Tissue nerve regeneration. Medical search. Frequent questions

The choice of which physical, chemical and biological cues to use is based on the properties of the nerve environment, which is critical in creating the most desirable environment for axon regeneration. (wikipedia.org)
The ideal treatment for promoting axon regeneration after spinal cord injury would inhibit the formation of scar tissue," says Professor Frank Bradke, who leads a working group at the DZNE's site in Bonn and who conducted the study. (medizin-aspekte.de)
Retinal ganglion cell expression of cytokine enhances occupancy of NG2 cell-derived astrocytes at the nerve injury site: Implication for axon regeneration. (neurotree.org)
Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells. (neurotree.org)
Park KK , Luo X, Mooney SJ , Yungher BJ , Belin S , Wang C , Holmes MM , He Z . Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats. (neurotree.org)
Hyperactivated Stat3 boosts axon regeneration in the CNS. (neurotree.org)
We have found a promising new approach to control inflammation and scar formation, which will be an important part of future strategies to encourage axon regeneration and recovery after spinal cord injury," Davies said. (sci-info-pages.com)

The resulting cavity causes many problems for tissue-engineered scaffolds because invasive implantation is required, and often the scaffold does not conform to the cavity shape. (wikipedia.org)
My project is now focused on the use of electrospun fiber scaffolds for nerve regeneration. (uc.edu)
A systematic review of animal models used to study nerve regeneration in tissue-engineered scaffolds. (thieme-connect.com)
Tissue engineering performs the culture of cells on scaffolds, aiming at the restoration of damaged tissue. (springer.com)
Scaffolds are of great interest in tissue engineering and nerve regeneration because they form a framework on which soft tissue is supported and thereby start its regeneration process. (nisenet.org)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
Changing surface characteristics of scaffolds was a way to promote regeneration and ion implantation was one of the methods to modify surface properties which play a huge role in enhancing the proliferation and integration of cells. (omicsonline.org)
Cardiovascular and nerve regeneration grafts and scaffolds. (jgh.ca)

Similar techniques are also being explored for nerve repair in the spinal cord but nerve regeneration in the central nervous system poses a greater challenge because its axons do not regenerate appreciably in their native environment. (wikipedia.org)
The present study results indicated that compared with the same number of 2D-cultured cells, microtissue could secrete more nerve regeneration related cytokines to promote SCs proliferation and axons growth. (biomedcentral.com)
Resveratrol increased the number of axons in the distal part of the injured nerve, indicating enhanced nerve regeneration. (vinomis.com)
2010). Although axons in peripheral nerves have the capacity to regenerate after injury, a number of clinical reports and studies in recent years have indicated that functional recovery, especially motor function, is far from satisfactory even with advances in surgical procedures (Ruijs et al. (vinomis.com)
We have conducted experiments in the adult rat visual system to assess the relative importance of an absence of trophic factors versus the presence of putative growth inhibitory molecules for the failure of regeneration of CNS axons after injury. (nih.gov)
The rats were left for 20 days and their optic nerves and retinae prepared for immunohistochemical examination of both the reaction to injury of axons and glia in the nerve and also the viability of Schwann cells in the grafts. (nih.gov)
Anterograde axon tracing with rhodamine-B provided unequivocal qualitative evidence of regeneration in each group, and retrograde HRP tracing gave a measure of the numbers of axons growing across the lesion by counting HRP filled retinal ganglion cells in retinal whole mounts after HRP injection into the optic nerve distal to the lesion. (nih.gov)
GAP-43-positive and rhodamine-B filled axons in the acellular peripheral nerve and cellular peripheral nerve groups traversed the lesion and grew distally. (nih.gov)
He and his colleagues are especially interested in how nerve cells are repaired in their longest-reaching sections, their axons . (innovationtoronto.com)
Axons can be up to a meter long in adult human nerve cells, extending away from the cell body toward neighboring nerve cells, with which they exchange signals. (innovationtoronto.com)
Restoring length to damaged axons is essential to restoring nerve function, but coordinating these repairs at a great distance from the cell's nucleus involves a mix of complex processes within each cell. (innovationtoronto.com)
As a reaction to damage, nerve axons can grow out to make new connections. (encyclopedia.com)
In short: through the same effect, namely microtubule stabilization, epothilone is able to inhibit directional movement in scar-forming cells while stimulating active growth in nerve cell axons. (medizin-aspekte.de)
The pseudo-nerve, which contains longitudinal Schwann cell columns without axons and surrounded by perineurium-like tissue but no axons (Q. Zhao, L.B. Dahlin, M. Kanje, G. Lundborg, Brain Res. (lu.se)
Surgery to repair the damaged nerve and maximize the number of axons that regenerate through the site of injury may be performed. (uspharmacist.com)
Optic nerve regeneration in mammals: Regenerated or spared axons? (neurotree.org)
Using a high-powered laser scanning microscope and protein chemistry to analyze tissue samples, Davies and co-workers were able to show that decorin infusion reduced inflammation, scar formation and the levels of some proteoglycans by 80-95 percent allowing nerve fibers (called axons) to grow across spinal cord injuries in just four days. (sci-info-pages.com)
6. Insulin-dependent diabetes: laboratory studies have demonstrated impaired nerve regeneration in diabetic animals, and diabetes in patients can lead to impaired regeneration of axons and recovery following investigational nerve injury as well as focal neuropathies such as ulnar neuropathy and carpal tunnel syndrome. (who.int)

A more recent approach proposes tissue engineering the electrode interface through the use of encapsulated neurons within hydrogel coatings. (frontiersin.org)

We used grafts constructed by microtissues and polycaprolactone (PCL) nerve conduit to repair sciatic nerve defects in rats. (biomedcentral.com)
Our group routinely carries out projects on nerve conduits, aiming at replacement of autologous nerve grafts. (uniklinik-freiburg.de)
Viable Schwann cells were found in the vitreal grafts in the cellular peripheral nerve group only, supporting the proposition that Schwann cell derived trophic molecules secreted into the vitreous stimulated retinal ganglion cell axon growth in the severed optic nerve. (nih.gov)
Self-alignment of Schwann cells within a tethered type-1 collagen matrix, followed by removal of interstitial fluid produces a stable tissue-like biomaterial that recreates the aligned cellular and extracellular matrix architecture associated with nerve grafts. (open.ac.uk)
Nerve regeneration in different types of grafts: experimental study in rabbits. (thieme-connect.com)

El-Karabaty H, Hetzel A, Galla TJ, Horch RE, Lucking CH, Glocker FX: The effect of carpal tunnel release on median nerve flattening and nerve conduction. (uniklinik-freiburg.de)
Neurapraxia is a reduction or complete block of conduction across a segment of a nerve with axonal continuity conserved. (medscape.com)
A nerve conduction study (NCS) can be effective in identifying peripheral nerve injury. (medscape.com)
[ 12 ] Peripheral nerves are stimulated by somatosensory evoked potentials (SSEPs), and if signal conduction is disrupted along any segment of the circuit, an evoked potentiation is not produced. (medscape.com)
Alpha-lipoic acid has been shown to have a positive effect on nerve conduction and to reduce neuropathic pain. (healthline.com)
3 The axon's continuity is retained, and although conduction across the nerve injury is inhibited, conduction within the nerve both proximal and distal to the lesion remains intact. (uspharmacist.com)
Furthermore, the electrophysiological analysis revealed the capacity of DDD-028 to restore near-normal sensory nerve conduction in paclitaxel-treated animals. (bvsalud.org)
In the late 1960s, neurophysiologic testing allowed the classification of CMT into 2 groups, one with slow nerve conduction velocities and histologic features of a hypertrophic demyelinating neuropathy (hereditary motor and sensory neuropathy type 1 or CMT1) and another with relatively normal velocities and axonal and neuronal degeneration (hereditary motor and sensory neuropathy type 2 or CMT2). (medscape.com)
Now a large and ever increasing number of genetic subtypes has been described, and major advances in molecular and cellular biology have clarified the understanding of the role of different proteins in the physiology of peripheral nerve conduction in health and in disease. (medscape.com)

A new combination of tissue engineering techniques provides a simple and effective method for building aligned cellular biomaterials. (open.ac.uk)
It is one of a number of analysis and characterisation facilities within the Department, and is predominantly used by members of the Biomaterials and Tissue Engineering theme . (sheffield.ac.uk)
Chen F, Liu X. Advancing biomaterials of human origin for tissue engineering. (scielo.br)
Our lab specializes in the development of engineered biomaterials for tissue repair. (uc.edu)
Biomaterials have been used in medicine for decades to improve the functions of tissues and organs. (omicsonline.org)
In summary the main objectives achieved included technical skills at the interface of Chemistry, Chemical Engineering, Biomaterials and Cell Biology and hands-on training in a variety of new techniques and equipment in both the return and outgoing research groups, leading to the development of excellent skills in basic research and their application to biomaterials, drug delivery and tissue engineering. (europa.eu)

Inactivation of p300 acetyltransferase reversed the resveratrol-induced expression of VEGFs and motor repair in rats that had undergone sciatic nerve crush injury. (vinomis.com)
592 (1992) 106-114), was applied as a graft to repair nerve defect in rats. (lu.se)
Infusing a naturally occurring anti-scarring agent called decorin into the damaged spinal cords of rats suppresses key molecules that block nerve regeneration after spinal cord injury, said Baylor College of Medicine (BCM) researchers in a study published today in the European Journal of Neuroscience. (sci-info-pages.com)
After treatment, rats were euthanized, and tail tissues were chemically fixed for histological analysis of nerves (PGP9.5, neuropeptide Y, calcitonin gene related protein) and mast cells (avidin, Alcian Blue/Safranin O).2 Single sections were doublestained for nerve fibers and mast cells to permit assessment of the degree of physical overlap. (cdc.gov)

Nobel Prize winner Alexis Carrel performed numerous experiments clearly showing that tissue explants, including connective tissue and heart tissue, could be cultured in vitro preserving their characteristics for prolonged periods of time [ 2 ] supporting the notion that entire organs could be cultured in vitro. (intechopen.com)
Through years of meticulous medical and scientific research, Sayer Ji has documented the published medical science on the most powerful plant-based molecules that regenerate organs and tissues in the human body . (naturalnews.com)
Cells Tissues Organs (2016) 202 (1-2): 85-101. (karger.com)

nerve repair was arrested in the absence of Mitf--demonstrating that Mitf is required for peripheral nerve repair and regeneration. (innovationtoronto.com)

This is, therefore, a useful new approach for generating anisotropic engineered tissues, and it can be used with Schwann cells to fabricate artificial neural tissue for peripheral nerve repair. (open.ac.uk)
Schwann cells receive crucial support with nerve repair from the fat tissue that surrounds nerves in the body. (innovationtoronto.com)
By double staining of S-100 and laminin we found that the longitudinally organized Schwann cell columns in the pseudo-nerve were surrounded by basal laminae and ensheathed by a layer of vascularized perineurium-like tissue. (lu.se)
Schwann cells, which are unique glial cells in peripheral nerves that dedifferentiate after peripheral nerve injury (PNI) and are released from degenerative nerves. (bvsalud.org)
Then we utilized ex vivo and in vitro models to investigate the effects of PGC-1α inhibition and activation on Schwann cell dedifferentiation and nerve degeneration. (bvsalud.org)
Our findings indicate that PGC-1α negatively regulates Schwann cell dedifferentiation and nerve degeneration. (bvsalud.org)
Through the use of RNA-seq, siRNA/plasmid transfection and reversal experiments, we identified that PGC-1α targets inhibit the expression of paraoxonase 1 (PON1) during Schwann cell dedifferentiation in degenerated nerves. (bvsalud.org)
In summary, PGC-1α plays a crucial role in preventing Schwann cell dedifferentiation and its activation can reduce peripheral nerve degeneration by targeting PON1. (bvsalud.org)
PGC-1α inhibits Schwann cell dedifferentiation and peripheral nerve degeneration. (bvsalud.org)
PGC-1α negatively regulates Schwann cell dedifferentiation and peripheral nerve degeneration after injury by targeting PON1. (bvsalud.org)

Wnt signaling promotes axonal regeneration following optic nerve injury in the mouse. (neurotree.org)

ABSTRACT: Nerve injuries cause considerable loss of function in many individuals. (uspharmacist.com)
ABSTRACT: Neurotoxicity of chemotherapeutics involves peculiar alterations in the structure and function, including abnormal nerve signal transmission, of both the peripheral and central nervous system. (bvsalud.org)

No fibres crossed the lesion in the optic nerve crush group and dense scar tissue was formed in the wound site. (nih.gov)
Present treatments to enhance nerve cell regeneration following injury seem to concentrate on diminishing present scar tissue. (healthjockey.com)
Following a traumatic injury in the nervous system like a stab wound or stroke, fibrinogen seemingly dischrages from impaired blood vessels into the brain and scar tissue starts to form. (healthjockey.com)
The MRL/MpJ mouse displays an accelerated ability to heal ear punch wounds without scar formation (whereas wounds on the dorsal surface of the trunk heal with scar formation), offering a rare opportunity for studying tissue regeneration in adult mammals. (brighton.ac.uk)
Reactionary dentin is tubular and relatively similar to secondary dentin in structure, while reparative dentin (also called fibrodentin or even "calcified scar tissue" [ 4 ] is believed to be relatively impermeable, forming a barrier between tubular dentin and pulp tissue. (tannlegetidende.no)
It is already known that inhibiting factors in newly formed scar tissue and other cellular processes block axon regrowth. (medizin-aspekte.de)
From their previous research, it was already known that stabilizing microtubules would reduce the formation of scar tissue and promote axonal growth. (medizin-aspekte.de)
Epothilone reduces the growth of scar tissue by inhibiting the formation of microtubules in the cells that form the scar tissue. (medizin-aspekte.de)
Scar tissue that develops at sites of injury stops the regeneration of connections in the adult central nervous system," said Dr. Stephen Davies, lead author on the study and an assistant professor of neurosurgery and neurosciences at BCM. (sci-info-pages.com)
Infusion of decorin into spinal cord injuries prevents the formation of proteoglycan rich scar tissue by suppressing inflammation. (sci-info-pages.com)
Misaligned scar tissue that forms at spinal cord injuries physically blocks nerve regeneration and contains molecules called chondroitin sulfate proteoglycans that inhibit nerve fiber growth. (sci-info-pages.com)
Decorin inhibits the action of pro - inflammatory molecules released in spinal cord injuries, called transforming growth factors, which are thought to promote the formation of scar tissue. (sci-info-pages.com)
Because the cannulas were so small, they did not contribute to the formation of scar tissue. (sci-info-pages.com)
In humans, our immune response causes scar tissue to form, which can stop parts of the retina from responding to light. (medlineplus.gov)

When direct suturing of the two stumps of a severed nerve cannot be accomplished without tension, the standard clinical treatment for peripheral nerve injuries is autologous nerve grafting. (wikipedia.org)
Due to the limited availability of donor tissue and functional recovery in autologous nerve grafting, neural tissue engineering research has focused on the development of bioartificial nerve guidance conduits as an alternative treatment, especially for large defects. (wikipedia.org)
At present, autologous nerve transplantation is still the standard gold method for treating long segmental nerve defects, but it has some limitations, such as limited donor sources, complications from second operations, and permanent denervation dysfunction of donor site [ 5 ]. (biomedcentral.com)
Therefore, effective autologous nerve replacement is critical in the field of peripheral nerve regeneration. (biomedcentral.com)
is fundamentally possible, but with a lower efficiency compared to the autologous nerve. (uniklinik-freiburg.de)

Tissue-engineered microtissue is an effective strategy for stem cell culture and therapy in nerve tissue engineering. (biomedcentral.com)
however, stem cell injection alone has been unsuccessful in many areas of neural regeneration. (karger.com)
Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)

But why is regeneration of these neurons and their long nerve fibers impeded? (medizin-aspekte.de)
Nerve fibers were assayed structurally by protein gene product 9.5 (PGP9.5) nerve immunostaining. (cdc.gov)
PGP9.5 binds an ubiquitin pathway protein present in all types of nerve fibers, but PGP9.5 levels may change with injury and alter identification consistency. (cdc.gov)
Discussion: PGP9.5, NPY and CGRP staining of nerve fibers and avidin-positive mast cells is feasible in rat tail sections. (cdc.gov)
The present study shows CGRP in some mast cells, but it is unknown whether this represents associated nerve fibers and/ or uptake with re-release during vasoregulation. (cdc.gov)
Previously, we demonstrated destruction of terminal nerve fibers by impact vibration.2 Nerve fibers can regenerate after damage. (cdc.gov)
Nerve fibers of different types regenerate to different degrees. (cdc.gov)
Vasoconstriction fiber (NPY) regeneration is expected to be higher than (CGRP) vasorelaxant fibers. (cdc.gov)
Histopathology evidence indicated that DDD-028 was able to counteract effectively paclitaxel-induced peripheral neurotoxicity by protecting against the loss of intraepidermal nerve fibers, restoring physiological levels of neurofilament in nerve tissue and plasma, and preventing morphological alterations occurring in the sciatic nerves and dorsal root ganglia. (bvsalud.org)
Wallerian degeneration is a series of stereotypical events that occurs in response to nerve fibers after PNI. (bvsalud.org)
The facial nerve (cranial nerve VII) carries motor, secretory, and afferent fibers from the anterior two thirds of the tongue. (medscape.com)
Afferent fibers from the anterior two thirds of the tongue enter the geniculate ganglion with the chorda tympani, as the greater and lesser petrosal nerve emerge from the superior part. (medscape.com)

Rodents lacking VEGFs showed impaired nerve regeneration (Sun et al. (vinomis.com)

Scientists have discovered a new chemical compound namely "1938" which can help damaged nerves regenerate after injury. (com.pk)

J Brachial Plex Peripher Nerve Inj 2008 3, 19. (uniklinik-freiburg.de)

Autologous platelets as a source of proteins for healing and tissue regeneration. (springer.com)
We are developing a nanoparticle based delivery vehicle (peptide amphiphile) for proteins to the penis and cavernous nerve to promote regeneration. (uic.edu)
PAX6 provides instructions for making proteins that drive tissue development in the fruit fly eye by turning on 'eye' genes and turning off 'non-eye' genes. (medlineplus.gov)

Sheets of this engineered neural tissue supported and directed neuronal growth in a co-culture model, and initial in vivo tests showed that a device containing rods of rolled-up sheets could support neuronal growth during rat sciatic nerve repair (5 mm gap). (open.ac.uk)
Further testing of this device for repair of a critical-sized 15 mm gap showed that, at 8 weeks, engineered neural tissue had supported robust neuronal regeneration across the gap. (open.ac.uk)
1 Because nerve trauma is the most common form of nervous system trauma encountered in clinical practice, neuronal death due to trauma is an important clinical issue. (uspharmacist.com)

Even though dentin is mineralized and the pulp a loose connective tissue, they form a developmentally interdependent and functionally integrated continuum, often referred to as the dentin‐pulp complex, where physiologic and pathologic reactions in one will also affect the other. (tannlegetidende.no)

Soft tissue engineering for both clinical use and as novel 3D in vitro models for improved laboratory studies. (sheffield.ac.uk)

Tissue-engineered nerve guidance conduits are a combination of many elements: scaffold structure, scaffold material, cellular therapies, neurotrophic factors and biomimetic materials. (wikipedia.org)
The superstructure of a conduit or scaffold is important for simulating in vivo conditions for nerve tissue formation. (wikipedia.org)
Tamaddon M, Samizadeh S, Wang L, Blunn G, Liu C. Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering. (scielo.br)
This scanning electron microscope image shows an electrospun scaffold grown for studying brain tissue engineering and nerve regeneration. (nisenet.org)
Researchers can tailor a scaffold to meet the requirements of the tissue they seek to regenerate. (nisenet.org)

A nerve guidance conduit (also referred to as an artificial nerve conduit or artificial nerve graft, as opposed to an autograft) is an artificial means of guiding axonal regrowth to facilitate nerve regeneration and is one of several clinical treatments for nerve injuries. (wikipedia.org)
Peripheral nerve injuries are generally associated with incomplete restoration of motor function. (vinomis.com)
Peripheral nerve injuries represent a significant source of patient morbidity and disability (Asplund et al. (vinomis.com)
[ 3 ] Seddon created a 3-grade classification, and Sunderland categorized nerve injuries into 5 grades. (medscape.com)
[ 1 ] To rule out bony and ligamentous injuries, all patients with axillary nerve injury should have radiographs taken of the shoulder and cervical spine. (medscape.com)
Kline & Hudson's Nerve Injuries. (thieme-connect.com)
Operative Results for Major Nerve Injuries, Entrapments, and Tumors. (thieme-connect.com)
Spinal cord injuries occur when blunt physical force damages the vertebrae, ligaments, or disks of the spinal column, causing bruising, crushing, or tearing of spinal cord tissue, and when the spinal cord is penetrated (eg, by a gunshot or a knife wound). (msdmanuals.com)

Unlike dorsal skin wounds, nerve regeneration in the ear wound preceded vascularisation, recapitulating early mammalian development. (brighton.ac.uk)

Various types of trauma can result in nerve injury, a significant cause of functional morbidity. (uspharmacist.com)

Most bone defects such as fractures have the capacity for spontaneous regeneration, which leads to treatment by conventional therapies. (scielo.br)
The autologous graft is still considered the gold standard, as it has the necessary properties for bone regeneration, in terms of combined osteoconduction, osteoinduction and osteogenesis [ 5 5. (scielo.br)
are used to develop new bone substitutes that restore, improve or prevent the deterioration of compromised tissue function [ 8 8. (scielo.br)
Differentiating between a peripheral nerve problem and an injury involving the spinal cord, brain, bone, or soft tissue is crucial. (medscape.com)
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
Intratemporally, the facial and vestibular cochlear nerves split, entering the fallopian canal of the temporal bone. (medscape.com)
GALNS deficiency induces the accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S) in multiple tissues, particularly bone, cartilage, heart valves, and cornea, whereas β-galactosidase deficiency induces the accumulation of only KS in those tissues. (medscape.com)

The extracellular matrix, which is mainly responsible for directing tissue growth and formation, has a complex superstructure created by many interwoven fibrous molecules. (wikipedia.org)
The regenerative response of acellular peripheral nerve-transplanted animals was probably promoted by residual amounts of these molecules present in the transplants after freezing and thawing. (nih.gov)
Our results suggest either that none of the above elements inhibit CNS regeneration after perineuronal neurotrophin delivery, or that the latter, in addition to mobilising and maintaining regeneration, also down regulates the expression of axonal growth cone-located receptors, which normally mediate growth arrest by engaging putative growth inhibitory molecules of the CNS neuropil. (nih.gov)
While most people (and doctors) believe that heart tissue, for example, can't be healed, Sayer has documented cardio-regenerative molecules found in specific plants that actually initiate the body's rebuilding of damaged heart tissue. (naturalnews.com)
Similarly, other powerful molecules can help heal nerves, ligaments, blood vessels and other tissues (see the photographic proof below). (naturalnews.com)

Whether the conduit is in the form of a biologic tube, synthetic tube or tissue-engineered conduit, it should facilitate neurotropic and neurotrophic communication between the proximal and distal ends of the nerve gap, block external inhibitory factors, and provide a physical guidance for axonal regrowth. (wikipedia.org)
The proximal hypoglossal nerve was inserted into the long arm and sutured to its wall. (uni-koeln.de)
The increase is localized to the site of regeneration and does not occur at proximal sites in the body column of the regenerate. (uni-muenchen.de)
Creation of the pseudo-nerve was accomplished by inserting the proximal and distal stumps of a cut sciatic nerve into a silicone tube. (lu.se)
When both proximal and distal inserts were isolated nerve segments the pseudo-nerve was still formed but thin, probably because of compromised vascular supply. (lu.se)

Subtype-specific survival and regeneration of retinal ganglion cells in response to injury. (neurotree.org)
But when a zebrafish's retina is damaged, certain cells trigger the affected tissue to regrow and restore vision, a process called "retinal regeneration. (medlineplus.gov)

In the optic nerves of all groups the astrocyte, microglia and macrophage reactions were similar. (nih.gov)
Her later research with fruit flies showed that this gene plays a key role in how their eyes and optic nerves develop. (medlineplus.gov)

PPARÎ³ coactivator-1 alpha (PGC-1α) is an essential transcription factor co-activator that regulates gene transcription and neural regeneration. (bvsalud.org)

Citation: Ding Z, Cao J, Shen Y, Zou Y, Yang X, Zhou W, Guo Q and Huang C (2018) Resveratrol Promotes Nerve Regeneration via Activation of p300 Acetyltransferase-Mediated VEGF Signaling in a Rat Model of Sciatic Nerve Crush Injury. (vinomis.com)
This study showed that the motor deficits caused by sciatic nerve crush injury were alleviated by daily systematic resveratrol treatment within 10 days. (vinomis.com)
We examined the expression of PGC-1α after sciatic nerve crush or transection using Western blotting and found that PGC-1α expression increased after PNI. (bvsalud.org)

Effects of chondroitinase ABC on intrathecal and peripheral nerve tissue. (lu.se)

Furthermore, microtissues could repair sciatic nerve defects in rat models more effectively than traditional 2D-cultured ASCs. (biomedcentral.com)
Although many benefits of resveratrol have been shown in the nervous system, it is not clear whether resveratrol could promote fast nerve regeneration and motor repair after peripheral nerve injury. (vinomis.com)
The above results indicated that daily systematic resveratrol treatment promoted nerve regeneration and led to rapid motor repair. (vinomis.com)
Resveratrol activated p300 acetyltransferase-mediated VEGF signaling in the affected ventral spinal cord, which may have thus contributed to the acceleration of nerve regeneration and motor repair. (vinomis.com)
Koulaxouzidis G, Reim G, Witzel C: Fibrin glue repair leads to enhanced axonal elongation during early peripheral nerve regeneration in an in vivo mouse model. (uniklinik-freiburg.de)
But, Twiss said, scientists still have a lot to learn about how nerve cells repair themselves. (innovationtoronto.com)
especially when it comes to nerve regeneration, the ability for nerves to heal and repair themselves. (innovationtoronto.com)
The repair process begins with the formation of the clot, accompanied by an inflammatory process with proliferation of granulation tissue. (scielo.br)
Technological advances in neurosurgical instrumentation and diagnostic imaging have led to great results in the repair of acute nerve injury. (medscape.com)
A 2017 review indicates that supplementing with B vitamins has the potential to promote nerve repair. (healthline.com)
We have recently shown that repair by hypoglossal-facial or facial-facial nerve surgical end-to-end anastomosis and suture [hypoglossal-facial anastomosis (HFA) or facial-facial anastomosis (FFA)] results in collateral axonal branching, polyinnervation of neuromuscular junctions (NMJs) and poor function. (uni-koeln.de)
We conclude that application of MS after hypoglossal-facial nerve repair using an isogenic Y-tube is contraindicated: it does not lead to functional recovery but, rather, worsens it. (uni-koeln.de)
In an alternative repair approach, a gap of 2.6 cm in length was repaired with a chitosan-based nerve guide. (thieme-connect.com)
1 Siemionow M, Brzezicki G. Chapter 8: current techniques and concepts in peripheral nerve repair. (thieme-connect.com)
5,6 Segmental demyelination and Wallerian degeneration are repair mechanisms that are relevant to traumatic nerve injury, whereas axonal degeneration is more characteristically seen in metabolic and toxic nerve disorders such as diabetes mellitus and renal failure. (uspharmacist.com)
Ulnar nerve repair by the silicone chamber technique. (lu.se)
Nerve repair and axonal transport. (lu.se)

Taken together, the results suggested that the pseudo-nerve contains the essential neurobiological elements to induce successful axonal elongation. (lu.se)

2014). In vivo, VEGFs are expressed after peripheral nerve injury (Li et al. (vinomis.com)
The pattern of depolarization matches that of the amputated limb and is correlated to the position and type of injury, revealing that information about damage is available to remote body tissues and is detectable non-invasively in vivo by monitoring the bioelectric state. (biologists.com)

Peripheral nerve injury (PNI) is one of the essential causes of physical disability with a high incidence rate. (biomedcentral.com)
The slow rate of nerve regeneration after injury may account for this. (vinomis.com)
During their study, the scientists conducted multiple experiments on heart tissue and nerve cells, and a sciatic nerve injury, to assess the effects of the PI3K pathway. (com.pk)
Professor James Phillips, of the UCL School of Pharmacy, who is a senior author of the study, said: "There are currently no approved medicines to regenerate nerves, which have been damaged as a result of injury or disease, so there's a huge unmet need. (com.pk)
These new experimental manipulations have taken researchers a step closer to understanding how nerve cells are repaired at their farthest reaches after injury. (innovationtoronto.com)
Our patient presented 12 months after nerve injury and, thus, his chances of recovery were small. (innovationtoronto.com)
Classification of nerve injury is based on the damage sustained by the nerve components, nerve functionality, and the ability for spontaneous recovery. (medscape.com)
[ 4 ] An important quality of the peripheral nervous system, as compared to the central nervous system, is its remarkable ability to recover after an injury through remyelination and regeneration of the axon. (medscape.com)
An untreated acute injury to a nerve can progress to chronic nerve injury. (medscape.com)
Once a nerve injury occurs, effects on the nerve, neuromuscular junction, and muscle begin to occur. (medscape.com)
Is the nerve injury complete or incomplete? (medscape.com)
What is the grade of the peripheral nerve injury? (medscape.com)
The workup of every patient with acute nerve injury begins with a complete history and a physical examination. (medscape.com)
Facial nerve injury is a common clinical trauma involving long-term functional deficits with facial asymmetry leading to associated psychological issues and social hardship. (uni-koeln.de)
Background The rabbit sciatic nerve injury model may represent a valuable alternative for critical gap distance seen in humans but often leads to automutilation. (thieme-connect.com)
In this study, we modified the complete sciatic nerve injury model for avoiding autophagy. (thieme-connect.com)
3 Geuna S. The sciatic nerve injury model in pre-clinical research. (thieme-connect.com)
Scars in the brain or spinal cord may obstruct connections between nerve cells and frequently keep injury patients from attaining complete recovery. (healthjockey.com)
Therapeutic regimens have been developed to manage the pain associated with nerve injury, as well as to restore the normal functioning of the nerve. (uspharmacist.com)
1 Many drugs used to manage pain due to nerve injury were developed as anticonvulsants and antidepressants, so it is important for pharmacists to be aware of the indication for which the drug is being used, as well as the recommended dosage for the particular indication. (uspharmacist.com)
and stretch injury (nerves can stretch 10%-20% before becoming structurally damaged). (uspharmacist.com)
Classification of nerve injury depends upon the nerve components affected, loss of functionality, and the ability to recover spontaneously. (uspharmacist.com)
2 Two grading systems are used to stage the extent of nerve injury: Seddon's system and, more recently, Sunderland's system. (uspharmacist.com)
Seddon proposed a three-tiered model for nerve injury: neurapraxia, axonotmesis, and neurotmesis, in order of increasing severity. (uspharmacist.com)
Neurotmesis , the most severe form of nerve injury, is associated with complete nerve division and disruption of the endoneurium. (uspharmacist.com)
Peripheral nerves respond to injury or disease in one or more of the following ways: segmental remyelination, Wallerian degeneration, and axonal degeneration. (uspharmacist.com)
Repeated nerve injury can invoke death of the nerve cell body and failure to regenerate. (cdc.gov)
As Wallerian degeneration plays a crucial role in PNI, we conducted a study to determine whether PGC-1α has an effect on peripheral nerve degeneration after injury. (bvsalud.org)
The keystone of successful surgical treatment for facial paralysis, the details of facial nerve anatomy, is recapitulated briefly to review topographic anatomy of the facial nerve and to enable the physician to localize the suspected site of injury. (medscape.com)
The bony canal-facial nerve diameter is an important clinical ratio, especially considering susceptibility to nerve injury. (medscape.com)

Research from 2021 shows that taking higher amounts can lead to nerve damage and cause symptoms of neuropathy. (healthline.com)

Comparison of sciatic nerve course in amphibians, reptiles and mammals. (thieme-connect.com)

Neurodegeneration and neurodegenerative diseases (including the shared mechanisms of nerve cell death that contribute to many diseases), Vascular Cognitive Impairment and Dementia (VCID), NINDS tissue/cell resources, basic invertebrate neuromuscular junction (NMJ). (nih.gov)
The stylomastoid branch of the posterior auricular artery provides vascular supply to the facial nerve during its intrafallopian course. (medscape.com)
5. Possessing any contraindication to decreased temperature such as cryoglobulinemia, cryofibrinogenemia, cold urticaria paroxysmal cold hemoglobinuria, or Raynaud's disease: the decreased temperature accompanying cryoneurolysis could result in local tissue/vascular compromise for patients with any of these cold-triggered syndromes/diseases. (who.int)

The photo doesn't even show how deep the laceration was, but it severed the lateral ligaments, finger nerves, blood vessels and part of the primary ligament that runs underneath the finger. (naturalnews.com)
After 8-9 weeks of nutrition, light therapy, sound therapy, prayer, massage and other natural modalities, my finger regenerated itself and regrew the nerves, ligaments and blood vessels . (naturalnews.com)
Patient experience reduced healing times due to the Gemini™ laser's ability to achieve homeostasis along with preventing edema by cauterizing and sealing blood vessels, capillaries, and the nerve lining. (drjamesamiller.com)

Following implantation into a TBI lesion cavity or peripheral nerve guidance conduit, MC elicits a minimal inflammatory response. (wikipedia.org)
[ 1 ] Imaging techniques, such as radiography, computed tomography (CT) scan, and magnetic resonance imaging (MRI) are valuable diagnostic tools for evaluating a peripheral nerve lesion. (medscape.com)

But a small 2012 study found that people with type 1 diabetes who took 300 milligrams per day of benfotiamine showed no significant improvements in nerve function or inflammation. (healthline.com)
Pulpal complications of caries, extensive wear or other external irritation may result in symptomatic or asymptomatic inflammation, followed by partial or progressive pulp tissue degradation and necrosis. (tannlegetidende.no)

A blastema-like structure develops and subsequently the structure of the wounded ear is restored, including cartilage, skin, hair follicles and adipose tissue. (brighton.ac.uk)

After 4 weeks, the pseudo-nerve was harvested, trimmed into a 10-mm long graft and transplanted into a corresponding defect of the contralateral sciatic nerve. (lu.se)
The results showed that the pseudo-nerve could induce nerve regeneration to a similar extend as a real nerve graft. (lu.se)

The most basic objective of a nerve guidance conduit is to combine physical, chemical, and biological cues under conditions that will foster tissue formation. (wikipedia.org)
Nerve growth factor combined with an epineural conduit for bridging a short nerve gap (10 mm). (thieme-connect.com)

2 As with axonotmesis, neurotmesis initiates Wallerian degeneration, but the prognosis for nerves is poor. (uspharmacist.com)

4. Neurologic deficit of the intercostal nerves of the fractured ribs: cryoneurolysis is theoretically a potent analgesic, but it does not "heal" injured nerves. (who.int)

CT scan and traditional MRI have certain limitations in distinguishing peripheral nerves from the surrounding structures, in which case magnetic resonance neurography (MRN) can help visualize both normal and abnormal peripheral nerves. (medscape.com)

The Gemini™ allows for soft tissue removal that is extremely precise and predictable while not to injuring dental pulp. (drjamesamiller.com)

The creation of artificial conduits is also known as entubulation because the nerve ends and intervening gap are enclosed within a tube composed of biological or synthetic materials. (wikipedia.org)
At the moment, our group is working on a joint interdisciplinary project with the Department Of Microsystems Engineering to use innovative 3D bioprinting technology to improve the efficacy of nerve conduits. (uniklinik-freiburg.de)

The new compound also helped reduce heart tissue damage after major trauma in animal models and regenerated lost motor function, the study said. (com.pk)
Damage to the body's peripheral nerves can cause pain and movement disorders. (innovationtoronto.com)
[ 3 ] Surgical intervention is based on the extent of nerve damage and functional viability of the nerve. (medscape.com)
Without treatment, it can cause permanent nerve damage. (healthline.com)
These organic conductors provide safe electrical stimulation of tissue while avoiding undesirable chemical reactions and cell damage. (frontiersin.org)
More commonly known as nerve damage, neuropathy is a clinical condition with many different causes, including deficiency of B vitamins, coupled by prolonged and repetitive movements that put stress on hands, legs or feet. (philstar.com)
Are you are already experiencing nerve damage and in need of a doctor's visit? (philstar.com)
As with every disease, early detection is crucial for recovery from nerve damage. (philstar.com)
This work is aimed at assessing whether DDD-028 is a disease-modifying agent by protecting the peripheral nervous tissues from chemotherapy-induced damage. (bvsalud.org)
Diseases that damage the retina or optic nerve (such as glaucoma ) can lead to permanent blindness. (medlineplus.gov)
Because nerve cells in the brain are particularly sensitive to phenylalanine levels, excessive amounts of this substance can cause brain damage. (medlineplus.gov)

4 Wrist drop secondary to prolonged external pressure that compresses the radial nerve at the spiral groove of the humerus is a clinical example of neurapraxia. (uspharmacist.com)

Trauma to peripheral nerves is relatively common. (medscape.com)

Committed nerve precursors were assayed by their ability to continue nerve differentiation following explanation of small pieces of tissue. (uni-muenchen.de)
The results show, furthermore, that redistribution of committed precursors does not play a major role in the pattern of nerve differentiation during regeneration. (uni-muenchen.de)

Anatomy57

Organisms14

Diseases16

Chemicals and Drugs24

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Psychiatry and Psychology1

Phenomena and Processes20

Disciplines and Occupations2

Technology, Industry, Agriculture6

Information Science1

Health Care2

Axon regeneration7

Scaffolds8

Axons18

Encapsulated neurons1

Grafts5

Conduction9

Biomaterials6

Rats4

Organs3

Required for peripheral nerve1

Schwann10

Axonal regeneration1

Abstract2

Scar14

Autologous nerve5

Stem5

Fibers12

Showed impaired nerve1

Regenerate after injury1

Brachial Plex Peripher Nerve Inj1

Proteins3

Neuronal3

Connective tissue1

Novel 3D in vitro1

Scaffold5

Injuries8

Dorsal1

Morbidity1

Bone7

Molecules5

Proximal5

Retinal2

Optic nerves2

Neural regeneration1

Sciatic nerve crush3

Peripheral nerve tissue1

Repair17

Elongation1

Vivo2

Injury30

20211

Mammals1

Vascular3

Blood vessels3

Lesion2

Inflammation2

Adipose Tissue1

Graft2

Conduit2

Wallerian1

Heal1

Abnormal1

Soft tissue1

Conduits2

Damage11

Clinical1

Trauma1

Differentiation2