• dimers
  • One of the common mutations of DNA involves two adjacent thymines or cytosine, which, in presence of ultraviolet light, may form thymine dimers, causing "kinks" in the DNA molecule that inhibit normal function. (wikipedia.org)
  • hydrogen
  • Thymine likely formed within some meteorite parent bodies, however may not have persisted within these bodies due to an oxidation reaction with hydrogen peroxide. (wikipedia.org)
  • oxidative
  • Brain samples from humans who died of stroke were found to be deficient in base excision repair of thymine glycol as well as other types of oxidative damages. (wikipedia.org)
  • damage
  • The rate of repair of thymine glycol damage in human fibroblasts was found to decrease with age. (wikipedia.org)
  • The effect of three sensitizers, misonidazole, p-nitroacetophenone and 4-hydroxy-2,2,6,6-tetramethylpiperidino-1-oxy (TMPN), on formation of thymine damage of the 5,6-dihydroxydihydrothymine type by irradiation with gamma rays was characterized in HeLa cells. (springer.com)
  • The formation of thymine base damage was measured in the presence of increasing concentrations of each of the three sensitizers with and without 500 Gy of cobalt-60 gamma rays, at ice temperature. (springer.com)
  • Therefore, the mechanism by which they sensitize under hypoxic conditions, such as found in solid tumors, is not by an increase in thymine base damage. (springer.com)
  • Remsen J.F. (1986) Radiosensitizers and Thymine Base Damage. (springer.com)
  • found
  • Thymine has not been found in meteorites, which suggests the first strands of DNA had to look elsewhere to obtain this building block. (wikipedia.org)