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Tissue Inhibitor of Metalloproteinase-1ThrombospondinsTissue Inhibitor of MetalloproteinasesTissue Inhibitor of Metalloproteinase-2Tissue Inhibitor of Metalloproteinase-3Thrombospondin 1Matrix Metalloproteinase 2Matrix Metalloproteinase 9MetalloendopeptidasesMatrix Metalloproteinase InhibitorsMatrix Metalloproteinase 3Matrix MetalloproteinasesMatrix Metalloproteinase 1Matrix Metalloproteinase 14GelatinasesADAM ProteinsCollagenasesMatrix Metalloproteinases, Membrane-AssociatedMetalloproteasesMatrix Metalloproteinase 13Matrix Metalloproteinase 7Matrix Metalloproteinase 8GlycoproteinsProcollagen N-EndopeptidaseProtease InhibitorsExtracellular MatrixMatrix Metalloproteinase 12Matrix Metalloproteinase 10RNA, MessengerCells, CulturedMatrix Metalloproteinase 11CollagenPlatelet Membrane GlycoproteinsEnzyme PrecursorsDisintegrinsExtracellular Matrix ProteinsMatrix Metalloproteinases, SecretedBlood PlateletsMatrix Metalloproteinase 16Molecular Sequence DataFibroblastsAmino Acid SequenceMatrix Metalloproteinase 15GelatinMicrobial CollagenaseReverse Transcriptase Polymerase Chain ReactionAntigens, CD36Phenylmercuric AcetateImmunohistochemistryAntigens, CD147Blotting, WesternCell MovementFibronectinsAggrecansMembrane GlycoproteinsGene Expression Regulation, EnzymologicCell AdhesionNeoplasm InvasivenessEnzyme-Linked Immunosorbent AssayEnzyme ActivationPeptide FragmentsUp-RegulationAntigens, CD47Receptors, CytoadhesinRecombinant ProteinsGene ExpressionTumor Cells, CulturedElectrophoresis, Polyacrylamide GelTransforming Growth Factor betaCollagen Type IProteoglycansCattleCulture Media, ConditionedGene Expression RegulationCartilage, ArticularCartilageEndothelium, VascularProtein BindingChondrocytesHeparinCell LineBlotting, NorthernMice, Inbred C57BLNeovascularization, PathologicTransfectionMice, KnockoutFibrinolysinFibrosisCell Line, TumorLamininFibrinogenBase SequenceIn Situ HybridizationDisease Models, AnimalCell Adhesion MoleculesSulfoglycosphingolipidsDipeptidesBinding SitesOsteoarthritisSynovial Membrane
TIMPsMMPsADAMTsDisintegrin and metalloproteinaseTIMPExtracellularProteinsCollagenProteinAdiposeEnzymesEndogenous inhibitorsMoleculesSerumMatricellularPlacentaCollagenaseAngiogenesisMatrix metalloproteaseGeneConnectiveCoagulationGelatinaseVascularTumorsHomogenatesProteolyticTherapiesAutophagyClinical trialsMiRNAsSolubleTherapeuticReceptorEnzymeAdditionallyInhibitionADAMTSsInhibitoryCells1994TendonPlasminogen ActivatorCancersPathogenesisSkeletalPulmonaryBoneMolecularEfficacyActivateTypeCoagulopathyProgressionMetastasis
TIMPs4
  • Fibroblasts produce TIMPs (1-4), which were previously called human fibroblast collagenase inhibitors. (biomedcentral.com)
  • Post-translationally, ADAMTS proteases are governed by tissues inhibitors of metalloproteinases (TIMPs), connections with cell-associated glycosaminoglycans, and endocytic clearance by low-density lipoprotein receptor-related proteins 1 (LRP1) (18). (acp2018.org)
  • This study aims to explore the association between the single-nucleotide polymorphisms (SNPs) of genes encoding ECM processing enzymes (a disintegrin and metalloproteinase with thrombospondin motifs [ADAMTSs]), ECM degrading enzymes (matrix metalloproteinases [MMPs]) and their tissue inhibitors of metalloproteinase (TIMPs), and POP. (scite.ai)
  • The substances that hamper angiogenesis are tissue inhibitors of metalloproteinases (TIMPs). (biomedcentral.com)
MMPs9
  • Invadopodia have been shown to concentrate MMPs (including MT1-MMP, MMP-2, and MMP-9) for localized release and activation. (wikipedia.org)
  • Finally, MMP-2 and several other MMPs have been shown to proteolytically activate TGF-β, which has been shown to promote epithelial mesenchymal transition (EMT), a key process involved in cancer metastasis. (wikipedia.org)
  • The response of target cells is further regulated by their microenvironment, involving the extracellular matrix, which may be modified by MSC-produced matrix metalloproteinases (MMPs) and tissue inhibitor of MMPs. (biomedcentral.com)
  • Matrix metalloproteinases (MMPs) are a large family of mostly secreted, extracellularly acting proteolytic enzymes. (nature.com)
  • Matrix metalloproteinases (MMPs) are extracellularly acting enzymes that have long been known to have deleterious roles in brain injury and disease. (nature.com)
  • MMPs now comprise a group of 18 different enzymes in man, including the classic fibroblast collagenase MMP-1 (collagenase-1), the mesenchymal form of MMP-8 (collagenase-2) and MMP-13 (collagenase-3). (biomedcentral.com)
  • Matrix metalloproteinases (MMPs) are enzymes capable of breaking down various connective tissue elements. (scite.ai)
  • Although the catalytic domain of MMPs is structurally highly similar, there are many differences with respect to substrate specificity, cellular and tissue localization, membrane binding and regulation that make this a very versatile family of enzymes with a multitude of physiological functions, many of which are still not fully understood. (evelinvahter.com)
  • Metzincins are a ubiquitously expressed family of multi-domain zinc (II)-dependent endopeptidases (Stocker and Bode 1995 ), the members of which include well-known metalloproteases such as the matrix metalloproteases (MMPs) (Nagase and Woessner 1999 ), a disintegrin and metalloproteases (ADAMs) (White 2003 ), the ADAMs with a thrombospondin motif (ADAMTS) (Tang 2001 ), the bacterial serralysins (Nakahama et al. (evelinvahter.com)
ADAMTs9
  • To investigate the potential role of 'a disintegrin-like and metalloproteinase with thrombospondin type motifs-2 (ADAMTS-2), collagen type-1, tissue inhibitor of metalloproteinases-3 (TIMP-3) and papilin' levels in the uterosacral ligament (USL) and cardinal ligament (CL) of the uterus on the etiopathogenesis of pelvic organ prolapse (POP) among postmenopausal women without stress urinary incontinence (SUI). (urotoday.com)
  • P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
  • We profiled the expression of the entire matrix metalloproteinase (MMP), tissue inhibitor of metalloproteinases (TIMP), and a disintegrin and metalloproteinase domain with thrombospondin motif (ADAMTS) gene families in these tissues using real-time reverse-transcription polymerase chain reaction. (qxmd.com)
  • ADAMTS ADAMTS and ADAMTS-like proteins are members of a superfamily of 26 secreted Chlorhexidine enzyme molecules comprising 2 related, but distinct families. (euromed2016.com)
  • ADAMTS are zinc-metalloproteinases with a thrombospondin motif, whereas ADAMTS-like molecules lack the thrombospondin motif [77]. (euromed2016.com)
  • ADAMTS Inhibitors ADAMTS-5 was validated as a drug target for OA and experimental ADAMTS-5 inhibitors were shown to reduce synovial joint damage in OA animal models. (euromed2016.com)
  • Additional novel ADAMTS-5 inhibitors Chlorhexidine are in the process of development. (euromed2016.com)
  • While not directly degrading the IVD, TNF-α and IL-1β act indirectly by promoting the production of degradative enzymes, such as matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) ( 5 - 7 ). (spandidos-publications.com)
  • Osteopontin cleavage by ADAMTS8 was inhibited by TIMP-3, an endogenous inhibitor of ADAMTS1, 4, and 5, aswell as by TIMP-2, without any reported inhibitory activity against other ADAMTS proteases previously. (acp2018.org)
Disintegrin and metalloproteinase1
  • ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin sort 1 motif, member 13) cleaving capability could also be overwhelmed, leading to thrombotic microangiopathies within the vessels of a number of organs in COVID-19. (dailymedicalnews.org)
TIMP4
  • This growth factor also stimulates production of collagens, proteoglycans, elastin, fibronectin, tenascin and thrombospondin, diminishes production of extracellularly active neutral endoproteinases belonging to the matrix metalloproteinase (MMP) and serine proteinase families, and stimulates production of endogenous MMP inhibitors (tissue inhibitor of metallo-proteinase [TIMP]) and serpins (plasminogen activator inhibitor-1). (biomedcentral.com)
  • The aim of the study was to evaluate the concentration of proteolytic enzymes, MMP-2 and MMP-9, and their tissue inhibitors, TIMP-1 and TIMP-2, in the blood of patients with benign and malignant pancreatic tumors. (biomedcentral.com)
  • MMP-2, MMP-9, TIMP-1, and TIMP-2 were evaluated in the patients with benign and malignant pancreatic tumors before surgery and in the 30-day follow-up. (biomedcentral.com)
  • In 1 month following the operation, the highest level of MMP-2 was also in patients with unresectable cancer and the highest level of TIMP-2 in patients with inflammatory tumors. (biomedcentral.com)
Extracellular7
  • It is know that the tendon tissue is poorly cellularized, with 5% of the normal tissue occupied by tenocytes that produce the extracellular matrix (ECM), based on type I collagen. (frontiersin.org)
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (wikipedia.org)
  • A complex of membrane type 1 MMP (MT1-MMP/MMP14) and tissue inhibitor of metalloproteinase 2 recruits pro-MMP 2 from the extracellular milieu to the cell surface. (wikipedia.org)
  • Abstract Background Thrombospondin-2 (TSP-2) is a secreted matricellular glycoprotein that is found to mediate cell-to-extracellular matrix attachment and participates in many physiological and pathological processes. (tmu.edu.tw)
  • In addition, nuclear factor κB (NF‑κB), c‑Jun N‑terminal kinase (JNK), extracellular signal‑regulated kinases and p38 mitogen‑activated protein kinase inhibitors and TNF‑α were used to determine the molecular mechanism of autophagy during the inflammatory conditions, and only the NF‑κB and JNK inhibitor were found to enhance the autophagy of rat NP cells. (spandidos-publications.com)
  • Elevated plasmin ranges might activate metalloproteinase molecules in modifying extracellular matrices important for leakage from capillaries and pulmonary edema. (dailymedicalnews.org)
  • Additional, SARS-CoV-2 infections are related to neutrophil extracellular lure (NET) formation (NETosis) in blood vessels, induced by complement activation and IL-8. (dailymedicalnews.org)
Proteins6
  • 2 Examples of such genes (called metastasis suppressor genes ) that get silenced and result in dissemination, often normally code for proteins that make cells 'stick' together but not only (Table 11). (cme30.eu)
  • Thrombospondins are proteins that regulate tissue genesis and remodelling. (cme30.eu)
  • MECs were found to express numerous proteinase inhibitors, anti-angiogenic factors, and tumour suppressors proteins. (biomedcentral.com)
  • C3 exoenzyme, a specific inhibitor of the prenylated small signaling Rho proteins, mimicked the inhibitory effects of simvastatin and L-839,867. (neuroprobe.com)
  • Metalloproteinases are proteolytic enzymes responsible for the degradation of ECM proteins and the basal membrane of the vessels. (biomedcentral.com)
  • The central dogma of molecular biology states that the transfer of genetic information within cells transpires sequentially from DNA to RNA to proteins, whose coding sequences comprise a paltry 1.5-2% of the human genome [ 2 , 3 ]. (biomedcentral.com)
Collagen3
Protein7
  • Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)
  • In SLE, it is being implied that the determinant shared by the host and the HERV-K env protein evokes an immune response and causes the destruction of cells and tissue. (cme30.eu)
  • Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. (pearltrees.com)
  • Platelet counts and coagulation inhibitors resembling protein C and antithrombin are diminished in extreme COVID-19. (dailymedicalnews.org)
  • Thrombospondin-2, C-reactive protein, TNF-receptor I, and placental growth factor were the analytes most highly associated with OS, all with Cox PH p -values ≤0.0001. (biomedcentral.com)
  • Although genetic and epigenetic aberrations that occur in components of the central dogma clearly elicit disease development in humans, recent findings also point to a prominent role for non-protein-coding regions of the genome in regulating cell and tissue homeostasis, as well as in contributing to the formation of human tumors. (biomedcentral.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) in samples from tissue homogenates or other biological fluids. (worldcarecouncil.org)
Adipose13
  • Our acute awareness of the cosmetic, psychosocial and sexual importance of subcutaneous adipose tissue contrasts dramatically with how poorly we have understood the biology of this massive, enigmatic, often ignored and much-abused skin compartment. (femininebeauty.info)
  • However, already the distribution of human superficial adipose tissue, by itself, questions how justified the popular belief is that 'skin fat' (which actually may be more diverse than often assumed) serves primarily thermoinsulatory purposes. (femininebeauty.info)
  • The increasing insights recently won into subcutaneous adipose tissue as a cytokine depot that regulates innate immunity and cell growth exemplarily serve to illustrate the vast open research expanses that remain to be fully explored in the subcutis. (femininebeauty.info)
  • The following public debate carries you from the evolutionary origins and the key functional purposes of adipose tissue, via adipose-derived stem cells and adipokines straight to the neuroendocrine, immunomodulatory and central nervous effects of signals that originate in the subcutis - perhaps, the most underestimated tissue of the human body. (femininebeauty.info)
  • MSCs can be isolated from a range of tissues, but the most commonly cited sources are bone marrow (BM), adipose tissue, muscle, bone, and perinatal tissues (e.g. (biomedcentral.com)
  • Excessive accumulation of adipose tissue in cultured fish is an outstanding problem in aquaculture. (biomedcentral.com)
  • Despite of the relevance of this issue, very little is known about the factors regulating the development of adipose tissue in fish, and the possible health alterations associated to an increased fat deposition. (biomedcentral.com)
  • In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
  • Therefore, growth of adipose tissue includes the hypertrophy of already existing adipocytes and the proliferation and differentiation of new ones from MSCs. (biomedcentral.com)
  • We have previously shown that fish primary preadipocytes differentiate into mature adipocytes in vitro and that these cells represent a very helpful model system to study adipose tissue development in fish [ 5 , 6 ]. (biomedcentral.com)
  • Obesity is attributed to adipose tissue dysfunction and expanded adipose tissue mass, which can lead to the upregulation of proinflammatory cytokines such as TNF-α and IL-6, resulting in a state of chronic low-grade inflammation, as previously discussed. (encyclopedia.pub)
  • Apigenin has been shown to inhibit an important inflammatory biomarker, CD38, in a metabolic syndrome model, as well as decrease adipose tissue mass and the levels of proinflammatory cytokines [ 7 ] . (encyclopedia.pub)
  • Several anti-diabetic strategies including adiponectin, ezetimibe, liraglutide, taurine, adipose tissue-derived stem cells (ADSCs) and even exercise as well as natural products such GABA tea, geniposide, guava extract, vitamin D have been shown to target autophagy. (frontiersin.org)
Enzymes1
  • The changes in the levels of the studied enzymes and their inhibitors can have a prognostic value in the clinical severity of pancreatic cancer. (biomedcentral.com)
Endogenous inhibitors2
  • LTP-associated MMP proteolysis is probably then terminated by an increase in the activity of endogenous inhibitors called tissue inhibitors of metalloproteinases. (nature.com)
  • We survey right here that ADAMTS8 displays striking distinctions in substrate repertoire, susceptibility to endogenous inhibitors, and endocytic legislation weighed against ADAMTS1, 4, 5, and 15. (acp2018.org)
Molecules1
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Serum5
Matricellular1
Placenta1
  • This process is often present in physiology as part of tissue healing, development of the placenta and endometrium [ 4 ]. (biomedcentral.com)
Collagenase1
  • 72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. (wikipedia.org)
Angiogenesis1
  • Specifically, the chronic exposure of cells to a chemokine-laced milieu is associated with macrophage and T cell accumulation, chronic activation of macrophages, abnormal angiogenesis and DNA damage due to the presence of reactive oxygen species [ 2 , 3 ]. (thno.org)
Matrix metalloprotease1
  • The matrix metalloprotease ADAMTS1 ( A Disintegrin And Metalloprotease with ThromboSpondin repeats 1 ) has been involved in tumorigenesis although its contributions appeared ambiguous. (oncotarget.com)
Gene1
  • Results Based on the gene expression omnibus database and immunohistochemistry, we found that TSP-2 increased with the progression of PCa, especially in metastatic PCa and is correlated with the matrix metalloproteinase-2 (MMP-2) expression. (tmu.edu.tw)
Connective1
  • They play a significant part in the development of many neoplastic diseases and diseases of the connective tissues [ 11 ]. (biomedcentral.com)
Coagulation1
  • As well as, serological ranges of fibrinogen, issue VIII, and tissue-type plasminogen activators (t-PA) are elevated, in response to the cytokine storm [especially interleukin (IL)-6] in COVID-19, with irregular coagulation and elevated tissue viscoelasticity. (dailymedicalnews.org)
Gelatinase1
  • Activity of MMP-2 relative to the other gelatinase (MMP-9) has been associated with severity of chronic airway diseases including Idiopathic interstitial pneumonia and Bronchiectasis. (wikipedia.org)
Vascular2
  • However, an active role of metalloproteinases (MMP), growth factors, such as vascular endothelial growth factor (VEGF) and a crucial role of inflammatory elements and cytokines was demonstrated. (frontiersin.org)
  • Pathologic changes seen on autopsy lack major cell and tissue injury but include signs of pleural effusion, pulmonary edema, ascites, and gastrointestinal mucosa bleeding ( 5 , 6 ), all indications of systemic vascular leakage. (cdc.gov)
Tumors1
  • The expression profile of TSP-2 on tumors is controversial, and it up-regulates in some cancers, whereas it down-regulates in others, suggesting that the functional role of TSP-2 on tumors is still uncertain. (tmu.edu.tw)
Homogenates3
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Mucin 5 Subtype B (MUC5B) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (lscwarsaw.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Mucin 5 Subtype B (MUC5B) in samples from tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (lscwarsaw.com)
  • Description: tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. (lscwarsaw.com)
Proteolytic1
  • Activation of MMP-2 requires proteolytic processing. (wikipedia.org)
Therapies1
  • Advancements in the understanding of the etiopathogenesis of aHUS paved the way for the successful development of anticomplement therapies (complement C5 inhibitors), which have revolutionized the treatment of aHUS. (jrheum.org)
Autophagy2
  • In the present study, autophagy activator and inhibitor were used to demonstrate the impact of autophagy on the catabolic effect induced by TNF‑α. (spandidos-publications.com)
  • Dysregulated autophagy in pancreatic β cells due to hyperglycemia, oxidative stress, and inflammation is associated with diabetes and accompanied by dysregulated autophagy in insulin target tissues and the progression of diabetic complications. (frontiersin.org)
Clinical trials2
  • A number of broad-spectrum matrix metalloproteinase inhibitors, used in cancer clinical trials, caused side effects of DD-like contractures. (qxmd.com)
  • As of this writing, a search of the PubMed data base using the search term, MMP-13 inhibitors/Osteoarthritis Clinical Trials failed to reveal any human OA trials as yet in which PF152 or its successor was evaluated for clinical efficacy. (euromed2016.com)
MiRNAs1
  • The molecular mechanism of TSP-2 on prostate cancer (PCa) metastasis was investigated through pharmaceutical inhibitors, siRNAs, and miRNAs analyses. (tmu.edu.tw)
Soluble1
  • ADAMs and ADAM Inhibitors We previously proposed a biological role for soluble IL-6 receptor (IL-6R) in OA [28]. (euromed2016.com)
Therapeutic2
  • 12 ] Recent small clinical studies have also demonstrated potential therapeutic effects of supplementing the fibrinolytic system, where exogenous administration of tissue plasminogen activator (tPA) resulted in improvement of respiratory function and reduced mortality in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS). (thieme-connect.com)
  • This has stimulated a flurry of studies into MMP inhibitors as therapeutic agents, as well as into measuring MMP levels as diagnostic or prognostic markers. (evelinvahter.com)
Receptor1
  • estrogen receptor inhibitor) modulates oxidative stress and causes the reproductive system regression realized by cell apoptosis. (bvsalud.org)
Enzyme1
  • Macrophages secrete matrix metalloproteinase 9 (MMP-9), an enzyme that weakens the fibrous cap of atherosclerotic plaques, predisposing them to plaque rupture and subsequent ischemic events. (neuroprobe.com)
Additionally1
  • Additionally, through binding to CD36 and integrin ανβ3, TSP-2 increased cell migration and MMP-2 expression. (tmu.edu.tw)
Inhibition3
  • Furthermore, changes in MMP-2 activity can come from alterations in levels of transcription, MMP secretion, MMP activation, or MMP inhibition. (wikipedia.org)
  • With inhibition of p38, ERK, and JNK, the TSP-2-induced cell migration and MMP-2 expression were abolished, indicating that the TSP-2's effect on PCa is MAPK dependent. (tmu.edu.tw)
  • Apigenin served as a potent therapy against UC in C57BL/6 mice through the inhibition of inflammatory cytokines,and COX-2, and through the reduction in immune cell infiltration in colon tissues [ 11 ] . (encyclopedia.pub)
ADAMTSs1
  • Although it was first shown to display anti-angiogenic properties [ 1 ], the contribution of ADAMTS1 (and other ADAMTSs) during tumorigenesis is still controversial [ 2 ]. (oncotarget.com)
Inhibitory2
  • Additional studies revealed similar but more profound inhibitory effects with L-839,867, a specific inhibitor of geranylgeranyl transferase. (neuroprobe.com)
  • Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit Introduction: The event of SARS-CoV-2 serological assessments is very large. (elisastrip.com)
Cells12
  • MSCs have multilineage differentiation potential, allowing them to differentiate, for example, into chondrocytes and osteoblasts, the key cells from the two tissues that constitute the osteochondral unit. (hindawi.com)
  • A focus is on the steps of mobilization of cells from the subchondral bone and repair tissue formation, including adherence of the bone marrow clot to the subchondral bone. (hindawi.com)
  • The basement membrane is important for maintaining tissue organization, providing structural support for cells, and influencing cell signaling and polarity. (wikipedia.org)
  • Therefore, basic elements-cells, growth factors, and matrix-should be used to enhance natural skin regeneration following injury [ 2 ]. (jwmr.org)
  • On the other hand, the animal studies revealed that the bone metastasis was abolished when TSP-2 was stably knocked down in PCa cells. (tmu.edu.tw)
  • Conclusions Taken together, our results indicate that TSP-2 enhances the migration of PCa cells by increasing MMP-2 expression through down-regulation of miR-376c expression. (tmu.edu.tw)
  • Tissues and Cells. (lu.se)
  • Structure of intermediate filament Intermediate filaments (IFs) are cytoskeletal components found in the cells of vertebrate animal species,[1][2] and perhaps also in other animals, fungi, plants, and unicellular organisms. (pearltrees.com)
  • Two major cell types cooperate to build up the ductal units: inner polarized luminal epithelial cells (LECs) embraced by a layer of myoepithelial cells (MECs), both cell types are rimmed by a cohesive basement membrane (BM) [ 2 ]. (biomedcentral.com)
  • Perturbations in endothelial cells after vWF launch present an excellent floor for thrombus formation intravascularly in SARS-CoV-2 infections. (dailymedicalnews.org)
  • Perivascular cells purified from skeletal muscle or nonmuscle tissues were myogenic in culture and in vivo. (neuroprobe.com)
  • Chemokines are known to be critical mediators of the inflammatory response by regulating recruitment of immune cells from both the innate and adaptive immune systems to diseased tissues. (thno.org)
19941
  • 2] Studies performed on rodents in 1994 have determined that netrins are vital to guidance cues. (pearltrees.com)
Tendon1
  • MSCs are actively being investigated for the repair and regeneration of both osteochondral and other musculoskeletal tissues, such as tendon/ligament and meniscus. (biomedcentral.com)
Plasminogen Activator1
  • Herein, we performed a prospective observational study to determine whether circulating plasma levels of plasminogen activator inhibitor-1 (PAI-1) and tPA may be significantly elevated in patients with severe COVID-19. (thieme-connect.com)
Cancers4
  • MMP production in many cancers may be upregulated in surrounding stromal tissue rather than simply in the tumor lesion. (wikipedia.org)
  • In a latest evaluate printed in Thrombosis Analysis , researchers reported the mechanisms concerned in coronavirus illness 2019 (COVID-19) coagulopathy and the importance of extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections for most cancers sufferers regarding outcomes, thromboembolic complication dangers and penalties of administration methods. (dailymedicalnews.org)
  • SARS-CoV-2-associated coagulopathy is related to considerably elevated D-dimer ranges with extra profound elevations than these amongst most cancers sufferers. (dailymedicalnews.org)
  • Anti-Podoplanin antibody Antibody-drug conjugates (ADCs), which encompass a monoclonal antibody (mAb), a linker, and a payload, can ship a drug to most cancers tissues. (elisastrip.com)
Pathogenesis1
  • It occurs during tissue and organ formation and has a critical role in the pathogenesis of degenerative diseases, such as osteoarthritis and Alzheimer's disease ( 10 , 11 ). (spandidos-publications.com)
Skeletal1
  • On the other hand, octocorallians, with very few exceptions, are all calcifiers in the sense that they produce sclerites, i.e. micrometric calcified skeletal elements found throughout the tissues [ 3 ]. (biomedcentral.com)
Pulmonary1
  • 2 , 4 , 5 Extrarenal manifestations (occurring in up to 38% of patients) may include strokes, seizures, and/or involvement of the cardiovascular, pulmonary, or gastrointestinal systems. (jrheum.org)
Bone2
  • Mobilized pluripotent MSCs from the subchondral bone migrate into the defect filled with the clot, differentiate into chondrocytes and osteoblasts, and form a repair tissue over time. (hindawi.com)
  • Over time, they form a fibrocartilaginous repair tissue in the defect and close the connection with the subchondral bone. (hindawi.com)
Molecular1
  • MSCs can be defined by their ability to adhere to tissue culture plastic, their expression of several cell surface molecular epitopes-cluster of differentiation CD73, CD90, and CD105, and others-as well as their lack of several surface markers, including CD45 [ 6 ]. (biomedcentral.com)
Efficacy1
  • Clinical efficacy of pelvic autologous tissue reconstruction in treating pelvic organ prolapse in 36 patients. (urotoday.com)
Activate1
Type1
  • Another pathway, TGF-β signaling pathway, appears to play a part in the progression of diabetes, insulin resistance, and autoimmunity in both type 1 and 2 diabetes and complications in diabetes. (frontiersin.org)
Coagulopathy1
  • SARS-CoV-2 an infection coagulopathy involving vessel wall thickening, stenosis, and microthrombi formation results in a hypercoagulable scenario, enhancing thromboembolic complication dangers, potentiated by in-dwelling strains and immobilization amongst hospitalized SARS-CoV-2-positive sufferers. (dailymedicalnews.org)
Progression1
Metastasis2
  • The role of TSP-2 on PCa metastasis in vivo was verified through xenograft in vivo imaging system. (tmu.edu.tw)
  • Essentially, all members of the MMP family have been linked to disease development, notably to cancer metastasis, chronic inflammation and the ensuing tissue damage as well as to neurological disorders. (evelinvahter.com)