Single photon emission computed tomography (SPECT) imaging of the heart is performed using a gamma camera to detect the gamma rays emitted by the technetium-99m as it decays. (wikipedia.org)
METHODS: A decision tree modeled patients who underwent parathyroidectomy for primary hyperparathyroidism using single preoperative localization modalities: (1) positron emission tomography using radiolabeled 18F-fluorocholine, (2) 4-dimensional computed tomography, (3) ultrasound, and (4) sestamibi single photon emission computed tomography (SPECT). (bvsalud.org)
Sestamibi single photon emission computed tomography and ultrasound were dominated strategies. (bvsalud.org)
Myocardial2
Technetium (99mTc) sestamibi is a lipophilic cation which, when injected intravenously into a patient, distributes in the myocardium proportionally to the myocardial blood flow. (wikipedia.org)
Either planar or tomographic imaging can be performed for diagnosis of ischemic heart disease and myocardial infarction, although SPECT should be performed whenever possible. (studylib.net)
Underwent1
METHODS: Twenty-five patients with untreated mild essential hypertension and normal coronary vessels and 10 control subjects underwent dipyridamole-rest Tc-99m sestamibi imaging. (cnr.it)
Cardiac2
A MIBI scan or sestamibi scan is now a common method of cardiac imaging. (wikipedia.org)
Careful evaluation of the patient's history and physical examination (including signs of congestion, such as jugular venous distention [JVD]) can provide important information about the underlying cardiac abnormality in heart failure. (medscape.com)
Sodium3
For intravenous injection after radiolabelling with sodium (Tc-99m) pertechnetate solution and is indicated for: - adjunct for diagnosis of ischaemic heart disease. (studylib.net)
The vial is reconstituted with a maximum of 11 GBq of oxidant-free sodium (Tc-99m) pertechnetate solution for injection in 1 - 5 ml. (studylib.net)
In cases of severe heart failure, however, prolonged, rigid sodium restriction, coupled with intensive diuretic therapy and the inability to excrete water, may lead to dilutional hyponatremia, which occurs because of a substantial expansion of extracellular and intravascular fluid volume and a normal or increased level of total body sodium. (medscape.com)
Coronary2
We assessed coronary flow reserve (CFR) by sestamibi imaging in hypertensive patients with normal coronary vessels. (cnr.it)
CONCLUSION: Sestamibi imaging may detect impaired coronary vascular function in response to dipyridamole in patients with untreated mild essential hypertension and normal coronary arteries. (cnr.it)
Diagnosis2
The suggested dose range for intravenous administration to a patient of average weight (70 kg) is: Diagnosis of ischaemic heart disease Two injections are required (at stress and at rest) in order to differentiate between transient and persistent perfusion defects. (studylib.net)
The ESC indicates that pulmonary function testing is generally not helpful in the diagnosis of heart failure. (medscape.com)
Liver1
This will promote rapid hepatobiliary clearance of technetium Tc-99m sestamibi resulting in less liver activity in the image. (studylib.net)
Common2
Congenital heart diseases (CHDs) are the most common major congenital anomaly at up to 28%1 and are responsible for 5.7% of all infant mortality.2. (annals.edu.sg)
The most common modalities are neck ultrasound (US) and sestamibi scanning. (bvsalud.org)
Disease1
[ 3 ] These tests reveal potential cardiovascular or thyroid disease as causes of heart failure. (medscape.com)
Negative2
Sestamibi is taken up by tissues with large numbers of mitochondria and negative plasma membrane potentials. (wikipedia.org)
this was 97.9% in dual localized patients (those with positive US and sestamibi), compared to 95.8% in the dual unlocalized group (those with negative US and sestamibi) (Pâ =â 0.33). (bvsalud.org)
Patients1
Serum electrolyte values are generally within reference ranges in patients with mild to moderate heart failure before treatment. (medscape.com)
More recently, breast radiologists administer lower doses of 99mTc sestamibi (approximately 150-300 MBq or 4-8 mCi) for Molecular Breast Imaging (MBI) scans which results in a high sensitivity (91%) and high specificity (93%) for breast cancer detection. (wikipedia.org)
The heart to background ratio will increase with time but the ideal imaging time, reflecting the best compromise between heart count rate and contrast, is approximately 15 - 60 min. (studylib.net)
Risk1
Longer delays are required for resting images and for stress with vasodilators alone because of the risk of higher subdiaphragmatic Tc-99m activity. (studylib.net)
Major1
Therefore, the corresponding radiopharmaceuticals have been a major focus, and some of them like 99m Tc-Annexin V, 18 F-ML-10, 18 F-CP18, and 18 F-ICMT-11 are currently under clinical investigations in Phase I/II or Phase II/III clinical trials on a wide scope of diseases. (oncotarget.com)
Methoxyisobutylisonitrile2
The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six (sesta=6) methoxyisobutylisonitrile (MIBI) ligands. (wikipedia.org)
Lack of technetium-99m methoxyisobutylisonitrile ((99m) Tc-MIBI) uptake is consistently reported to predict poor response to subsequent chemotherapy in a variety of human malignant tumours. (cnr.it)
MIBI6
A MIBI scan or sestamibi scan is now a common method of cardiac imaging. (wikipedia.org)
Lack of MIBI uptake in the thyroid is compatible with a form of thyroiditis (type-2 AIT) which may respond to treatment with steroids. (wikipedia.org)
Since (99m) Tc-MIBI accumulates within mitochondria, which also play a central role in apoptosis through the integration of death signals by Bcl-2 family members, we tested whether early (99m) Tc-MIBI uptake is affected by alterations of the apoptotic pathway. (cnr.it)
Forty-two breast cancer patients were intravenously injected with 740 MBq of (99m) Tc-MIBI and planar images were obtained 10 min post injection with the patients in the prone lateral position. (cnr.it)
Ten carcinomas failed to accumulate (99m) Tc-MIBI and could not be visualised on scintigraphic images despite being larger than 1. (cnr.it)
Thirty-two of the 42 breast carcinomas showed focal uptake of (99m) Tc-MIBI (MIBI positive), and 10 min tumour-to-background ratios (T/B) varied between 1. (cnr.it)
Mitochondria1
Sestamibi is taken up by tissues with large numbers of mitochondria and negative plasma membrane potentials. (wikipedia.org)
Intravenously1
Technetium (99mTc) sestamibi is a lipophilic cation which, when injected intravenously into a patient, distributes in the myocardium proportionally to the myocardial blood flow. (wikipedia.org)
Breast cancer1
More recently, breast radiologists administer lower doses of 99mTc sestamibi (approximately 150-300 MBq or 4-8 mCi) for Molecular Breast Imaging (MBI) scans which results in a high sensitivity (91%) and high specificity (93%) for breast cancer detection. (wikipedia.org)