ProteinMouse ThrombospondinRepeatsSynthesis of thrombospondinDisintegrin and metalloproteinaseReceptorPlateletsTHBS1MetalloproteinaseTHBS2AngiogenesisGlycoproteinsBindsELISAExtracellularTumorGlycoproteinTSP1ProteinsTHBS3MonocytesFragmentInduceAntigenMonoclonalTissuesMembraneStructuralHumanPlateletMacrophagesPromotesDomainCell linesBloodComponentsSignificant
Protein12
- The family consists of thrombospondins 1-5 and can be divided into 2 subgroups: A, which contains TSP-1 and TSP-2, and B, which contains TSP-3, TSP-4 and TSP-5 (also designated cartilage oligomeric protein or COMP). (wikipedia.org)
- This study describes the identification of the P. falciparum thrombospondin-related apical merozoite protein homologue in P. vivax (PvTRAMP) and examines its potential to be further evaluated as vaccine candidate. (biomedcentral.com)
- Thrombospondin was initially termed "thrombin-sensitive protein" based upon its release by thrombin-activated platelets (4,5). (goprolytix.com)
- Through the collective efforts of a number of different investigators employing both peptide chemistry and cDNA analytical techniques, distinct heparin, Ca2+-ion, platelet, and protein binding domains within thrombospondin have been identified (23). (goprolytix.com)
- secretion was totally blocked by cycloheximide (1 microgram/mL). 35S-thrombospondin was isolated from 35S-methionine-labeled human monocyte postculture medium with rabbit polyclonal anti-thrombospondin coupled to protein A-Sepharose. (cornell.edu)
- CD47 belongs to the immunoglobulin superfamily [1] and partners with membrane integrins and also binds the ligands thrombospondin-1 ( TSP-1 ) and signal-regulatory protein alpha ( SIRPα ). (wikidoc.org)
- Because levels of the matricellular protein thrombospondin-4 (TSP4) rapidly rise in hypertension and are elevated in cardiac stress overload and heart failure, we hypothesized that TSP4 is involved in this adaptive mechanism. (johnshopkins.edu)
- Deletion of Pofut2 (Protein O -fucosyltransferase 2) in mouse developing limb mesenchyme blocks O -fucosylation of Thrombospondin type-1 repeats (TSR) and significantly shortens limb bones. (sstis.org)
- The expression of osteopontin (OPN) correlated with the metastatic phenotype, whereas thrombospondin-1 (TSP-1) and tyrosinase-related protein-1 (TYRP-1) correlated with the nonmetastatic phenotype of independent MDA-MB-435 cell lines implanted orthotopically into athymic mice. (elsevierpure.com)
- Réponse immunitaire anti-TRAP (thrombospondin related adhesive protein) et morbidité palustre dans une zone d' hyperendémie palustre du Mali (Afrique de l' ouest) / présentée par Amagana Dolo. (who.int)
- Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. (pearltrees.com)
- The protein encoded by this gene serves as a receptor for thrombospondin in platelets and various cell lines, and is the fourth major glycoprotein of the platelet surface. (thermofisher.com)
Mouse Thrombospondin2
- Description: A sandwich quantitative ELISA assay kit for detection of Mouse Thrombospondin 3 (THBS3) in samples from plasma. (myelisakit.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Mouse Thrombospondin 1 (THBS1) in samples from plasma, tissue homogenates or other biological fluids. (ksiazkiwnauce.pl)
Repeats2
- Many extracellular matrix (ECM) associated proteins that influence ECM properties have Thrombospondin type 1 repeats (TSRs) which are modified with O- linked fucose. (sstis.org)
- A subfamily of ADAM proteases that are distinguished by the presence of one or more THROMBOSPONDIN type-1 repeats (TSRs). (bvsalud.org)
Synthesis of thrombospondin2
- The synthesis of thrombospondin by endothelial cells (12), fibroblasts (13), monocytes and macrophages (14), and osteoblasts (15) has been reported. (goprolytix.com)
- Thus, monocytes and macrophages from two different species synthesize and secrete thrombospondin, and the rate of synthesis of thrombospondin appears to depend on the state of activation of the cells. (cornell.edu)
Disintegrin and metalloproteinase6
- Description: A sandwich ELISA kit for detection of A Disintegrin And Metalloproteinase With Thrombospondin 5 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (isogem.org)
- Description: A sandwich quantitative ELISA assay kit for detection of Human A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) in samples from tissue homogenates, cell lysates or other biological fluids. (isogem.org)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) in tissue homogenates, cell lysates and other biological fluids. (isogem.org)
- Description: Quantitativesandwich ELISA kit for measuring Human A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) in samples from serum, plasma, cell culture supernates, tissue homogenates. (master-sistemisanitari-medicinenonconvenzionali.org)
- Proteases produced by macrophages, such as matrix metalloproteinases and members of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family, play potential roles in regulating atherosclerotic plaque stability. (cardiff.ac.uk)
- GLPG1972/S201086 is a disintegrin and metalloproteinase with thrombospondin motif-5 (ADAMTS-5) inhibitor in development as an osteoarthritis disease-modifying therapy. (lu.se)
Receptor5
- A thrombospondin-specific membrane receptor has also been partially characterized (10). (goprolytix.com)
- CD47 is a high affinity receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis, and in this later capacity the TSP1-CD47 interaction inhibits nitric oxide signaling at multiple levels in vascular cells. (wikidoc.org)
- Results implicate receptor ligand functionality in driving systemic effects, exemplified by an identified 59-mer thrombospondin fragment, replete with CD36 modulatory motifs, that when synthesized produced an anti-angiogenic response in vitro matching that of the peptide fraction. (cdc.gov)
- CD47 functions as an adhesion molecule and thrombospondin receptor and is non-covalently associated with β3 integrins CD51/CD61, CD41/CD61. (biolegend.com)
- Adhesion molecule and thrombospondin receptor. (biolegend.com)
Platelets8
- Thrombospondin (TSP) is a glycoproteins secreted from the alpha-granules of platelets upon activation. (dadamo.com)
- Thrombospondin is a high-molecular weight, heparin-binding glycoprotein constituent of human platelets (1). (goprolytix.com)
- Ranging from 30-50 µg per 109 platelets, thrombospondin is one of the most abundant proteins in the platelet a-granule (2,3). (goprolytix.com)
- The binding of thrombospondin to the surface of both resting and thrombin-activated platelets has been reported (9). (goprolytix.com)
- Thrombospondin is not an exclusive product of platelets and megakaryoctes. (goprolytix.com)
- Our human thrombospondin (TSP-1) is prepared from the supernatant of activated platelets by heparin-agarose affinity and gel filtration chromatography (25). (goprolytix.com)
- Thrombospondin 1 (TSP1) is a multidomain, multifunctional glycoprotein from platelets and certain vascular cells which has been shown to play an important role in cell-cell and cell-matrix interactions. (bioporto.com)
- Thrombospondin, one of the major glycoproteins released from alpha-granules of thrombin-stimulated platelets, is a disulfide-linked trimer of 160,000-dalton subunits. (cornell.edu)
THBS13
- The first member of the family, thrombospondin 1 (THBS1), was discovered in 1971 by Nancy L. Baenziger. (wikipedia.org)
- Thrombospondin 1 (TSP-1) is encoded by THBS1. (wikipedia.org)
- Strikingly, thrombospondin-1 (Thbs1) ranked as the most differentially expressed gene, along with the well-documented injury-response genes Atf3 and Jun. (miami.edu)
Metalloproteinase1
- To Study the Role of Plasma Von Willebrand Factor Antigen (vWF) to A Disintegrin-like and Metalloproteinase With Thrombospondin Type-1 Motifs 13 (ADAMTS-13) Activity Ratio as a Predictor of Development of Extrahepatic Organ Failure in Acute on Chronic Liver Failure (ACLF) Patients. (who.int)
THBS24
- Description: A competitive ELISA for quantitative measurement of Rat Thrombospondin 2(THBS2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (stemcellcharter.org)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Thrombospondin 2 (THBS2) in serum, plasma and other biological fluids. (stemcellcharter.org)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Thrombospondin 2 (THBS2) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (stemcellcharter.org)
- Description: A competitive ELISA for quantitative measurement of Human Thrombospondin 2(THBS2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (fslregister.nl)
Angiogenesis4
- Thrombospondins (TSP) are secreted proteins with the ability to inhibit angiogenesis. (dadamo.com)
- Thrombospondin-1 and -2 messenger RNA expression in normal and neoplastic endometrial tissues: correlation with angiogenesis and prognosis. (elsevierpure.com)
- The role of thrombospondin (TSP) in tumor angiogenesis and progression remains controversial. (elsevierpure.com)
- Dive into the research topics of 'Thrombospondin-1 and -2 messenger RNA expression in normal and neoplastic endometrial tissues: correlation with angiogenesis and prognosis. (elsevierpure.com)
Glycoproteins1
- Thrombospondins (TSPs) are a family of secreted glycoproteins with antiangiogenic functions. (wikipedia.org)
Binds2
- Monoclonal antibody C6.7, which binds to the COOH-terminal region of thrombospondin, inhibited haptotaxis in a dose-dependent optimal manner. (rupress.org)
- It binds to collagen, thrombospondin, anionic phospholipids, and oxidized LDL, and directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. (thermofisher.com)
ELISA1
- Description: A sandwich ELISA kit for detection of Thrombospondin 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (myelisakit.com)
Extracellular2
- Thrombospondin interacts with a variety of extracellular macromolecules including heparin (1,17), collagen (18), fibrinogen and fibronectin (19), plasminogen (20), plasminogen activator (21), and osteonectin (22). (goprolytix.com)
- Based upon its specific interactions with both cells and extracellular matrix components, thrombospondin has been hypothesized to be a member of a class of extracellular proteins which may modulate cell-matrix interactions (24). (goprolytix.com)
Tumor5
- Thrombospondin-induced tumor cell migration: haptotaxis and chemotaxis are mediated by different molecular domains. (rupress.org)
- Using a modified Boyden chamber assay, tumor cells migrated to a gradient of soluble thrombospondin (chemotaxis). (rupress.org)
- Tumor cells also migrated in a dose-dependent manner to a gradient of substratum-bound thrombospondin (haptotaxis). (rupress.org)
- Synthetic peptides GRGDS (50 micrograms/ml), but not GRGES, blocked tumor cell haptotaxis on fibronectin, but had minimal effect on thrombospondin or laminin haptotaxis. (rupress.org)
- Separate structural domains of thrombospondin are therefore required for tumor cell haptotaxis vs. chemotaxis. (rupress.org)
Glycoprotein1
- Structurally, thrombospondin is a 450,000 molecular weight glycoprotein (1) consisting of three, identical, disulfide-linked polypeptide chains (6-8). (goprolytix.com)
TSP11
- Thrombospondin-1 (TSP1) is a biological marker playing a role in synaptogenesis. (tubitak.gov.tr)
Proteins1
- The thrombospondins are a family of multifunctional proteins. (wikipedia.org)
THBS31
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Thrombospondin 3 (THBS3) in Plasma. (myelisakit.com)
Monocytes1
- Monocytes and macrophages synthesize and secrete thrombospondin. (cornell.edu)
Fragment1
- The 140-kD fragment of thrombospondin lacking the heparin-binding amino-terminal region retained the property to fully mediate haptotaxis but not chemotaxis. (rupress.org)
Induce1
- Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration. (hal.science)
Antigen2
- The PfTRAMP homologue in P. vivax , here denoted as PvTRAMP, is a 340-amino-acid long antigen encoded by a single exon that could have a potential role in cytoadherence, as indicated by the presence of a thrombospondin structural homology repeat (TSR) domain. (biomedcentral.com)
- Another minor antigen is thrombospondin type 1 domain-containing 7A (THSD7A). (medscape.com)
Monoclonal3
- In contrast, monoclonal antibody A2.5, heparin, and fucoidan, which bind to the NH2-terminal heparin-binding domain of thrombospondin, inhibited thrombospondin chemotaxis but not haptotaxis. (rupress.org)
- Monoclonal antibody A6.1 directed against the internal core region of thrombospondin had no significant effect on haptotaxis or chemotaxis. (rupress.org)
- 1. Matthias LJ, Gotis-Graham I, Underwood PA, McNeil HP, Hogg PJ (1996) Identification of monoclonal antibodies that recognize different disulphide bonded forms of thrombospondin 1. (bioporto.com)
Tissues1
- Thrombospondin is also an integral component of the basement membrane in a number of different tissues (16). (goprolytix.com)
Membrane1
- Thrombospondin Type 1 Domain-Containing 7A (THSD7A) Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes. (sfb1192.de)
Structural1
- Human A2058 melanoma cells which exhibit a strong haptotactic and chemotactic response to thrombospondin were used to study the structural domains of thrombospondin required for the response. (rupress.org)
Human4
- Thrombospondin induces the migration of human melanoma and carcinoma cells. (rupress.org)
- A series of human melanoma and carcinoma cells were compared for their relative motility stimulation by thrombospondin haptotaxis vs. chemotaxis. (rupress.org)
- Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status. (elsevierpure.com)
- Dive into the research topics of 'Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status. (elsevierpure.com)
Platelet1
- Functionally, platelet-derived thrombospondin may play a role in platelet adherence and aggregation (11). (goprolytix.com)
Macrophages1
- Elicited peritoneal macrophages harvested from mice pretreated with endotoxin, casein, or thioglycollate secreted much less thrombospondin than did resident macrophages harvested from control mice. (cornell.edu)
Promotes1
- Despite being an anti-angiogenic therapeutic candidate, Thrombospondin -1 ( TSP-1 ) promotes invasion and metastasis of some carcinomas . (bvsalud.org)
Domain1
- The domain structure of the thrombospondin monomer is represented. (goprolytix.com)
Cell lines1
- Some cell lines exhibited a stronger haptotactic response compared to their chemotactic response while other lines exhibited little or no migration response to thrombospondin. (rupress.org)
Blood1
- Blood neurofilament light chain and thrombospondin-1 levels of patient" by CEM PAKETÇİ, ÇAĞATAY ERMİŞ et al. (tubitak.gov.tr)
Components1
- Thrombospondin-1 is highly expressed in desmoplastic components of invasive ductal carcinoma of the breast and associated with lymph node metastasis. (bvsalud.org)
Significant1
- C6.7 had no significant effect on thrombospondin chemotaxis. (rupress.org)