• Alzheimer's
  • We and others have examined patients with various neurodegenerative and behavioral neurological conditions, such as Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Alzheimer's disease (AD) and Autistic Spectrum Disorders ([ASD], including Autism, Attention Deficit Disorder, Asperger Syndrome), and found evidence for systemic intracellular bacterial and viral infections in a majority of patients. (townsendletter.com)
  • They include: Alzheimer's disease Acute disseminated encephalomyelitis Viral meningitis Multiple sclerosis Bell's palsy Neuroborreliosis presenting with symptoms consistent with amyotrophic lateral sclerosis has been described. (wikipedia.org)
  • New research from the University of Toronto Mississauga definitively puts to rest a theory that Lyme disease causes Alzheimer's. (iospress.nl)
  • While researching his book " The Alzheimer's Epidemic-Searching for Causes and a Cure " (Emeritus Books), U of T Mississauga Professor Emeritus Danton O'Day was intrigued to discover studies and popular professional opinion supporting a potential link between Lyme disease and Alzheimer's deaths. (iospress.nl)
  • Alzheimer's disease affects 750,000 Canadians. (iospress.nl)
  • Alzheimer's disease causes a similar loss of cognitive ability and, eventually, death. (iospress.nl)
  • In contrast, the causes of Alzheimer's disease remain unknown and there is no cure. (iospress.nl)
  • Together with Andrew Catalano , a recent PhD graduate from O'Day's research group who is now a post-doctoral fellow at City College of New York, O'Day compared data to see if states with high incidences of Lyme disease also showed a high incidence of deaths related to Alzheimer's. (iospress.nl)
  • The pair found, in fact, that the 13 states with the highest incidence of Lyme disease actually reported the lowest number of deaths due to Alzheimer's. (iospress.nl)
  • Furthermore, seven of the states with high incidences of Alzheimer's deaths were among the 13 states with the lowest incidence of Lyme disease. (iospress.nl)
  • Statistical analyses revealed a complete lack of correlation between the two diseases, strongly suggesting that Lyme disease could not be the cause Alzheimer's," O'Day said. (iospress.nl)
  • Because of this growing impact Alzheimer's disease will have in Canada and world-wide, we need to understand the true factors that underlie the disease," said O'Day. (iospress.nl)
  • We need to quickly rule out concerns, like Lyme disease, that unnecessarily cause widespread fear and interfere with attempts to fully understand the causes of Alzheimer's disease. (iospress.nl)
  • The research, which was published in the August 2014 issue of the Journal of Alzheimer's Disease , was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC). (iospress.nl)
  • bite
  • Ehrlichiosis anaplasmosis (formerly human granulocytic ehrlichiosis or HGE) Organism: Ehrlichia chaffeensis, E. equi (renamed to Anaplasma phagocytophilum, see Human granulocytic anaplasmosis for another example) Vector: Lone star tick (Amblyomma americanum), I. scapularis Region (US): South Atlantic, South-central Bartonella: Bartonella transmission rates to humans via tick bite are not well established but Bartonella is common in ticks. (wikipedia.org)
  • The illness follows a lone star tick bite, and clinically resembles Lyme disease, but sufferers usually test negative for Lyme. (wikipedia.org)
  • Immediately upon the onset of a tick bite, it transmits a pain killer, anti-histamine and an anti-coagulant. (lymebook.com)
  • antibiotics
  • In the US, neuroborreliosis is typically treated with intravenous antibiotics which cross the blood-brain barrier, such as penicillins, ceftriaxone, or cefotaxime. (wikipedia.org)
  • However, about 10-15% of patients with Lyme arthritis fail the initial course of antibiotics, and some of those develop a chronic inflammatory arthritis optimally treated with local or systemic immunosuppressive agents. (springer.com)
  • 11 In contrast, if the SF-36 was used to determine Quality of Life (QOL) in post-Lyme patients, the average SF-36 physical component summary (40±9, range 29-44) and mental component summary (39±14, range 23-46) of the QOL assessment were worse than the general USA population, and they could be significantly improved by anti-Lyme antibiotics (46% versus 18%, p =0.007). (blogspot.com)
  • His clinical work has involved advising upon infectious disease for cardiac transplant patients, advising on antibiotics and their use, teaching at the University of North Carolina at Chapel Hill and becoming involved in clinical research associated with these fields. (lymediseaseaction.org.uk)
  • The doctor rashly (pun intended) diagnosed Lyme's disease (I'd also been feasted upon by four ticks in the previous 2 weeks) and put me on antibiotics. (blogspot.de)
  • Lyme disease can be easily detected and cured with antibiotics," O'Day said. (iospress.nl)
  • neurological
  • 1-5 One of the biochemical changes found in essentially all neurological degenerative diseases is the over-expression of oxidative free radical compounds (oxidative stress) that cause lipid, protein, and genetic structural changes. (townsendletter.com)
  • An attractive model for neurodegeneration resulting in neurological disease involves the action of toxic products produced as a result of chronic bacterial and/or viral infections. (townsendletter.com)
  • Can microbes and immune reactions to them actually contribute to cognitive decline, degenerative neurological disease, developmental disabilities, mental illness, personality changes and, at the most extreme, even violent and criminal behavior? (psychologytoday.com)
  • Although most patients with Lyme/tick-borne disease do not become violent, a small percent of patients who become infected develop a type of neurological dysfunction that can increase their risk of aggressiveness. (psychologytoday.com)
  • ALS is a motor neuron disease, also spelled "motor neurone disease", which is a group of neurological disorders that selectively affect motor neurons, the cells that control voluntary muscles of the body, including amyotrophic lateral sclerosis (ALS), primary lateral sclerosis, progressive muscular atrophy, progressive bulbar palsy, pseudobulbar palsy, and spinal muscular atrophy. (wikipedia.org)
  • systemic
  • Patients with neurodegenerative diseases and behavioral disorders often have systemic bacterial, viral, and/or fungal infections that are important in disease progression and severity. (townsendletter.com)
  • In the first part of this review we considered neurodegenerative and neurobehavioural diseases and the findings that these diseases commonly are associated with systemic and central nervous system bacterial and viral infections. (blogspot.com)
  • infections
  • 1 In addition to genetic changes and changes in gene expression, it is thought that nutritional deficiencies, head trauma, environmental toxins, chronic bacterial and viral infections, autoimmune immunological responses, vascular diseases, accumulation of fluid in the brain, changes in neurotransmitter concentrations, and other causes are involved in various neurodegenerative diseases. (townsendletter.com)
  • B . hispanica and B . crocidurae infections have been detected in northern and southern Morocco, respectively, along with the tick vectors responsible for their transmission ( Ornithodoros erraticus and O . sonrai , respectively) ( 8 ). (cdc.gov)
  • 1 In this second part we continue with psychiatric diseases, autoimmune diseases, fatiguing illnesses, and other chronic diseases where chronic infections play an important role. (blogspot.com)
  • Endemic
  • Lyme disease is most endemic in Northern Hemisphere temperate regions, but sporadic cases have been described in other areas of the world. (wikipedia.org)
  • This might be due to the very low incidence in an endemic region (0.2%, CI 95% 0.0% to 1.1%) as demonstrated in 517 patients hospitalized for psychiatric diseases. (blogspot.com)
  • rash
  • this rash occurs in 75% of patients infected with Lyme disease and tends to resolve from the inside-out, leaving a bull's eye mark on the skin (Frey 2002). (davidson.edu)
  • bacterium
  • Transmission of the bacterium that causes Lyme disease is well understood to require a substantial feeding period. (wikipedia.org)
  • This is because OspA allows the bacterium to adhere to the gut of the tick by binding to the tick receptor for OspA (TROSPA) to colonize. (davidson.edu)
  • ELISA
  • the components in each fraction were identified, and the immunogenicity of each fraction was determined by ELISA using sera from Lyme disease patients. (borrelioosi.net)
  • Africa
  • With so many vectors, the underlying assumption behind this checklist is that Lyme is not rare in North America, Europe, South America, Russia, Africa or Asia. (lymebook.com)
  • The disease is rarely detected in northern Africa and Mediterranean countries ( 3 , 6 , 7 ). (cdc.gov)
  • 2016
  • Lyme Disease Differential Diagnoses: Diagnostic Considerations Updated: Mar 14, 2016 CDC Two-step Laboratory Testing Process Page last reviewed: March 4, 2015. (wikipedia.org)
  • incidence
  • Those wishing to know the incidence of tick-borne diseases in their town or state can search the LMZ surveillance database. (wikipedia.org)
  • For the most part, the causes and mechanisms of this collection of brain diseases remain largely unknown, and they are increasing in incidence in the developed as well as the underdeveloped world. (townsendletter.com)
  • Vermont was the only state that reported a high incidence of both diseases. (iospress.nl)
  • doxycycline
  • Several studies from Europe have suggested oral doxycycline is equally as effective as intravenous ceftriaxone in treating neuroborreliosis. (wikipedia.org)
  • Doxycycline kills the symbiotic Wolbachia bacteria in the reproductive tracts of parasitic filarial nematodes, making the nematodes sterile, and thus reducing transmission of diseases such as onchocerciasis and elephantiasis. (wikipedia.org)
  • spirochetes
  • Detection of Lyme disease spirochetes in the skin of naturally infected wild sikd deer (Cervus nippon yesoensis) by PCR. (nii.ac.jp)
  • The spirochetes involved are well suited to survive in either the tick or a mammalian host and expresses different proteins depending on which host it invades. (davidson.edu)
  • patients
  • showed that patients with neuroborreliosis demonstrate a blood brain barrier disturbance with 62 % showing an elevated albumin ratio and 60 % revealing an increased IgG index, indicative of intrathecal IgG synthesis. (upmc.edu)
  • Use of bisphosphonates in patients with conditions or diseases affecting renal function is not recommended. (issuu.com)
  • In working with a number of patients with Lyme/tick-borne diseases it is apparent to many clinicians these conditions can cause reduced frustration tolerance, irritability, depression , cognitive impairments and mood swings, but more significantly, in a few patients, suicidal and aggressive tendencies. (psychologytoday.com)
  • We found that 20.5% of patients with an unexplained fever in northwestern Morocco had tick-borne relapsing fever. (cdc.gov)
  • Dr. Jemsek s Clinic sees more new patients for Lyme Disease than any other facility in the country. (lymediseaseaction.org.uk)
  • More recently he became involved in the care of patients with Lyme Disease and he is a member of the International Lyme and Associated Diseases Society (ILADS). (lymediseaseaction.org.uk)
  • Amblyomma
  • Typhus Several diseases caused by Rickettsia bacteria (below) Rocky Mountain spotted fever Organism: Rickettsia rickettsii Vector: Wood tick (Dermacentor variabilis), D. andersoni Region (US): East, Southwest Vector: Amblyomma cajennense Region (Brazil): São Paulo, Rio de Janeiro, Minas Gerais. (wikipedia.org)
  • Epidemic
  • Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities. (springer.com)
  • 1975
  • Lyme disease was diagnosed as a separate condition for the first time in 1975 in Old Lyme, Connecticut. (wikipedia.org)
  • It was first identified in 1975 in the town of Old Lyme, CT after an outbreak of juvenile rheumatoid arthritis. (davidson.edu)