• While most of the gut organs are endodermally derived, the spleen is derived from mesenchymal tissue. (wikipedia.org)
  • If it isn't treated right away, RMSF can cause damage to the lining of your blood vessels, tissues, and organs. (healthline.com)
  • Under certain circumstances, however, this apparently inert lead will leave the bones and reenter the blood and soft tissue organs. (cdc.gov)
  • Cells Tissues Organs (2021) 209 (4-6): 209-214. (karger.com)
  • Cells Tissues Organs (2019) 207 (1): 15-20. (karger.com)
  • Cells Tissues Organs (2008) 188 (1-2): 139-149. (karger.com)
  • Cells Tissues Organs (2008) 187 (3): 186-198. (karger.com)
  • Bone marrow-derived stem cells Hematopoietic stem cells Adipogenesis Fibrin gel culture, 3-dimensional cultures Original Paper Cells Tissues Organs 2008;187:186 198 DOI: 10.1159/000111804 Accepted after revision: August 29, 2007. (karger.com)
  • Cells Tissues Organs (2005) 180 (4): 195-203. (karger.com)
  • Other important organs in this system include the bone marrow, spleen, thymus and gut-associated lymphoid tissue (GALT), which is the lymphatic tissue associated with the gastrointestinal (GI) tract. (petplace.com)
  • The lymphatic system is composed of a network of lymph vessels referred to as lymphatics, as well as certain organs and tissues, including the lymph nodes, bone marrow, spleen, thymus and GALT. (petplace.com)
  • Most anatomical compartments, including mucosal surfaces and solid organs, host large populations of tissue-resident lymphocytes which are uniquely placed to provide local networks for immune surveillance and defence against infection ( Fan and Rudensky, 2016 ). (elifesciences.org)
  • Lymphatic tissue or circulating lymphocytes may also be located in other regions of the body, such as the skin, small intestine, liver, and other organs. (rarediseases.org)
  • Parasites infect the tissues of major organs, especially the liver , spleen, and bone marrow. (medicinenet.com)
  • The immune system contains a network of cells, tissues, and organs that work together to protect the body. (kidshealth.org)
  • Lymphocytes travel between organs like the spleen, tonsils, and lymph nodes. (kidshealth.org)
  • A liver and spleen scan is a nuclear scan that is done to look at these organs for disease. (wellspan.org)
  • Exposure to radiation can wreak indiscriminate havoc on cells, tissues, and organs. (sciencedaily.com)
  • Community participation and involvement was mobilized that integrated non-governmental organizations, Organs rich in lymphoid tissue such as the liver, spleen, thymus, religious and faith-based entities and school children. (who.int)
  • Like the thymus, the spleen possesses only efferent lymphatic vessels. (wikipedia.org)
  • Thymus, spleen, and lymph nodes. (nih.gov)
  • Lymphatic tissues also include the thymus, a relatively small organ behind the breastbone that is thought to play an important role in the immune system until puberty, as well as the bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. (rarediseases.org)
  • In the current study, Lahav, Weissleder, and their team looked at tissues in mice that have very different sensitivities to ionizing radiation yet are known to express comparable levels of p53 -- the spleen and thymus, which are highly vulnerable, and the large and small intestines, which are more radioresistant. (sciencedaily.com)
  • By contrast, p53 in the spleen and thymus remained high over the same time period. (sciencedaily.com)
  • While the bone marrow is the primary site of hematopoiesis in the adult, the spleen has important hematopoietic functions up until the 5th month of gestation. (wikipedia.org)
  • The soft, spongy tissue found in bone cavities. (uhhospitals.org)
  • Sickle cell anemia may become life-threatening when damaged red blood cells break down (hemolytic crisis), when the spleen enlarges and traps the blood cells (splenic sequestration crisis), or when a certain type of infection causes the bone marrow to stop producing red blood cells (aplastic crisis). (health.am)
  • The bone marrow consists of connective tissue, the cells of which form a delicate meshwork within the marrow cavity. (petplace.com)
  • Many affected individuals have widespread disease at diagnosis, with involved regions often including multiple lymph nodes, the spleen, and, potentially, the bone marrow, the liver, and/or regions of the digestive (gastrointestinal) tract. (rarediseases.org)
  • The clinical manifestations of Waldenström macroglobulinemia result from the presence of the IgM paraprotein and malignant lymphoplasmacytic cell infiltration of the bone marrow and other tissue sites. (medscape.com)
  • and neoplasm = new abnormal growth, such as a precancer or cancer), the blood-producing cells in the bone marrow (precursor cells, also called stem cells) develop and reproduce excessively or are crowded out by an overgrowth of fibrous tissue. (msdmanuals.com)
  • 272 bone marrow biopsies and 113 spleen biopsies were studied. (bvsalud.org)
  • By analysing iNKT cells from lymphoid tissues of mice and humans we demonstrate that their T cell receptor (TCR) repertoire is highly diverse and is distinct for cells from various tissues resulting in differential lipid-antigen recognition. (elifesciences.org)
  • Non Hodgkin's lymphoma (NHL) and tuberculosis were the most common lesions in lymph nodes and extranodal lymphoid tissues. (bvsalud.org)
  • The spleen houses antibody-producing lymphocytes in its white pulp and monocytes which remove antibody-coated bacteria and antibody-coated blood cells by way of blood and lymph node circulation. (wikipedia.org)
  • Pristane-induced chronic inflammation has been characterized by the continuous recruitment of leukocytes, including lymphocytes, neutrophils, and macrophages, to the peritoneal cavity and the spleen [ 6 - 8 ]. (hindawi.com)
  • Tissue homeostasis is critically dependent on the function of tissue-resident lymphocytes, including lipid-reactive invariant natural killer T (iNKT) cells. (elifesciences.org)
  • Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes. (rarediseases.org)
  • Lymphocytes are stored within lymph nodes and may also be found in other lymphatic tissues. (rarediseases.org)
  • However, adrenal CL uptake of simvastatin (1.55 ml/min/g tissue) was larger than hepatic CL uptake , and simvastatin was distributed to other tissues more easily than rosuvastatin. (aspetjournals.org)
  • Simvastatin was less liver-specific (it also distributed to the spleen and adrenal). (aspetjournals.org)
  • Lymph is collected from the fluid of various tissues and eventually is returned to the blood circulatory system. (petplace.com)
  • Bolus intravenous doses (5 mg/kg) of radiolabeled rosuvastatin, pravastatin, and simvastatin were administered to rats, and initial uptake clearance (CL uptake ) in various tissues was calculated. (aspetjournals.org)
  • The spleen is an organ found in almost all vertebrates. (wikipedia.org)
  • In addition, the abnormal shaped red blood cells cause damage to the spleen, an organ that helps fight against infection (4). (bartleby.com)
  • The spleen is an organ shaped like a shoe that lies relative to the 9th and 11th ribs and is located in the left hypochondrium and partly in the epigastrium. (medscape.com)
  • The spleen, a spongy, soft organ about as big as a person's fist, is located in the upper left part of the abdomen, just under the rib cage. (msdmanuals.com)
  • A tough capsule of fibrous tissue covers the spleen. (petplace.com)
  • The spleen has a covering of fibrous tissue (the splenic capsule) that supports its blood vessels and lymphatic vessels. (msdmanuals.com)
  • The spleen is located near the stomach in the left forward part of the abdomen. (petplace.com)
  • Thus, the spleen is situated between the fundus of the stomach and the diaphragm. (medscape.com)
  • The gastric impression is for the fundus of the stomach, which is the largest and most concave impression on the spleen. (medscape.com)
  • There are four ligaments attached to the spleen: gastrosplenic ligament, splenorenal ligament, colicosplenic ligament, and phrenocolic ligament. (wikipedia.org)
  • An herb used for the treatment of wounds (antiulcer, connective tissue tonic). (joyfulbelly.com)
  • Obesity is a chronic low-grade pro-inflammatory condition, with adipose tissue exhibiting both paracrine and endocrine functions. (peerj.com)
  • Leptin is secreted by adipose tissue, where it then circulates to the hypothalamus to act as a satiety hormone. (peerj.com)
  • Serum leptin levels are directly related to adipose tissue mass, which leads to increased leptin levels associated with the obese (OB) phenotype ( Al Maskari & Alnaqdy, 2006 ). (peerj.com)
  • Grossly, 4 animals had pinpoint brown or black foci on coelomic adipose tissue. (usgs.gov)
  • Adipose tissue is adjacent to the granuloma. (who.int)
  • The spleen, in healthy adult humans, is approximately 7 to 14 centimetres (3 to 5+1⁄2 in) in length. (wikipedia.org)
  • Other functions of the spleen are less prominent, especially in the healthy adult: Spleen produces all types of blood cells during fetal life Production of opsonins, properdin, and tuftsin. (wikipedia.org)
  • Within the spaces of this tissue, the immature and adult stages of different blood cells exist. (petplace.com)
  • Notching of the superior border of the adult spleen is evidence of its multiple origin (see the image below). (medscape.com)
  • The system allows for the generation of mice with specific overexpression of AAVR through breeding with available Cre mouse lines, as well as the option to detarget AAV from other tissue when paired with Aavr -KO mice. (nature.com)
  • Plasma cell hyperplasia is a common, often mild, lesion in the spleen of rodents, particularly mice. (nih.gov)
  • Small foci of plasma cells that blend in with normal splenic cellular constituents frequently occur in spleens of aged rats and mice. (nih.gov)
  • SF significantly increased IL-1β and TNF-α gene expression in fat and TGF-β1 expression in spleen relative to controls, but only in wild-type mice. (peerj.com)
  • Taken together, these findings suggest that leptin deficiency affects cytokine gene expression differently in the brain compared to peripheral tissues with minimal interaction from acute SF. (peerj.com)
  • Within peripheral tissues iNKT cell recent thymic emigrants exhibit a different TCR repertoire than mature cells, suggesting that the iNKT population is shaped after arrival to the periphery. (elifesciences.org)
  • Leukocytes in the spleen or in the peritoneal cavity were quantified by flow cytometry. (hindawi.com)
  • We found that the loss of IL-6 decreased macrophage recruitment to the spleen and the peritoneal cavity during pristane-induced inflammation. (hindawi.com)
  • As the two major cell types in the spleen, B cells and T cells produce cytokines and chemokines [ 18 ]. (hindawi.com)
  • This suggests that unique tissue-specific factors (including local lipid antigens, cytokines and/or hormones) may shape the population of iNKT cells resident in those tissues, ultimately regulating local immune responses. (elifesciences.org)
  • The GALT is made up of lymph tissue scattered throughout the GI tract including the tonsils and intestines. (petplace.com)
  • In cirrhosis, healthy tissue in the liver is replaced with scar tissue. (wellspan.org)
  • Where polyclonal antibodies are purified directly from the serum of the immunized host, and monoclonals are purified from either hybridoma-derived tissue culture supernatant or ascites, recombinant antibodies are instead purified from the tissue culture supernatants of transfected host cell lines. (cellsignal.com)
  • This research often requires the tissue-specific expression of transgenes to better mirror human diseases, to visualize pathways being studied or to modulate the expression of a disease-related gene. (nature.com)
  • We hypothesized that AAV transgene expression could be targeted to specific tissues or cell types by selectively overexpressing AAVR. (nature.com)
  • The flexibility to purify high-quality total RNA from a wide range of tissue types ensures that samples can be purified for a range of gene expression analysis applications. (qiagen.com)
  • Lymphotoxin alpha (LT α ) and TNF α were shown to induce the expression of homing chemokines in B and T cell areas of the spleen [ 13 ]. (hindawi.com)
  • An easy way to remember the anatomy of the spleen is the 1×3×5×7×9×10×11 rule. (wikipedia.org)
  • The study reveals anatomy - pathological tissue calcification compatible with Echinococcus granulosus. (bvsalud.org)
  • When patients experience dehydration, infection, and low oxygen supply, these fragile red blood cells assume a crescent shape, causing red blood cell destruction and poor flow of these blood cells through blood vessels, resulting in a lack of oxygen to the body's tissues. (health.am)
  • Five hours after last injection rats were sacrificed, and the liver and spleen were harvested for subsequent total protein assay. (bvsalud.org)
  • The easy accessibility of hematopoietic cells, which are not tightly embedded in tissue, has supported. (karger.com)
  • Cell proliferation in proper axillary and renal nodes, as well as in the spleen was also assessed. (cdc.gov)
  • The other side of the spleen is divided by a ridge into two regions: an anterior gastric portion, and a posterior renal portion. (wikipedia.org)
  • Chronic inflammation is associated with an increased number of leukocytes in the spleen, which are then redirected to the site of inflammation. (hindawi.com)
  • The spleen is underneath the left part of the diaphragm, and has a smooth, convex surface that faces the diaphragm. (wikipedia.org)
  • The influence of lipoic acid on total protein concentration in the liver and spleen tissue in rats during lipopolysaccharide-induced oxidative stress]. (bvsalud.org)
  • THE AIM OF THE STUDY To evaluate the influence of lipoic acid on total protein concentration in the liver and spleen in rats during endotoxemia . (bvsalud.org)
  • Lipoic acid administration led to a significant increase in total protein concentration in the liver and spleen tissue of endotoxemic rats when compared to control. (bvsalud.org)
  • The aim of the present study was to investigate, and compare with pravastatin and simvastatin, the tissue-specific distribution of rosuvastatin in rats. (aspetjournals.org)
  • The spleen plays very important roles in regard to red blood cells (erythrocytes) and the immune system. (wikipedia.org)
  • Hereditary Spherocytosis is a condition that is passed down from parent to child and it affects the red blood cells and the spleen" (Genetics Home Reference). (bartleby.com)
  • Spherocytosis causes the red blood cells to change shape, therefore making it difficult to move through the spleen (Wint). (bartleby.com)
  • However over time little pieces of their membranes are removed when the cells pass through the spleen. (bartleby.com)
  • However, only macrophage recruitment was inhibited in the absence of T cells in the spleen. (hindawi.com)
  • Yet, if and how the tissue environment shapes the antigen specificity of iNKT cells remains unknown. (elifesciences.org)
  • Beyond the common features shared by all iNKT cells (including their CD1-restriction and innate-like properties), cells found in discrete tissues have distinct phenotypes and functions that critically modulate the outcome of immunity ( Crosby and Kronenberg, 2018 ). (elifesciences.org)
  • 0.001) larger than that of pravastatin (0.703 ml/min/g tissue), and rosuvastatin was taken up by the hepatic cells more selectively and efficiently than pravastatin. (aspetjournals.org)
  • Anytime you're exposed to radiation, there's a small chance of damage to cells or tissue. (wellspan.org)
  • If this damage cannot be repaired, particularly to DNA, cells will self-destruct to protect the surrounding tissue and organism as a whole. (sciencedaily.com)
  • Sometimes, blood-producing cells appear and reproduce in the spleen and liver. (msdmanuals.com)
  • Lipoic acid administration during early phase of LPS-induced oxidative stress increase protein level in the liver and spleen tissue , which indicate an increase of antioxidant properties of an organism. (bvsalud.org)
  • Yet, levels of this sentinel protein are often similar in tissues with vastly different sensitivities to radiation, posing the question: How is p53 involved? (sciencedaily.com)
  • Immunoprecipitation of CD38 protein from mouse spleen tissue extracts. (cellsignal.com)
  • Increased cell proliferation in spleen and lymph nodes peripheral to contact allergen application site. (cdc.gov)
  • It is concluded that dermal application of a contact allergen, as exemplified by OX and HCA, may induce cell proliferation in the neighboring lymph nodes and spleen indicative of hapten and/or haptenated proteins diffusing through the skin to peripheral nodes and the blood to produce systemic sensitization. (cdc.gov)
  • It also carries proteins and other substances away from tissues that cannot be removed or transported directly into the blood system. (petplace.com)
  • Limitations in the usage of AAV in murine models include cell types that are refractory to transduction and difficulties achieving tissue-specificity. (nature.com)
  • Cell Tissue Res 257:459-470. (nih.gov)
  • Spleen - Hyperplasia, Plasma cell in a female B6C3F1/N mouse from a chronic study. (nih.gov)
  • We used the CliniMACS Plus system located in our Cell and Tissue. (karger.com)
  • Nonetheless, how signals from the tissue environment shape the iNKT cell population to best fit their function in their tissues of residency remains unclear. (elifesciences.org)
  • In vulnerable tissues, p53 levels go up and remain high, leading to cell death. (sciencedaily.com)
  • However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)
  • Trunk blood and tissue samples from the periphery (liver, spleen, fat, and heart) and brain (hypothalamus, prefrontal cortex, and hippocampus) were collected. (peerj.com)
  • Rat brain and spleen lysates. (abcam.com)
  • Ichthyophonus was grown from fresh tissues in tissue explant broth cultures of the heart, liver, and/or spleen. (usgs.gov)