Thiazides and diuretics like them are mostly used to treat high blood pressure and fluid retention that causes swelling. (medlineplus.gov)
[ 1 , 10 ] For Black patients, ACEIs and ARBs are less effective than thiazide diuretics and CCBs in lowering blood pressure and preventing stroke. (medscape.com)
Thiazide diuretics are used as monotherapy, or they can be administered adjunctively with other antihypertensive agents. (medscape.com)
Thiazide diuretics inhibit reabsorption of sodium and chloride mostly in the distal tubules. (medscape.com)
Bendroflumethiazide has a role in the treatment of mild heart failure although loop diuretics are better for reducing overload. (wikipedia.org)
However, they have not been frequently used to in CKD patients, perhaps because they are assumed to be less efficient than relatively newer loop diuretics, 7 despite recent evidence demonstrating that thiazides can achieve diuresis and sodium balance among patients with lower glomerular filtration rate. (annals.edu.sg)
Several antihypertensive medications, including thiazide diuretics, beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and calcium channel blockers, in principle, can be used as initial monotherapy in patients with hypertension. (medscape.com)
If the BP goal is not achieved, thiazide-type diuretics should be used as initial therapy for most patients, either alone or in combination with one of the other classes (ie, ACE inhibitors, ARBs, beta-blockers, calcium channel blockers) that have also been shown to reduce one or more hypertensive complications in randomized controlled outcome trials. (medscape.com)
Variations in diuretic-mediated inhibition of carbonic anhydrase-dependent chloride transport in platelets and vascular smooth muscle could account for the contrasting efficacy of the thiazide and thiazide-like diuretics in reducing cardiovascular morbidity in patients with hypertension. (nih.gov)
The mechanism of the antihypertensive effects of thiazide diuretics are poorly understood . (pulsenotes.com)
Thiazide diuretics act on the distal convoluted tubule (DCT) of the nephron where it inhibits the Na + /Cl - co-transporter. (pulsenotes.com)
Reluctance to use thiazide diuretics stems from the pos- sibility of hypokalemia-induced arrhythmias and long- term elevations of serum cholesterol. (nih.gov)
The long established pri- macy of the thiazide diuretics is being challenged principally by the growing popularity of the beta- adrenergic blocking drugs. (nih.gov)
This trend has been in- fluenced, on the one hand, by the opinion that beta-blockers may protect the heart against fatal ar- rhythmias and on the other, by recent criticisms concerning the thiazide diuretics. (nih.gov)
It is not known if subjects with a high ratio have aldosteronism or aldosterone-sensitive hypertension is debated but it is important to know whether spironolactone is superior to other diuretics such as bendroflumethiazide in this setting. (elsevierpure.com)
Importance: Thiazide diuretics are commonly prescribed for the treatment of hypertension, a disease highly prevalent among older individuals and in those with chronic kidney disease. (bvsalud.org)
How specific thiazide diuretics compare in regard to safety and clinical outcomes in these populations remains unknown. (bvsalud.org)
In this article, he reported on a study of several different drugs, including two thiazide diuretics, a beta-blocker, and an angiotensin converting enzyme (ACE) inhibitor. (nih.gov)
18. Renal outcomes of diabetic patients treated with combination therapy of ACE inhibitors plus either thiazide diuretics or calcium channel blockers: comparative retrospective cohort study in Northwestern Ethiopia. (nih.gov)
Indapamide3
Indapamide is chemically not a thiazide, although its structure and function are very similar. (medscape.com)
Bendroflumethiazide Chlorothiazide Chlorthalidone Hydrochlorothiazide Hydroflumethiazide Indapamide Methyclothiazide Metolazone Other medicines may also contain thiazide. (nih.gov)
Pill with imprint G 531 is White, Round and has been identified as Bendroflumethiazide and Nadolol 5 mg / 40 mg. (drugs.com)
Bendroflumethiazide/nadolol is used in the treatment of High Blood Pressure and belongs to the drug class beta blockers with thiazides . (drugs.com)
Bendroflumethiazide/nadolol 5 mg / 40 mg is not a controlled substance under the Controlled Substances Act (CSA). (drugs.com)
In a Veterans Administration study nadolol reduced blood pressure more in whites than in blacks, while the reverse was true with hydrochloro- thiazide. (nih.gov)
In one such trial the beta-blocker nadolol was com- pared with the diuretic bendroflumethiazide and with the combination of the two (1). (nih.gov)
The reduction in diastolic blood pressure was essentially the same with the two drugs, averaging 12.4 mm Hg with nadolol and 12.9 mm Hg with bendroflumethiazide. (nih.gov)
Hypertension8
General recommendations established by the Eighth Report of the Prevention, Detection, Evaluation, and Treatment of the Joint National Committee on High Blood Pressure (JNC 8) and the American College of Cardiology/American Heart Association (ACC/AHA) guidelines for initial pharmacologic treatment of stage 1 hypertension include a thiazide-type diuretic, angiotensin-converting enzyme inhibitors (ACEIs), calcium channel blockers (CCBs), or angiotensin-receptor blockers (ARBs). (medscape.com)
Bendroflumethiazide, formerly bendrofluazide, trade name Aprinox, is a thiazide diuretic used to treat hypertension. (wikipedia.org)
For many years, hypertension guidelines have recommended the use of thiazides in non-CKD patients. (annals.edu.sg)
BETA-BLOCKER VERSUS THIAZIDE AS INITIAL TREATMENT Is the most effective drug for the initial or primary treatment of hypertension a beta-blocker or a di- uretic? (nih.gov)
أدرس بدقة موضوعات البحث "Does the aldosterone: Renin ratio predict the efficacy of spironolactone over bendroflumethiazide in hypertension? (elsevierpure.com)
how does bendroflumethiazide compare hypertension beta-blocker drugs with ephedrine in lower blood pressure without medication codeine. (cnrs.fr)
Chlorthalidone2
Both chlorthalidone, which potently inhibits platelet carbonic anhydrase, and bendroflumethiazide, which has much less effect on this enzyme, increased the amount of epinephrine needed to induce platelet aggregation when compared with the absence of a diuretic. (nih.gov)
They have been shown to reduce risk of cardiovascular events, heart failure and stroke, and while treatment with thiazides may result in hypokalemia, hyponatremia and hypomagnesemia, using lower doses and concurrent RAS inhibitors or concurrent potassium-sparing agent manages these side effects. (annals.edu.sg)
Hydrochlorothiazide1
A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE . (nih.gov)
Diuretic agents2
Keep in mind that all available loop and thiazide diuretic agents, except ethacrynic acid, possess a sulfonamide group, which has important clinical relevance to those individuals with allergies to sulfonamide agents. (medscape.com)
Thiazide diuretic agents are widely used for prevention of the recurrence of kidney stones, but data regarding the efficacy of such agents as compared with placebo are limited. (bvsalud.org)
Chronic kidney1
Common adverse effects: feeling dizzy due to orthostatic hypotension dry mouth or feeling thirsty nausea stomach ache fatigue diarrhea or constipation joint pain due to gout Rare adverse effects: thrombocytopenia agranulocytosis photosensitivity rash pancreatitis chronic kidney disease Bendroflumethiazide is known to have an adverse interaction with alcohol. (wikipedia.org)
Carbonic1
We assessed platelet carbonic anhydrase activity and catecholamine-induced platelet aggregation in the presence of a thiazide and a "thiazide-like" inhibitor of the sodium-chloride cotransporter. (nih.gov)
Distal convol1
Bendroflumethiazide is a thiazide diuretic which works by inhibiting sodium reabsorption at the beginning of the distal convoluted tubule (DCT). (wikipedia.org)
Antihypertensive drugs3
Thiazides have been available since the 1950s, are safe, effective, well-tolerated and in most countries are the least expensive antihypertensive drugs. (annals.edu.sg)
Thiazides are also used in combination with other antihypertensive drugs and in patients with heart failure. (nih.gov)
An alternative regimen which is both highly effective and well tolerated is the combination of small doses of both a thiazide diuretic and captopril. (nih.gov)
Diuresis1
Intense diuresis with large doses of bendroflumethiazide can decrease breastmilk production, especially during the neonatal period. (nih.gov)
Overdose1
Thiazide overdose occurs when someone takes more than the normal or recommended amount of this medicine. (medlineplus.gov)
Hyponatremia5
Thiazide-associated hyponatremia (TAH) is fairly common. (providence.org)
There are also multiple case series in the literature of severe hyponatremia in elderly pts attributed to initiation of a thiazide-ARB combination, even when the thiazide dose was low. (providence.org)
This is a unique case of hyponatremia in which ARB on thiazide therapy seems to have precipitated severe hyponatremia. (providence.org)
Given the temporal correlation of initiating irbesartantherapy to her symptoms, previously normal sodium levels on chlorthalidonealone, improvement with isotonic saline, resolution of hyponatremia with discontinuation of these medications, and no evidence of other underlying etiology, her severe hyponatremia was attributed to the addition of the ARB to her thiazide diuretic. (providence.org)
Cases of severe hyponatremia can occur with thiazides alone, but can be further promoted in combination with ARBs. (providence.org)
Sodium reabsorption1
Thiazides reduce plasma volume and therefore blood pressure through inhibiting sodium reabsorption in the distal convoluted tubules. (providence.org)
Low-dose thiazides are now recognized as achieving maximal effects on BP with minimal adverse effects. (medscape.com)
Secondary objectives - To determine whether bendroflumethiazide induces adverse metabolic abnormalities, especially in subjects with high aldosterone: renin ratios and if baseline renin measurement predicts the antihypertensive response to spironolactone and/or bendrofluazide. (elsevierpure.com)
Medication1
Flumezide is a brand name medication included in a group of medications called Thiazides, plain . (rxwiki.com)
Doses1
Bendroflumethiazide has been used to suppress lactation in oral doses of 5 mg twice daily for 5 days, and in doses of 10 mg in the morning and 5 mg in the afternoon. (nih.gov)
Treatment1
Methods/design: The study is a double-blind, randomised, crossover, controlled trial that will randomise 120 hypertensive subjects to 12 weeks treatment with spironolactone 50 mg once daily and 12 weeks treatment with bendroflumethiazide 2.5 mg once daily. (elsevierpure.com)
Blood pressure2
Thiazides are medicines used to treat high blood pressure. (medlineplus.gov)
Thiazides do not affect normal blood pressure. (medscape.com)
High1
Primary objective- To test the hypothesis that the aldosterone: renin ratio predicts the antihypertensive response to spironolactone, specifically that the effect of spironolactone 50 mg is greater than that of bendroflumethiazide 2.5 mg in hypertensive subjects with high aldosterone: renin ratios. (elsevierpure.com)
Recent1
Indeed the recent ALLHAT1study suggests that thiazides should be given first to virtually all hypertensives. (elsevierpure.com)
Effects1
Bendroflumethiazide may also impair the user's motor skills, therefore it is important to be aware of its effects and to take caution when operating machinery of driving. (wikipedia.org)
Type1
Thiazides are a type of medicine called a diuretic. (medlineplus.gov)