tumor through the skin of the abdomen. (uchealth.org)
  • Once cancer is found, the first step is to determine the type of cancer cell by examining it under a microscope. (medlineplus.gov)
  • Epidemiologic factors were discussed under five subheadings including hereditary factors, cancer stem cells, hormonal influences, environmental factors, and lifestyle choices. (biomedres.us)
  • Ovarian cancer stem cells that reside within the tumor play a role in cancer recurrence and progression. (biomedres.us)
  • Although some reviews are available on this topic, this review is comprehensive and provides novelty as it includes the role of cancer stem cells in ovarian cancer development in addition to other risk factors. (biomedres.us)
  • Ovarian cancer is the most common cause of cancer death from gynecologic tumors in the United States. (medscape.com)
  • Cancer limited to testicles and testicular tissues. (planetayurveda.net)
  • Normally, HCG levels are tested in a woman who may have irregular tissue developing in her uterus, a molar pregnancy, or a cancer in the uterus rather than a normal pregnancy. (bearcreekbb.net)
  • Major types of testicular cancer include germ-cell testicular cancer and non-germ-cell testicular cancer. (osmosis.org)
  • Testicular cancer occurs when some cells in the testicles begin to grow out of control. (steptohealth.com)
  • In this case, testicular cancer originates in the stroma , a supporting tissue that also produces testicular hormones. (steptohealth.com)
  • The exact cause of ovarian tumors is unknown, but it is believed that there may be links to hormones and genetics.Ovarian tumors are the second most common gynecological cancer. (knowcancer.com)
  • Treatment for ovarian tumors depends on how widespread the cancer is, as well as the type and grade of the tumor. (knowcancer.com)
  • Pruefer FG, Lizarraga F, Maldonado V, Melendez-Zajgla J. Participation of Omi Htra2 serine-protease activity in the apoptosis induced by cisplatin on SW480 colon cancer cells. (ijmhr.org)
  • In clinical practice, she concentrates on germ cell tumors, while her epidemiologic research primarily focuses on colorectal cancer screening and prevention. (dana-farber.org)
  • Freezing of prepubertal testicular tissue containing spermatogonia is a fertility preservation option proposed to prepubertal boys with cancer prior to highly gonadotoxic treatments. (elifesciences.org)
  • A cancer treatment will usually result in the - temporary or permanent - disappearance of the menstrual cycle in women, and the production of sperm cells in men. (brusselsoncofertility.be)
  • In the context of a cancer treatment especially one (biological) fact is important: the fertility of women is largely defined by the (remaining) stock of egg cells, often referred to as the ovarian reserve. (brusselsoncofertility.be)
  • Radiation aims for the local destruction of cancer cells. (brusselsoncofertility.be)
  • Unfortunately, radiotherapy is not selective for cancer cells: it causes the damage of all cells in the irradiated body area. (brusselsoncofertility.be)
  • This means that not only cancer cells are destroyed but e.g. also cells covering the gastrointestinal tract, the cells in the bone marrow and the cells generating one's hair (that is why the hair loss occurs). (brusselsoncofertility.be)
  • Testicular cancer is a disease in which cells in the testicle divide and multiply in an abnormal and uncontrolled way. (virtually.healthcare)
  • There are two main types of testicular cancer, both of which develop from the testicles germ cells which produce sperm. (virtually.healthcare)
  • Tumors or cancer of the LIVER. (lookformedical.com)
  • Tumors or cancer of the PANCREAS. (lookformedical.com)
  • Tumors or cancer of the SKIN. (lookformedical.com)
  • Men with a history of undescended testicles (cryptorchidism) are more likely to develop a tumour than other men, risk being 8 out of 100 patients. (horizonhospital.org)
  • Heretofore, the localization of StAR in human adult and fetal tissues has not been defined. (elsevierpure.com)
  • The presence of StAR in cells that do not express cholesterol side-chain cleavage enzyme cytochrome P450, including renal distal tubules, Sertoli cells, and fetal oocytes, suggests that StAR has roles in metabolic processes in addition to stimulating pregnenolone synthesis. (elsevierpure.com)
  • Fetal type Leydig cells disappear soon after birth (during first 2 weeks after birth) and are replaced by adult type Leydig cells [ 22 , 23 ]. (hindawi.com)
  • these are rare tumors that are malignant in only about 10% of the cases. (medscape.com)
  • In addition, she is cochair of two national protocols that opened in 1999 for the treatment of low-risk and high-risk pediatric germ cell tumors and chair of the COG Germ Cell subcommittee in COG Rare Tumors. (dana-farber.org)
  • They increase the tumor marker protein called alpha fetoprotein as well as HCG. (planetayurveda.net)
  • This type also increases the alpha fetoprotein levels in tumors. (planetayurveda.net)
  • The objective of the present study is to investigate the modulation of antioxidant defence status in neonatal persistent hypothyroid rats before their sexual maturation and also to identify the specific testicular cell populations vulnerable to degeneration during neonatal hypothyroidism in immature rats. (hindawi.com)
  • 15. Sato Y, Nozawa S, Yoshiike M, Arai M, Sasaki C, Iwamoto T. Xenografting of testicular tissue from an infant human donor results in accelerated testicular maturation. (ac.ir)
  • Ovarian germ cell tumours and stromal tumours constitute about 10 per cent of the ovarian tumours. (cancertame.com)
  • Ovarian germ cell tumours and stromal tumours affect young women usually below 20 years of age. (cancertame.com)
  • Ovarian germ cell tumours and stromal tumours remain asymptomatic during initial stages of the disease. (cancertame.com)
  • Common presenting symptoms of the ovarian germ cell tumours and stromal tumours include mass in the abdomen and vaginal bleeding. (cancertame.com)
  • The cells can multiply to form tumours. (virtually.healthcare)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • Histological staining of DM rat kidney tissue with hematoxylin and eosin, Masson's trichome and Periodic acid-Schiff demonstrated glomerular and tubule lesions, and an increase in collagen compared with control rats. (bvsalud.org)
  • Shah N, Dizon D.S. New-generation platinum agents for solid tumors. (ijmhr.org)
  • Evaluation of prevalence and outcomes of serial tyrosine kinase inhibitor use in pediatric patients with advanced solid tumors. (dana-farber.org)
  • Solitary tumors of the uterus which arise de novo from the mesenchymal cells of the myometrium. (brainscape.com)
  • At the same time, Sertoli cells secrete Müllerian inhibiting factor that induces regression of Müllerian ducts that in females would differentiate into the uterus. (e-kjgm.org)
  • Ovarian tumors include luteoma of pregnancy, arrhenoblastoma, hilar-cell tumor, masculinizing ovarian stromal cell tumor, and Krukenberg tumor. (health.am)
  • The term "Krukenberg tumor" is used in practice to include all metastatic ovarian tumors although only 40% of ovarian metastases are due to Krukenberg tumor which is a signet cell gastrointestinal malignancy [1]. (symptoma.com)
  • We don't use CT scans to biopsy an ovarian tumor, but we can use it to help biopsy a suspected metastasis in a procedure called a CT-guided needle biopsy. (uchealth.org)
  • Procedures used in the diagnosis and evaluation of a germ cell ovarian tumour include pelvic examination, ultrasound, CT scan and biopsy. (cancertame.com)
  • Surgery and a biopsy of the cells is necessary for a specific and confirmed diagnosis of ovarian tumors. (knowcancer.com)
  • The operation is paused while the pathologist rapidly reviews the biopsy tissues. (symptoma.com)
  • The gene has been found to interact with FAT3, a tumor suppressor gene, as well as INTS2 a gene that is involved in snRNA processing and transcription. (wikipedia.org)
  • Wilms' tumor suppressor gene 1 (WT1) is the gene responsible for the developmental process of AGP. (biomedcentral.com)
  • Produces a "barrel cervix" if the tumor encircles the cervix and invades the underlying stroma. (brainscape.com)
  • Sertoli cell proliferation reaches its maximum level just before birth and ceases by the age of 3 weeks [ 24 ]. (hindawi.com)
  • Hodgkin Lymphoma Hodgkin lymphoma is a localized or disseminated malignant proliferation of cells of the lymphoreticular system, primarily involving lymph node tissue, spleen, liver, and bone marrow. (msdmanuals.com)
  • Evaluation after induction showed very good tumour response with three remaining localisations: two abdominal and one pelvic . (symptoma.com)
  • These cells are responsible for sperm production. (planetayurveda.net)
  • As opposed to what happens to men during sperm production, women do not produce new reproductive cells once they are born. (brusselsoncofertility.be)
  • The further development of CIS into invasive germ cell tumors may depend on signals from their postpubertal niche of somatic cells, including hormones and growth factors from Leydig and Sertoli cells. (ku.dk)
  • It is used to produce hormones and cell membranes and is transported in the blood plasma of all mammals. (absoluteastronomy.com)
  • CIS cells were suggested to arise from primordial germ cells or gonocytes. (ku.dk)
  • The cells that make up EOC have several forms that can be recognized under the microscope. (news-medical.net)
  • The affected tissue when examined under a microscope appears like an early embryo. (planetayurveda.net)
  • These are the tumors that if examined under a microscope will look like each of the three layers of embryo. (planetayurveda.net)
  • They are broken down into many subtypes, which are determined by a number of the tumors' features, such as how their cells look under a microscope. (moffitt.org)
  • The cells are looked at under a microscope. (knowcancer.com)
  • After putting together the clinical findings, special studies on tissues (if needed), and the microscope findings, the pathologist arrives at a definitive diagnosis. (symptoma.com)
  • The Leydig cell cytoplasm contains an abundant supply of smooth endoplasmic reticulum and mitochondria with tubular cristae, both features being characteristic of steroidogenic cells. (ac.ir)
  • The molecule of MF, a small hydrophilic cation, is transported from the extracellular space to the cytoplasm of the target cell through organic cation transporters-1 and -2 (OCT1, OCT2), multidrug and toxin extrusion transporters (MATE), and ATM (ataxia telangiectasia mutated) transporter, and OCT1 and OCT2 are considered as the main functional units of MF transmembrane transport [ 7 ] . (encyclopedia.pub)
  • In stage III, the tumour metastasises to the abdominal lymph nodes and abdominal organs such as the intestines and surface of the liver. (cancertame.com)
  • An ovarian cyst is an abnormal growth of tissue that forms on the surface of the ovary and includes fluid. (cancer.net)
  • Epithelial ovarian tumors develop from the cells that cover the outer surface of the ovary. (news-medical.net)
  • Symptoms usually do not become apparent until the tumor compresses or invades adjacent structures, ascites develops, or metastases become clinically evident. (news-medical.net)
  • Clinical manifestations are due to the primary tumor as well as due to the metastases. (symptoma.com)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • Using single-cell RNA sequencing (RNAseq), we studied the development of ProSG, their SG descendants and testicular somatic cells during the perinatal period in mice. (biologists.com)
  • Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)
  • Histological, RT-qPCR, western blot analyses and steroid hormone measurements were performed on in vitro cultured mouse prepubertal testicular tissues and age-matched in vivo controls. (elifesciences.org)
  • The organotypic culture procedure, which preserves testicular tissue architecture, microenvironment and cell interactions, has been used successfully to obtain spermatozoa from fresh or frozen/thawed mouse prepubertal testicular tissues ( 3 - 6 ). (elifesciences.org)
  • It has been previously shown that supplementing organotypic culture media with retinol improves the in vitro production of spermatids and spermatozoa in prepubertal mouse testicular tissues cultured at a gas-liquid interphase ( 5 , 7 ). (elifesciences.org)
  • Protein expression levels of LC3II, P62, collagen IV (COL-IV) and α-SMA were increased in DM rats and HG-induced NRK-52E cells compared with those in the control groups. (bvsalud.org)
  • The effect of anabolic-androgenic steroids on sexual behavior and reproductive tissues in male rats. (ac.ir)
  • For in vitro studies, immature Leydig cells were isolated from 35-day-old male rats and treated with 50 μM piperine in the presence of different steroidogenic stimulators/substrates for 24 h. (frontiersin.org)
  • The stage of the tumor can be ascertained during surgery, when it can be determined how far the tumor has spread from where it started in the ovary. (news-medical.net)
  • Stage IA - Growth is limited to one ovary and the tumor is confined to the inside of the ovary. (news-medical.net)