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  • Dabigatran
  • Hirudin and derivatives were originally discovered in Hirudo medicinalis: Hirudin Bivalirudin (transient inhibition - is cleaved by thrombin) Lepirudin Desirudin Univalent DTIs include: Argatroban Inogatran Melagatran (and its prodrug ximelagatran) Dabigatran Thrombin demonstrates a high level of allosteric regulation. (wikipedia.org)
  • These agents include direct thrombin inhibitor(dabigatran) and factor Xa inhibitor (rivaroxaban, apixaban and edoxaban) and they have been shown to be as good or possibly better than the coumarins with less serious side effects. (wikipedia.org)
  • protein
  • The activation of protein C is greatly enhanced following the binding of thrombin to thrombomodulin, an integral membrane protein expressed by endothelial cells. (wikipedia.org)
  • Hi folks Does anyone know of any bead technology that exists that allows efficient removal of thrombin protease after cleavage of a fusion protein? (bio.net)
  • Proteinase-activated receptor 1 (PAR1) also known as Protease-activated receptor 1 or coagulation factor II (thrombin) receptor is a protein that in humans is encoded by the F2R gene. (wikipedia.org)
  • It is involved both in disruption and maintaining of endothelial barrier integrity, through interaction with either thrombin or activated protein C, respectively. (wikipedia.org)
  • In the beginning protein C Inhibitor (PCI) was identified as an inhibitor of activated protein C (APC), it is currently clear that this inhibitor has an expansive specificity, inhibiting several blood coagulation enzymes counting thrombin and factor Xa. (wikipedia.org)
  • enzyme
  • My main interest of research, which has been funded by Research Corporation and the NIH, involves determining structural features of the bovine clotting enzyme thrombin which control its reactivity with other clotting factors in the blood. (csbsju.edu)
  • bovine
  • This work involves purification and characterization of many proteins from bovine blood and lungs, synthesis of peptides (by manual solid state techniques) and characterization (by chemical and chromatographic techniques), and the production of rabbit antibody fragments recognizing thrombin. (csbsju.edu)
  • After separating the plasma from the whole blood by centrifugation, bovine thrombin is added to the sample of plasma. (wikipedia.org)
  • serine proteases
  • As the name indicates the cascade is a multi-step procedure where the main product thrombin is made by activating various proenzymes (mainly serine proteases) in each step of the cascade. (wikipedia.org)
  • Hemostasis
  • Thus, the prothrombinase complex is required for the efficient production of activated thrombin and also for adequate hemostasis. (wikipedia.org)
  • units
  • Newborn levels of thrombin steadily increase after birth to reach normal adult levels, from a level of around 0.5 units/mL 1 day after birth, to a level of around 0.9 units/mL after 6 months of life. (wikipedia.org)
  • Freeze-dried human thrombin (1.5NIH units/mL) with calcium. (bio-medicine.org)
  • hirudin
  • Simulations of the effect of hirudin indicate that factor V is predominantly activated by thrombin and not by factor Xa. (ebi.ac.uk)
  • factor
  • Values of the reaction rate constants as determined in purified systems are used and the model is tested by comparison of simulations of factor Xa, factor Va and thrombin generation curves with experimental data obtained in thromboplastin-activated plasma. (ebi.ac.uk)
  • drugs
  • This is not a list of all drugs or health problems that interact with thrombin. (drugs.com)
  • You must check to make sure that it is safe for you to take thrombin with all of your drugs and health problems. (drugs.com)
  • therapeutic
  • The primary therapeutic compounds marketed by the company include Thrombin-JMI and Levoxyl On May 30, 2000 the company became a wholly owned subsidiary of King Pharmaceuticals (NYSE:KG), based in Bristol, Tennessee. (wikipedia.org)
  • However
  • However, binding of the active fragment of thrombomodulin appears to allosterically promote the active conformation of thrombin by inserting this N-terminal region. (wikipedia.org)