• iodide
  • This enzyme catalyses the following chemical reaction 3,3',5'-triiodo-L-thyronine + iodide + A + H+ ⇌ {\displaystyle \rightleftharpoons } L-thyroxine + AH2 The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. (wikipedia.org)
  • decrease
  • It is believed this decrease in AChE and MEP structural changes could be the result of over stimulation of thyroxin blocking the axoplasmic flow of trophic factors down the axon terminal especially considering thyroxine's role in nervous system growth and metabolism regulation. (wikipedia.org)
  • Research suggests thyroxine directly causes a decrease in protein kinase affinity to cAMP within muscle fibers This causes an increase in cAMP within the muscle fibers since protein kinases are not inactivating cAMP. (wikipedia.org)
  • compounds
  • The thyroxine hormones are organoiodine compounds that are required for health and the reason for government-mandated iodization of salt. (wikipedia.org)
  • known
  • Thyroxine 5-deiodinase also known as type III iodothyronine deiodinase (EC number 1.21.99.3) is an enzyme that in humans is encoded by the DIO3 gene. (wikipedia.org)
  • usually
  • Some drugs such as lithium, which is usually used for bipolar disorder, and amiodarone, a cardiac drug, may affect thyroxine levels. (wisegeek.com)
  • Research
  • Other research indicates muscle fiber fatigue, weakness, and degradation associated with TM is the direct action thyroxine has on the muscle fibers themselves. (wikipedia.org)
  • drug
  • Although these products have been offered for many years without FDA approval (thyroxine products are "grand fathered"), the FDA has stated that it requires manufacturers to file a New Drug Application with the agency. (patentgenius.com)
  • evidence
  • With the onset of TM due to thyroxine toxicity, there is evidence to suggest that structural changes in MEPs could lead to muscle fiber degradation, weakness, and fatigue. (wikipedia.org)