• activation
  • The chronic inflammatory condition prevailing in the plaque explains the presence of numerous macrophages and the activation of their phospholipase A2, which releases AA from membrane phospholipid pools. (rupress.org)
  • Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697" (PDF). (wikipedia.org)
  • IP receptor) to from TP-IP heterodimers that, with respect to TPα-IP heterodimers, trigger particularly intense activation of adenyl cyclase. (wikipedia.org)
  • Thromboxane A2 (TX2) has a positive feedback in platelet activation. (wikipedia.org)
  • Activation also induces a conformational change in the glycoprotein IIb/IIIa (GPIIb/IIIa) receptor, giving it high affinity for fibrinogen. (wikipedia.org)
  • PI3K activation leads to inhibitory phosphorylation of the tau kinase glycogen synthase kinase 3 beta (GSK3B), which alters the activity of tau protein, a protein involved in stabilizing microtubules. (wikipedia.org)
  • Through binding of ApoER2 in the hippocampus, it plays a role in the NMDA receptor activation that is required for long-term potentiation, a mechanism by which two neurons gain a stronger, longer-lasting transmission due to simultaneous firing. (wikipedia.org)
  • IP is classified as a relaxant type of prostenoid receptor based on its ability, upon activation, to relax certain pre-contracted smooth muscle preparations and smooth muscle-containing tissues such as those of pulmonary arteries and veins. (wikipedia.org)
  • DP1 activation also causes the mobilization of calcium in HEK293 cells transfected with this receptor. (wikipedia.org)
  • pathway
  • The study is the first to examine simultaneously all key proteins involved in this pathway including TXA(2) receptors and results suggest that the TXA(2) pathway may be a potential target for PCa prevention/therapy(10). (blogspot.ca)
  • ApoER2 plays a critical role as a receptor in the reelin signalling pathway, which is important for brain development and postnatal function of the brain. (wikipedia.org)
  • An intermediate arachidonic acid is created from diacylglycerol via phospholipase-A2, then brought to either the cyclooxygenase pathway or the lipoxygenase pathway. (wikipedia.org)
  • A biochemical cascade, also known as a signaling cascade or signaling pathway, is a series of chemical reactions which are initiated by a stimulus (first messenger) acting on a receptor that is transduced to the cell interior through second messengers (which amplify the initial signal) and ultimately to effector molecules, resulting in a cell response to the initial stimulus. (wikipedia.org)
  • intracellular
  • In the first one, first messenger cross through the cell membrane, binding and activating intracellular receptors localized at nucleus or cytosol, which then act as transcriptional factors regulating directly gene expression. (wikipedia.org)
  • PGE2
  • Studies of mice selectively lacking each of the four known EP receptors have indicated that the potentiating effect of PGE2 is mediated solely by EP3 ( 14 ). (rupress.org)
  • 20-Hydroxyeicosatetraenoic acid (20-HETE) is a full agonist and certain isoprostanes, e.g. 8-iso-PGF2 alpha and 8-iso-PGE2, are partial agonists of the TP receptor. (wikipedia.org)
  • cardiovascular
  • The cardiovascular events significantly morefrequently occurred during 12 and 18 months in resistant diabetics and in the patients with an allele lacking the *2/*3 CYP2C9 (zeige CYP2C9 ELISA Kits ) gene function and AT/TT polymorphism of the thromboxane synthase gene TBS1. (antikoerper-online.de)