Tissue endothelial cells. Medical search. Frequent questions

Endothelial dysfunction is a critical initiating factor contributing to cardiovascular diseases, involving the gut microbiome-derived metabolite trimethylamine N-oxide (TMAO). (nature.com)
This study aims to clarify the time-dependent molecular pathways by which TMAO mediates endothelial dysfunction through transcriptomics and metabolomics analyses in human microvascular endothelial cells (HMEC-1). (nature.com)
The discrepancies between studies on TMAO-induced endothelial dysfunction may be attributed to different cell types and animal models used, including different metabolic backgrounds, as well as to distinct TMAO treatment concentrations and durations. (nature.com)
These cells are non-regenerative in vivo and therefore, approximately 40% of corneal transplants undertaken worldwide are a result of damage or dysfunction of endothelial cells. (ulster.ac.uk)
Recently, endothelial dysfunction (ED) has been demonstrated in these patients, but the mechanisms remain elusive. (mdpi.com)
The hematologic changes of preeclampsia, ie, thrombocytopenia and microangiopathic hemolytic anemia, are similar to those found in thrombotic thrombocytopenic purpura or hemolytic uremic syndrome - disorders in which endothelial dysfunction is thought to be important. (health.am)
Activation of the clotting cascade and increased sensitivity to pressors are compatible with endothelial cell dysfunction. (health.am)
Adverse stimuli such as pro-fibrotic and pro-inflammatory cytokines or reactive oxygen species, induce endothelial injury and dysfunction. (rug.nl)
When persistent, this dysfunction can result in endothelial-to-mesenchymal transition (EndMT) which contributes to fibro-proliferative disease. (rug.nl)

Since hypoxia activates hypoxia-inducible factor (HIF-1)-dependent transcription in cancer cells that, in a paracrine fashion, drive tumor angiogenesis, we investigated the effects of UCN-01 on HIF-1-responsive promoter constructs. (karger.com)
We report that, in addition to direct inhibitory effects on endothelial cell growth, UCN-01 abrogates hypoxia-mediated transactivation of HIF-1-responsive promoters in a prostate cancer cell line. (karger.com)
We conclude that UCN-01, at clinically relevant concentrations, exerts an anti-neovascularization effect by blocking two important steps in vessel formation: (1) the response of cancer cells to hypoxia, and (2) endothelial cell proliferation. (karger.com)
Hypoxia and ischemia are known to stimulate production of VGEF in some cells. (medscape.com)
This pathway is basally active in mesenteric artery endothelial cells, but, after exposure to intermittent hypoxia to mimic sleep apnea, nuclear factor of activated T cells c3 nuclear translocation and CSE expression are decreased, concomitant with decreased CSE-dependent vasodilation. (unboundmedicine.com)
To assess this phenomenon, we established tumor myofibroblasts cell line and analyzed the up-regulating genes in myofibroblasts upon exposure with hypoxia and/or serum starvation. (nii.ac.jp)
In this treatment, we identified that CD44 is up-regulated under the hypoxia and this molecule supports stemness of cancer stem cells and induces drug resistance of cancer cells. (nii.ac.jp)
In order to improve the tissue hypoxia in the tumor microenvironment, it is required to normalize very leaky and immature tumor vasculature. (nii.ac.jp)
A circulating angiopoietin-like protein that is expressed in a variety of tissues in response to HYPOXIA. (bvsalud.org)

Serum bioactivity (with and without exosomal fractions) was assessed via 1) serum cumulative inflammatory potential (SCIP) assay on mouse brain endothelial cells (MBEC) and 2) myography using naïve thoracic aorta from male C57BL6 mice incubated with 1% serum from exposed mice to evaluate vasodilatory changes. (cdc.gov)

TMAO treatment for either 24H or 48H induces reduced cell viability and enhanced oxidative stress. (nature.com)
UCN-01, a protein kinase C (PKC) inhibitor, induces growth arrest and apoptosis in cancer cells and was recently introduced in a phase I clinical trial. (karger.com)
Cells labelled at relatively high concentrations appear dark with less contrast, whereas labelling at low concentrations induces positive contrast. (au.dk)
Ample evidence shows that pro-atherosclerotic disturbed flow induces sustained activation of atherogenic genes in endothelial cells to promote their oxidation, inflammation, cell cycle progression and proliferation, whereas pulsatile shear stress tends to maintain endothelial cells in a quiescent and less proliferative state with a low level of oxidation and inflammation [16] , [17] . (plos.org)

Functional characterization of embryonic stem cell-derived endothelial cells. (ca.gov)
Endothelial cells (EC) derived from embryonic stem cells (ESC) require additional functional characterization before they are used as a cell therapy. (ca.gov)
Endothelial cells (EC) derived from embryonic stem cells (ESC) require additional functional characterization before they are used as a cell therapy in order to enhance their potential for engraftment and proliferation. (ca.gov)

The corneal endothelium is the posterior monolayer of cells that are responsible for maintaining overall transparency of the avascular corneal tissue via pump function. (ulster.ac.uk)
Endothelial cells (ECs) form the endothelium, a layer of single-cell thickness that coats the interior wall of all blood vessels including arteries, capillaries, and veins. (beckman.com)
Depending on their nature and function, ECs form either a continuous or porous endothelium, allowing various levels of passage of fluids and nutrients between the lumen and surrounding tissues. (beckman.com)
Compared to the endothelium, the molecular mechanisms involved in the interaction of infiltrated or tissue-resident immune cells with parenchymal barriers have not been so extensively studied. (hindawi.com)
The vascular endothelium produces a number of important substances including endothelial-derived relaxing factor or nitric oxide, endothelin-1, prostacyclin, and tissue plasminogen activator. (health.am)
Originally thought to behave as supporting cells for the lung epithelium and endothelium with a singular f. (researchgate.net)
The blood microvascular endothelium consists of a heterogeneous population of cells with regionally distinct morphologies and transcriptional signatures in different tissues and organs. (researchgate.net)
Originally regarded as a passive barrier, the endothelium has become appreciated as a complex tissue with multiple functions and critical for shaping health. (rug.nl)
Neutrophils, haemorrage, necrosis, oedema and activated vascular endothelium represent components of an active inflammatory process, at the same time chronicity is observed as fibroplasia, mononuclear leukocytes and neovascularisation are present in the tissue. (helsinki.fi)
Kaposi sarcoma is a vascular neoplasm composed of endothelium-lined vascular spaces and spindle-shaped cells. (bvsalud.org)
Kaposi's sarcoma is a neoplasm of vascular endothelium that is characterized by proliferation of spindle cells, neoangiogenesis, inflammation and edema 17 . (bvsalud.org)

Thereafter, a distinct subpopulation of endothelial cells lining the cardinal vein starts differentiating by expressing the TF PROX1, the master regulator of lymphatic endothelial cell (LEC) identity, via the TFs SOX18 and COUPTFII. (nature.com)
Negative WT1 staining implies a nonproliferative nature of the oral lymphangiomas, thus growth is most likely secondary to enlargement of lymphatic vessels and not neoplastic proliferation of lymphatic endothelial cells. (medscape.com)

Showing that angiogenic factors stimulate trypsinogen 4 expression, which hydrolyses TFPI-2 favoring a pro-migratory situation, our study suggests a new pathway linking tumor microenvironment signals to endothelial cell migration, which is essential for angiogenesis and blood vessel remodeling. (unimib.it)
Based on our findings, we conclude that VEGF , a major regulator of angiogenesis, and CD4(+), CD8(+), and CD45RO(+) memory T cells play a key role in CsA-induced gingival overgrowth . (bvsalud.org)
Altogether, by identifying a pro-angiogenic VEGF/miR-101/EZH2 axis in endothelial cells we provide evidence for a functional link between growth factor-mediated signaling, post-transcriptional silencing, and histone-methylation in the angiogenesis process. (plos.org)
Angiogenesis - the formation of new blood vessels - occurs during tissue growth and development, but also during wound healing and cancer [1] , [2] . (plos.org)
The functionality of the matured microvasculature networks was demonstrated through the enhancement of cell-cell adhesion, angiogenesis process, and. (lu.se)
The functionality of the matured microvasculature networks was demonstrated through the enhancement of cell-cell adhesion, angiogenesis process, and perfusion tests with microparticles, FITC-dextran, and whole mouse blood. (lu.se)
It acts by inducing angiogenesis and endothelial cell migration. (bvsalud.org)

This monolayer of cells acts as a barrier to separate the vascular lumen from surrounding tissues and regulates the passage of fluid and nutrients between the two. (beckman.com)
4 In addition, vascular endothelial growth factor (VEGF) is an angiogenic factor that regulates endothelial survival, proliferation, differentiation, and vascular permeability, and has been shown to be an important candidate for cancer therapy as it is upregulated in many tumors. (beckman.com)

The vascular BM surrounds the islet capillary network and directly contacts mouse endocrine cells. (nature.com)
The characteristic renal lesion of preeclampsia "glomeruloendotheliosis" is manifested primarily by swelling of the glomerular capillary endothelial cells. (health.am)
Aberrant vascular remodeling contributes to the progression of many aging-associated diseases, including idiopathic pulmonary fibrosis (IPF), where heterogeneous capillary density, endothelial transcriptional alterations and increased vascular permeability correlate with poor disease outcomes. (researchgate.net)
After a short period, capillary vasodilatation occurs secondary to local histamine release, and the cells of inflammation are able to migrate to the wound bed. (medscape.com)

During development, the blood vascular system arises from endothelial cell progenitors that differentiate from mesodermal cells, mostly through the expression of the transcription factor (TF) ETV2. (nature.com)
Medina RJ , Barber CL , Sabatier F , Endothelial progenitors: a consensus statement on nomenclature . (avma.org)
As greater understanding of the growth factors involved in wound healing emerges, future patient care may include scarless wound healing and transplant of tissues engineered from stem cell progenitors. (medscape.com)

Chylomicrons produced by the intestinal epithelial cells from dietary lipids have diameter up to 1000 nm which prevents them from passing through the LSEC fenestrae. (wikipedia.org)
Polarized epithelial cells compartmentalize tissue cavities and are often exposed to inflammatory challenges such as toxics or infections in non-lymphoid tissues. (hindawi.com)
We also discuss recent findings showing that the loss of apicobasal polarity increases leukocyte adhesion to epithelial cells and the consequences that this could have for the inflammatory response towards damaged, infected or transformed epithelial cells. (hindawi.com)
These areas are often made up of polarized parenchymal epithelial cells that form barriers to compartmentalize functions in cavities of the liver, intestine or lungs (Figure 1 ). (hindawi.com)
In endothelial and epithelial cells the tight junctional complex safeguards barrier function. (meduniwien.ac.at)

Morphology, growth characteristics, and expression of endothelial surface antigens and other cellular markers were evaluated. (nih.gov)
We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)

The aim of this study is to evaluate CD4(+), CD8(+), and CD45RO(+) T cells , and vascular endothelial growth factor ( VEGF ) expression in cyclosporin A (CsA)-induced rat overgrown gingival tissue during an 8-week period. (bvsalud.org)
The spheroids were cultured in the presence or absence of vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (bFGF) or RA synovial fluid (SF). (ucytech.com)
VEGF, produced in large amounts by cancer cells during tumor growth, interacts with its receptors VEGFR1 and VEGFR2 thereby causing endothelial cell survival, proliferation, and sprouting [7] . (plos.org)
We previously showed that VEGF signaling in primary endothelial cell cultures caused overexpression of VEGFR2 in a positive feed-forward loop, which is at least partly regulated by loss of miRNA-mediated control of VEGF receptor degradation. (plos.org)
Moreover, we found that glioblastoma cells, notorious for their VEGF production, elicited a similar response when co-cultured with endothelial cells [11] . (plos.org)

Pancreatic pericytes directly support β-cells through mostly unidentified secreted factors. (nature.com)
Thus, we hypothesized that pericytes regulate β-cells through the production of BM components. (nature.com)
Thus, alongside ECs, pericytes are a significant source of the islet BM, which is essential for proper β-cell function. (nature.com)
A study published in Scientific Reports identifies pericytes as potential target cells for early interventions. (lu.se)
Previous cell culture studies indicate that α-synuclein requires the presence of pericytes to induce hyperpermeability in endothelial cells. (lu.se)
The next step would be to investigate which proteins are secreted from pericytes and endothelial cells in α-synuclein mouse models. (lu.se)

Melero-Martin JM , Khan ZA , Picard A , In vivo vasculogenic potential of human blood-derived endothelial progenitor cells . (avma.org)
So far, most of the in vivo and in vitro approaches to study leukocyte migration across the tissue parenchyma have addressed the role of each single tissue barrier that immune cells encounter in their journey to the inflammatory focus. (hindawi.com)
The enzyme that produces H2S, cystathionine γ-lyase (CSE), is decreased in rat mesenteric artery endothelial cells (EC) following in vivo IH exposure. (unboundmedicine.com)
In vivo acoustic patterning of endothelial cells for tissue vascularization. (rochester.edu)
This study examines the possibility of labelling limited numbers of axolotl blastema cells (aBC) and pig endothelial progenitor cells (pEPC) with VSOP and detecting these in vitro and in vivo using a traditional clinical 1.5 T scanner. (au.dk)
In vivo, cells labelled at low concentration appeared bright with positive contrast, whereas cells labelled at higher concentration again appeared dark. (au.dk)

We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs), combining RNA-Seq and CAGE-Seq. (nature.com)
The number of available corneal donor tissues is limited worldwide, hence, cultivation of human corneal endothelial cells (hCECs) in vitro has been attempted in order to produce tissue engineered corneal endothelial grafts. (ulster.ac.uk)
Although the LSECs make up only about 3% of the total liver cell volume, their surface in a normal adult human liver is about 210 m2, or nearly the size of a tennis court. (wikipedia.org)
The current objective was to develop a technique for selective isolation and culture of endothelial cells from human SC. (nih.gov)
Cannulation of SC with gelatin-coated suture material is an effective method for the isolation of human SC cells and provides a cellular model to study the potential role of SC cells in aqueous humor outflow function. (nih.gov)
We report that human endothelial cells (EC) express the trypsinogen 4 isoform of the serine protease 3 (PRSS3), and lack both PRSS2 and PRSS1. (unimib.it)
METHODS: Spheroids were generated by culturing RA fibroblast-like-synoviocytes (RAFLS), human umbilical vein endothelial cells (ECs) and monocyte-derived macrophages in a collagen-based 3D scaffold. (ucytech.com)
We demonstrate that UCN-01, at concentrations lower than those necessary to inhibit cancer cell growth, inhibit proliferation of human endothelial cells in vitro. (karger.com)
Thus, human endocrine cells are not in direct contact with the vascular BM components but with the invaginated peri-islet membrane. (nature.com)
Serum from preeclamptic women, when applied to human umbilical vein endothelial cell cultures, produces no morphologic abnormalities in the cells but releases procoagulants, vasoconstrictors, and mitogens. (health.am)
Application of unidirectional pulsatile shear stress to human umbilical vein endothelial cells (HUVECs) decreased PDCD4 protein but not mRNA level. (plos.org)
Programmed cell death 4 (PDCD4) is an important tumor suppressor in the development of various human cancers [1] and inhibits translation rather than transcription. (plos.org)
A Non-Aggressive, Highly Efficient, Enzymatic Method for Dissociation of Human Brain-Tumors and Brain-Tissues to Viable Single-Cells. (worthington-biochem.com)
Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics. (worthington-biochem.com)
Thus, our results can establish the potential risk for autoimmunity and multi-system disorders with COVID-19 that may come from cross-reactivity between our own human tissues and this dreaded virus, and thus ensure that the badly-needed vaccines and treatments being developed for it are truly safe to use against this disease. (frontiersin.org)
In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
Here, we propose a technique combining multi-material extrusion and ultrasound standing wave forces to create a network structure of human umbilical vein endothelial cells within a mixture of calcium alginate and decellularized extracellular matrix. (lu.se)

The hallmarks of joint synovial inflammation are cellular proliferation, extensive neoangiogenesis and infiltration of immune cells, including macrophages. (ucytech.com)
These cases suggest that diseases associated with endothelial inflammation could be associated with TSPyV infection. (cdc.gov)
This monolayer of cells is an important endocrine organ, and has been shown to play a major role in regulating blood fluidity, the transfer of solutes and macromolecules, immune responses and inflammation. (beckman.com)
During the inflammatory response, immune cells egress from the circulation and follow a chemotactic and haptotactic gradient within the tissue, interacting with matrix components in the stroma and with parenchymal cells, which guide them towards the sites of inflammation. (hindawi.com)
Exposure to radiation can damage the basal cell layer of the skin and result in inflammation, erythema, and dry or moist desquamation. (cdc.gov)

Schlemm's canal cell isolates reacted with antibodies specific for CD44 (hyaluron receptor), CD54 (intercellular adhesion molecule-1, ICAM-1), tissue-type plasminogen activator, and TM-inducible glucocorticoid-responsive protein-myocilin (TIGR-MYOC). (nih.gov)

In addition, at 48H, BPs linked to inflammatory phenotypes were activated (confirming KEGG results), while BPs linked to extracellular matrix (ECM) structural organisation, endothelial cell proliferation, and collagen metabolism were repressed. (nature.com)
Edwards N , Langford-Smith AWW , Wilkinson FL , Endothelial progenitor cells: new targets for therapeutics for inflammatory conditions with high cardiovascular risk . (avma.org)
Here, we present the engineering of a spheroid-based model of RA synovial tissue which mimics 3D interactions between cells and pro-inflammatory mediators present in the inflamed synovium. (ucytech.com)
This model may be used to dissect the role of specific cell types in inflammatory responses in RA, to study specific signaling pathways involved in the disease pathogenesis and examine the effects of novel diagnostic (molecular imaging) and therapeutic compounds, including small molecule inhibitors and biologics. (ucytech.com)
Leukocyte recruitment into the inflamed parenchyma requires successive interactions with cellular and stromal barriers that establish mechanical, chemotactic and haptotactic gradients to guide immune cells towards the inflammatory focus. (hindawi.com)
On the one hand, similar to endothelial cells, parenchymal epithelia must guide leukocytes to traverse them in order to reach a localized inflammatory focus, for example, in the lung or intestinal mucosa. (hindawi.com)
On the other hand, these barriers contain damaged or infected cells that are part of the inflammatory focus and the endpoint of the leukocyte migratory journey, so some sort of footprint, which is not completely understood, must exist in these cells to promote a preferential adhesion with infiltrated leukocytes. (hindawi.com)
We believe that successfully combining our current knowledge about leukocyte extravasation, three-dimensional migration through the stroma and the sequential interactions with parenchymal cell barriers, which include adopting unified experimental models, will help shed light on the entire migratory route of each immune cell type and on the specificity of the innate inflammatory responses in each type of tissue. (hindawi.com)
Endothelial and epithelial barriers determine the different stages of leukocyte migration in its journey towards the inflammatory focus in complex tissues. (hindawi.com)
We have shown that chronic inflammatory disease impacts endothelial progenitor cell (EPC) biology, through reducing their circulating numbers and by impairing their function. (rug.nl)
Histological hallmark is a severe focal inflammatory cell infiltration, which is dominated by eosinophils and disrupts the tissue architecture of the small intestine. (helsinki.fi)

Cell viability and reactive oxygen species (ROS) generation were also evaluated. (nature.com)

The adipose tissue stromal vascular fraction (adipose-SVF) might provide an alternative source for endothelial cells as adipose tissue can easily be obtained by liposuction. (vu.nl)
Since adipose-EC are now gaining more interest in tissue engineering, we aimed to extensively characterize endothelial cells from adipose tissue (adipose-EC) and compare them with endothelial cells from dermis (dermal-EC). (vu.nl)
In conclusion, we show here that adipose tissue provides for an excellent source of endothelial cells for tissue engineering purposes, since they are readily available, and easily isolated and amplified. (vu.nl)
White adipose tissue (WAT) has key metabolic and endocrine functions and plays a role in regulating energy homeostasis and insulin sensitivity. (springer.com)
Conversely, brown adipose tissue (BAT) and browning of WAT represent potential therapeutic approaches, since dysfunctional white adipocyte-induced lipid overspill can be halted by BAT/browning-mediated oxidative anti-lipotoxic effects. (springer.com)
Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities. (springer.com)
White adipose tissue (WAT) plays a key homeostatic role, not only by ensuring efficient energy storage but also by its quick mobilisation (lipids) to ensure peripheral demands. (springer.com)
The 'adipose tissue expandability model' identifies the limited capacity and dysfunctionality of WAT, preventing its expansion and accommodation of surplus of energy, as key determinants for the onset and progression of obesity-associated metabolopathologies as a result of ectopic deposition of toxic lipid species in metabolic organs (i.e. muscle or liver [also known as lipotoxic insult]) [ 7 ]. (springer.com)
There is also evidence that the deleterious effects mediated by dysfunctional white adipocyte-induced lipid overspill can be halted by the pro-oxidative anti-lipotoxic effects mediated by brown adipose tissue (BAT) activation. (springer.com)

abstract = "Tissue-engineered constructs need to become quickly vascularized in order to ensure graft take. (vu.nl)
article{2985125c-4fa1-47e4-9792-4bb6d8b1d6c4, abstract = {{Generating functional and perfusable micro-vascular networks is an important goal for the fabrication of large and three-dimensional tissues. (lu.se)
From the abstract: 'A blood test done in early pregnancy that measures cell-free DNA methylation could represent a novel way to predict the risk of preterm pre-eclampsia. (cdc.gov)

Evaluating the Efficacy of Platelet-Rich Fibrin Matrix versus Subepithelial Connective Tissue Grafts in Den. (medscimonit.com)

The blood and lymphatic vascular systems are essential for the efficient transport of oxygen, nutrients, signaling molecules, and leukocytes to and from peripheral tissues, the removal of waste products, and the preservation of fluid homeostasis. (nature.com)
Vascular barrier function is critical for the maintenance of blood flow and tissue homeostasis. (meduniwien.ac.at)
Low PDCD4 level was associated with reduced proliferation but not apoptosis or phosphorylation of endothelial nitric oxide synthase caused by pulsatile shear stress to help maintain the homeostasis of endothelial cells. (plos.org)

Suppression of trypsinogen 4 expression by siRNA inhibited the angiogenic milieu-induced migration of EC from cancer specimens (tumor-EC), but did not affect EC from normal tissues. (unimib.it)
Spheroid expansion and cell migration were quantified for all conditions using confocal microscopy and digital image analysis. (ucytech.com)
The formation of new vessels in the hypoxic area restores blood flow, provides oxygen and nutriments to the surviving cells, and promotes the migration and engraftment of new cells. (elifesciences.org)
The timeline for cell migration in a normal wound healing process is predictable. (medscape.com)

One complementary therapy could be 're-activating' vasculogenesis (i.e. the differentiation of precursor cells into mature endothelial cells), a mechanism that occurs in the heart during development but is quiescent in adult hearts. (elifesciences.org)

CONCLUSION: We present a novel spheroid based model consisting of RAFLS, ECs and macrophages that reflects the RA synovial tissue microenvironment. (ucytech.com)

Is Crosslinked Corneal Donor Tissue Beneficial in PK? (medscape.com)
Huang and colleagues looked into whether the "strengthening" of the cornea that occurs with corneal crosslinking (a procedure most commonly performed for eyes with progressive keratoconus) might be beneficial in corneal donor tissue. (medscape.com)

WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)

PCS (n = 17), PCS/CFS (n = 13), and healthy controls (HC, n = 14) were screened for serum anti-endothelial cell autoantibodies (AECAs) and dysregulated cytokines. (mdpi.com)
Checkpoint Blockade-Induced Dermatitis and Colitis Are Dominated by Tissue-Resident Memory T Cells and Th1/Tc1 Cytokines. (massgeneral.org)

The mechanism of how the calcification signal from endothelial cells is transmitted to vascular smooth muscle cells (VSMCs) remains unknown. (spandidos-publications.com)

Mesenchymal cells in the lung are crucial during development, but also contribute to the pathogenesis of fibrotic disorders, including idiopathic pulmonary fibrosis (IPF), the most common and deadly form of fibrotic interstitial lung diseases. (researchgate.net)

Our cases comprised 1 patient with metastatic lung adenocarcinoma involving the brain (case 1), 1 patient with meningioma (case 2), and 1 patient with a metastatic perivascular epithelial cell tumor involving the liver ( Table ). (cdc.gov)
As a result, when tumor vasculature was focused, we found that cancer stem cells existing near myofibroblasts abundantly localizing at perivascular area show drug resistance. (nii.ac.jp)
Brain and cord: lymphocytic perivascular cuffing, endothelial cell swelling, diffuse gliosis, focal necrosis, neuronal degeneration Striated muscle: degeneration and and necorsis of myofibers, calcification. (cdc.gov)

In vitro , the sprouting and migratory properties of primary endothelial cell cultures were reduced by inhibiting EZH2 through up-regulation of miR-101, siRNA-mediated knockdown of EZH2, or treatment with 3-Deazaneplanocin-A (DZNep), a small molecule inhibitor of EZH2 methyltransferase activity. (plos.org)

Although PDCD4 in general suppresses the development and progression of tumors, its specific biological functions differ by cell type [8] . (plos.org)

With the exception of CXCR4, which was expressed on 29% of endothelial cells, all other chemokine receptors (CXCR1, 2, 3, and CCR2) were expressed on less than 5% of the endothelial cell populations. (vu.nl)

Endothelial cells form a semi-permeable barrier between the blood and surrounding tissues within all blood vessels in the body. (beckman.com)
We previously reported that short-term MWCNT exposure produces serum bioactivity that impairs endothelial function leading to vasodilatory insufficiencies, as well as induction of blood-brain barrier (BBB) impairments. (cdc.gov)
The peri-islet membrane, which encapsulates the islets, separates the endocrine cells from the exocrine pancreas and serves as a barrier from immune cell infiltration to the islets. (nature.com)
Therefore, tight junction adaptor proteins, such as cingulin and its interaction domains with the cytoskeleton and exchange factors of RhoGTPases could be used to protect barrier function in endothelial junct ions. (meduniwien.ac.at)
Modulation of tight junction structure in blood-brain barrier endothelial cells. (worthington-biochem.com)
Interestingly, changes such as pericyte activation and blood-brain-barrier leakage are already observed at the early stages of the disorder, even before behavioral changes or dopaminergic cell loss can be detected, explains Gesine Paul-Visse. (lu.se)

Activation of the VEGFA/VEGFR2 signaling and expression of blood vascular endothelial cell (BEC) markers, such as NRP1 and EphrinB2, further differentiate these precursor cells into BECs, which then form the hierarchical network of blood vessels 4 . (nature.com)

[ 7 ] One of the angiogenic factors known to be associated with ROP is vascular endothelial growth factor (VGEF). (medscape.com)

Our results demonstrated that these immature cells have a natural capacity to differentiate into endothelial cells in infarcted hearts. (elifesciences.org)
[ 7 ] Retinal endothelial cells give rise to primitive capillaries that further differentiate into mature vessels. (medscape.com)

Vascular endothelial cells, as a monolayer in direct contact with the flowing blood, bear the most of the wall shear stresses and have important homeostatic functions in response to stress [16] . (plos.org)

En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)

The size of circulating chylomicrons is gradually reduced to chylomicron remnants by lipoprotein lipase on endothelial cells of systemic capillaries. (wikipedia.org)

In the Dalecki lab, efforts concentrate on identifying the molecular, cellular, physiological, and physical mechanisms for the interaction of ultrasound fields with biological tissues. (rochester.edu)

A novel 3D spheroid model of rheumatoid arthritis synovial tissue incorporating fibroblasts, endothelial cells, and macrophages. (ucytech.com)

Primordial endothelial cells specialize into tissue-specific phenotypes of arterial, venous, hemogenic, and lymphatic subtypes with distinct functions for vascular development. (beckman.com)

Willoughby, C 2021, ' Biomaterials for corneal endothelial cell culture and tissue engineering ', Journal of Tissue Engineering , vol. 12. (ulster.ac.uk)
It is one of a number of analysis and characterisation facilities within the Department, and is predominantly used by members of the Biomaterials and Tissue Engineering theme . (sheffield.ac.uk)

In this thesis we investigated how local environmental cues dictate endothelial plasticity. (rug.nl)

Vascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico. (unboundmedicine.com)

Adipose- and dermal-EC expressed the typical endothelial markers PECAM-1, ICAM-1, Endoglin, VE-cadherin and VEGFR2 to a similar extent, with 80-99% of the cell population staining positive. (vu.nl)
approaches simulating RA synovial tissue are crucial in preclinical and translational research to evaluate novel diagnostic and/or therapeutic markers. (ucytech.com)
We further characterized the subphenotype of our ESC-EC and observed both venous and arterial markers on individual cells with a larger percentage of the cells exhibiting a venous phenotype. (ca.gov)

The origin of new endothelial cells (i.e. resident or infiltrating) as well as the underlying mechanism leading to their proliferation (partial endothelial-to-mesenchymal transition [EndMT] or not) have long been debated. (elifesciences.org)

Journal Article] Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells. (nii.ac.jp)

We identified tissue factor pathway inhibitor-2 (TFPI-2), a matrix associated inhibitor of cell motility, as the functional target of trypsinogen 4, which cleaved TFPI-2 and removed it from the matrix put down by tumor-EC. (unimib.it)
We present a rate equation model for the TGF-b pathway in endothelial cells together with novel measurements. (lu.se)
Among the many protease inhibitors in plasma, tissue factor pathway inhibitor (TFPI) and antithrombin are the ones that are most specifically involved in inhibition of coagulation factors. (medscape.com)

In addition to providing biomechanical support to the islets, ECM components are required for β-cell development, proliferation, survival, and proper insulin secretion. (nature.com)
Up to now, the fabrication of micro-vascular networks is a complicated multitask involving several different factors such as time consuming, cells survival, micro-diameter vasculature and strict alignment. (lu.se)

Liver sinusoidal endothelial cells (LSECs) form the lining of the smallest blood vessels in the liver, also called the hepatic sinusoids. (wikipedia.org)

A wide range of cells in the intestine of horses with IFEE have been shown to express mRNA of eotaxin, which is the major cytokine to recruit eosinophils to the tissue. (helsinki.fi)

Particular attention has been paid to elucidating how leukocytes can migrate through the stroma, the way these cells remodel their morphology and sense cues that guide them towards dysfunctional tissue areas. (hindawi.com)

We believe the answer is probable, since some of the systemic disease clinical manifestations of COVID-19 cannot be explained solely by the binding of SARS-CoV-2 spike proteins with cell membranes of tissues that exhibit angiotensin-converting enzyme 2 (ACE2). (frontiersin.org)
After injury to tissue occurs, the cell membranes, damaged from the wound formation, release thromboxane A2 and prostaglandin 2-alpha, potent vasoconstrictors. (medscape.com)

Journal Article] Cell-sheet Therapy With Omentopexy Promotes Arteriogenesis and Improves Coronary Circulation Physiology in Failing Heart. (nii.ac.jp)
It is well established that endothelial cells (EC) play a crucial role in vascular physiology. (rug.nl)

Other important receptors on LSECs are L-SIGN (liver/lymph node-specific ICAM-3 grabbing nonintegrin), LSECtin (liver and lymph node sinusoidal endothelial cell C-type lectin), Lyve-1 (lymphatic vessel endothelial hyaluronan receptor‐1), and LRP‐1 (low‐density lipoprotein receptor‐related protein‐1). (wikipedia.org)
Schlemm's canal cells endocytosed low-density lipoprotein and acetylated low-density lipoprotein, and in the presence of Matrigel organized into multicellular tubelike structures. (nih.gov)

Anatomy54

Organisms10

Diseases10

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes45

Disciplines and Occupations2

Information Science3

Dysfunction9

Hypoxia9

Brain endothelial cells1

Induces4

Characterization3

Endothelium11

Lymphatic endothelial2

Angiogenesis7

Regulates2

Capillary4

Progenitors3

Epithelial cells5

Antigens5

VEGF5

Pericytes6

Vivo6

Human17

Inflammation5

Plasminogen Activator1

Inflammatory11

Reactive oxygen1

Adipose Tissue9

Abstract3

Grafts1

Homeostasis3

Migration4

Differentiation1

Microenvironment1

Corneal donor2

Extracellular matrix1

Cytokines2

Vascular smooth muscl1

Mesenchymal Cells1

Perivascular3

Cultures1

Tumors1

Chemokine1

Barrier6

Precursor1

Angiogenic1

Differentiate2

Monolayer1

Aortic1

Capillaries1

Mechanisms1

Fibroblasts1

Phenotypes1

Biomaterials2

Plasticity1

Biology1

Markers3

EndMT1

Metastasis1

Pathway3

Survival2

Blood vessels1

MRNA1

Cues1

Membranes2

Physiology2

Density2