In addition, the erythrocytes generated an antiviral immune gene activation after PRV infection, with significant up-regulation of IFN-α, RIG-I, Mx and PKR transcripts. (biomedcentral.com)
In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES , and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways. (lookformedical.com)
Introduction Myxovirus resistance protein 1 (Mx1) is a type I/III interferons-induced protein conferring the hosts an antiviral property against several viruses. (edu.vn)
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. (thermofisher.com)
Interferon-stimulated1
IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence. (lookformedical.com)
Encodes1
The 15.2 kb genome is non-segmented, single stranded and encodes 11 proteins in 10 genes [ 3 ]. (biomedcentral.com)
Cytokines1
STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. (thermofisher.com)
INTERFERONS1
The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. (thermofisher.com)
Multiplex assay2
Gene expression and cytokine/chemokine secretion were assessed by real-time PCR and multiplex assay, respectively. (karger.com)
serum proteins were measured with a customized 31-protein multiplex assay. (neurology.org)
Inflammatory2
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. (lookformedical.com)
Theoretically, the possibilities include (1) a primary T-cell mediated autoimmune response causing muscle damage, (2) a primary degenerative process involving abnormal protein processing leading to a secondary inflammatory response, and (3) separate and independent immune and degenerative processes caused by an external trigger. (medscape.com)
Serum1
Increased percentage of detectable serum human epididymis protein 4 (HE4) levels have been used as an aid to monitor the recurrence and progression of disease in patients with invasive epithelial ovarian cancer. (sekbio.com)
Lytic2
Enhanced PCR-based methods were used to investigate expression of 75 immune-related genes and 6 EBV genes associated with latent and lytic infection. (biomedcentral.com)
EBV genes were detected in brain samples from 9 of 11 MS patients with expression patterns suggestive of in situ activation of latent infection and, less frequently, entry into the lytic cycle. (biomedcentral.com)
Cellular1
To test this hypothesis, we analyzed expression of viral and cellular genes in brain-infiltrating immune cells. (biomedcentral.com)
APOPTOSIS2
Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS . (lookformedical.com)
STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. (thermofisher.com)
Transcription3
PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA , and activates transcription. (lookformedical.com)
A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression . (lookformedical.com)
After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. (thermofisher.com)
Chromosome2
There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. (thermofisher.com)
Genes related to T cell activation, cytotoxic cell-mediated (or type 1) immunity, B cell growth and differentiation, pathogen recognition, myeloid cell function, type I interferon pathway activation, and leukocyte recruitment were found expressed at different levels in most or all MS brain immune infiltrates. (biomedcentral.com)
Multivariate analysis grouped genes expressed in meningeal and white matter immune infiltrates into artificial factors that were characterized primarily by genes involved in type 1 immunity effector mechanisms and type I interferon pathway activation. (biomedcentral.com)
Simultaneous Inhibition of ALK2 and ALK3 Down-Regulates the BMP Pathway and Sets off the Activation of Genes Feature for Articular Cartilage in Adult Individual MSCs. (bakingandbakingscience.com)
Induction2
Host proteases have been shown to play important roles in many viral activities such as entry, uncoating, viral protein production and disease induction. (biomedcentral.com)
Conclusion Vitamin D enhances IFN-β induction of multiple proteins and also reverses the Th1/Th2 bias in MS seen with IFN-β alone. (neurology.org)
Viruses1
They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions. (lookformedical.com)
Clinical3
These two important mechanisms of approaching cancer, principally through the clinical application of the P53 tumor suppressor gene and other apoptotic players that for the past 15 years have been included in my cancer strategy as a diagnostic, prognosis, and follow up treatment. (biobran.org)
Human epididymis protein 4 (HE4) combined with CA125 has high clinical value in the early diagnosis of epithelial ovarian cancer, disease monitoring, postoperative recurrence monitoring, as well as in the differential diagnosis of benign tumors. (sekbio.com)
The association of human epididymis protein 4 (HE4) levels with clinical responsiveness to treatment or recurrence status in patients with ovarian cancer examined by CT imaging suggests that human epididymis protein 4 (HE4) may be an important indicator of ovarian cancer recurrence. (sekbio.com)
ELISA2
em J /em ) VEGF secreted by hMSCs was assessed by ELISA at time 2, time 7 and time 14 of lifestyle. (bakingandbakingscience.com)
Here, Biobran's anti-SARS-CoV-2 activity was assessed using MTT and plaque reduction assays, RT-PCR, ELISA techniques, and measurements of SARS-CoV-2-related gene expression and protein levels. (biobran.org)
Infection2
Ex vivo infection of PBLs with VSV elicited upregulated expression of RIG-I, MDA-5, tetherin, IFITM3, and MxA . (karger.com)
Comparison of data obtained in meningeal and white matter infiltrates revealed higher expression of genes related to interferonγ production, B cell differentiation, cell proliferation, lipid antigen presentation, and T cell and myeloid cell recruitment, as well as more widespread EBV infection in the meningeal samples. (biomedcentral.com)
Patterns1
Such a process helps the learners become aware of socially expected patterns of communication in L1 and L2 in terms of the choices of speech act, formulaic expressions, sequential organization and politeness orientation. (edu.au)
Response1
Proteins secreted by vertebrate cells in response to a wide variety of inducers. (lookformedical.com)
Survival3
CONCLUSIONS: VSARR with reimplantation is associated with better overall survival and lower risk of need for reintervention over time compared with VSARR with remodeling. (bvsalud.org)
Regarding overall survival, we observed a time-varying effect that favored the reimplantation technique up to 4 years of follow-up, but not beyond this time point. (bvsalud.org)
As the time of cancer increases, the 5-year survival rate of patients decreases from 70%-90% to 20%, so early diagnosis is crucial to the cure rate of ovarian cancer. (sekbio.com)
Type2
It functions as a transcriptional activator for the INTERFERON TYPE I genes. (lookformedical.com)
To characterize the type from the hMSC-derived cartilaginous tissue attained by GNAS treatment with the various compounds, gene-expression adjustments of the -panel of transient or articular cartilage personal genes were assessed by quantitative RT-PCR. (bakingandbakingscience.com)
Control1
binding to ALK1 being a mechanism involved with this model (Fig. S1and and and and 0.05) in expression weighed against the control. (bakingandbakingscience.com)
Next time2
If you log out, you will be required to enter your username and password the next time you visit. (medscape.com)
Save my name, email, and website in this browser for the next time I comment. (worldcarecouncil.org)
Types1
Many types of fish migrate on a regular basis, on time scales ranging from daily to annually or longer, and over distances ranging from a few metres to thousands of kilometres. (wikipedia.org)
Treatment3
Expression of s-IBM is variable, but all cases eventually evolve into a syndrome of diffuse, progressive, asymmetric, proximal, and distal weakness that is generally refractory to immunosuppressive treatment. (medscape.com)
The time point at which treatment with the inhibitor was most potent, was found to coincide with the expected moment of entry of the virion with the host cell. (biomedcentral.com)
At this time, treatment of severe RSV disease consists of supportive care, such as hydration and oxygenation. (biomedcentral.com)
Production1
In the last years higher attention focused on the role of immunoregulation both in the insulin production by β-cell of Langerhans-islets and in the insulin sensitivity (resistance) of insulin receptors. (biobran.org)
Patients1
Unfortunately, patients are already in the terminal stage at this time, and the cancer cells have already invaded the surrounding organs or metastasized far away, which leads to the loss of the curative chance for most patients ( 1 ). (frontiersin.org)
Factors1
Compared with the glycoantigen CA125, which is less disturbed by external factors, the cancer antigen 125 marker is generally disturbed by many factors such as inflammation, endometriosis, and pregnancy, which can cause elevation, whereas human epididymis protein 4 (HE4) is generally not affected by these factors. (sekbio.com)
Test1
The combined test of human epididymis protein 4 (HE4) and CA125 is more meaningful for detecting ovarian cancer. (sekbio.com)
Cancer3
HE4, called human epididymis protein 4, is a sensitive indicator for detecting ovarian cancer and is one of the antigen markers . (sekbio.com)
Human epididymis protein 4 (HE4) is not expressed in the normal ovarian surface epithelium, while it is significantly highly expressed in serous ovarian cancer and endometrioid ovarian cancer. (sekbio.com)
Human epithelial protein (HE4) also has some sensitivity in the diagnosis of endometrial cancer. (sekbio.com)
Form1
Abstract Staphylococcus aureus is a notorious foodborne pathogen since it has ability to produce variety of toxins including heat-stable enterotoxin, form biofilm, and acquire resistance to antibiotics. (edu.vn)