Tissue 1999 adult stem stem cell research. Medical search. Frequent questions

after transplantation to the recipient region, single cells are vulnerable to the interference of various factors, such as ischemia and inflammation, leading to cell loss or death [ 16 ]. (biomedcentral.com)
Today, more than 50 years after the first successful bone marrow transplantation, clinical application of hematopoietic stem cells is a routine procedure, saving the lives of many every day. (hindawi.com)
The most efficient method to expand limbal stem cells (LSCs) in vitro for clinical transplantation is to culture single LSCs directly on growth-arrested mouse fibroblast 3T3 cells. (drcremers.com)
Organ and tissue transplantation can give a second chance at life to thousands of people. (medindia.net)
Preferred Term is Hematopoietic stem cell transplantation. (medindia.net)
This re- view discusses stem cell applications in transplantation, stem cell-based carriers, induced-pluripotent stem cells, can- cer stem cells, and potential of stem cells engineering to revolutionize cancer treatment. (bmrat.org)
These strategies range from cell transplantation to the administration of growth factors. (jneurosci.org)
Fetal cell/tissue transplantation has been arduously studied as a potential way to repair the injured brain. (jneurosci.org)
This phase might provide an optimal therapeutic window for transplantation because it may increase functional integration of the graft into the host tissue. (jneurosci.org)
Before transplantation, lesion was produced in adult mice by aspiration of the motor cortex, leaving the corpus callosum intact. (jneurosci.org)
The results thus demonstrated that delaying transplantation within a specific time window increased graft survival and integration into host brain tissue. (jneurosci.org)
performed additional studies to compare the effect of 7 d delay and immediate transplantation on survival and integration of grafted cells into host brain tissue at 4, 7, and 14 d after transplantation. (jneurosci.org)
Their results showed that delaying transplantation increased cell proliferation, without increasing apoptosis, consequently leading to increased graft size in the delayed condition. (jneurosci.org)
as well as diagnostic techniques, drug development and tissue transplantation. (who.int)
These epithelial organoid cultures are genetically and phenotypically extremely stable, allowing transplantation of the cultured offspring of a single stem cell, as well as disease modeling by growing organoids directly from diseased patient tissues (32, 47, 53). (hubrecht.eu)
However, the Senate bill does allow for therapeutic cloning, known as 'nuclear transplantation', for research on therapies that could cure several serious and life-threatening diseases. (boloji.com)
The Society is concerned that a ban on nuclear transplantation might thwart research directed at finding cures and treatments for diseases and disabilities which solely, predominantly or differently affect women,' says their president, Phyllis Greenberger. (boloji.com)
Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial. (medscape.com)

This led to his finding that LGR5 is a stem cell marker in other organs as well, including the stomach and hair follicles. (wikipedia.org)
Regenerative medicine is a revolutionary area of medicine that can completely heal damaged tissues and organs, treating a wide range of orthopedic conditions. (jenningsclinic.com)
Biomaterials have been used in medicine for decades to improve the functions of tissues and organs. (omicsonline.org)
They are in an early stage of development and have the ability to become any type of cell to form skin, bones, organs or other body parts. (cbc.ca)
They are found in adult organs. (cbc.ca)
My PhD focussed on investigating the distributions and possible functions of nitric oxide/nitric oxide synthases in the physiology and pathology of a variety of tissues and organs and I was fortunate enough to publish some of the first papers on the involvement of these molecules in human diseases, notably in the cardiovascular system. (nottingham.ac.uk)
Organs and tissues are built up by specialized cells from the pool of stem cells that form shortly after fertilization. (bmrat.org)
Stem cells are widely defined by two main characteristics: the ability to self-renew (divide in a way that reproduces more identical stem cells) and to differentiate (to turn stem cells into specialized cells that form different organs and tissues). (bmrat.org)
Lymphatic tissue or circulating lymphocytes may also be located in other regions of the body, such as the skin, small intestine, liver, and other organs. (rarediseases.org)
The Organoid group, previously Clevers group, studies the molecular mechanisms of tissue development and cancer of various organs using organoids made from adult Lgr5 stem cells. (hubrecht.eu)
As the cell begins to divide, scientists believe stem cells can be extracted and grown into tissue or organs. (boloji.com)
Participants were less willing to allow the use of tissue or organs from a deceased relative. (who.int)

Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
However, transplanting other than hematopoietic stem and progenitor cells is still limited to a few applications, and it mainly applies to mesenchymal stromal cells (MSCs) isolated from bone marrow. (hindawi.com)
But research progressed and different trials explore the clinical potential of human MSCs isolated from bone marrow but also from other tissues including adipose tissue. (hindawi.com)
Recently, MSCs isolated from bone marrow (bmMSCs) were shown to be a blend of distinct cells and MSCs isolated from different tissues show besides some common features also some significant differences. (hindawi.com)
The MSCs have been described for the first time as colony forming fibroblasts (CFU-F), a rare population of cells residing in the bone marrow of guinea-pigs or mice [ 1 , 2 ]. (hindawi.com)
It seems that the term "stem cell" became more popular although the "stemness" was only shown in a more strict sense for MSCs involved in osteogenesis and bone repair. (hindawi.com)
Nowadays, experts agree that MSCs may generate upon appropriate stimulation quite different mature cells including osteoblasts, chondrocytes, tenocytes, adipocytes, smooth muscle cells, and stromal cells of the bone marrow [ 9 ]. (hindawi.com)
These adult stem cells, such as from fat (adipose derived) or bone marrow, have the ability to transform into different cells. (drcremers.com)
Paracrine effect of mesenchymal stem cells derived from human adipose tissue in bone regeneration. (renudermatology.com)
Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year-followup. (renudermatology.com)
Mesenchymal stem cell-based HLA-independent cell therapy for tissue engineering of bone and cartilage. (renudermatology.com)
In this stem cell from bone marrow are injected into a recipient after treating them with growth factor. (medindia.net)
Embryonic stem cells come from embryos, embryonic germ cells from testes, and adult stem cells can come from bone marrow. (cbc.ca)
From 1999 onwards my research has been focused primarily on osteoblast biology and approaches to tissue engineer and model bone biology, pathology and repair. (nottingham.ac.uk)
My research interests focus mainly on stem cells (embryonic, 'adult' and fetal origins) and their applications in tissue engineering, particularly the osteoblast and bone tissue. (nottingham.ac.uk)
Adult stem cells were firstly isolated from bone marrow in mice (Spangrude, Heimfeld, and Weissman, 1988) and later in humans. (bmrat.org)
Two-color flow cytometric analysis of CD31 expression on BALC/c mouse bone marrow cells. (bdbiosciences.com)
Bone marrow cells were stained with APC Rat Anti-Mouse CD45R/B220 antibody (Cat. (bdbiosciences.com)
Two-color flow cytometric dot plots show the correlated expression patterns of CD31 (or Ig Isotype control staining) versus CD45R/B220 for gated events with the forward and side light-scatter characteristics of viable bone marrow cells. (bdbiosciences.com)
Lymphatic tissues also include the thymus, a relatively small organ behind the breastbone that is thought to play an important role in the immune system until puberty, as well as the bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. (rarediseases.org)
We combine in vivo genetic mouse models with in vitro tissue culture and molecular biology techniques to better understand the role of specific signaling pathways and transcription factors in regulation of bone and joint development as well as in the onset and progression of osteoarthritis. (rochester.edu)
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. (rochester.edu)
People with this disease die of bone marrow failure, likely due to stem cell loss. (hopkinsmedicine.org)
Subsequent regenerative dental procedures include the development of guided tissue or bone regeneration (GTR, GBR) procedures and distraction osteogenesis 2 the application of platelet rich plasma (PRP) for bone augmentation 17 . (bvsalud.org)
Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
Malignant plasma cells in meningeal MM out of 2000 patients with bone marrow produce an immunoglobulin, MM, was reported was by Schluterman et al. (who.int)
The prevalence production, lytic lesions and increased of leptomeningeal infiltration in breast can- plasma cells in the bone marrow [ 1 ]. (who.int)

The report notes that the AAR, which bills itself as the leading citizen advocacy organization for improving the health of older Americans, "also happens to receive funding from private-sector biotechnology companies that have a financial stake in the outcome of the stem-cell debate, including Geron," the for-profit corporation that isolated embryonic stem cells in 1998. (christianitytoday.com)
What experiments were completed in 1996, 1997 and 1998 that we won't know about until 1999 to 2001 - if then? (globalchange.com)
1998. Armed Forces Radiobiology Research Institute. (cdc.gov)

Then they were told these cells could be grown from 1) excess human embryos or 2) fetal tissue donated to research. (lifeissues.org)
The differences between fetal and adult scars suggest the possibility of manipulating skin scarring outcomes. (rbcp.org.br)
For example, embryonic stem cells exist only at the earliest stage of embryo and adult stem cells appear during fetal development and are retained throughout life. (bmrat.org)
1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)

Haematopoietic and mesenchymal stem-cell. (health-abstracts.com)
The Jonason laboratory is interested in the signaling mechanisms that govern mesenchymal stem cell differentiation as well as maturation of committed chondrocytes and osteoblasts during skeletal development. (rochester.edu)

Human bmMSCs were described in the late nineties as well [ 6 ] and at the same time a breakthrough study investigated the expression of typical cell surface markers and the proliferation and differentiation properties of human MSCs in more detail [ 7 ]. (hindawi.com)
They display differentiation capacities and therefore qualify as multipotent progenitor cells (Figure 1 ). (hindawi.com)
Overview on self-renewal or differentiation of stem cells in their respective stem cell niche. (hindawi.com)
In this study, it was observed that the ion implantation stimulated the neural proliferation and the implantation of different ions on cell culture surfaces was essential to determine the effects of this technique on adhesion, proliferation, differentiation and apoptosis properties of cells in details. (omicsonline.org)
Derivation and differentiation of haploid human embryonic stem cells. (nature.com)
At this time I also began working with mouse and human embryonic stem cells resulting in the publication of some of the first papers describing the osteogenic differentiation of mouse ES and human cells in vitro and in vivo . (nottingham.ac.uk)
Differential cell surface marker expression and divergent responses to differentiation conditions suggest that the NP subtypes may correspond to distinct maturation stages and represent distinct NP cell subpopulations. (biomedcentral.com)
In stratified epithelia proliferative basal cells adherent to the underlying basement membrane undergo cell cycle arrest then outward migration and terminal differentiation. (stanford.edu)
This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
The function of histone modifying epigenetic regulators and noncoding RNA as central mediators of epithelial stem cell renewal and differentiation represent major emerging areas of study in the lab. (stanford.edu)
Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair. (rochester.edu)
Like cell division and differentiation, cell death is also critical for normal development and maintenance of healthy tissues. (hopkinsmedicine.org)

Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
At the same time, by asymmetric cell division or after specific activation, stem cells must be able to generate more mature progenitor cells or differentiated effector cells (Figure 1 ). (hindawi.com)
CC-ASC generated epithelial cells with undifferentiated morphology in all culture methods, among which CC-ASC in 3D culture supported the highest cell doubling (cells doubled 9.0 times compared to cells doubled 4.9 times in control) while maintained the percentage of putative limbal stem/progenitor cells compared to the control. (drcremers.com)
Mei H, González S, Nakatsu MN, Baclagon ER, Chen FV, Deng SX (2017) Human adipose-derived stem cells support the growth of limbal stem/progenitor cells. (drcremers.com)
Braun S., Moss J., Toni N. , Jessberger S. "Programming hippocampal neural stem/progenitor cells into oligodendrocytes enhances remyelination in the adult brain after injury" Cell Reports , 2015 Jun 23;11(11):1679-85. (chuv.ch)

This poll asked whether people opposed or supported research in which live human embryos would be destroyed or discarded. (lifeissues.org)
Also in May, a presidential advisory commission judged that it was ethical for the government to pay for such controversial research, as long as the embryos are not created solely for research purposes. (lifeissues.org)
President Bush, saying he wanted to "proceed with great care," announced in a national address on August 9 that he would allow federal funding of an existing 60 stem-cell lines but would not permit tax dollars to pay for the destruction of any additional human embryos. (christianitytoday.com)
The rule circumvented a 1995 congressional ban on using federal money for biomedical research on embryos outside the womb by allowing researchers to use stem cells extracted by a third party. (christianitytoday.com)
The groups argue that rather than waste embryos that will be destroyed along with their stem cells, researchers should use them to help save those whose lives are being cut short by disease. (christianitytoday.com)
Indeed, some observers believe the demand for stem cells is dangerously close to spawning a huge commercial industry around the sale of and experimentation on human embryos. (christianitytoday.com)
Already, news that Advanced Cell Technology-a Massachusetts-based, privately held biotech company-and Virginia Medical School's Jones Institute had created or planned to create human embryos for the sole purpose of extracting their stem cells has troubled those on both sides of the debate. (christianitytoday.com)
Leeb, M. & Wutz, A. Derivation of haploid embryonic stem cells from mouse embryos. (nature.com)
Researchers there are working on technology that induces human skin cells to change into the kind of stem cells that have been created by embryos. (cbc.ca)
Some argue that the possibility of mimicking stem cells without acquiring them from embryos, side-steps that moral dilemma. (cbc.ca)
This new method of generating stem cells does not require embryos as starting points and could be used to generate cells from many adult tissues, such as a patient's own skin cells,' said principal author Andras Nagy, senior investigator at Mount Sinai's Samuel Lunenfeld Research Institute. (cbc.ca)
Cortical neurons from the presumptive motor cortex of embryonic day 14 (E14) mouse embryos were transplanted into the injured motor cortex of 3- to 6-month-old adult mice. (jneurosci.org)
The bill also applies Federal ethical regulations on human subject research and outlaws the transfer of cloned embryos to a woman's uterus or to any artificial womb. (boloji.com)
At the same time, the statement calls for a five-year moratorium on the use of cloning to create human embryos for research purposes. (boloji.com)
While supporting research that would help to determine whether stem cells have therapeutic effects, they point out that those adult stem cells, umbilical cord stem cells, and embryonic stem cells not derived from embryos created for research can be used. (boloji.com)

He moved to the University Medical Center Utrecht in 2002 as a professor in molecular genetics, and started his lab at the Hubrecht Institute for Developmental Biology and Stem Cell Research (Hubrecht Institute). (wikipedia.org)
Although regenerative medicine was practiced years ago, advances in immunology as well as developmental and cell biology have unleashed new opportunities to improve existing regenerative treatments as well as develop new ones. (jenningsclinic.com)
The cell biology of the blood-brain barrier. (sagepub.com)
I returned full time to Imperial College in 1999 to take up a lectureship in cell biology and tissue engineering and was also actively involved in establishing the Tissue Engineering Centre. (nottingham.ac.uk)
I cover mainly cell biology and physiology. (nottingham.ac.uk)
Our cell lines yield novel insights into NP biology and provide promising new tools for studies of IVD development, cell function and disease. (biomedcentral.com)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
In mammals, physiological Wnt signaling is intimately involved with the biology of adult stem cells and self-renewing tissues (18,19). (hubrecht.eu)
We were the first to link Wnt signaling with adult stem cell biology, when we showed that TCF4 gene disruption leads to the abolition of crypts of the small intestine (8), and that TCF1 gene knockout severely disables the stem cell compartment of the thymus (2). (hubrecht.eu)
Development: For advances in developmental biology and stem cells. (lu.se)
Thomas RK, Re D, Wolf J, Diehl V. Part I: Hodgkin's lymphoma--molecular biology of Hodgkin and Reed-Sternberg cells. (medscape.com)

Building on this discovery, in 2009, his group published a landmark paper, describing for the first time how organoids, which are 3-dimensional in vitro structures that behave anatomically and molecularly like the organ from which they are derived, were generated from adult stem cells, creating organoids of the small intestine. (wikipedia.org)
Expansion of MSCs was shown to be limited to a few passages of in vitro culture and the cells underwent replicative senescence [ 11 ]. (hindawi.com)
Therefore, available in vitro protocols for expansion of MSCs do not yield true stem cells. (hindawi.com)
To reduce possible xenobiotic contamination from 3T3s, primary human adipose-derived stem cells (ASCs) were examined as feeder cells to support the expansion of LSCs in vitro . (drcremers.com)
Hematopoietic Stem Cell and Leukaemic Stem Cell environmental stress responses (In vitro biomimicry of hypoxia, normoxia, hypothermia, hyperthermia, hypoglycemia and hyperglycemia): Effect on cellular growth, cell cycle distribution, apoptosis and cellular metabolism. (imperial.ac.uk)
However, most growth factor research is done in vitro and does not reflect the challenges that penetration has on those molecules. (gcimagazine.com)
The latter encompass human skin regenerated on immune deficient mice as well as organotypic constructs with epithelial and stromal cells embedded within architecturally faithful mesenchyma in vitro. (stanford.edu)
Lgr5 resides in Wnt receptor complexes and mediates signaling of the Wnt-agonistic R-spondins (31), explaining the unique dependence of Lgr5 stem cells on secreted R-spondins in vivo and in vitro. (hubrecht.eu)
Relating in vitro to in vivo exposures with physiologically-based tissue dosimetry and tissue response models. (cdc.gov)
[ 8 ] T cells in oral lichen planus contain mRNA for TNF and secrete TNF in vitro. (medscape.com)

This work was supported by National Eye Institute grants (5P30EY000331 and 1R01EY021797), by a California Institute for Regenerative Medicine Early Translational Award (TR2-01768), and an unrestricted grant from Research to Prevent Blindness. (drcremers.com)
Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. (renudermatology.com)
He is also interim president of the state's new stem cell agency, the California Institute for Regenerative Research. (latimes.com)
During more recent years, his reseach has been conducted in the field of regenerative medicine, focussed on antigen expression and immune recognition of human embryonic stem cells and bioartificial heart valves, the latter tissues being of animal origin. (gu.se)
Stem cells are not only widely used for regenerative medicine, but are also considered as a useful tool for cancer treatment. (bmrat.org)
Thus, a kind of 'regenerative medicine' gives people access to therapies derived from their own cells. (boloji.com)
Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue to revitalize teeth. (bvsalud.org)
Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
One novel approach to restore tooth structure is based on regenerative endodontic procedures by application of tissue engineering. (bvsalud.org)
Regenerative endodontic procedures can be defined as biologically based procedures designed to replace damaged structures, including dentin and root structures, as well as cells of the pulp-dentin complex. (bvsalud.org)
The purpose of this article is to review the biological principles of tissue engineering and the hurdles that must be overcome to develop regenerative endodontic procedures. (bvsalud.org)
The major areas of research that might have application in the development of regenerative endodontic techniques are (a) postnatal stem cells, (b) scaffold materials, (c) morphogen/growth factors, (d) implantation. (bvsalud.org)
The most valuable cells for regenerative endodontics are postnatal or adult stem cells. (bvsalud.org)

The prolife lobby also received help from Do No Harm, a coalition of researchers, bioethicists, and doctors who spearheaded a nationwide petition urging Bush to oppose destructive human embryonic stem-cell research. (christianitytoday.com)
Bush's announcement grieved patients' groups and many in the scientific and medical communities who believe embryonic stem-cell research could provide a cure for millions. (christianitytoday.com)
A report published by the nonpartisan Center for Public Integrity (CPI) quoted a National Institutes of Health official who said that "the fledgling stem-cell industry would profit tremendously from federal funding that would cover embryonic stem-cell research. (christianitytoday.com)
Gene therapy and monoclonal antibodies didn't arrive with even a fraction of the hype surrounding embryonic stem cell research. (latimes.com)
In my opinion there is no question but that the scientific information on stem cell research included in this science text book being used in Illinois schools incorporates some inaccurate scientific facts, and seems to be very partial to the use of human embryonic "stem cell" research. (lifeissues.net)

hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
We therefore briefly discuss differences found in subsets of human bmMSCs and in MSCs isolated from some other sources and touch upon how this could be utilized for cell-based therapies. (hindawi.com)
Biotechnology companies specializing in stem-cell research stand to reap huge financial windfalls from successful therapies developed via this science," said the CPI report. (christianitytoday.com)
Stem Cells and other innovative intra-articular therapies for osteoarthritis: What does the future hold? (renudermatology.com)
In this essay, I focus on the crucial issue of how to develop therapies to delay and eventually cure aging in adult human beings after we understand the causes of aging . (senescence.info)
In May 2007, Ontario and California announced a $30-million stem cell research deal aimed at finding new therapies for those diseases. (cbc.ca)
Although only a handful of cell and gene therapies are on the market, FDA officials predicted in 2019 that the agency will receive more than 200 investigational new drug applications per year for cell and gene therapies, and that by 2025, it expects to have accelerated to 10 to 20 cell and gene therapy approvals per year. (ajmc.com)
In total, 3 CAR T-cell therapies are now on the market, all targeting the CD19 antigen. (ajmc.com)
Detailed understanding of the ontogenetic, cellular and molecular characteristics of functional intervertebral disc (IVD) cell populations is pivotal to the successful development of cell replacement therapies and IVD regeneration. (biomedcentral.com)
Successful development of cell replacement therapies and IVD regeneration is crucially dependent on an in-depth understanding of cellular and molecular characteristics of the functional IVD. (biomedcentral.com)
This explains why researchers are now focusing attention on developing stem cell therapies using postnatal stem cells donated by the patients themselves or their close relatives. (bvsalud.org)

5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)

The development of new primary human cell culture technologies such as 3D culture, microfluidics and microfabrication in combination with human induced pluripotent stem cell (iPSC) derived models promise to generate more relevant human physiological systems for drug testing 11 . (nature.com)
Using our recently established haploid human pluripotent stem cells (hPSCs), we generated a genome-wide loss-of-function library targeting 18,166 protein-coding genes to define the essential genes in hPSCs. (nature.com)
This is known as induced pluripotent stem cells (IPS). (gcimagazine.com)
Embryonic stem cells are pluripotent - they have the ability to become virtually any type of cell within the body. (cbc.ca)
In- duced pluripotent stem cells have been used to create active T cells to support cancer immunotherapy. (bmrat.org)
Embryonic stem cells are pluripotent, meaning they are able to produce all cell types in the body. (bmrat.org)
These cells are called induced pluripotent stem cells (iPSCs). (bmrat.org)
2007). As the name implies, pluripotent cells are able to generate all other specialized cell types. (bmrat.org)
Similarly, destruction of neonatally abundant pluripotent stem cells would likely have a more pervasive outcome than destruction of The value of incorporating immunologic appeared more severe and/or persistent when single lineages or differentiated cells that pre- data for the toxicologic assessment of drugs, the exposure occurred perinatally when com- dominate in adults. (cdc.gov)
ES cells are pluripotent cells, which mean that they can give rise to all differentiated cell types derived from all three germ layers. (bvsalud.org)

The present study results indicated that compared with the same number of 2D-cultured cells, microtissue could secrete more nerve regeneration related cytokines to promote SCs proliferation and axons growth. (biomedcentral.com)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
Changing surface characteristics of scaffolds was a way to promote regeneration and ion implantation was one of the methods to modify surface properties which play a huge role in enhancing the proliferation and integration of cells. (omicsonline.org)
Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series. (renudermatology.com)
Concise Review: The Clinical Application of Mesenchymal Stem Cells for Musculoskeletal Regeneration: Current Status and Perspectives Andre F. Steinert, Lars Rackwitz, Fabian Gilbert, Ulrich Nöth and Rocky S. Tuan. (renudermatology.com)
Stem cell therapy for cartilage regeneration in osteoarthritis. (renudermatology.com)
To address this and to also study the oncogenic potential of unregulated function of dominant regulators of epithelial homeostasis noted above, we developed Multi-Functional Human Tissue Genetics noted above which, when combined with skin tissue regeneration on immune deficient mice, has permitted the molecular reconstruction of events sufficient to trigger human cancer. (stanford.edu)
There are limited numbers of publications about ES cells in pulp regeneration, due to the restricted policies regarding ES cell research over the past few years. (bvsalud.org)

Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study. (renudermatology.com)
The adult stem cells used were autologous and were extracted from infraumbilical adipose tissue prior to abdominoplasty. (rbcp.org.br)

The increase of chromosomal aberrations and genetic mutations observed in glioma cells turns TGF-β into an oncogene. (sagepub.com)
Wutz, A. Haploid mouse embryonic stem cells: rapid genetic screening and germline transmission. (nature.com)
Genetic modification and screening in rat using haploid embryonic stem cells. (nature.com)
Suffering from Fabry Ailment (a genetic problem in which the body fails to metabolize lipids) his total daily life, it ultimately caused a heart attack in 1999. (fingersmurphy.com)
These new models, which we term Multi-Functional Human Tissue Genetics, allow up to 10 alleles or more to be altered simultaneously, permitting genetic experiments with an unprecedented degree of rapidity and complexity. (stanford.edu)
5:832-835, 1999) and of genetic diseases (PNAS. (hopkinsmedicine.org)
5. Most countries in the African Region have no specific regulations and policies governing genetic manipulations for assisted conception, treatment and research. (who.int)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)
In therapeutic cloning on the other hand, genetic material from a body cell is inserted into an egg cell, replacing the nucleus. (boloji.com)
ABSTRACT The aim of this study was to determine the attitude of Saudi Arabians to research involving storage and use of human tissues from which genetic information may be derived and to assess their willingness to donate tissue samples to biobanks. (who.int)
Concordance for Hodgkin's disease in identical twins suggesting genetic susceptibility to the young-adult form of the disease. (medscape.com)

Immuno-allergic Implications], 1992- 1995, Research contract with the Academy of Medical Sciences 5. (health-abstracts.com)
Experimental and Clinical Studies], 1992-1995, Research contract with the Ministry of Education and with the Ministry of Research and Technology 6. (health-abstracts.com)

Jennings Orthopaedic Associates is now offering Lipogems, a cutting edge technology that uses fat tissue from the patient's stomach or thigh area to cushion and support areas of injury or damage as your body heals itself. (jenningsclinic.com)
The Mend Stem Cell Institute is a general public-provider firm shaped to teach, train, and help patients with persistent conditions and problems to uncover experienced medical doctors who give Adult Stem Cells to enhance the patient's high quality of existence. (fingersmurphy.com)
Nor are they sure how well a patient's body will accept stem cell treatments derived from cells donated by a stranger, or whether the growth of implanted cells can be managed. (latimes.com)
New therapeutic concepts in anti-tumor therapy aim to modulate the patient's immune system to increase its aggressiveness or targeted effects toward tumor cells. (frontiersin.org)

The hypothesis is that chronic antigenic stimulation secondary to the autoimmune disorder leads to chronic proliferation of lymphoid tissue, which eventually undergoes a mutation that leads to the development of lymphoma. (medscape.com)

Marrow stromal cells as stem cells for nonhematopoietic tissues. (renudermatology.com)

But recent evidence suggests it may be possible to reprogram adult stems to repair tissues. (cbc.ca)
At last, scientists had devised a way to reprogram a person's own T cells to attack tumor cells. (ajmc.com)
Recently, scientists have discovered how to reprogram normal cells to behave like embryonic stem cells. (bmrat.org)

His group identified the TCF1 protein, a member of the TCF gene family and a crucial downstream component of the Wnt signaling pathway, making it central in immune responses, embryonic development and tissue repair. (wikipedia.org)
Although safety remains a concern, investigators are breaking ground in cell and gene therapy, and many believe that ultimately, a string of cancer cures will follow. (ajmc.com)
Gene therapy modifies or manipulates cell expression. (ajmc.com)
Juliette Hordeaux, PhD, senior director of translational research for the University of Pennsylvania's gene therapy program, is cautious about the FDA's predictions, saying she'd be "thrilled" with 5 cell and/or gene therapy approvals annually. (ajmc.com)
Safety has been the main brake around adeno-associated virus vector (AAV) gene therapy," added Hordeaux, whose hospital's program has the institutional memory of both Jesse Gelsinger's tragic death during a 1999 gene therapy trial as well as breakthroughs by Carl June, MD, and others in CAR T-cell therapy. (ajmc.com)
Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
The Tcf4-driven target gene program in colorectal cancer cells is the malignant counterpart of a physiological gene program in selfrenewing crypts (13, 14). (hubrecht.eu)
Amongst the intestinal Wnt target genes (13), we found the Gpr49/Lgr5 gene to be unique in that it marks small cycling cells at crypt bottoms. (hubrecht.eu)
The Wnt target gene encoding the transcription factor Achaete scute-like 2 controls intestinal stem cell state (26). (hubrecht.eu)
Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease. (medscape.com)

Cell Stem Cell 2018 Apr 18. (chuv.ch)

MSCs were also investigated for stem cell qualities in vivo. (hindawi.com)
Immortalized cells were clonally expanded and characterized based on collagen type I, collagen type II, α1 (COL2A1), and SRY-box 9 (SOX9) protein expression profiles, as well as on expression of a subset of established in vivo NP cell lineage markers. (biomedcentral.com)
Therefore, ex vivo NK cell expansion protocols are currently being developed. (frontiersin.org)
In a proof of concept in vivo study, we also observed a therapeutic effect of adoptively transferred IL-15 expanded and IL-21 boosted NK cells in combination with image guided high precision radiation therapy using a luciferase-transduced RMS xenograft model. (frontiersin.org)
In summary, this two-phased feeder cell-free ex vivo culturing protocol combined efficient expansion and high cytolytic functionality of NK cells for treatment of radiation-resistant RMS. (frontiersin.org)
In vivo development and survival of NK cells require cytokines ( 6 - 8 ). (frontiersin.org)
In this context, cytokines have been shown to activate NK cells potently during ex vivo expansion ( 9 - 12 ). (frontiersin.org)

A high throughput histology (microTMA) platform was applied for testing drugs against tumors in a novel 3D heterotypic glioblastoma brain sphere (gBS) model consisting of glioblastoma tumor cells, iPSC-derived neurons, glial cells and astrocytes grown in a spheroid. (nature.com)
Telomerase is required for cells that undergo many rounds of divisions, especially tumor cells and some stem cells. (hopkinsmedicine.org)

Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. (nature.com)
Androgenetic haploid embryonic stem cells produce live transgenic mice. (nature.com)
Embryonic stem cells were first identified in mice (Martin, 1981). (bmrat.org)
Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice. (rochester.edu)
Elsegeiny established a mouse model that proved that a single application of rituximab could cause P. jiroveci infection in mice and weaken the type II immune response in the lungs, inactivating the role of CD4+ T cells in the protective immune response[ 8 ]. (ijpsonline.com)
The lab also is using the telomerase null mice to explore the essential role of telomerase stem cell viability. (hopkinsmedicine.org)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)

Mathematical modeling of Hematopoietic Stem Cell and Leukaemic Stem Cell culture systems. (imperial.ac.uk)
they include hematopoietic stem cells and adult and embryonic stem cells. (ajmc.com)

1. Stem cells have long been known to have the ability to differentiate (ie become/transform) into "good/normal" tissue. (drcremers.com)
Embryonic stem cells are intriguing because they can differentiate into any of the specialized tissue cells of the body. (latimes.com)
Our bodies contain a pool of stem cells that have the ability to differentiate into any other cell type in the body. (bmrat.org)
Embryonic cortical neurons transplanted into the injured adult cortex were shown to differentiate into pyramidal glutamatergic neurons and form synaptic structures. (jneurosci.org)
A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)

The standard method to culture LSCs on 3T3 feeder cells that have been used in clinical study is cultivating single LSC directly on top of the growth-arrested 3T3 feeder cells [ 14 ]. (drcremers.com)
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields. (omicsonline.org)
Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. (renudermatology.com)
20 Research Articles On: Preclinical and clinical data for the use of mesenchymal stem cells in articular cartilage tissue engineering. (renudermatology.com)
received grants for clinical research from Pfi zer Inc., Astellas Pharma, Inc., Charles River Laboratories. (cdc.gov)
has disclosed the following relevant fi nancial relationships: received grants for clinical research from Astellas Pharma, Inc., Millenium, Pfi zer Inc. (cdc.gov)
received grants for clinical research from Pfi zer Inc. Alison G. Freifeld, MD, has disclosed the following relevant fi nancial relationships: received grants for clinical research from Streck Inc., Chimerix. (cdc.gov)
Loreen Herwaldt, MD, has disclosed the following relevant fi nancial relationships: received grants for clinical research from 3M. (cdc.gov)
The first clinical trials involving a patient receiving human embryonic stem cells began in October 2010 at the Shepard Center, a spinal cord injury hospital in Atlanta. (cbc.ca)
1. Quality and safety assessment in clinical and toxicological application of stem cells (FP6 integrated proj- ect, SAFESTEM), section 'Advanced genomics and its applications for health' Project coordinator for Romania: Dr. Carmen Bunu, senior lecturer 2. (health-abstracts.com)
Many culturing strategies are based on the addition of feeder or accessory cells, which need to be removed prior to the clinical application of the final NK cell product. (frontiersin.org)
We will also explore whether lower MIH will be related to higher cell-free mtDNA (ccf-mtDNA) levels and poor clinical outcomes. (bvsalud.org)

Overview of studies published regarding MSCs using the term "stem cell" or "stromal cell" in the last 20 years accessed by a web search in July 2015 (Google Scholar). (hindawi.com)
When the biological properties of MSCs were explored in more detail, questions arose whether these cells met the criterion of a true stem cell [ 8 ]. (hindawi.com)
Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)
These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)

Mesenchymal stem cells for cartilage repair in osteoarthritis. (renudermatology.com)

Using this surface modification method, it was aimed to improve surface characteristics and achieve a bioactive surface for neural stem cells. (omicsonline.org)

1999. Toxicological profile for ionizing radiation. (cdc.gov)

By making research easy to access, and puts the academic needs of the researchers before the business interests of publishers. (intechopen.com)
Bush promised in January to review a Clinton administration rule that allowed federal funding for researchers experimenting on embryo cells from fertility clinics. (christianitytoday.com)
Researchers value the cells for their ability to replicate quickly and turn into any kind of human tissue. (christianitytoday.com)
Wisconsin Alumni Research Foundation, known as WARF, is a nonprofit foundation that patents discoveries made by researchers at the University of Wisconsin. (referenceforbusiness.com)
However, researchers at the Harvard Stem Cell Institute say reprogrammed cells won't eliminate the need or value of studying embryonic stem cells. (cbc.ca)
The cells come from aborted foetuses, if the women allow the tissue to be used by the researchers. (lu.se)
This cannot become a common method as long as the researchers have to use cells from aborted foetuses. (lu.se)

We have shown that anti-apoptotic Bcl-2 family proteins can be converted into killer molecules (Science 278:1966-8, 1997), that Bcl-2 family proteins interact with regulators of caspases and regulators of cell cycle check point activation (Molecular Cell 6:31-40, 2000). (hopkinsmedicine.org)

In this area, our recent research has included studying cutaneous shave biopsies for diagnosing primary colonic adenocarcinoma as well as growth inhibition and apoptosis in human brain tumor cell lines using selenium. (hopkinsmedicine.org)
In the later generations, when telomeres are short, cells die via apoptosis or senescence. (hopkinsmedicine.org)
Apoptosis and other forms of cell death are required for trimming excess, expired and damaged cells. (hopkinsmedicine.org)
After antigen recognition and activation, CD8 + cytotoxic T cells may trigger keratinocyte apoptosis. (medscape.com)
Current data suggest that oral lichen planus (OLP) is a T-cell-mediated autoimmune disease in which autocytotoxic CD8 + T cells trigger the apoptosis of oral epithelial cells. (medscape.com)

Sokullu E, Dağcı T, Gözen O, Ersoy F, Öztarhan A (2017) The Effects of Carbon and Gold Ion Implanted Surfaces on Neuronal Stem Cells' Functions. (omicsonline.org)

Skin healing results after implantation of adult stem cells derived from adipose tissue were satisfactory. (rbcp.org.br)
His current research shows long term implantation of flexible microprobes in rodent brains to present a promising path to chronic coupling. (uni-freiburg.de)

Stem cell scaffold bioprocessing. (imperial.ac.uk)
I work on various biochemical and biophysical approaches to investigate and control cell-cell, cell-scaffold interactions. (nottingham.ac.uk)
The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)

I was also affiliated with the Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM), part of the Centre for Biomolecular Sciences, which is now the Biodiscovery Institute. (nottingham.ac.uk)

hPSC-enriched essential genes mainly encode transcription factors and proteins related to cell-cycle and DNA-repair, revealing that a quarter of the nuclear factors are essential for normal growth. (nature.com)
Fig. 2: Analysis of cell-essential genes. (nature.com)
But previous approaches required the use of viruses to deliver the four genes needed to activate the cell and accomplish that task. (cbc.ca)
They took a cell from Dr Jose Cibelli, a research scientist and combined it with a cows egg from which the genes had already been removed. (globalchange.com)
The genes activated and the egg began to divide in the normal way up to the 32 cell stage at which it was destroyed. (globalchange.com)
This is done by re-activating critical genes that define embryonic stem cells to make adult stem cells to revert to an embryonic-like state of pluripotency. (bmrat.org)
Two other Wnt target genes, RNF43 and ZNRF3, encode stem cell-specific E3 ligases that downregulate Wnt receptors in a negative feedback loop (35). (hubrecht.eu)

Clinically, grade 3B follicular lymphoma is treated like diffuse large B-cell lymphoma . (medscape.com)

Johannes (Hans) Carolus Clevers (born 27 March 1957) is a Dutch molecular geneticist, cell biologist and stem cell researcher. (wikipedia.org)
Clevers has served at a number of scientific organizations, including on the board of directors of the American Association for Cancer Research (2013-2016), and the Scientific Advisory Board of the Swiss Institute for Experimental Cancer Research at the École Polytechnique Fédérale de Lausanne (2005-2015), the Research Institute of Molecular Pathology in Vienna (2015-2021) and the Francis Crick Institute in London. (wikipedia.org)
He is currently on the advisory board of various scientific journals, including The EMBO Journal, Disease Models & Mechanisms, Cell, Cell Stem Cell and EMBO Molecular Medicine. (wikipedia.org)
Nonetheless, it appears that in order to cure aging we will need to target multiple types of cells and possibly address different types of molecular damage and malfunction. (senescence.info)
Noninvasive detection and imaging of molecular markers in live cardiomyocytes derived from human embryonic stem cells Biophysical Journal. (nottingham.ac.uk)
In APC-deficient colon carcinoma cells, we demonstrated that ß-catenin accumulates and is constitutively complexed with the TCF family member TCF4, providing a molecular explanation for the initiation of colon cancer (5). (hubrecht.eu)

Toni N ., Song H., Ming GL "Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain", PNAS 2015 July 13. (chuv.ch)

All cells are grown in an environment that is typically called "growth media. (gcimagazine.com)
Some people are very uneasy about creating a human embryo and then dismembering it, however early the stage, to obtain embryonic stem cells from which useful tissues might be grown. (globalchange.com)
When these cells are isolated from the blastocyst and grown in a lab dishes, they can continue dividing indefinitely. (bmrat.org)

In a study published in the online journal Nature on March 1, 2009, Canadian researches described a new method for generating stem cells from adult human tissue. (cbc.ca)
Our experimental focus is on the mammalian setting using multiomics, informatics, mouse genetics, human genetics, single cell studies, and new human tissue platforms. (stanford.edu)

Sanchez-Pascual I., O'Laoi R., El M'Ghari I., Kocher-Braissant J., Ellisman MH, Toni N . "Fine processes of Nestin-GFP positive radial glia-like stem cells in the adult dentate gyrus ensheathe local synapses and vasculature. (chuv.ch)
1984. The reversal potential of excitatory amino acid action on granule cells of the rat dentate gyrus. (cdc.gov)

A vaccine that stimulates CD8 T regulatory cells helps to prevent self-destructive immune reactions in autoimmune diseases and organ transplant rejection. (medindia.net)
Essentially, you can kill any cancer cell that has an antigen that is recognized by the immune cell," Hwu said. (ajmc.com)
Cell therapy involves cultivating or modifying immune cells outside the body before injecting them into the patient. (ajmc.com)
For a long time, stem cells have been utilized to renew the immune system for radiation or chemo- therapy treated patients. (bmrat.org)
Besides surgery, radiotherapy and chemotherapy, immune activation by direct application of cytokines, antibodies or adoptive cell therapy are promising approaches. (frontiersin.org)
With their ability to detect and directly destroy virally infected or malignant cells, natural killer (NK) cells form an important part of the first line defense of the immune system. (frontiersin.org)
The role of autoimmunity in the pathogenesis is supported by many autoimmune features of oral lichen planus, including its chronicity, onset in adults, predilection for females, association with other autoimmune diseases, occasional tissue-type associations, depressed immune-suppressor activity in patients with oral lichen planus, and the presence of autocytotoxic T-cell clones in lichen planus lesions. (medscape.com)

To optimize the ASC-supported culture, freshly isolated limbal epithelial cells in the form of single cells (SC-ASC) or cell clusters (CC-ASC) were cultured using three different methods: LSCs seeded directly on feeder cells, a 3-dimensional (3D) culture system and a 3D culture system with fibrin (fibrin 3D). (drcremers.com)
The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye, which acts as a protective barrier and is critical for clear and stable vision. (wjgnet.com)
The control of this transition from epithelial stem cell to differentiated corneocyte, which is abnormal in epidermal cancers, is not well understood. (stanford.edu)
These cells represent the epithelial stem cells of the small intestine and colon (23), the hair follicle (24), the stomach (28) and many other tissue stem cell types. (hubrecht.eu)

He remains an advisor and guest scientist or visiting researcher to his research groups at the Princess Máxima Center and Hubrecht Institute. (wikipedia.org)

When germ-free cell cultures became a laboratory routine, hopes were high for using this novel technology for treatment of diseases or replacement of cells in patients suffering from injury, inflammation, or cancer or even refreshing cells in the elderly. (hindawi.com)
Research Engineer in the Chemical and Biochemical Process Technology and Control Laboratory, Department of Chemical Engineering, Faculty of Engineering, Katholieke Universiteit Leuven, Belgium. (imperial.ac.uk)
Research Engineer in the Laboratory of Food Chemistry and Technology of the School of Chemical Engineering, National Technical University of Athens, Greece. (imperial.ac.uk)
We hope that we will be able to use stem cells cultivated in the laboratory in the future. (lu.se)

In recent years, the rapid development of tissue engineering technology provides a new therapeutic method for repairing PNI. (biomedcentral.com)
Recently, stem cells are being engineered to carry therapeutic reagents to target tumor sites. (bmrat.org)
The Society for Women's Health Research, a non-profit group, agrees that therapeutic cloning should be allowed. (boloji.com)
More research is needed to better understand risk factors contributing to jALS, which could lead to earlier diagnosis and therapeutic interventions. (cdc.gov)

Kite Pharma, a subsidiary of Gilead, received an accelerated approval in July 2020 for brexucabtagene autoleucel (Tecartus) for adults with relapsed or refractory mantle cell lymphoma. (ajmc.com)
Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, which is a form of cancer that affects the lymphatic system. (rarediseases.org)
Mantle cell lymphoma belongs to a group of diseases known as non-Hodgkin's lymphomas, which are related malignancies (cancers) that affect the lymphatic system. (rarediseases.org)

Our results demonstrated high potential of IL-15 for NK cell expansion, while IL-21 triggered NK cell maturation and functionality. (frontiersin.org)

The cells carry the potential to cure neurological diseases, diabetes, and many other illnesses. (christianitytoday.com)
REVIEW - Mesenchymal stem cells in arthritic diseases. (renudermatology.com)
Since then, there has been a flurry of announcements about developments in stem cell research and hints of promising treatments for diseases such as Alzheimer's, Parkinson's and cancer. (cbc.ca)
This makes them perfect for a wide range of medical uses, from repairing tissue to treating diseases such as Parkinson's and Alzheimer's. (cbc.ca)
California voters received, instead, a TV campaign promising cures tomorrow for a host of diseases, some of which may never respond to stem cell therapy. (latimes.com)
Despite intensive research in recent decades the prognosis for patients with metastatic or relapsed diseases has hardly improved. (frontiersin.org)
Reported associations between oral lichen planus and systemic diseases may be coincidental, because (1) oral lichen planus is relatively common, (2) oral lichen planus occurs predominantly in older adults, and (3) many drugs used in the treatment of systemic diseases trigger the development of oral lichenoid lesions as an adverse effect. (medscape.com)
Author to whom correspondence should be addressed: Mahdi Rahbar, Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran. (bvsalud.org)

The most common cell type is diffuse large-cell lymphoma, either associated or unassociated with mucosa-associated lymphoid tissue (MALT) lymphoma (MALToma). (medscape.com)
Staal SP, Ambinder R, Beschorner WE, Hayward GS, Mann R. A survey of Epstein-Barr virus DNA in lymphoid tissue. (medscape.com)

Lgr6 marks multipotent skin stem cells (29). (hubrecht.eu)

The use of fat was documented during World War I to aid in the healing of soldiers' battle wounds.1 Since then, a large body of research has shown a variety of promising applications for fat in healing and regenerating damaged tissues. (jenningsclinic.com)
Your own fat has been shown a variety of promising applications in healing and regenerating damaged tissues in orthopaedic surgery. (jenningsclinic.com)

As PhD students, we found it difficult to access the research we needed, so we decided to create a new Open Access publisher that levels the playing field for scientists across the world. (intechopen.com)
Scientists have been all abuzz in the last few years over stem cells - cellular magicians that promise to dazzle and amaze. (cbc.ca)
Scientists say embryonic stem cells are the most useful type because they have the potential to become any type of cell within the body. (cbc.ca)
Scientists are fascinated by the ability of stem cells to become any type of cell. (cbc.ca)
Scientists have already made geep (combined sheep and goat), and camas (combined camels and lamas) simply by rolling two balls of cells together after fertilisation. (globalchange.com)
Dr. Zach W. Hall is one of our most distinguished scientists and experienced research administrators, with posts at USC's medical school, UC San Francisco, and the National Institutes of Health on his glittering resume. (latimes.com)
This may allow scientists to culture healthy tissue cells in the lab to replace damaged ones in the human body. (latimes.com)
most also demonstrate immunotoxicity after group was composed of scientists from academia, the chemical and pharmaceutical industries, and adult exposure. (cdc.gov)

Robert identified a doctor who was employing clients very own Grownup Stem Cells taken from his peripheral blood to aid rebuild damaged heart tissue. (fingersmurphy.com)
A complete blood cell count (CBC) with differential should be obtained, including examination of the peripheral blood smear if the differential is abnormal. (medscape.com)
Peripheral blood mononuclear cells (PBMCs) were used to measure the enzymatic activities of citrate synthase and complexes I, II, and IV and mtDNA copy number. (bvsalud.org)

Long-term clonal culturing of organoids from Lgr5 stem cells. (hubrecht.eu)
Based on these combined insights, we have established Lgr5/R-spondin-based culture systems that allow the outgrowth of single mouse or human Lgr5 stem cells into ever-expanding organoids. (hubrecht.eu)

MCL is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. (rarediseases.org)
In the last years, adoptive transfer of natural killer (NK) cells came into the focus of translational medicine, because of their high cytotoxic potential against transformed malignant cells. (frontiersin.org)

Arguably, the fact that included in the 150 growth factors and cytokines made by human cells are cancer-fighting factors, it can be assumed that they provide the balance the skin needs to reverse aging without amplifying the cancer risk. (gcimagazine.com)
In this study, we addressed feeder cell-free expansion methods using common γ-chain cytokines, especially IL-15 and IL-21. (frontiersin.org)
Activated CD8 + T cells (and possibly keratinocytes) may release cytokines that attract additional lymphocytes into the developing lesion. (medscape.com)

Sandström J., Eggermann E., Charvet I., Roux A., Toni N ., Greggio C., Broyer A., Monnet-Tschudi F., Stoppini L. "Development and characterization of a human embryonic stem cell-derived 3D neural tissue model for neurotoxicity testing. (chuv.ch)
Gebara E., Bonaguidi M., Beckervordersandforth R., Sultan S., Udry F., Gijs P., Lie C., Ming G., Song H., Toni N . "Morpho-functional characterization of adult neural hippocampal stem cells reveals two morphotypes of radial glia-like cells. (chuv.ch)
Here we report the generation of clonal NP cell lines from nondegenerate human IVD tissue and present a detailed characterization of NP cellular subpopulations. (biomedcentral.com)

Anatomy22

Organisms2

Diseases1

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Psychiatry and Psychology3

Phenomena and Processes14

Disciplines and Occupations10

Anthropology, Education, Sociology and Social Phenomena9

Technology, Industry, Agriculture3

Humanities20

Information Science1

Named Groups1

Health Care11

Geographicals1

Transplantation18

Organs12

Bone27

19983

Fetal4

Mesenchymal stem2

Differentiation13

Progenitor5

Embryos15

Biology11

Vitro10

Regenerative13

Embryonic stem-cel5

Therapies11

20011

Pluripotent10

Regeneration9

Autologous2

Genetic11

19952

Patient's4

Proliferation1

Stromal cells1

Reprogram3

Gene10

20181

Vivo7

Tumor cells2

Mice7

Hematopoietic2

Differentiate5

Clinical12

MSCs4

Osteoarthritis1

Neural stem1

Toxicological1

Researchers7

19971

Apoptosis5

20171

Implantation2

Scaffold3

Centre1

Genes7

Diffuse large B-1

Molecular6

Neurons1

Grown3

Human tissue2

Dentate gyrus2

Immune7

Epithelial4

Hubrecht Institute1

Laboratory4

Therapeutic4

Mantle cell lym3

Maturation1

Diseases8

Lymphoid2

Multipotent1

Healing and regener2

Scientists8

Peripheral blood3

Organoids2

Malignant2

Cytokines3

Characterization3