The biopsy specimen from the right maxillary sinus showed soft tissue infiltration with myeloid leukemic cells, consistent with a chloroma. (contemporarypediatrics.com)
AML affects the ocular system through direct infiltration of tissues, secondary to hematological abnormalities, or in the form of chloroma or myeloid sarcoma in the brain or orbit consequently leading to a variety of manifestations depending on the ocular tissue involved. (dovepress.com)
Expression detected in several myeloid leukemic, colon cancer, and prostate cancer cell lines. (lu.se)
Chloroma2
Rarely, a bony or soft-tissue chloroma may precede the development of marrow infiltration by AML (granulocytic sarcoma). (medscape.com)
Chloroma: the focal infiltration of leukemic cells. (ucoz.com)
Spleen3
Detected in spleen, lung and muscle, probably as a result of leucocyte infiltration in these tissues. (lu.se)
Main clinical manifestations are anemia, bleed, spleen lymphadenectasis, and infiltration of central nervous system and so on. (biomedres.info)
Hodgkin Lymphoma Hodgkin lymphoma is a localized or disseminated malignant proliferation of cells of the lymphoreticular system, primarily involving lymph node tissue, spleen, liver, and bone marrow. (msdmanuals.com)
Bone10
However, once the initial diagnosis has been established by prior bone marrow biopsy, a recurrence can also be documented by peripheral blood smear or identification of leukemic cells in cerebrospinal fluid. (alaska-disability.com)
Patients with acute myelogenous leukemia (AML) present with symptoms resulting from bone marrow failure, symptoms resulting from organ infiltration with leukemic cells, or both. (medscape.com)
Patients with a high leukemic cell burden may present with bone pain caused by increased pressure in the bone marrow. (medscape.com)
[18] Whereas, with CLL, diseased cells propagate from within the bone marrow, in SLL they propagate from within the lymphatic tissue. (wikipedia.org)
Lymphatic tissues also include the thymus, a relatively small organ behind the breastbone that is thought to play an important role in the immune system until puberty, as well as the bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. (rarediseases.org)
These occur because of the infiltration of the bone marrow by these leukemic cells affecting adequate production of platelets and red blood cells. (amazonaws.com)
In addition a failure of the bone marrow and infiltration of cancer cells into organs will occur. (furrycritter.com)
Chronic eosinophilic leukemia is a disease in which too many eosinophils (a type of white blood cell) are found in the bone marrow, blood, and other tissues. (furrycritter.com)
Anemia develops due to substitution of bone-marrow spaces by osseous and osteoid tissues, i.e. due to osteosclerosis. (poznayka.org)
Lymphoid1
Later came to be used to describe all forms of lymphoid neoplastic proliferations that arise as discrete tissue masses. (fdocuments.net)
Malignant3
In general, two distinct forms are recognized-an epitheliotropic form (in which there is infiltration by malignant lymphocytes into the epidermis and adnexa) and a nodular, nonepitheliotropic form. (merckvetmanual.com)
Targeted agents, defined as drugs designed to target specific gene mutations in malignant tissue, inhibit oncogenic signaling cascades associated with tumor growth. (nejm.org)
Skin tumor (top) from a representative patient with BPDCN showing infiltration by malignant cells (haematoxylin and eosin (H&E), left) expressing the pDC marker TCL1 (immunohistochemistry, right). (medicalxpress.com)
Acute4
Signs and symptoms of pediatric acute myelocytic leukemia (AML) can be divided into the following: (1) those caused by a deficiency of normally functioning cells, (2) those due to the proliferation and infiltration of the abnormal leukemic cell population, and (3) constitutional symptoms. (medscape.com)
Although HAstV-MLB has been recovered from fecal samples of patients with acute flaccid paralysis ( 6 ), to our knowledge, no reports have documented this variant in cerebrospinal fluid (CSF) or central nervous system (CNS) tissue samples. (cdc.gov)
Q. Is tumor-cell infiltration of the kidneys a common cause of acute kidney injury in patients with leukemia and lymphoma? (nejm.org)
However, renal infiltration causes acute kidney injury in only 1% of patients with acute leukemia and in even fewer patients with lymphoma or chronic leukemia. (nejm.org)
Marrow1
However, the leukemic cells are staying in the marrow instead of entering the bloodstream, where they would be visible in a blood test. (furrycritter.com)
Leukemia1
Occasionally, patients have skin rashes due to infiltration of the skin with leukemic cells (leukemia cutis). (medscape.com)
Infiltrates1
A. The kidney is the most common extrareticular site of leukemic and lymphomatous infiltration, and tumor-cell infiltrates in the kidney are seen in up to 30% of patients with lymphoma and up to 60% of patients on autopsy. (nejm.org)
Tumor tissue1
NK cell infiltration into tumor tissue is associated with better disease prognosis in colorectal cancer, clear cell renal cell carcinoma, and lung carcinomas ( 9 - 11 ). (frontiersin.org)
Cells12
Alternatively, symptoms may be the result of organ infiltration with leukemic cells. (medscape.com)
Signs relating to organ infiltration with leukemic cells include hepatosplenomegaly and, to a lesser degree, lymphadenopathy. (medscape.com)
Microscopically, there was a dense infiltration of mature plasma cells beneath the squamous epithelium, separated by thick collagen bundles. (pathologyoutlines.com)
It is characterized by a diffuse and intense infiltration of mature plasma cells in the subepithelial gingiva. (pathologyoutlines.com)
Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes. (rarediseases.org)
The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions. (bvsalud.org)
If the leukemic cells invade the central nervous system, then neurological symptoms (notably headaches) can occur. (furrycritter.com)
The cells within our body live in very different environments depending on which organ or tissue they're in," says study co-senior author Andrew Lane, MD, Ph.D., of Dana-Farber and the Broad Institute. (medicalxpress.com)
Nanoscale extracellular vesicles (EVs) represent a unique cellular derivative that reflect the therapeutic potential of mesenchymal stem cells (MSCs) toward tissue engineering and injury repair without the logistical and safety concerns of utilizing living cells. (izon.com)
Quiescent normal adult stem cells serve as a source of self-renewal in the maintenance of multiple adult epithelial tissues. (biomedcentral.com)
Meanwhile, these non-engineered viruses sometimes inevitably infect and spread to normal tissues, indiscriminately killed both tumor and normal cells, causing a series of unpredicted side effects. (biomedcentral.com)
By the genetic recombination the viruses were conferred with high specificity against tumor cells without targeting normal tissues. (biomedcentral.com)
Chronic2
The labelling of interleukin-2 (IL-2) with 123I and its in vivo application for imaging chronic pathological lymphocytic infiltrations are described. (nih.gov)
HHV-5, also known as cytomegalovirus (CMV), causes a primary infection of the salivary glands and other tissues, and it is believed to have a chronic form. (medscape.com)
Lymphocytes2
Lymphocytes are stored within lymph nodes and may also be found in other lymphatic tissues. (rarediseases.org)
Lymphatic tissue or circulating lymphocytes may also be located in other regions of the body, such as the skin, small intestine, liver, and other organs. (rarediseases.org)
Thrombocytopenia1
4-6 They are caused by direct neoplastic cell infiltration or indirect complications secondary to hematologic abnormalities (thrombocytopenia, anemia and hyperviscosity state). (dovepress.com)
Symptoms2
It is characterized by an extremely elevated blast cell count and symptoms of decreased tissue perfusion. (wikipedia.org)
Symptomatic Hyperleukocytosis (Leukostasis) is defined by a tremendously high blast cell count along with symptoms of decreased tissue perfusion. (wikipedia.org)
Diffuse1
Cutaneous involvement consists of perivascular or more diffuse dermal infiltrations without epidermotropism. (cancer.gov)
Liver1
1 Consequently, AML can affect various tissues and organs (liver, skin, central nervous system), including the eye and orbit. (dovepress.com)
Tumors2
Moreover, these tumors grow either from the vertebral body, or from the tissues of the dura mater. (ucoz.com)
This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. (cancerindex.org)
Leukostasis1
Increased blood viscosity due to large leukemic blast populations which are less deformable than mature leukocytes may lead to leukostasis. (wikipedia.org)
Bony1
Bony erosion and extra-sinus infiltration was found in 15 of 46 (33%) patients on imaging. (biomedcentral.com)
Occur1
Severe local tissue necrosis can occur if there is extravasation during administration. (nih.gov)
Occurs1
Infiltration occurs most commonly in patients with the monocytic subtypes of AML. (medscape.com)
VASCULAR1
MSC-derived azido-EVs exhibit comparable morphological and functional properties as their non-labeled EV counterparts and, when immobilized within collagen hydrogel implants via click chemistry, they elicited more robust host cell infiltration, angiogenic and immunoregulatory responses including vascular ingrowth and macrophage recruitment compared to ten times the higher dose required by non-immobilized EVs. (izon.com)
Patients1
Patients with gum infiltration often present to their dentist first. (medscape.com)
Vivo1
In conclusion, this technique is highly specific and easy to perform and we suggest its application in humans for in vivo detection of areas of lymphocytic infiltration. (nih.gov)
Lung1
Microvasculature damage to the lungs is only second to neurological damage because the body is already experiencing hypoxic conditions, which lead to lung tissue damage as the second leading cause of fatalities. (wikipedia.org)
Masses1
A maxillofacial and brain CT scan revealed bilateral destructive soft tissue masses in the region of the maxillary sinuses. (contemporarypediatrics.com)
Damage1
Tissue damage caused by CS exposure is mediated, at least in part, by oxidative stress induced by its toxic and pro-oxidant components. (izon.com)
High1
The disposition profile shows a rapid distributive phase with a very high volume of distribution presumably reflecting extensive tissue binding. (nih.gov)
Common1
The most common (95%) - a tumor of the glial tissue (gliomas). (ucoz.com)
Soft1
Bilateral circumferential soft tissue densities were seen in the extraconal regions of the orbit with severe proptosis. (contemporarypediatrics.com)
Normal1
Oncolytic virotherapy (OVT) is a promising anti-tumor modality that utilizes oncolytic viruses (OVs) to preferentially attack cancers rather than normal tissues. (biomedcentral.com)
Multiple1
The study, published online today by the journal Nature , is one of the first to uncover the "genetic travelog" of a cancer that evolves across multiple different tissues. (medicalxpress.com)