Tissue sertoli cells. Medical search. Frequent questions

however, the gene is not present in the interstitial cells of Leydig in the testes. (wikipedia.org)
Fetal type Leydig cells disappear soon after birth (during first 2 weeks after birth) and are replaced by adult type Leydig cells [ 22 , 23 ]. (hindawi.com)
The two key somatic cell types in the testis, Leydig and Sertoli cells, express melatonergic receptors. (preprints.org)
Melatonin acts as a local modulator of the endocrine activity in Leydig cells. (preprints.org)
Common phenotypes of DICER1 syndrome include PPB, MNG, cystic nephroma and Sertoli-Leydig cell tumour. (bmj.com)
Ex vivo exposure of first trimester testes to CBD, THC, or CBD/THC [ratio 1:1] at 10 −7 to 10 −5 M altered testosterone secretion by Leydig cells, AMH secretion by Sertoli cells, and impacted testicular cell proliferation and viability as early as 72 h post-exposure. (biomedcentral.com)
Despite a conserved density of Leydig cells after 30 days of culture (D30), transcript levels of adult Leydig cell and steroidogenic markers were decreased. (elifesciences.org)
hCG was insufficient to facilitate Leydig cell differentiation, restore steroidogenesis and improve sperm yield. (elifesciences.org)
In conclusion, this study reports the failure of adult Leydig cell development and altered steroid production and signaling in tissue cultures. (elifesciences.org)
Transcript levels of the androgen receptor (AR)-regulated gene Rhox5 were decreased at the end of the culture period, suggesting that testosterone production by Leydig cells and/or AR transcriptional activity was impaired in organotypic cultures ( 8 ). (elifesciences.org)
The interstitial tissue between the seminiferous tubules, is composed of loose connective tissue, blood and lymph vessels, and Leydig cells in polyhedral shape. (bvsalud.org)
Sertoli cell and Leydig cell tumours are rare. (gpnotebook.com)
Pure Leydig cell tumours are very rare, and may be referred to as lipid cell tumours. (gpnotebook.com)
0.01), which could be associated with Leydig cell hypertrophy. (biomedcentral.com)
In the interstitial compartment, however, short-term exposure leads to both histological and functional changes of the Leydig cells. (biomedcentral.com)
Testosterone is essential for male fertility, mediating its biological effects through the androgen receptor (AR) present in somatic Leydig, peritubular, and Sertoli cells. (biomedcentral.com)
Epidermal growth factor (EGF) modulates Leydig cell proliferation, steroidogenesis, spermiogenesis, and Sertoli cell activity. (metu.edu.tr)
The ipsilateral ischemic testis of the EGF21 group showed Leydig cell hyperplasia, and the contralateral non-ischemic testes in this group were similar to the control group. (metu.edu.tr)
We also molecularly defined the development of Sertoli, Leydig and peritubular myoid cells during the perinatal period, allowing us to identify candidate signaling pathways acting between somatic and germ cells in a stage-specific manner during the perinatal period. (biologists.com)
Administration of POS extract reversed the ACR-induced epididymides weight loss with improved semen quality and count, ameliorated the ACR-decreased testicular lesion scoring, testicular oxidative stress, testicular degeneration, Leydig cell apoptosis and the dysregulated PCNA and Caspase-3 expression in a dose-dependent manner. (biomedcentral.com)
It upregulated the declined level of serum testosterone and the expression of steroidogenic genes such as CYP11A1 and 17β3-HSD with an obvious histologic improvement of the testes with re-establishment of the normal spermatogenic series, Sertoli and Leydig cells. (biomedcentral.com)
In addition, the ACR-induced reproductive toxicity is associated with a dramatic reduction in testosterone level due to disruption of the Leydig cells steroidogenic pathway [ 10 ]. (biomedcentral.com)
The two main types of stromal tumors are Leydig cell tumors and Sertoli cell tumors. (medlineplus.gov)
Appearance of Leydig cells. (en-academic.com)
Outside the tubule, there's connective tissue with capillaries , as well as Leydig cells - another supportive cell which produces testosterone , which is a hormone necessary for the proper development of sperm . (osmosis.org)
Non-germ cell testicular cancers come from the Sertoli cells or the Leydig cells which can secrete excess sex hormones . (osmosis.org)
Leydig cell hyperplasia may also occur with aging. (medscape.com)

This compromised testicular antioxidant status might have contributed to poor growth and development by affecting the spermatogenesis and steroidogenesis in rats before puberty as indicated by reduced germ cell number, complete absence of round spermatids, decreased seminiferous tubule diameter, and decreased testosterone level. (hindawi.com)
1992) that chloroquine treatment of rats eventually would lead to infertility by resulting in late germ cell developmental with depletion of spermatids (Abayomi O, 1992).This suggested the requirement for the quinine to occupied a place as a male contraceptive agent in humans (Osinubi et al. (researchgate.net)
It has been previously shown that supplementing organotypic culture media with retinol improves the in vitro production of spermatids and spermatozoa in prepubertal mouse testicular tissues cultured at a gas-liquid interphase ( 5 , 7 ). (elifesciences.org)
Cortactin, an actin binding protein, has been associated with Sertoli cell ectoplasmic specializations in vivo , based on its immunolocalization around the heads of elongated spermatids, but not previously identified in isolated Sertoli cells. (biomedcentral.com)
The results suggest that PRKRA functions in the nuage as an element of RNA silencing system and plays unknown role in the ectoplasmic specialization and at the tubulobulbar complexes of Sertoli cells attaching the head of late spermatids. (hindawi.com)
Here, we report an important role for Rlim in testis where it is highly expressed in post-meiotic round spermatids as well as in Sertoli cells. (umass.edu)

Melatonin released from the pineal gland to the circulation is taken up by peripheral tissues including testes. (preprints.org)
This study reports useful information on the limits of the organotypic culture of neonatal mouse testes, which has been regarded as an experimental strategy that can be extended to humans in the clinical setting for the conservation and subsequent re-use of testicular tissue. (elifesciences.org)
The evidence that the culture of testicular fragments of 6.5-day-old mouse testes does not allow optimal differentiation of steroidogenic cells is compelling and should enable further optimizations in the future. (elifesciences.org)
From the microscopic analysis of the testes were identified: vaginal and tunica albuginea, formed by dense connective tissue modeled with large amount of collagen fibers. (bvsalud.org)
Likewise, Sertoli cells isolated from pre-pubertal rat testes have been marked for later detection by the phagocytosis of latex beads [ 10 ]. (biomedcentral.com)
In the G21 group, the bilateral testes showed Sertoli cell only syndrome in some sections, and most of the cells were undergoing apoptosis. (metu.edu.tr)
A gene in the sex-determining region of the short arm of the Y, now referred to as SRY , has been found to direct production of a protein which binds to DNA, inducing differentiation of cells derived from the genital ridges into testes. (en-academic.com)

SPATA16, also known as NYD-SP12, is a developmental protein that aids in differentiation of germ cells for spermatogenesis and participates in acrosome formation for appropriate sperm-egg fusion. (wikipedia.org)
particularly the Sertoli cells, which play a major role in spermatogenesis and are the main cell type in the testis which expresses T 3 receptors [ 16 ]. (hindawi.com)
NANOS2 has also been identified as a key stem cell regulator in Spermatogonial Stem Cells (SSC) of mature individuals by maintaining the stem cell fate during spermatogenesis in mice 10 . (nature.com)
In Sertoli cells, melatonin influences the oxidation state and the energy metabolism, and consequently may regulate spermatogenesis. (preprints.org)
A complete in vitro spermatogenesis has been obtained from mouse prepubertal testicular tissue, although with low efficiency. (elifesciences.org)
In vitro spermatogenesis could indeed be proposed to patients with testicular localization of residual tumor cells, for whom testicular tissue autografting is not indicated (about 30% of patients with acute leukemia). (elifesciences.org)
Spermatogenesis, the process of sperm formation, occurs in the seminiferous tubules and involves the coordinated development of germ cells with the support of Sertoli cells. (diva-portal.org)
These provide structural and nutritional support for germ cells, regulate spermatogenesis, and maintain the blood-testis barrier. (diva-portal.org)
The male generative glands also contain Sertoli cells, which require testosterone for spermatogenesis. (hotelteacounty.com)

Sertoli cell proliferation reaches its maximum level just before birth and ceases by the age of 3 weeks [ 24 ]. (hindawi.com)
This study aimed to investigate the effects of chrysophanol on the proliferation, pyroptosis, migration, and invasion of GC cells. (techscience.com)
Human GC cell lines MKN 28 and AGS cells were treated with different concentrations of chrysophanol, then cell proliferation, migration, invasion and pyroptosis were determined by CCK-8, colony-forming assay, wound healing assay, Transwell assay, and flow cytometry. (techscience.com)

Cells exposed to no hormone and no beads appeared to have a ubiquitous distribution of cortactin throughout the cytoplasm. (biomedcentral.com)
Cortactin immunostaining was diffuse throughout the Sertoli cell cytoplasm when incubated without beads (Fig. 1A ). (biomedcentral.com)
Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. (edu.au)

Double-labeling experiments in HeLa cells invaded with S. flexneri showed a near perfect co-localization of cortactin with actin in the entry structure and at the periphery of the phagosome [ 17 ]. (biomedcentral.com)
The presence or absence of FSH had no apparent effect on the distribution or localization of cortactin within Sertoli cells. (biomedcentral.com)
Previously, we investigated the localization of several nuage-resident proteins in the nuage structures of spermatogenic cells by immunoelectron microscopy (IEM) [ 22 - 26 ]. (hindawi.com)
In vitro functional analyses of the novel variant suggested no impairment to NR5A1 mRNA or protein expression relative to wild-type, and immunofluorescence confirmed similar localization of NR5A1 mutant to the cell nucleus. (biomedcentral.com)
Despite extensive research on Sertoli cells, their protein expression patterns and spatial localization in relation to other testicular cell types remain poorly characterized. (diva-portal.org)
This project aimed to investigate the expression patterns and spatial localization of proteins in Sertoli cells. (diva-portal.org)
Localization of bacterial adherence to skin tissues was confirmed by immunohistochemistry. (bioone.org)

The seminiferous tubules are coiled and coated internally by spermatogenic epithelium consisting of Sertoli cells, surrounded by a basement membrane in the presence of myoid cells. (bvsalud.org)
The nuage of the spermatogenic cells has function similar to the P-bodies. (hindawi.com)
We study whether PRKRA localizes to nuage of spermatogenic cells of rat and mouse. (hindawi.com)
On the other hand, there are specific cytoplasmic foci similar to the P-bodies in spermatogenic cells, which are called nuage [ 15 - 18 ]. (hindawi.com)
Russell and Frank [ 19 ] classified the nuage of spermatogenic cells into six different types according to its morphology and relationship with other surrounding organelles. (hindawi.com)
In addition, we determined that several nuage proteins localize to spermatogenic cell-specific structures, including mitochondria-associated granules (MAG), granulated bodies (GB), reticulated bodies (RB), and ribosome aggregates (RA) [ 22 - 26 ]. (hindawi.com)
Targeting the conditional Rlim cKO specifically to the spermatogenic cell lineage largely recapitulates this phenotype. (umass.edu)

Depending on the molecules and testis age, highly deleterious effects of phytocannabinoid exposure were observed on testis tissue after 14 days, including Sertoli and germ cell death. (biomedcentral.com)
101 proteins were successfully stained and localized within testis tissue and subcellular locations in Sertoli cells were annotated. (diva-portal.org)

The objective of the present study is to investigate the modulation of antioxidant defence status in neonatal persistent hypothyroid rats before their sexual maturation and also to identify the specific testicular cell populations vulnerable to degeneration during neonatal hypothyroidism in immature rats. (hindawi.com)

Granulosa cell tumours are the most common, and account for 5% of all solid ovarian tumours. (gpnotebook.com)
Thecomas are one third as common as granulosa cell tumours. (gpnotebook.com)
Often, tumours have both granulosa and thecal elements - granulosa-theca cell tumours. (gpnotebook.com)
Fibromas are solid benign tumours which consist entirely of fibrous tissue and do not secrete steroids. (gpnotebook.com)
Others, most commonly Sertoli cell tumours (SCT), may present with signs of feminization. (vin.com)
In humans, AMH has been shown to be a specific marker of Sertoli cell origin in gonadal tumours. (vin.com)
AMH is a promising biomarker for the diagnosis of Sertoli cell tumours in dogs. (vin.com)
In human medicine AMH is used to diagnose Granulosa cell tumours (GCT) (Fig. 1). (laboklin.com)

Whereas melatonin exerts anti-proliferative and anti-inflammatory effects on testicular macrophages, it provides protective effects against oxidative stress in testicular mast cells. (preprints.org)
Together, the results suggest that smoking traditional and e-cigarettes can increase oxidative stress , or cell death, which has been linked to tissue and DNA damage. (snopes.com)

This epithelium has principal and basal cells, the main cell design stereocilia toward the lumen of the epididymal duct. (bvsalud.org)

Herein, models of heat-exposed mouse testicular tissue and heat-excited cells were successfully established. (techscience.com)

Seminiferous epithelium of both groups of rats displayed normal histology without any loss of germ cells. (biomedcentral.com)
In the testis, Sertoli cells serve as supporting cells and reside as a basal epithelial lining within the seminiferous epithelium. (biomedcentral.com)
This intermediate (I)-ProSG subset translocates from the center of seminiferous tubules to the spermatogonial stem cell (SSC) 'niche' in its periphery soon after birth. (biologists.com)
Studies on male rodents suggested that chronic ACR exposure resulted in testicular cytotoxicity indicated by vacuolization, multiple nuclei formation, abnormal giant cell, atrophy of the seminiferous tubules and apoptosis. (biomedcentral.com)
A seminiferous tubule has a thick wall of epithelial cells that surround a fluid-filled lumen, a bit like a garden hose. (osmosis.org)
Sertoli cells are supportive cells that provide nutrients to developing sperm cells, and contribute to the blood-testis barrier by only allowing certain molecules, like testosterone , into the seminiferous tubules . (osmosis.org)
Degeneration and hyalinization of the seminiferous tubules with poor germ cell development is frequently observed. (medscape.com)

Histological, RT-qPCR, western blot analyses and steroid hormone measurements were performed on in vitro cultured mouse prepubertal testicular tissues and age-matched in vivo controls. (elifesciences.org)
Freezing of prepubertal testicular tissue containing spermatogonia is a fertility preservation option proposed to prepubertal boys with cancer prior to highly gonadotoxic treatments. (elifesciences.org)
The organotypic culture procedure, which preserves testicular tissue architecture, microenvironment and cell interactions, has been used successfully to obtain spermatozoa from fresh or frozen/thawed mouse prepubertal testicular tissues ( 3 - 6 ). (elifesciences.org)

Müllerian duct structures typically develop on the gonadal side not containing testicular tissue. (medscape.com)
Wolffian duct structures tend to be observed on the gonadal side containing functioning testicular tissue. (medscape.com)

As the AMH secretion take place in the Sertoli cells, AMH concentrations above the reference value indicate presence of testicular tissue (Tab. (laboklin.com)

The epididymal ducts showed pseudostratified columnar epithelium with secretory cells of which stereocilia design, situated on a basement membrane filled by myoid cells. (bvsalud.org)

These findings suggest that while channel proteins found in sperm cells from different species look similar and serve similar roles, they are activated in ways that can be very different. (elifesciences.org)
Nanos are RNA-binding proteins playing crucial roles in germ cell development and maintenance. (nature.com)
The Nanos proteins family regroups highly conserved RNA-binding proteins in higher eukaryotes implicated in germ cell development and maintenance. (nature.com)
A conceptualization of the pathogenetic sequence beginning with 2,5-hexanedione modification of tubulin consisted of the following: tubulin crosslinking leading to microtubule assembly alteration leading to shorter and more numerous microtubules, loss of sertoli cell cytoskeletal integrity, and altered microtubule associated proteins (MAPs) leading to germ cell sloughing and necrosis followed by irreversible germ cell loss. (cdc.gov)
Single-cell RNA sequencing data and immunohistochemistry stainings from the Human Protein Atlas were used to choose candidate proteins to be visualized in a multiplex Immunofluorescence panel. (diva-portal.org)
Additionally, a list of uncharacterized proteins in Sertoli cells were identified. (diva-portal.org)
The employed workflow demonstrated its potential for identifying Sertoli cell-specific proteins and can be applied to future research. (diva-portal.org)
Additional validation is required to verify the presence and identify function of these proteins in Sertoli cells. (diva-portal.org)
Cell surface proteins that bind gastrointestinal hormones with high affinity and trigger intracellular changes influencing the behavior of cells. (edu.au)

The aim of this study was to evaluate the effects of sustained and local administration of EGF on improving bilateral testicular tissue after torsion. (metu.edu.tr)

Ovarian tumors include luteoma of pregnancy, arrhenoblastoma, hilar-cell tumor, masculinizing ovarian stromal cell tumor, and Krukenberg tumor. (health.am)
Their five main subtypes include seminomas, teratomas , yolk sac tumors or endodermal sinus tumors, choriocarcinoma or placental tissue tumors, and embryonal carcinomas. (osmosis.org)

The ECS, which is sensitive to phytocannabinoids, plays a fundamental physiological role in the brain and peripheral tissues, as well as in many pathological conditions [ 14 ]. (biomedcentral.com)

Using immunohistochemistry, AMH has been shown to be a useful marker of immature and neoplastic Sertoli cells in dogs. (vin.com)

Pediatric cancer treatments such as chemotherapy have recognized toxicity on germline stem cells, which could lead to infertility at adulthood ( 1 , 2 ). (elifesciences.org)

They create a specialized microenvironment to support the germ cell development especially through the formation of the blood-testis barrier (BTB). (biomedcentral.com)
In all documented biopsied cases, there is a significant decline in germ cell development and an increase in tubular sclerosis by puberty. (medscape.com)

Transmission has also been reported through blood products by mucocutaneous contact or needlestick injury during patient care or laboratory work ( 7 , 8 ) and by blood transfusion ( 9 , 10 ) or organ ( 11 ) or blood stem cell ( 12 ) transplants. (cdc.gov)

In mice, the suppression of Nanos3 expression in PGC resulted in the complete loss of germ cells in both sexes 9 . (nature.com)
Using single-cell RNA sequencing (RNAseq), we studied the development of ProSG, their SG descendants and testicular somatic cells during the perinatal period in mice. (biologists.com)

Several fertility restoration approaches, whose aim is to mature cryopreserved tissues in vivo or in vitro in order to produce spermatozoa, are being developed. (elifesciences.org)
In an in vitro model of Sertoli cell-spermatid binding, cortactin was identified around debris and dead germ cells. (biomedcentral.com)

We determined the expression of components of the ECS in the human fetal testis from 6 to 17 developmental weeks and assessed the direct effects of phytocannabinoids Δ9-trans-tetrahydrocannabinol (THC) and cannabidiol (CBD) on the testis morphology and cell functions ex vivo. (biomedcentral.com)

Any mammalian ovary has a solid structure to it and is bounded by epithelium along with a thick layer of fibrous tissue, also known as tunica albuginea. (vedantu.com)
Same as that of the T.S. of the mammalian ovary, the T.S. of mammalian testis also has a thick fibrous tissue covering it known as tunica albuginea. (vedantu.com)

Internal to the tunica albuginea is the tunica vasculosa, containing a plexus of blood vessels and connective tissue. (medscape.com)
Ovotestes are usually compartmentalized, with connective tissue separating the ovarian components from the testicular components. (medscape.com)

The wall of the tubule is made up of two kinds of cells: at the periphery , there's the germ cells known as spermatogonia, which are the primordial sperm cells that begin dividing over and over in puberty , and give rise to male gametes. (osmosis.org)
In stallions AMH is produced by the Sertoli cells and remains high through puberty where it then declines to low levels with increasing testosterone production. (laboklin.com)

during the final changes of cell division, the nearly mature sperm call is deposited into the lumen of the semeniferous tubule. (ivf1.com)
Next to them are Sertoli cells which are large cells that extend from the margin all the way to the lumen of the tubule. (osmosis.org)

There is no current form of systemic treatment able to destroy abnormal cells without causing harm or death to normal cells. (bvsalud.org)
3 state no systemic treatment for cancer is currently available with the ability to destroy tumor cells without causing the death of at least some normal cells. (bvsalud.org)

Present study was designed to establish a causal connection between changes in the cell-cell junction protein expression at the blood-testis barrier and alterations in the adult rat testis histology following an anti-androgen flutamide exposure. (biomedcentral.com)

Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. (bioparadigms.org)
A diagnosis of OT-DSD is based solely on the presence of ovarian and testicular tissue in the gonad and not on the characteristics of the internal and external genitalia, even if ambiguous. (medscape.com)
Patients with ovotesticular disorder of sexual development are individuals who have both ovarian and testicular tissue. (medscape.com)
Additionally, testicular and ovarian tissue may develop on the same side of the pelvis as a separate ovary and testis. (medscape.com)

1). AMH is in male animals a useful biomarker for active testicular tissue therefore useful to diagnose cryptorchidism. (laboklin.com)

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. (cancerindex.org)
A role of this gene in Germinal Stem Cells maintenance may be evolutionarily conserved as Nanos2 is specifically expressed both in oogonia and in spermatogonia of adult medaka 11 and in a subpopulation of undifferentiated A spermatogonia in juvenile and spermiating male trout 12 . (nature.com)
The X-linked gene Rlim plays major roles in female mouse development and reproduction, where it is crucial for the maintenance of imprinted X chromosome inactivation in extraembryonic tissues of embryos. (umass.edu)
We identified both gene and protein markers for three temporally distinct ProSG cell subsets, including a migratory cell population with a transcriptome distinct from the previously defined T1- and T2-ProSG stages. (biologists.com)

In the ovary, both paralogs were detected in germinal and somatic cells. (nature.com)
Mammalian ovary is a reproductive organ in females inside which sex cells like eggs or ova are produced. (vedantu.com)
Each ovary consists of an outer cortex that contains follicles, interstitial cells, and oocytes. (vedantu.com)
In female animals, AMH is expressed by granulosa cells of the ovary controlling the formation of primary follicles by inhibiting excessive follicular recruitment by FSH. (laboklin.com)

Os túbulos seminíferos são enovelados e revestidos internamente por epitélio estratificado constituído por células espermatogênicas e células somáticas de Sertoli, envolvidos por uma membrana basal com presença de células mioides. (bvsalud.org)
As shown by examination of semi-thin and ultrathin sections, cell surface occupied by the basal ES connecting neighboring Sertoli cells and the number of gap and tight junctions coexisting with the basal ES were apparently reduced in flutamide-treated rats. (biomedcentral.com)

Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. (bioparadigms.org)

Cell Transplantation. (lu.se)

check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)

HN - 2008 BX - Von Ebner's Glands MH - Cumulus Cells UI - D054885 MN - A05.360.319.114.630.535.200.500 MN - A06.407.312.497.535.300.500 MN - A11.436.300.500 MS - The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. (bvsalud.org)
HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)

Pathological study of infected tissues revealed sections of parasite, severe acute and chronic inflammation, fibrosis and atrophy. (scialert.net)

Previously, to assess mosaicism 1 in multiple tissues obtained when the patient's age ranged from 11 months to age 15 years, DNA was analysed using a Fluidigm Access Array and the HaloPlex HS Target Enrichment System, followed by deep sequencing. (bmj.com)

Stem Cells and Development. (lu.se)

The testis was considered to be a thyroid hormone unresponsive tissue [ 3 ]. (hindawi.com)
We have now detected p.Gly1809Arg in the thyroid lesions, while various other tissues were negative. (bmj.com)

In order to produce sperm, testosterone production form other cells in the testicles is needed. (ivf1.com)

Anatomy18

Organisms2

Diseases8

Chemicals and Drugs18

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes8

Disciplines and Occupations1

Leydig27

Spermatids6

Testes7

Spermatogenesis9

Proliferation3

Cytoplasm3

Localization7

Spermatogenic7

Testis tissue2

Testicular cell1

Tumours8

Oxidative stress2

Epididymal duct1

Mouse testicular1

Seminiferous7

Prepubertal3

Gonadal2

Secretion1

Myoid cells1

Proteins9

Bilateral1

Tumors2

Peripheral tissues1

Immunohistochemistry1

Infertility1

Germ cell development2

Transplants1

Mice2

Vitro2

Vivo1

Fibrous tissue2

Connective tissue2

Puberty2

Lumen2

Systemic2

Blood-testis1

Ovarian4

Biomarker1

Gene4

Ovary4

Basal2

Fetal1

Transplantation1

Adjacent1

Granulosa cells2

Pathological1

Previously1

Development1

Thyroid2

Testosterone production1