AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
Partial Thromboplastin TimeProthrombin TimeBlood Coagulation TestsBlood CoagulationBlood Coagulation DisordersThrombin TimeThromboplastinHeparinAnticoagulantsHemostasisAntithrombinsBlood Coagulation FactorsDisseminated Intravascular CoagulationBleeding TimeThrombelastographyAntithrombin IIIHirudin TherapyLupus Coagulation InhibitorHirudinsFibrinogenFactor VIIIPipecolic AcidsKaolinHemorrhagic DisordersBlood Coagulation Disorders, InheritedPlatelet CountFactor XIHemorrhageProtein CThrombinFactor XaHemophilia AFibrinolysisProthrombinHypoprothrombinemiasHemophilia BCoagulantsFactor XIIInternational Normalized RatioHeparin AntagonistsThrombosisFactor IXCoagulation Protein DisordersFibrin Fibrinogen Degradation ProductsFibrinolytic AgentsFactor XI DeficiencyWhole Blood Coagulation TimeFactor XFactor VIIVitamin K DeficiencyThrombophlebitisSolar ActivityBlood Cell CountCarotid Artery ThrombosisFactor XIaPlatelet AggregationPlasmaThromboembolismFactor VAntiphospholipid SyndromePostoperative HemorrhageHeparinoids4-Hydroxycoumarinsbeta-AlanineFactor VIIaHemostasis, SurgicalProtein SActivated Protein C ResistancePrekallikreinFactor XIIaPlatelet Function TestsVitamin KFibrinopeptide AFactor X DeficiencyFibrinThrombophiliaContusionsSeaweedKininogensChromogenic CompoundsHeparin, Low-Molecular-WeightPhaeophytaDrug MonitoringHemodilutionEnoxaparinAntibodies, AnticardiolipinFactor IXaWarfarinAfibrinogenemiaHematologic TestsThrombocytopeniaAntifibrinolytic AgentsDermatan SulfateBlood PlateletsHemostatic TechniquesHydroxyethyl Starch DerivativesIndicators and ReagentsDogsDose-Response Relationship, Drugvon Willebrand Factor
APTTPlasminogen activatorThrombin ClotPlateletProthrombin TimesPhospholipidExtrinsicMucosalMucous membranesOrgansLiverReagentsDeficiencyBleedsCoagulation panelDefectClot formationCalciumProteinConnectiveFactorTypicallyDecreasesFibrinolysisCohortHeparinParametersBlood to clotBonyClinicalInitiationPlasmaMiceAssaysSoftCellsResultsPatient'sSignificantlyNormalBleedingThrombolysisImmune systemThrombosisAnticoagulantAnticoagulationRecipientPatients
APTT16
Plasminogen activator8
Thrombin Clot1
Platelet6
  • The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). (lookformedical.com)
  • Tissue factor , also called platelet tissue factor , factor III , or CD142 is a protein encoded by the F3 gene , present in subendothelial tissue and leukocytes . (wikidoc.org)
  • There was no difference between the total monocytic TF expressions between the critically ill and sepsis cohorts as well as between those with and without coagulopathy (platelet 9 /L, prothrombin time >15 sec, activated partial thromboplastin time >35 sec or fibrinogen (isth.org)
  • TT involves adding thrombin from human or bovine sources to platelet-poor plasma and measuring the time to fibrin clot formation. (openanesthesia.org)
  • This study investigated the in vivo effect of alum on platelet aggregation and bleeding time in rabbits. (who.int)
  • contradiction in the mechanism of action of alum, we evaluated the in vivo effect of Alum (aluminium potassium sulfate) is a alum in terms of collagen-induced platelet food additive and traditional remedy used to aggregation and bleeding time. (who.int)
Prothrombin Times1
Phospholipid5
  • NP antibodies have in vitro anti-coagulant activity similar to those observed in anti-phospholipid syndrome, suggesting that they may have pro-coagulant effects in polyp tissue. (northwestern.edu)
  • Constituent composed of protein and phospholipid that is widely distributed in many tissues. (lookformedical.com)
  • Both pathways lead to the activation of factor X (the common pathway) which combines with activated factor V in the presence of calcium and phospholipid to produce thrombin (thromboplastin activity). (wikidoc.org)
  • In modern clinical practice, it is commonly used to assess the "intrinsic pathway" of hemostasis and is performed by adding calcium, phospholipid, and an activator such as kaolin to citrated blood, and the time to coagulation is measured. (e-jnc.org)
  • PT measures the time it takes plasma to clot when exposed to thromboplastin (a mixture of tissue factor, calcium, and phospholipid). (openanesthesia.org)
Extrinsic3
  • Together with factor VIIa, tissue factor forms the tissue factor or extrinsic pathway of coagulation. (wikidoc.org)
  • The PT is a laboratory test developed to assess the function of the "extrinsic pathway" whereby calcium and tissue factor (TF) are added to citrated blood and the time to coagulation is measured. (e-jnc.org)
  • The prothrombin time (PT) measures the time it takes plasma to clot when exposed to tissue factor and it assesses the extrinsic and common pathways of coagulation. (openanesthesia.org)
Mucosal2
  • unlike the soft tissue bleeds and hemarthroses that characterize hemophilia A and B, abnormal bleeding in FXI deficiency typically involves mucosal tissues, which are rich in fibrinolytic activity (eg, the oral and nasal cavities and urinary tract). (medscape.com)
  • decreases were seen in tissues and mucosal secretions, critically decreasing potential for virus transmission. (cdc.gov)
Mucous membranes2
  • Other findings on physical examination may be brick-red mucous membranes with a rapid capillary refill time, indicative of distributive shock. (vin.com)
  • The clinical manifestation of AHA includes mostly spontaneous hemorrhages into skin, mucous membranes, muscles, soft tissues, or joints. (seedmedicalpublishers.com)
Organs4
  • According to the model of retrograde menstruation, endometrial tissues are shed through the fallopian tubes into the pelvic cavity during menstruation, resulting in the formation of ectopic endometriotic lesions on the peritoneal tissue or pelvic organs. (biomedcentral.com)
  • A diagnostic imaging test that uses high-frequency sound waves and a computer to make images of blood vessels, tissues, and organs. (stanfordchildrens.org)
  • After the animals were sacrificed, the weight of the major organs and tissues was measured and histopathological examination on the organs from 8 animals in each group (4/sex/group) was performed. (scirp.org)
  • Septicemia that has started to affect your organs or tissue function is a medical emergency. (cura4u.com)
Liver4
  • A shortened activated partial thromboplastin time has no diagnostic meaning, but it may be due to extensive cancer, when the liver is not involved or after an acute hemorrhage. (bloodhealthadvice.com)
  • For example, neoplasia (abnormal growth of tissues and cells), and inflammation of the liver will cause a reduction in the breaking down of blood clots, and a deficiency in the production of coagulation proteins. (wagwalking.com)
  • A tissue sample is taken from your child's liver and checked for any problems. (stanfordchildrens.org)
  • Yang, Stinson J, Belsky MR. Live-related liver donation: Involving partial resection from donor and trans- plantation of the resected portion into the recipient. (binaryoptiontradingscam.com)
Reagents1
Deficiency1
Bleeds1
  • A cerebral hemorrhage occurs when a blood vessel in the brain ruptures and bleeds into the surrounding brain tissue. (medicinenet.com)
Coagulation panel1
Defect3
  • A defect in the head and neck that involves a large amount of soft tissue and a long segment of bone increases the functional impact on speech and swallowing. (medscape.com)
  • If, predominantly, bone is missing, accompanied by only a small soft tissue defect in which sensation and mobility are not likely an issue, the use of an iliac crest or fibular flap may be the best reconstructive option. (medscape.com)
  • For the most difficult situation, which is a significant defect of both components, one option is to use 2 free flaps, such as a sensate RFFF for the soft tissue and an iliac crest free flap for the bone. (medscape.com)
Clot formation1
  • In addition to conventional laboratory parameters, rotational thromboelastometry (ROTEM) provides evidence for net coagulation capacity and insight into clot formation time, clot firmness and fibrinolysis in the critically ill patients [ 12 ]. (biomedcentral.com)
Calcium1
  • Note that one of factor VIIa's domains, GLA domain , binds in the presence of calcium to negatively charged phospholipids , and this binding greatly enhances factor VIIa binding to tissue factor. (wikidoc.org)
Protein1
  • Patients treated with anticoagulation were more likely to require invasive mechanical ventilation (29.8% vs. 8.1%) and to have significantly increased prothrombin time, activated partial thromboplastin time, lactate dehydrogenase, ferritin, C-reactive protein, and d -dimer values. (the-hospitalist.org)
Connective3
  • as part of an evaluation for antiphospholipid antibody syndrome , as part of the evaluation of patients with connective tissue disease. (labtestsonline.org.uk)
  • if you have lupus or a related connective tissue disease. (labtestsonline.org.uk)
  • Serologic tests for Leptospira and Rickettsia tsutsugamushi and connective tissue diseases were also negative. (cdc.gov)
Factor9
  • The PTT indirectly measures action of the following coagulation factors: I (fibrinogen), II (prothrombin), V (proaccelerin), VIII (anti-hemophilic factor), X (Stuart-Prower factor), XI (plasma thromboplastin antecedent), and XII (Hageman factor). (wikipedia.org)
  • The test is termed "partial" due to the absence of tissue factor from the reaction mixture. (wikipedia.org)
  • In each patient, intrinsically (contact activation, INTEM) and extrinsically (tissue factor activation, EXTEM) activated test assays were performed to analyze the clot dynamics in both coagulation pathways. (biomedcentral.com)
  • At the same time, the mixing study showed immediate correction at time 0, which was, however, prolonged once again after two hours of incubation at 37 °C (98,6°F), suspecting the presence of time- and temperature-dependent clotting factor inhibitors. (drpaulalexander.com)
  • Acquired hemophilia onset was immediately suspected due to the possible presence of time-dependent clotting factor inhibitors and confirmed with low FVIII (7.9 %, normal value 70-130 %), associated with the presence of high FVIII autoantibody inhibitor titer (64 Bethesda Unit - BU). (drpaulalexander.com)
  • Thromboplastin defines the cascade that leads to the activation of factor X - the tissue factor pathway. (wikidoc.org)
  • [1] In addition to the membrane-bound tissue factor, soluble form of tissue factor was also found which results from alternatively spliced tissue factor mRNA transcripts, in which exon 5 is absent and exon 4 is spliced directly to exon 6. (wikidoc.org)
  • The best known function of tissue factor is its role in blood coagulation . (wikidoc.org)
  • Monocytic surface expression of tissue factor (TF) may contribute to sepsis-associated coagulopathy. (isth.org)
Typically1
  • Partial thromboplastin time is typically analyzed by a medical technologist or a laboratory technician on an automated instrument at 37 °C (as a nominal approximation of normal human body temperature). (wikipedia.org)
Decreases1
  • This further decreases blood flow to brain tissue and its cells. (medicinenet.com)
Fibrinolysis1
  • Roughly biphasic effects of rivaroxaban and dabigatran but not apixaban or edoxaban on fibrinolysis were observed through Max n 1 and the fibrinolysis peak time, which was defined as a time length from the time when Max p 1 (Max p 1 time) to the time when Max n 1 appears (Max n 1 time). (elsevierpure.com)
Cohort1
  • ECASS Study Group, The ECASS 3-hour cohort: secondary analysis of ECASS data by time stratification. (jamanetwork.com)
Heparin3
  • Apart from detecting abnormalities in blood clotting, partial thromboplastin time is also used to monitor the treatment effect of heparin, a widely prescribed drug that reduces blood's tendency to clot. (wikipedia.org)
  • The heparin effect was determined by comparing the clotting time of the INTEM with the clotting time of the HEPTEM, where heparinase is added. (biomedcentral.com)
  • If the patient is receiving heparin by intermittent injection, the sample should be drawn 30-60 minutes before the next dose, while, if the patient is receiving a continuous heparin infusion, the sample can be drawn at any time. (medscape.com)
Parameters1
  • Methods: The experimental conditions were optimized according to how t-PA concentrations and a time length after t-PA adjustment affect parameters of CFWA. (elsevierpure.com)
Blood to clot1
  • Your PTT test results will show how much time it took for your blood to clot. (medlineplus.gov)
Bony1
  • In some instances, the surgeon may need to compromise on either the soft tissue or the bony component of the reconstruction. (medscape.com)
Clinical3
  • In adults, a high probability scan with high clinical suspicion is correctly predictive of PE 96% of the time. (medscape.com)
  • We include updates from clinical trial findings that were not available at the time of these publications. (e-jnc.org)
  • We found that like non-adapted wild-type EBOV, guinea pig-adapted EBOV resulted in widespread tissue infection, variably associated with tissue pathology, and alterations in clinical and immunological analytes in the absence of overt disease. (cdc.gov)
Initiation1
  • To adjust for differential length of stay and anticoagulation initiation, anticoagulation duration was used as a covariate and intubation was treated as a time-dependent variable. (the-hospitalist.org)
Plasma5
  • The blood is mixed, then centrifuged to separate blood cells from plasma (as partial thromboplastin time is most commonly measured using blood plasma). (wikipedia.org)
  • Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. (lookformedical.com)
  • Clotting time of PLASMA mixed with a THROMBIN solution. (lookformedical.com)
  • the area under the plasma concentration-time curve was 1,374 +/- 340 min x g/l for HES 650/0.42/2.8 and 1,697 +/- 411 min x g/l for HES 650/0.42/5.6 (P = 0.026). (silverchair.com)
  • L'agrégation plaquettaire induite par le collagène dans des échantillons de plasma riche en plaquettes de 14 lapins sains a été mesurée par turbidimétrie en utilisant un agrégomètre, avant et une heure après une injection intra- veineuse d'alun. (who.int)
Mice1
  • Notably, infection with either non-lethal variant did not greatly differ from lethal mouse-adapted EBOV until near the time end-point criteria are reached in these mice. (cdc.gov)
Assays1
  • The second type are lupus anticoagulant assays, which are functional tests that measure the time it takes for a patient's sample to clot, and they require the presence and action of phosopholipids for clotting to occur. (labtestsonline.org.uk)
Soft6
  • Reconstruction after head and neck cancer extirpative surgery frequently requires the replacement of bone and soft tissue to provide the most optimal functional and aesthetic result. (medscape.com)
  • 3] The RFFF's popularity has stemmed from its superior soft tissue characteristics, which offer a large amount of thin, pliable skin that conforms well to the native contours of the recipient site. (medscape.com)
  • The RFFF is frequently used as the soft tissue component in this situation. (medscape.com)
  • The authors believe that a better option is a single microvascular procedure, which has ideal soft tissue characteristics and provides enough bone to reconstruct the mandible and minimize complications. (medscape.com)
  • A soft tissue mass with lobulated margins was seen on computed tomography (CT) scan. (biomedcentral.com)
  • No evidence of soft tissue hematomas was found. (drpaulalexander.com)
Cells2
  • Venoms from Loxosceles spiders exhibit a wide range of activities on different cells, tissues and systems, being specially evident their ability to cause a dermonecrotic lesion. (usp.br)
  • An autoimmune disease is where your immune system becomes hyperactive and attacks healthy cells and tissues by mistake. (chronichealthinfo.com)
Results2
  • But the results of a PTT test may show a slow clotting time. (medlineplus.gov)
  • Often, different biomarker results are made available at different time intervals. (ultalabtests.com)
Patient's3
  • So far, there has only been a partial solution to this problem, namely developing automated oxygen delivery systems adjusted to the complexity of the patient's condition. (romanianjournalcardiology.ro)
  • The INR is calculated as a ratio of the patient's PT to a control PT obtained using a World Health Organization (WHO)-approved thromboplastin reagent. (openanesthesia.org)
  • The INR will be similar on a blood sample tested in any laboratory and allows comparison of the patient's tests performed at different times and/or locations. (openanesthesia.org)
Significantly1
  • Bleeding time from an ear puncture in 8 rabbits was also significantly prolonged after intravenous alum injection. (who.int)
Normal1
  • A PSMA-positive metastatic lesion should not correspond to a normal tissue structure or benign lesion. (who.int)
Bleeding2
  • AHA should be suspected when a patient with no history of hemorrhages presents with bleeding and an unexplained prolonged activated partial thromboplastin time. (seedmedicalpublishers.com)
  • This loss of blood supply can be ischemic because of lack of blood flow, or hemorrhagic because of bleeding into brain tissue. (medicinenet.com)
Thrombolysis1
  • Prothrombin time-based INR values were measured before thrombolysis and 6 and 24 hours thereafter. (neurology.org)
Immune system1
  • They are also involved in tissue repair and other functions involving the immune system. (ultalabtests.com)
Thrombosis1
Anticoagulant1
  • Invert the tubegently several times to mix the anticoagulant, but do not agitate it. (medscape.com)
Anticoagulation1
  • But after a few weeks, we reached an intuitive feeling that anticoagulation was of benefit and, at the same time, the literature was beginning to say clots were important in this disease," Dr. Fuster said. (the-hospitalist.org)
Recipient1
  • Microvascular free flaps have the advantage of providing healthy, vascularized, non-irradiated tissue for recipient sites that may have been compromised by surgery, radiation, chemotherapy, or a combination of the three. (medscape.com)
Patients4
  • Objective: To compare APA levels (anti-cardiolipin, anti-phosphatidylethanolamine (anti-PE), and anti-β 2 -glycoprotein (anti-B2GP)) in nasal polyp (NP) tissue with tissue from control and CRS without nasal polyp (CRSsNP) patients, we tested whether NP antibodies affect coagulation, and correlate APAs with anti-dsDNA IgG and markers of coagulation. (northwestern.edu)
  • Another systematic review on 61 patients reported that excessive oxygen therapy reduces coronary blood fl ow by 29%, increasing at the same time cardiovascular resistance. (romanianjournalcardiology.ro)
  • If a dose of [HA627 trade name] is missed within 12 hours of the time it is usually taken, patients should be instructed to take the dose of [HA627 trade name] with food as soon as possible. (who.int)
  • Ces résultats semblent indiquer que l'utilisation de l'alun en tant qu'antiplaquettaire oral pourrait faire l'objet d'études complémentaires, en tenant compte des effets secondaires éventuels notamment chez les patients dont la fonction rénale est altérée. (who.int)