• The healing of bone defects can be challenging for clinicians to manage, especially after exposure to ionizing radiation. (biomedcentral.com)
  • Radiation injury is damage to tissues caused by exposure to ionizing radiation. (msdmanuals.com)
  • Today, up to 60% of cancer patients receive radiotherapy as a part of their treatment regimens 1 and yet most are never fully aware of the risks involved with exposure to ionizing radiation. (endalldisease.com)
  • failed verification] The risk of cancer caused by ionizing radiation is well documented at radiation doses beginning at 100mSv and above. (wikipedia.org)
  • The natural background exposures are frequently used as a standard of comparison for exposures to various man-made sources of ionizing radiation. (cdc.gov)
  • The consensus of researchers studying RILI is that ionizing radiation could induce damage to epithelial cells and endothelial cells, dysfunction of the blood-air barrier, and increase vascular permeability. (biomedcentral.com)
  • The ionizing radiation further activates alveolar macrophages and upregulates transforming growth factor (TGF)-β1, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-12 (especially the key factor TGF-β1) [ 4 ]. (biomedcentral.com)
  • Radiation ulcers are wounds caused by the acute or chronic effects of ionizing radiation. (medscape.com)
  • Ionizing radiation may come from high-energy photons that can be the product of natural decay of radioactive material, such as gamma rays, or the product of artificial bombardment of electrons onto Tungsten, such as x-rays. (medscape.com)
  • According to their frequency and energy, electromagnetic waves can be classified as either ionizing radiations or non-ionizing radiations (NIR). (intechopen.com)
  • Ionizing radiations are extremely high frequency electromagnetic waves (X-rays and gamma rays), which have enough photon energy to produce ionization by breaking the atomic bonds that hold molecules in cells together. (intechopen.com)
  • Gamma (γ)-rays are highly penetrating electromagnetic ionizing radiation that have been extensively applied in diagnostic radiography, radiation oncology, and military weapons [ 1 ]. (biomedcentral.com)
  • Ionizing radiation has been reported to be closely associated with bone metabolism. (biomedcentral.com)
  • Given its high calcium content, bone tissue is sensitive to ionizing radiation and absorbs nearly 40% more radiation than the surrounding tissues [ 2 ]. (biomedcentral.com)
  • The risk of exposure of the general public or military personnel to high levels of ionizing radiation from nuclear weapons or radiological accidents is a dire national security matter. (biomedcentral.com)
  • All of the isotopes of uranium are radioactive and decay into thorium, radium, etc., isotopes of lead (progeny or decay products) until a stable nonradioactive isotope of lead is produced (the complete radioactive decay series for 235 U and 238 U are shown in Appendixes A and B). This process of radioactive decay also emits ionizing radiation (alpha particles, beta particles, or gamma rays) with each nuclear transformation. (health.mil)
  • The acute effect of ionizing radiation is direct cell damage to DNA. (medscape.com)
  • Large doses of ionizing radiation can cause acute illness by reducing the production of blood cells and damaging the digestive tract. (msdmanuals.com)
  • A very large dose of ionizing radiation can also damage the heart and blood vessels (cardiovascular system), brain, and skin. (msdmanuals.com)
  • Ionizing radiation can increase the risk of cancer. (msdmanuals.com)
  • In general, ionizing radiation refers to high-energy electromagnetic waves (x-rays and gamma rays) and particles (alpha particles, beta particles, and neutrons) that are capable of stripping electrons from atoms (ionization). (msdmanuals.com)
  • By changing molecules in the highly ordered environment of the cell, ionizing radiation can disrupt and damage cells. (msdmanuals.com)
  • Depending on the magnitude of the dose, organs exposed, and types of radiation cellular damage caused by ionizing radiation can cause acute illness, increase the risk of developing cancer, or both. (msdmanuals.com)
  • Ionizing radiation is emitted by radioactive substances (radionuclides), such as uranium, radon, and plutonium. (msdmanuals.com)
  • However, because of their lower energy, these forms of radiation are not ionizing, and thus public exposure to these common sources does not damage cells. (msdmanuals.com)
  • In this discussion, "radiation" refers exclusively to ionizing radiation. (msdmanuals.com)
  • The roentgen (R) is a measure of the ionizing ability of radiation in air and is commonly used to express the intensity of exposure to radiation. (msdmanuals.com)
  • The ionizing radiation interrupts the growth of cancerous cells by causing direct damage to the DNA and other cell components, or through the formation of free radicals. (biomedcentral.com)
  • The contrast in CMR images is generated from protons in different chemical environments and, therefore, enables high-resolution imaging and specific tissue characterization in vivo, without the use of potentially harmful ionizing radiation. (hif-signaling.com)
  • RADIOTHERAPY, ALSO KNOWN as radiation therapy, is a treatment where ionizing x-ray and gamma ray radiation are directed at tumors and used to kill cancer cells. (endalldisease.com)
  • and within a few years, ionizing radiation was put to use on cancer patients. (endalldisease.com)
  • We characterized elevated plus maze (EPM) indicators of cognitive and motor impairment in rats exposed to brain-damaging doses of gamma radiation to develop a model for neurological component of the acute radiation syndrome. (ac.ir)
  • Many different forms of radiation have since been discovered, and applications have been developed for medical, industrial, and military use. (medscape.com)
  • Gamma rays are often produced alongside other forms of radiation such as alpha or beta . (wikidoc.org)
  • As it would be unethical to expose the animals to such a degree of radiation damage, a model developing the most severe forms of radiation injuries is not the scope of this study and thus not discussed in further detail. (biomedcentral.com)
  • This is evidenced by a study that observed mice with neutrons and have RBEs that vary with the tissue type and strain. (wikipedia.org)
  • Treatment of mice with rosemary extract prior to irradiation is reported herein to prolong life and reduce the symptoms of radiation sickness. (tfljournal.org)
  • The present investigation reports the radiomodulatory effect of Rosmarinus officinalis (rosemary) leaf extract against radiation-induced hematological alterations in Swiss albino mice at various post-autopsy intervals (i.e., between 24 hours to day 30). (tfljournal.org)
  • Bansal, S. and Chhibber, S. Curcumin alone and together with augmentin protects in opposition to pulmonary irritation and acute lung harm generated throughout Klebsiella pneumoniae B5055-induced lung an infection in BALB/c mice. (fairpeel.com)
  • Topical application of PGG followed by chronic exposure to UVB radiation in the dorsal skin of hairless mice resulted in a significant decrease in the progression of inflammatory skin damages, leading to inhibited activation of NF-κB signaling and expression of pro-inflammatory mediators. (molcells.org)
  • Research on the use of plant extracts to protect against radiation exposure is not widely known, however the low toxicity and minimal side effects of many plant products are well known in both western science and traditional medicine. (tfljournal.org)
  • Two major health concerns are related to the use of DU in military applications: heavy-metal toxicity effects and radiation effects. (health.mil)
  • Cardioprotective effect of saffron extracts against acute doxorubicin toxicity in isolated rabbit hearts submitted to ischemia-reperfusion injury. (sciendo.com)
  • It can also be useful in preventing osteoradionecrosis of the mandible when dental work is needed after radiation. (medscape.com)
  • Analysis of the soft tissues and mandible within the radiation field revealed severe unilateral alopecia and dermatitis of the skin, extensive inflammation of the submandibular gland with loss of serous secretory cells, hyperkeratinization and dense connective fiber bundles of the gingival tissue, and disturbed tooth development with necrosis of the pulp. (biomedcentral.com)
  • The UV radiation is a part of the electromagnetic spectrum of solar radiation that can be divided into UVA, UVB, and UVC bands by wavelength. (molcells.org)
  • Gamma rays are generally characterized as electromagnetic radiation having the highest frequency and energy, and also the shortest wavelength (below about 10 picometer ), within the electromagnetic spectrum . (wikidoc.org)
  • Experimental models are needed to better understand the pathophysiology of neurodegenerative diseases to develop novel therapeutics. (ac.ir)
  • Matrine ameliorates anxiety and depression-like behaviour by targeting hyperammonemia-induced neuroinflammation and oxidative stress in CCl4 model of liver injury. (ac.ir)
  • Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication. (ac.ir)
  • The skin is the outermost organ of the human body and is continually exposed to environmental stimuli such as solar radiation, which lead to oxidative stress and induce inflammation through increasing the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). (molcells.org)
  • One important heat shock protein is discussed further in the blog entry HSP70 to the rescue The relatively recent blog entries Mitohormesis and Radiation hormesis define hormesis in more detail and discuss it as it relates to mitochondrial oxidative stress and stress induced by radiation. (anti-agingfirewalls.com)
  • The mechanisms of radiation-induced lung injury (RILI) and the mechanisms by which mesenchymal stem cells (MSCs) alleviate it. (biomedcentral.com)
  • However, the mechanisms of radiation-induced bone loss at the cellular level are yet to be fully elucidated. (biomedcentral.com)
  • The neuropathology and clinical signs of acute radiation syndrome resemble those of neurodegenerative conditions. (ac.ir)
  • EPM indicators of cognitive and motor impairment, anxiety, and depression were observed concomitantly and increased with the severity of acute radiation syndrome-like systemic and neurological signs. (ac.ir)
  • Our results suggest that irradiated rat performance in the EPM paradigm reflects disease severity and could be used to perform both acute and subchronic pharmacological studies in acute radiation syndrome-like diseases in rats. (ac.ir)
  • Acute radiation syndrome (ARS) is an illness in humans involving multiple organ systems caused by total- or partial-body exposure to radiation of greater than 2 Gy at a high dose rate. (biomedcentral.com)
  • Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat. (kyoto-u.ac.jp)
  • We enrolled arriving international air travelers in a severe acute respiratory syndrome coronavirus 2 genomic surveillance program. (cdc.gov)
  • Since mesenchymal stem cells (MSCs) have effective immune-modulatory features, inhibit T-lymphocyte proliferation, and have a high regenerative capacity, they can play a vital role in the reconstruction of injured tissues, including bronchioles, in pulmonary diseases. (biomedcentral.com)
  • RILI can be divided into two phases-radiation pneumonitis (RP) and radiation-induced pulmonary fibrosis (RIPF)-which represent acute and late phases in the development of RILI, respectively. (biomedcentral.com)
  • To me, the LSS is the strongest evidence out there for how minimal the actual risk of radiation is, especially at low doses. (undark.org)
  • Radiation can also be produced by high energy particles that are a product of radioactive decay. (medscape.com)
  • Gamma rays (denoted as γ ) are a form of electromagnetic radiation or light emission of frequencies produced by sub-atomic particle interactions, such as electron-positron annihilation or radioactive decay . (wikidoc.org)
  • The types of tumors in humans who are exposed to space radiation will be different from those who are exposed to low-LET radiation. (wikipedia.org)
  • In this paper, we review and present our new data of LED treatment on cells grown in culture, on ischemic and diabetic wounds in rat models, and on acute and chronic wounds in humans. (researchgate.net)
  • The aim of this study was to establish a rat model where a certain radiation dose gives reproducible tissue reactions in the mandibular area corresponding to injuries obtained in humans. (biomedcentral.com)
  • Radiation is the biggest threat to humans than nuclear, terrorism, or circumstances change. (undark.org)
  • The largest risks for adults who have been studied include several types of leukemia, including myeloid leukemia and acute lymphatic lymphoma as well as tumors of the lung, breast, stomach, colon, bladder and liver. (wikipedia.org)
  • It is unknown whether high-LET radiation could cause the same types of tumors as low-LET radiation, but differences should be expected. (wikipedia.org)
  • However, a number of common side effects quickly became known, including burns, skin disease and the formation of tumors, but society failed to take these warnings seriously and by 1922, over 100 radiologists and many others working in the medical industry had died from cancer caused by x-rays. (endalldisease.com)
  • Unlike the speculation about the effects of various doses of various types of radiation on which the LNT argument is based, the LSS followed 86,000 actual people - the hibakusha - the survi of atomic bombs, who were exposed to various doses of various types of radiation, both at the moment of the detonation and for weeks and months afterward via fallout. (undark.org)
  • Repeated and chronic exposure to UV radiation induces photodamage in the skin, resulting in clinical, histological, and functional changes in the areas of habitually sun-exposed skin. (molcells.org)
  • Hyperbaric oxygen treatment is of value in healing of tissues of the head and neck, anus, and rectum. (medscape.com)
  • In its most severe form late radiation injuries of the head and neck can progress to cutaneous fistulas, trismus, pathologic fractures and osteoradionecrosis [ 8 ]. (biomedcentral.com)
  • Tissues affected by acute high-dose radiation, as in industrial accidents, manifest progressive obliterative endarteritis culminating in tissue necrosis. (medscape.com)
  • At the risk of generalizing these data beyond their context, by any reckoning, the magnitude of recordable injury and illness percentages in these warehouses are quite significant and considerably higher than the aggregate data for the industry as a whole for all job classifications. (iloencyclopaedia.org)
  • Over the last few decades numerous studies have reported the beneficial effects of mesenchymal stem cells (MSCs) on tissue repair and regeneration. (biomedcentral.com)
  • Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model. (kyoto-u.ac.jp)
  • [ 4 ] Long-term radiation injury results in fibrosis of the dermal and subcutaneous tissues. (medscape.com)
  • for example, elevated T2 signal is consistent with edema and helps differentiate acute from chronic myocardial injury, and the extent of myocardial fibrosis as imaged by contrast-enhancecl CMR correlates with adverse patient outcome in ischemic and nonischemic cardiomyopathies. (hif-signaling.com)
  • In vitro and in vivo (animal and human) studies utilized a variety of LED wavelength, power intensity, and energy density parameters to begin to identify conditions for each biological tissue that are optimal for biostimulation. (researchgate.net)
  • Hard X-rays overlap the range of "long"-wavelength (lower energy) gamma rays. (wikidoc.org)
  • The true incidence of radiation injury to normal tissue is unknown. (medscape.com)
  • Radiation technology focuses on delivering the radiation as precisely as possible to the tumor, nonetheless both acute and long-term damage to surrounding normal tissue may develop. (biomedcentral.com)
  • Nevertheless, radiation injuries do occur in normal tissue and are commonly classified as acute, consequential or late complications. (biomedcentral.com)
  • In this regard, radiation therapy and accidental exposure to gamma (γ)-ray radiation have been shown to inhibit bone formation and increase the risk of fractures. (biomedcentral.com)
  • This agent is being developed as a radiation MCM for H-ARS following the US FDA Animal Rule since the efficacy of such agents cannot be investigated in a clinical setting under phase II and phase III due to ethical reasons [ 14 ]. (biomedcentral.com)
  • I have recently shown that synovial tissue poly-T-cells can predict RA-patient stratification, correlate with disease progression in RA and PsA and importantly, are present at the joints of at risk-individuals prior to development of clinical-inflammation. (dcu.ie)
  • Applications in clinical radiology and radiation protection. (lu.se)
  • Therefore, many scientists have attempted to treat radiation sickness with MSCs. (biomedcentral.com)
  • Treatment of animals with rosemary extract (1000 mg/ kg body wt) prior to irradiation was found to delay the onset of mortality and reduced the symptoms of radiation sickness such as ruffled hairs, lethargy, anorexia and diarrhea in comparison to radiation alone treated animals. (tfljournal.org)
  • While in space, astronauts are exposed to radiation which is mostly composed of high-energy protons, helium nuclei (alpha particles), and high-atomic-number ions (HZE ions), as well as secondary radiation from nuclear reactions from spacecraft parts or tissue. (wikipedia.org)
  • In light of the various nuclear power plant accident, military and terrorism scenarios that have entered the world consciousness over the past two generations, there is tremendous practical value to understanding how to neutralize or reduce the damaging (and lethal) effects of radiation on the body. (tfljournal.org)
  • However, depleted uranium (DU), a by-product of the enrichment process, is used commercially in medicine (radiation shields), aviation (counterweights), space (satellite ballast), and petroleum exploration (drilling equipment). (health.mil)
  • Although much less radioactive than naturally occurring uranium, DU is radioactive and poses a potential health risk from internal and external radiation exposure. (health.mil)
  • This is because both enriched and natural uranium are much more radioactive than DU and, therefore, would have a greater radiation effect than would DU. (health.mil)
  • Gamma rays were discovered by Paul Villard , a French chemist and physicist, in 1900, while studying uranium. (wikidoc.org)
  • The development of advanced molecular biodosimetry methods, those that measure biological response, such as transcriptomics, to screen large populations of radiation-exposed victims is key to improving survival outcomes during radiological mass casualty scenarios. (biomedcentral.com)
  • Doctors remove as much external and internal (that which is inhaled or ingested) radioactive material as possible and treat symptoms and complications of radiation injury. (msdmanuals.com)
  • 4 At the peak of popularity in the United States, there were at least 10,000 shoe-fitting x-ray fluoroscopes in use, and despite the massive radiation exposure (equal to more than 1000 chest x-rays) and the significant amount of scatter radiation emitted from these "cancer boxes," the horrifying nature of the technology was largely brushed off by the government and medical community. (endalldisease.com)
  • Sarma, L., and Kesavan, P. C. Protecting results of chlorogenic acid, curcumin and beta-carotene in opposition to gamma-radiation-induced in vivo chromosomal injury. (fairpeel.com)
  • These tissue changes are not only used to help identify the etiology of Temsirolimus mw cardiomyopathies, but also allow for a better understanding of tissue pathology in vivo. (hif-signaling.com)
  • Morphological alterations of the soft tissues, bone and tooth formation, as well as alterations of salivation, vascularity and collagen content were assessed. (biomedcentral.com)
  • There may be tremendous practical value to understanding how to neutralize or reduce the damaging (and lethal) effects of radiation on the human body. (tfljournal.org)
  • The Gy and Sv are similar, except the Sv takes into account the effectiveness of different types of radiation to cause damage and the sensitivity of different tissues in the body to radiation. (msdmanuals.com)
  • Case A. Cutaneous injury caused by irradiation of the chest wall to treat advanced lung cancer with metastases to the head and spine. (medscape.com)
  • In this study, nonhuman primates were exposed to either 12.0 Gy cobalt-60 gamma (total-body irradiation, TBI) or X-ray (partial-body irradiation, PBI) 24 h after administration of a potential radiation medical countermeasure, gamma-tocotrienol (GT3). (biomedcentral.com)
  • An individual's radiation dose can be increased in two ways, contamination and irradiation. (msdmanuals.com)
  • The energy delivered to the tissues is measured in electron volts. (medscape.com)
  • The photoelectric effect is the dominant energy transfer mechanism for x-ray and gamma ray photons with energies below 50 keV (thousand electron volts ), but it is much less important at higher energies. (wikidoc.org)
  • Then CBSCs were subjected to 6 Gy γ-ray radiation followed by treatment with various concentrations of melatonin. (biomedcentral.com)
  • As in younger populations, cognitive-behavioral therapy is indicated for treatment of acute or chronic depressive disorders, concurrent with antidepressant medications when indicated. (forex-consultant.com)
  • Individuals developing H-ARS or GI-ARS are considered to benefit from treatment with radiation medical countermeasures (MCMs) and have generally been the focus of research efforts for developing MCMs and for the identification of biomarkers. (biomedcentral.com)
  • As cancer therapy becomes increasingly effective, patients are living long enough to have the adverse late effects of their radiation treatment. (medscape.com)
  • In general terms, these data suggest that order selectors have virtually a 3 in 10 chance of experiencing a back injury involving medical treatment and/or lost time in any given year. (iloencyclopaedia.org)
  • Endpoint was six weeks after last radiation treatment, and the test group was compared to non-irradiated controls. (biomedcentral.com)
  • Acute effects are observed during or within a few weeks after treatment. (biomedcentral.com)
  • There is no known treatment to date other than administration of convalescent blood or experimental monoclonal antibodies, which both often fail. (racehorseherbal.net)
  • Understanding the basic concepts in radiation physics, chemistry, and biology is important to the evaluation and interpretation of radiation-induced adverse health effects and to the derivation of radiation protection principles. (cdc.gov)
  • This appendix presents a brief overview of the areas of radiation physics, chemistry, and biology and is based to a large extent on the reviews of Mettler and Moseley (1985), Hobbs and McClellan (1986), Eichholz (1982), Hendee (1973), and Early et al. (cdc.gov)
  • The ionization patterns in molecules, cells, tissues and the resulting biological effects are distinct from typical terrestrial radiation (x-rays and gamma rays, which are low-LET radiation). (wikipedia.org)
  • NIR can not cause ionization however have been shown to produce other biological effects, for instance by heating, altering chemical reactions or inducing electrical currents in tissues and cells. (intechopen.com)
  • Once in the body, radioactive material may be transported to various sites, such as the bone marrow, where it continues to emit radiation, increasing the person's radiation exposure, until it is removed or emits all its energy (decays). (msdmanuals.com)
  • Galactic cosmic rays (GCRs) from outside the Milky Way galaxy consist mostly of highly energetic protons with a small component of HZE ions. (wikipedia.org)
  • Gamma rays consist of high energy photons with energies above about 100 keV . (wikidoc.org)
  • There are three sub-syndromes of ARS characterized both by the different organ systems affected and by the aggregate absorbed dose of radiation. (biomedcentral.com)
  • Electromagnetic waves at low frequencies are referred to as electromagnetic fields and those at very high frequencies are called electromagnetic radiations ( 1 , 2 ). (intechopen.com)
  • Studies are being conducted on populations accidentally exposed to radiation (such as Chernobyl, production sites, and Hiroshima and Nagasaki). (wikipedia.org)
  • X-ray screening of large groups of persons for diseases of the lung and heart by means of radiography of the chest. (lookformedical.com)
  • In normal wound healing, this inflammation response may subside and induce a vicious cycle of further inflammation once radiation pneumonitis happens, finally leading to the poor prognosis. (biomedcentral.com)
  • Radiation protection is at a cross-road after radiation incidents and unacceptable tragedies such as those at Chernobyl and Three Mile Island. (tfljournal.org)
  • 9 Over the course of a month, he wrote, "the tumour gets more than 40,000 mSv [millisieverts] and the peripheral healthy tissue as much as 20,000 mSv - that is five times the fatal dose experienced by some Chernobyl workers. (endalldisease.com)
  • LED produced improvement of greater than 40% in musculoskeletal training injuries in Navy SEAL team members, and decreased wound healing time in crew members aboard a U.S. Naval submarine. (researchgate.net)
  • This study provides insight into radiation-induced changes in jejunal transcriptional profiles, supporting the investigation for the identification of biomarkers for radiation injury and countermeasure efficacy. (biomedcentral.com)
  • The NHP model is considered the gold standard of animal models for developing radiation MCMs, and identifying and validating biomarkers for radiation injury and countermeasure efficacy [ 15 ]. (biomedcentral.com)
  • X-ray photons are generated by energetic electron processes, gamma rays by transitions within atomic nuclei. (wikidoc.org)
  • The various approaches to setting acceptable levels of radiation risk are summarized below: Unlimited Radiation Risk - NASA management, the families of loved ones of astronauts, and taxpayers would find this approach unacceptable. (wikipedia.org)
  • We have established an animal model of radiation injury demonstrating physiological and histological changes corresponding to human radiation injuries, which can be used for future therapeutic evaluations. (biomedcentral.com)
  • Chronic radiation injury decreases the ability of the body to tolerate bacterial contamination. (medscape.com)
  • Materials for shielding gamma rays are typically measured by the thickness required to reduce the intensity of the gamma rays by one half (the half value layer or HVL). (wikidoc.org)
  • For example, gamma rays that require 1 cm (0.4 inches) of lead to reduce their intensity by 50% will also have their intensity reduced in half by 6 cm (2½ inches) of concrete or 9 cm (3½ inches) of packed dirt. (wikidoc.org)