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  • anion-binding
  • The C-terminal domain makes numerous electrostatic interactions with an anion-binding exosite of thrombin, while the last five residues are in a helical loop that forms many hydrophobic contacts. (wikipedia.org)
  • calcium
  • In the presence of calcium the carrier subunits dissociate from the catalytic subunits, leading to a 3D change in conformation of factor XIII and hence the exposure of catalytic cysteine residue. (wikipedia.org)
  • fibroblasts
  • Fibrin itself adheres to collagen, and factor XIII stimulates increased collagen biosynthesis by activating fibroblasts. (google.com)
  • The process includes the following steps: Following damage to the blood vessel, FVII leaves the circulation and comes into contact with tissue factor (TF) expressed on tissue-factor-bearing cells (stromal fibroblasts and leukocytes), forming an activated complex (TF-FVIIa). (wikipedia.org)
  • Willebrand
  • This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until an injury that damages blood vessels occurs. (wikipedia.org)
  • Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. (wikipedia.org)
  • In the blood, it mainly circulates in a stable noncovalent complex with von Willebrand factor. (wikipedia.org)
  • It is a receptor for fibrinogen and von Willebrand factor and aids platelet activation. (wikipedia.org)
  • heparin
  • Given this broad action of thrombin it stands as a good drug target for anticoagulant drugs such as heparin, warfarin and DTIs and antiplatelet drugs like aspirin. (wikipedia.org)
  • In some aspects, hirudin has advantages over more commonly used anticoagulants and thrombolytics, such as heparin, as it does not interfere with the biological activity of other serum proteins, and can also act on complexed thrombin. (wikipedia.org)
  • One contains a binding site for thrombin, another for high molecular weight kininogen, a third one for factor IX, heparin and glycoprotein Ib and the fourth is implicated in forming the factor XI homodimer, including a cysteine residue that creates a disulfide bond. (wikipedia.org)
  • Protein C inhibitor is activated by heparin against thrombin. (wikipedia.org)
  • molecules
  • 2. The thrombin-conjugated nanoparticles according to claim 1, wherein the thrombin molecules are covalently-bonded to the surface of the nanoparticles. (patentgenius.com)
  • 3. The thrombin-conjugated nanoparticles according to claim 2, wherein the nanoparticles are magnetic iron oxide-containing nanoparticles having a coating on their surface, and wherein the thrombin molecules are covalently-liniked to saidcoating. (patentgenius.com)
  • plasma
  • 1. An enriched plasma derivative composition useful for accelerated hemostasis and optimized control of wound closure, consisting essentially of thrombin, a desiccating and stabilizing agent, and a fibrinolysis inhibitor, the constituents of the composition being in powdery state, and said composition being in the form of a sprayable admixture. (google.ca)
  • 13. A plasma derivative composition as claimed in any of claims 1, 4, or 9, wherein a solvent propellant is employed and wherein the solvent used as the propellant boils below 10 C. at atmospheric pressure (100 kPa). (google.ca)
  • Factor XIII has two forms: a plasmatic form that flows freely in the blood plasma, and a cellular form carried inside platelet alpha-granules. (wikipedia.org)
  • Der zunächst nur geringe Klebeeffekt, der mit an Fibrinogen angereichertem Plasma und Thrombin erzielt wurde, gestattete dem Verfahren keine weitere Verbreitung. (springer.com)
  • It does not bind to plasma proteins (other than thrombin) or to red blood cells. (wikipedia.org)
  • Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade. (wikipedia.org)
  • residue
  • Amino acid residues 1-3 form a parallel beta- strand with residues 214-217 of thrombin, the nitrogen atom of residue 1 making a hydrogen bond with the Ser-195 O gamma atom of the catalytic site. (wikipedia.org)
  • recombinant
  • In the early 1990s, pharmaceutical companies began to produce recombinant synthesized factor products, which now prevent nearly all forms of disease transmission during replacement therapy. (wikipedia.org)
  • extrinsic pathway
  • These are the contact activation pathway (also known as the intrinsic pathway), and the tissue factor pathway (also known as the extrinsic pathway), which both lead to the same fundamental reactions that produce fibrin. (wikipedia.org)
  • wherein
  • Thrombin-conjugated nanoparticles, wherein said nanoparticles comprise one or more organic and/or inorganic compounds and process for preparing the same are provided. (patentgenius.com)
  • 1. Thrombin-conjugated nanoparticles, wherein said nanoparticles comprise one or more organic and/or inorganic compounds, wherein the nanoparticles are selected fromthe group consisting of magnetic iron oxide-containing nanoparticles, albumin nanoparticles, solid or hollow silica nanoparticles and nanoparticles made of organic polymeric core coated with a silica shell, optionally having magnetic layer interposedbetween said core and said silica shell. (patentgenius.com)
  • inhibition
  • The thrombin generation test (TGT) was used to evaluate thrombin function and antithrombin resistance assay was applied to assess the extent of impaired antithrombin inhibition of mutation carriers. (bmj.com)
  • The thrombin Arg596Gln variant in patients' plasma presented strong resistance to antithrombin inhibition. (bmj.com)
  • Conclusion Prothrombin Arg596Gln mutation is a risk factor for Chinese patients with VTE due to its moderately decreased clotting activity but strong resistance to antithrombin inhibition. (bmj.com)
  • pathway
  • Thrombin is one trigger which can stimulate endothelial-cell release of P-selectin and recent studies suggest an additional Ca2+-independent pathway involved in release of P-selectin. (wikipedia.org)
  • FVIII
  • Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). (wikipedia.org)
  • No longer protected by vWF, activated FVIII is proteolytically inactivated in the process (most prominently by activated protein C and factor IXa) and quickly cleared from the blood stream. (wikipedia.org)
  • consists
  • The specific gene that encodes RhoA, ARHA, is located on chromosome 3 and consists of four exons, which has also been linked as a possible risk factor for atherothrombolic stroke. (wikipedia.org)
  • Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. (wikipedia.org)
  • Factor VIII protein consists of six domains: A1-A2-B-A3-C1-C2, and is homologous to factor V. The A domains are homologous to the A domains of the copper-binding protein ceruloplasmin. (wikipedia.org)
  • molecule
  • The exact structure and chemical data such as molecular weight are unknown, but it has been elaborated that the glycosylation of the molecule is an important factor. (wikipedia.org)
  • Interaction
  • These structural arrangements provide interaction sites that can interact with effectors and guanine factors in order to stabilize and signal the hydrolysis of GTP. (wikipedia.org)
  • VIII
  • In humans, factor VIII is encoded by the F8 gene. (wikipedia.org)
  • Factor VIII is produced in liver sinusoidal cells and endothelial cells outside the liver throughout the body. (wikipedia.org)
  • The factor VIII gene produces two alternatively spliced transcripts. (wikipedia.org)
  • Factor VIII was first characterized in 1984 by scientists at Genentech. (wikipedia.org)
  • The gene for factor VIII is located on the X chromosome (Xq28). (wikipedia.org)
  • The gene for factor VIII presents an interesting primary structure, as another gene is embedded in one of its introns. (wikipedia.org)
  • Factor VIII is not affected by liver disease. (wikipedia.org)
  • the incidence of these inhibitors is dependent of various factors, including the factor VIII product itself. (wikipedia.org)
  • In the 1980s, some pharmaceutical companies such as Baxter International and Bayer sparked controversy by continuing to sell contaminated factor VIII after new heat-treated versions were available. (wikipedia.org)
  • tissue factor
  • While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. (wikipedia.org)
  • The process includes the following steps: Following damage to the blood vessel, FVII leaves the circulation and comes into contact with tissue factor (TF) expressed on tissue-factor-bearing cells (stromal fibroblasts and leukocytes), forming an activated complex (TF-FVIIa). (wikipedia.org)
  • Recombinant
  • risk of platelet alloimmunization) Recombinant factor VIIa, AryoSeven or NovoSeven FDA approved this drug for the treatment of the disease on July 2014. (wikipedia.org)
  • In the early 1990s, pharmaceutical companies began to produce recombinant synthesized factor products, which now prevent nearly all forms of disease transmission during replacement therapy. (wikipedia.org)