Thiazides loop diuretics diuretics. Medical search. Frequent questions

Loop diuretics (such as frusemide/furosemide, bumetanide and torasemide) are preferable to thiazide. (healthy.net)
We found 9 trials studying the blood pressure-lowering ability of 5 different loop diuretics (furosemide, cicletanine, piretanide, indacrinone and etozolin) in 460 participants. (cochrane.org)
Nine trials evaluated the dose-related blood pressure-lowering efficacy of five drugs within the loop diuretics class (furosemide 40 mg to 60 mg, cicletanine 100 mg to 150 mg, piretanide 3 mg to 6 mg, indacrinone enantiomer -2.5 mg to -10.0/+80 mg, and etozolin 200 mg) in 460 people with baseline blood pressure of 162/103 mmHg for a mean duration of 8.8 weeks. (cochrane.org)
Loop diuretic doses were titrated to a dose of at least 960 mg/day of IV furosemide equivalents before a thiazide diuretic was added. (news-medical.net)
If doses in excess of furosemide 80 mg twice daily are needed, either a different loop diuretic should be considered or a thiazide should be added. (acc.org)
It may reduce the effects of the loop (furosemide) or thiazide (hydrochlorothiazide) diuretics. (foot-pain-explained.com)
Loop diuretics, like furosemide, and thiazide diuretics like chlorothiazide and hydrochlorothizide increase urination and cause potassium loss. (livestrong.com)

Angiotensin converting enzyme (ACE) inhibitors, angiotensin-II receptor blockers (ARBs), diuretics and nonsteroidal anti-inflammatory drugs (NSAIDs) all have the potential to decrease renal function. (bpac.org.nz)
Reduced renal clearance related to decreased GFR, hyperinsulinism, renal vasoconstriction or diuretic usage. (standardofcare.com)
Right heart catheterizations should be considered when symptoms persist despite adequate diuretic dose, worsening renal function with attempts to use higher dose therapies including diuretics or those with repeated hospitalizations for decompensation. (acc.org)

Some types of diuretics may also help in other ways. (medlineplus.gov)
There are many types of diuretics. (adam.com)
Different types of diuretics have different risks if you take too many. (livestrong.com)

Diuretics in this class (such as hydrochlorothiazide) increase the activity of vitamin D and can lead to inappropriately high calcium levels in the blood. (progressivehealth.com)

Diuretics cause natriuresis and are therefore used to treat patients with volume overload, including hypertension, liver cirrhosis, nephrotic syndrome, and congestive heart failure ( Ives, 2001 ). (aspetjournals.org)
Diuretics are used in medicine to treat heart failure, liver cirrhosis, hypertension , and some kidney diseases. (ilpi.com)
Loop diuretics are indicated and used to treat hypertension, but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from randomized controlled trial (RCT) evidence has not been conducted. (cochrane.org)
To determine the dose-related decrease in systolic or diastolic blood pressure, or both, as well as adverse events leading to participant withdrawal and adverse biochemical effects (serum potassium, uric acid, creatinine, glucose and lipids profile) due to loop diuretics versus placebo control in the treatment of people with primary hypertension. (cochrane.org)
We included double-blind randomized placebo-controlled trials of at least three weeks duration comparing loop diuretic with a placebo in people with primary hypertension defined as blood pressure greater than 140/90 mmHg at baseline. (cochrane.org)
Importance: Thiazide diuretics are commonly prescribed for the treatment of hypertension, a disease highly prevalent among older individuals and in those with chronic kidney disease. (bvsalud.org)
Onset of new hypertension or worsening of preexisting hypertension, especially in patients taking thiazides or loop diuretics. (medscape.com)
In hypertension, it is used as an adjunct to prolonged therapy with thiazides and similar agents to prevent potassium depletion. (janusinfo.se)

Based on the limited number of published RCTs, the systolic/diastolic blood pressure-lowering effect of loop diuretics is -8/-4 mmHg, which is likely an overestimate. (cochrane.org)
However, the effect of loop diuretics on lithium clearance relative to thiazide diuretics is generally minor. (onesingapore.org)

Diuretics may also cause hypokalemia , abnormally low potassium level. (ilpi.com)
Patients taking diuretics are sometimes given potassium supplements to prevent hypokalemia, but one should only take these on advice of a physician. (ilpi.com)
Depleted levels of potassium or hypokalemia are often due to water loss as a result of excessive sweating, diarrhea, poor water intake and overuse of diuretics. (vitamedica.com)
Beta-agonists worsen hypokalemia caused by nonpotassium-sparing diuretics (such as loop or thiazide diuretics). (pharm-europe.com)

NSAIDS: Reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (pediatriconcall.com)

To elucidate the molecular mechanisms for the tubular excretion of diuretics, we have elucidated the interactions of human organic anion transporters (hOATs) with diuretics using cells stably expressing hOATs. (aspetjournals.org)
In addition, because the binding of diuretics to plasma proteins is generally high (more than 90%), tubular secretion is the main route of urinary excretion of the diuretics. (aspetjournals.org)
Co-administration with a thiazide or loop diuretic, decreases the urinary excretion of magnesium which occurs when a thiazide or loop diuretic is used alone. (pediatriconcall.com)
Therefore, loop diuretics increase magnesium and calcium excretion. (pharmacology2000.com)
In circumstances that result in hypercalcemia, calcium excretion can be enhanced by administration of loop diuretics with saline infusion. (pharmacology2000.com)

That's been calculated in many different ways, but we looked at change in weight over the study period, divided by the cumulative loop diuretic dose that was required to get this change in weight, which has been shown in many different cohorts to be prognostically significant. (medscape.com)
The primary outcome was diuretic efficiency (diuretic response) expressed as the cumulative change in weight per cumulative loop diuretic dose (IV and oral) from enrolment to day 5 or discharge, if sooner. (news-medical.net)

Long-term antihypertensive effects of thiazides appear due to reduce vascular resistance. (pharmacology2000.com)

ACE inhibitors or ARBs and diuretics are commonly prescribed together, either as individual medicines or combination formulations, however, prescribers should remember that using these medicines together (the "double whammy") can increase the risk of AKI. (bpac.org.nz)

People who take potassium-sparing diuretics , thiazide diuretics and ACE inhibitors may also be at risk of ingesting too little potassium. (medicalnewstoday.com)
The term "triple whammy" refers to the concurrent use of an angiotensin converting enzyme (ACE) inhibitor or an angiotensin-II receptor blocker (ARB), with a diuretic and a non-steroidal anti-inflammatory drug (NSAID), including cyclo-oxygenase-2 (COX-2) inhibitors. (bpac.org.nz)

The dose-ranging effects of loop diuretics could not be evaluated. (cochrane.org)
A spot urine sample was collected after the initial IV loop diuretic dose, but before dapagliflozin administration, to measure baseline diuretic-induced urine sodium, potassium, and creatinine. (news-medical.net)
According to the most recent guidelines from the European Society of Cardiology, diuretics are recommended to maintain or achieve euvolemia at the lowest possible dose. (medscape.com)
Diuretics should be added as needed and dose should be titrated to achieve decongestion. (acc.org)
If the dose of diuretic you're taking isn't lowering your blood pressure or reducing fluid retention, talk with your doctor rather than increasing your dose on your own. (livestrong.com)
Treatment should be started with a low dose of Amiloride, i.e. 5mg (1 tablet), plus a low dosage of the other diuretic agent. (janusinfo.se)

The tubular secretion of diuretics in the proximal tubule has been shown to be critical for the action of drugs. (aspetjournals.org)
Loop diuretics cause increased uric acid reabsorption in the proximal tubule, secondary to hypovolemic states. (pharmacology2000.com)

Medications that deplete potassium include thiazide and loop diuretics (rid the body of sodium and potassium), corticosteroids, antacids and laxatives. (vitamedica.com)

Both groups had structural usual care, meaning that their intravenous (IV) diuretic regimen was protocolized and titrated to 3-5 L of urine output a day. (medscape.com)
Diuretics cause or increase urine production or urine flow out of the body. (ilpi.com)
Diuretics regulate urine production by stimulating or inhibiting the body's natural hormones. (ilpi.com)
A standardized protocol for IV loop diuretic dosing and titration every 12-24 hours was used for both study arms throughout the study period to target a urine output of 3-5 L/day. (news-medical.net)
Regarding exploratory endpoints, dapagliflozin significantly increased both 24-hour natriuresis (p=0.025) and 24-hour urine output (p=0.005), and decreased both time to completing IV diuretic therapy (p=0.006) and time to hospital discharge (p=0.007). (news-medical.net)

The estimated degree of risk that patients are exposed to when taking combinations of an ACE inhibitor/ARB, diuretic and NSAID varies according to study design. (bpac.org.nz)
Early initiation of the sodium glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin did not result in a statistically significant improvement in diuretic efficiency relative to structured usual care in hospitalized patients with acute decompensated heart failure (ADHF), according to late breaking research presented in a Hot Line session today at ESC Congress 2023. (news-medical.net)
The DICTATE-AHF trial examined the efficacy and safety of dapagliflozin initiated within 24 hours of hospital presentation on diuretic response in patients with hypervolaemic ADHF. (news-medical.net)
The study enrolled adult patients with type 2 diabetes and an estimated glomerular filtration rate (eGFR) of at least 30 mL/min/1.73m 2 admitted to hospital with ADHF and current or planned treatment with intravenous (IV) loop diuretics. (news-medical.net)
Amiloride has potassium-conserving activity in patients receiving kaliuretic-diuretic agents. (pediatriconcall.com)
Diuretics should be used with caution in patients with liver disease since minor alterations of fluid and electrolyte balance may precipitate hepatic coma. (pediatriconcall.com)
Loop diuretics combined with thiazides may be considered in patients with refractory edema unresponsive to loop diuretics alone. (medscape.com)
Updated ACC guidelines note that lower doses of loop diuretics might be necessary for initiation and/or optimal titration of an ARNI/ACEI/ARB to avoid hypotension in patients with a systolic blood pressure ≤ 100 mmHg. (medscape.com)
Referral to a HF specialist should be considered in patients needing inotropes, NYHA class IIIB/IV symptoms or persistently elevated natriuretic peptides, end-organ dysfunction, EF ≤35%, ICD shocks, recurrent hospitalizations, congestion despite escalating diuretics, low blood pressure and/or high heart rate, and progressive intolerance to GDMT needing down-titration. (acc.org)
In congestive heart failure, Amiloride Hydrochloride may be effective alone, but its principal indication is for concomitant use in patients receiving thiazides or more potent diuretic agents. (janusinfo.se)
Gradual weight reduction in cirrhotic patients is especially desirable to reduce the likelihood of untoward reactions associated with diuretic therapy. (janusinfo.se)

Diuretics at Cardiovascular Pharmacology. (ilpi.com)

The most common electrolyte imbalance, hyponatremia , having too little sodium, can result from the use of diuretics. (ilpi.com)
Hypernatremia , too much sodium, can also be caused by diuretics. (ilpi.com)
Some diuretics eliminate sodium from the body. (livestrong.com)
Taking overdoses of loop and thiazide diuretics can cause not only dehydration from excessive urination but also low levels of potassium, sodium and other electrolytes. (livestrong.com)

Potassium-sparing diuretics such as triamterine and spironolactone, often given in conjunction with loop diuretics, conserve potassium and help prevent potassium depletion. (livestrong.com)

That's a great question because although we don't know all the mechanisms that probably lead to the chronic benefits, for acute efficacy, we looked at the benefits across diuresis, natriuresis, and diuretic response, looking for any additive benefit acutely for a diuretic decongestive outcome and then safety across all the other outcomes. (medscape.com)
Your goal was not a diuretic, rather your goal was the diuresis however you got there. (medscape.com)
Loop diuretics generate a diuresis that is more intense but shorter in duration than that produced by thiazides. (medscape.com)
Although Amiloride Hydrochloride may be used alone, its principal indication is as concurrent therapy with thiazides or more potent diuretics in order to conserve potassium during periods of vigorous diuresis and during long-term maintenance therapy. (janusinfo.se)
It may be used with more potent diuretics when a greater diuresis is required while maintaining a more balanced serum electrolyte pattern. (janusinfo.se)

Care should be taken when taking diuretics to avoid dehydration (excessive body water loss) and electrolyte imbalance . (ilpi.com)
Water pills, medically known as diuretics, have many legitimate uses, but can cause dehydration and irregular heartbeats if you take them in excess. (livestrong.com)

Thiazides and loop diuretics exhibit their diuretic effects from the luminal side by inhibiting the Na + -Cl - cotransporter of the distal tubule and the Na + -K + -2Cl - co-transporter of the loop of Henle, respectively ( Ives, 2001 ). (aspetjournals.org)
The Bowman's capsule produces filtrate, which travels down the proximal convoluted tubule, descending loop of Henle, the ascending loop of Henle and the distal convoluted tubule. (flashcardmachine.com)
An additional 20% is reabsorbed in the descending loop of Henle. (flashcardmachine.com)

While more commonly used to reduce water retention, loop diuretics are are also indicated for lowering elevated blood pressure. (cochrane.org)

Loop diuretics and thiazide diuretics decrease filtration fraction. (wikipedia.org)
Diuretics also decrease extracellular fluid volume. (ilpi.com)

The review did not provide a good estimate of the incidence of harms associated with loop diuretics because of the short duration of the trials and the lack of reporting of adverse effects in many of the trials. (cochrane.org)
Diuretic effects may be decreased. (medicscientist.com)

Proper electrolyte balance is essential to good health, and diuretics may cause electrolyte imbalance. (ilpi.com)

Should diet and exercise prove unsuccessful in lowering the blood pressure, the doctor might decide to prescribe medications such as diuretics or antihypertensives. (informit.com)

As shown in Table 1 , thiazide and loop diuretics, which carry as a common chemical characteristic a sulfamoyl group (sulfonamide diuretics), are weak organic acids. (aspetjournals.org)
Amiloride is a potassium-conserving drug that possesses weak natriuretic, diuretic and antihypertensive activity. (pediatriconcall.com)
Do-administration of drugs that inhibit weak acid secretion (e.g. probenecid or indomethacin) may alter loop diuretic clearance. (pharmacology2000.com)
Potassium-sparing diuretics are weak diuretics used to treat high blood pressure. (livestrong.com)

We found no clinically meaningful blood pressure-lowering differences between different drugs within the loop diuretic class. (cochrane.org)
Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity. (cochrane.org)
Allergic reactions -- if you are allergic to sulfa drugs, you should not use thiazides. (adam.com)

When Amiloride is used with a diuretic which is given on an intermittent basis, it should be given at the same time as the diuretic. (janusinfo.se)
Usually half 'Amiloride' tablet (2.5mg) given once a day together with the usual antihypertensive dosage of the thiazide concurrently employed. (janusinfo.se)
Initially half 'Amiloride' tablet (2.5mg) a day together with the usual dosage of the diuretic concurrently employed, subsequently adjusted if required, but not exceeding two 'Amiloride' tablets (10mg) a day. (janusinfo.se)
Amiloride 5 mg Tablets BP - Summary of Product Characteristics (SmPC) - print friendly - (eMC) diuretic response. (janusinfo.se)

Diuretics help your body get rid of extra fluid. (medlineplus.gov)

Previous studies of diuretic combinations improved decongestion, but these diuretic combinations inherently did not optimize GDMT and were not associated with improved post-discharge outcomes. (news-medical.net)
How specific thiazide diuretics compare in regard to safety and clinical outcomes in these populations remains unknown. (bvsalud.org)

Prescribing a NSAID concurrently with an ACE inhibitor/ARB and a diuretic increases the risk of AKI considerably. (bpac.org.nz)

The primary efficacy outcome that we looked at was diuretic efficiency. (medscape.com)
The best estimate of systolic/diastolic blood pressure-lowering efficacy of loop diuretics was -7.9 (-10.4 to -5.4) mmHg/ -4.4 (-5.9 to -2.8) mmHg. (cochrane.org)
Thiazide diuretic agents are widely used for prevention of the recurrence of kidney stones, but data regarding the efficacy of such agents as compared with placebo are limited. (bvsalud.org)

There are also diuretic pills that contain a combination of two of the medicines above. (adam.com)

Diuretics (Water Pills) for High Blood Pressure at WebMD. (ilpi.com)
Abusing diuretics as a weight-control method is not only risky but ineffective, since water weight will re-accumulate when you stop taking the pills. (livestrong.com)

Optimal dosage is determined by diuretic response and the plasma potassium level. (janusinfo.se)

Diuretics work of different parts of the kidney and have different properties. (livestrong.com)

After adjusting for baseline weight, the odds ratio (OR) for diuretic efficiency with dapagliflozin versus structured care was 0.65, 95% confidence interval (CI) 0.41 to 1.01, p=0.06. (news-medical.net)

Thus, tubular secretion has been thought to be critical for the action of loop and thiazide diuretics. (aspetjournals.org)

Common household diuretics include coffee, alcohol , and cranberry juice. (ilpi.com)

Anatomy3

Diseases9

Chemicals and Drugs39

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes6

Health Care7

Furosemide7

Renal3

Types of diuretics3

Hydrochlorothiazide1

Hypertension8

Effect of loop diuretics2

Hypokalemia4

NSAIDs1

Excretion5

Cumulative loop diuretic dose2

Antihypertensive effects1

ARBs1

Inhibitors2

Dose6

Proximal tubule2

Deplete1

Urine5

Patients11

Pharmacology1

Sodium4

Spironolactone1

Diuresis5

Dehydration2

Henle3

Commonly1

Decrease2

Effects2

Electrolyte Imbalance1

Medications1

Weak4

Drugs3

Amiloride4

Fluid1

Outcomes2

Concurrently1

Efficacy3

Medicines1

Water2

Dosage1

Kidney1

Efficiency1

Secretion1

Alcohol1