• body's
  • Play media Distributive shock is a medical condition in which abnormal distribution of blood flow in the smallest blood vessels results in inadequate supply of blood to the body's tissues and organs. (wikipedia.org)
  • It is one of four categories of shock, a condition where there is not enough oxygen-carrying blood to meet the metabolic needs of the cells which make up the body's tissues and organs. (wikipedia.org)
  • vascular
  • Endothelial cells are involved in many aspects of vascular biology, including: Barrier function - the endothelium acts as a semi-selective barrier between the vessel lumen and surrounding tissue, controlling the passage of materials and the transit of white blood cells into and out of the bloodstream. (wikipedia.org)
  • Moreover, Lp(a) also is hypothesized to be involved in wound healing and tissue repair, interacting with components of the vascular wall and extra cellular matrix. (wikipedia.org)
  • factor
  • Platelet activation can occur through different mechanisms such as a vessel wall breach that exposes collagen, or tissue factor encryption. (wikipedia.org)
  • The prolongation of coagulation (or prothrombin time, PT) occurs following either tissue factor or contact-phase stimulation and is dose-dependent. (wikipedia.org)
  • inflammatory
  • These anti-inflammatory effects of the serine protease inhibitors result in a reduced amount of free radicals and less lipid peroxidation with the amount of malonaldehyde in the heart tissue being reduced. (wikipedia.org)
  • blood
  • Due to its contribution to fibrinolysis, tissue plasminogen activator is used medically to treat blood clot-related disorders including thrombotic or embolic stroke, myocardial infarction, and pulmonary embolism. (wikipedia.org)
  • Clinically, the TEM is useful for near real-time measurement of activated fibrinolysis for at-risk patients, such as those experiencing significant blood loss during surgery. (wikipedia.org)
  • Blood Coagul Fibrinolysis. (wikipedia.org)
  • Blood clotting (thrombosis & fibrinolysis). (wikipedia.org)
  • In a small blood vessel, blood flow may be completely cut off (termed an occlusive thrombus), resulting in death of tissue supplied by that vessel. (wikipedia.org)
  • PAI-1 is mainly produced by the endothelium (cells lining blood vessels), but is also secreted by other tissue types, such as adipose tissue. (wikipedia.org)
  • The cause of inadequate tissue perfusion (blood delivery to tissues) in distributive shock is a lack of normal responsiveness of blood vessels to vasoconstrictive agents and direct vasodilation. (wikipedia.org)
  • inflammation
  • Excessive or prolonged increases in permeability of the endothelial monolayer, as in cases of chronic inflammation, may lead to tissue edema/swelling. (wikipedia.org)
  • Restricted mainly to certain tissues in the normal adult, it is strongly induced during oncogenesis, inflammation and tissue repair. (wikipedia.org)
  • acute
  • A special situation with temporarily enhanced fibrinolysis is thrombolytic therapy with drugs which activate plasminogen, e.g. for use in acute ischemic events or in patients with stroke. (wikipedia.org)
  • endothelial
  • The foundational model of anatomy makes a distinction between endothelial cells and epithelial cells on the basis of which tissues they develop from, and states that the presence of vimentin rather than keratin filaments separate these from epithelial cells. (wikipedia.org)
  • invasion
  • MMP-1 was expressed in tumour-free peritoneum and in the invasion zone between tumour and peritoneal tissue, but not in tumour-invaded areas. (springer.com)
  • Defensins and other antimicrobial peptides and proteins coat mucosal surfaces and are among the primary early mediators of host defense against colonization and tissue invasion by pathogenic microbes. (asmscience.org)
  • However
  • However, neither its effectiveness in improving neurologic outcome nor its safety in living tissue has been fully established. (ahajournals.org)
  • patients
  • The clinical presentation among invasive disease is also dominated by skin and soft tissue infections, including a small subset of patients presenting with severe necrotizing fasciitis. (wikipedia.org)