Terutroban is a thromboxane/prostaglandin endoperoxide receptor antagonist. (chemspider.com)
in vivo: Terutroban is a selective antagonist of the thromboxane/prostaglandin endoperoxide receptor, in preventing retinal ischaemia in a model of diabetes in rats. (chemspider.com)
1989. Adenosine produces pulmonary vasoconstriction in sheep: Evidence for thromboxane A2- prostaglandin endoperoxide receptor activation. (hopkinsmedicine.org)
Receptor antagonist2
To identify the chemical mediators involved in the pathogenesis of allergic rhinitis, we studied the effects of the thromboxane (TX) A 2 receptor antagonist seratrodast, the peptide leukotriene receptor antagonist pranlukast and the antihistamine azelastine using a guinea pig model of allergic rhinitis. (aspetjournals.org)
Exposure of isolated bovine coronary arteries to high glucose (30 mmol/l d -glucose) but not to osmotic control mannitol (30 mmol/l) switched angiotensin II-stimulated prostacyclin (PGI 2 )-dependent relaxation into a persistent vasoconstriction that was sensitive to either indomethacin, a cyclooxygenase inhibitor, or SQ29548, a selective thromboxane receptor antagonist. (diabetesjournals.org)
TXA27
Thromboxane A2 (TXA2) is a type of thromboxane that is produced by activated platelets during hemostasis and has prothrombotic properties: it stimulates activation of new platelets as well as increases platelet aggregation. (wikipedia.org)
Receptors that mediate TXA2 actions are thromboxane A2 receptors. (wikipedia.org)
TXA2 is very unstable in aqueous solution, since it is hydrated within about 30 seconds to the biologically inactive thromboxane B2. (wikipedia.org)
Thromboxane A2 (TXA2) receptor is a member of the family of G protein-coupled receptors and performs an essential role in hemostasis by interacting with TXA2 to induce platelet aggregation. (jci.org)
The levels of prostaglandin E2 (PGE2), PGF2 alpha, PGI2, thromboxane A2 (TXA2), and leukotriene B4 (LTB4), which represent the cyclooxygenase and 5-lipoxygenase pathways, were determined in 21 pairs of surgically excised human colon cancer and histologically normal mucosa samples 5 to 10 cm away from the tumor. (nih.gov)
BACKGROUND: 11-Dehydro-thromboxane B2 (11-dehydro-TXB2) is the final stable metabolite of thromboxane A2 (TXA2) and is involved in thrombus formation. (bvsalud.org)
Receptors3
Data from a radiolabeled ligand‑binding assay indicated that LGP exhibited apparent competing effects on thromboxane receptor (TP) and P2Y12 receptors. (spandidos-publications.com)
Ramatroban is an orally bioavailable, potent, dual antagonist of the thromboxane A 2 (TPr) and PGD 2 (DPr2) receptors. (researchsquare.com)
Sandhu, H, Xu, C-B & Edvinsson, L 2009, ' DMSO-Lipid Soluble Cigarette Smoking Particles Upregulate Contractile Endothelin Type B And Thromboxane A2 Receptors Of Rat Middle Cerebral Arteries ', Hypertension , vol. 54, no. 5, pp. 1175-1176. (lu.se)
EICOSANOIDS2
The study was based on the hypothesis that poultry PM would induce the release of inflammatory cytokine interleukin-8 (IL-8) by respiratory epithelial cells under the upstream regulation by cytosolic phospholipase A2 (cPLA2) activation and subsequent formation of cyclooxygenase (COX)- and lipoxygenase (LOX)-catalyzed arachidonic acid (AA) metabolites (eicosanoids). (cdc.gov)
Poultry PM also significantly induced the release of COX- and LOX-catalyzed eicosanoids (prostaglandins, thromboxane A2 and leukotrienes B4 and C4) and upstream activation of AA LOX in the cells. (cdc.gov)
2002) Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. (scirp.org)
Aspirin, which exerts its antiplatelet effects by inhibiting thromboxane A2 production, has been the mainstay of antiplatelet therapy in patients with ACS. (jabfm.org)
Prostacyclin2
Biochemical evidence includes an imbalance in the prostacyclin:thromboxane ratio and high circulating concentrations of von Willebrand factor, endothelin, and cellular fibronectin. (health.am)
There is an overwhelming mass of evidence demonstrating the development of endothelial dysfunction in animal models of diabetes and in human blood vessels from diabetic patients, as evidenced by increased release of reactive oxygen species, decreased nitric oxide (NO) bioactivity, decreased release of prostacyclin (PGI 2 ), and enhanced endothelial production of vasoconstrictor thromboxane (Tx)A 2 /prostaglandin (PG)H 2 in early stages of diabetes ( 1 - 3 ). (diabetesjournals.org)
Vasoconstrictor1
Thromboxane A2 is also a known vasoconstrictor and is especially important during tissue injury and inflammation. (wikipedia.org)
Synthase1
Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (news-medical.net)
Leukotriene B41
Leukotriene B4, thromboxane B2, and inflammatory products also have been discovered within herniated human disks after surgery. (medscape.com)
A high level of phospholipase A2 (PLA2), an enzyme that helps to regulate the initial inflammatory cascade, has been demonstrated in herniated disk material from surgical samples in humans. (medscape.com)
Synthesis1
It was also found that LGP exhibited marked inhibitory effects on the activation of αIIbβ3 integrin, the secretion of serotonin from granules, and the synthesis of thromboxane A2. (spandidos-publications.com)
Systemic1
Pulmonary vascular effects of prostaglandin D2 but not its systemic vascular or airway effects are mediated through thromboxane receptor activation. (hopkinsmedicine.org)
Contraction2
Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697" (PDF). (wikipedia.org)
Arterial thromboxane A2-induced transient contraction after IL-1β exposure. (go.jp)
Platelet activation1
Thromboxane A 2 also increases vascular permeability, contracts bronchial smooth muscle, triggers and amplifies platelet activation, and promotes a prothrombotic state. (researchsquare.com)
Arterial1
Injections of the thromboxane A 2 mimetic U-46619 (10 and 20 μg) into the left atrium of anesthetized rabbits evoked decreases in heart rate (HR) and arterial blood pressure (ABP) followed by an increase in ABP. (elsevierpure.com)
Concentrations1
Urinary 11-dehydro-thromboxane beta-2 (11DhTx2) concentrations measured by immunoassay are the primary outcome measures. (scirp.org)
Platelets2
They contain denser granules, secrete more serotonin and β -thromboglobulin, produce more thromboxane A2 and have more adhesion molecules (like P-selectin and platelet glycoprotein-GP-IIbIIIa), than smaller platelets. (hindawi.com)
ADP, thromboxane A2, and other mediators induce activation and aggregation of additional platelets on the injured endothelium. (msdmanuals.com)
Intracellular1
Ago also reduced AA-induced increase in thromboxane B2 (TxB2) production, intracellular calcium levels and P-selectin expression at plasma membrane. (bvsalud.org)
Adhesion1
We performed aggregation and adhesion assays, thromboxane B2 (TxB2), cAMP and cGMP measurements, intra-platelet calcium registration and flow cytometry assays. (bvsalud.org)
Activation1
This is achieved by activating the thromboxane receptor, which results in platelet-shape change, inside-out activation of integrins, and degranulation. (wikipedia.org)
Human1
Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder. (jci.org)
Treatment1
The increased thromboxane B2 level and decreased 6-keto-prostaglandin F1α level induced by HG were significantly attenuated by maprotiline treatment. (bvsalud.org)