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BacteroidesBacteroides fragilisBacteroides InfectionsChondroitinases and Chondroitin LyasesChondroitin LyasesPrevotella melaninogenicaFusobacteriumBacteria, AnaerobicGerm-Free LifeRuminococcusStarchCefoxitinChondro-4-SulfataseDNA, BacterialCefotetanCholesteatomaChondroitin SulfatesFructansChondroitinClindamycinPolysaccharidesAnaerobiosisCecumDNA Transposable ElementsPeptostreptococcusMetronidazoleFecesCefmetazoleMaltosePectinsAmyloseGlycoside HydrolasesMethanobrevibacterConjugation, GeneticIntestinesCephamycinsMicrobial Sensitivity TestsGenes, BacterialSulfatasesGlucansSpecies SpecificityClostridiumBacterial ProteinsXylansMolecular Sequence DataCarbohydrate MetabolismBacteriaSymbiosisAnti-Bacterial AgentsBacterial Outer Membrane ProteinsMutagenesis, InsertionalColonalpha-GlucosidasesPrevotellaFermentationFoot RotGastrointestinal TractRNA, Ribosomal, 16SEscherichia coliCulture MediaAbscessPorphyromonasBacteria, AerobicBacteroidaceaeGene Expression Regulation, BacterialStructural Homology, ProteinSequence Analysis, DNAMucusGram-Negative Anaerobic BacteriaDrug Resistance, MicrobialPlasmidsNucleic Acid HybridizationChromosomes, BacterialPhylogenyMouth
FragilisBacteriaSpeciesBacteriumMicrobe Bacteroides thetaiotaomicronCommensalIntestinalGenusAnaerobeCharacterizationEnzymesMicrobiotaColiGenomePrevotellaUtilizationEncodesMiceDegradationResistantHumanBacteriaOrganismGerm-free miceFragilis strInfectionsMoleculeObligateGeneCarbonResponsesGroupStudyResolution
Fragilis4
Bacteria9
  • Colonic bacteria, exemplified by Bacteroides thetaiotaomicron, play a key role in maintaining human health by harnessing large families of glycoside hydrolases (GHs) to exploit dietary polysaccharides and host glycans as nutrients. (rcsb.org)
  • Bacteroides thetaiotaomicron (white) living on mammalian cells in the gut (large pink cells coated in microvilli) and being activated by exogenously added compounds (small green dots) to express specific genes, such as those encoding light-generating luciferase proteins (glowing bacteria). (nih.gov)
  • The human genome does not contain a single enzyme known to be involved in pectin digestion, and therefore, in order to modify HG fibers and potentially extract nutritional value, humans rely on a consortium of symbiotic intestinal bacteria, such as Bacteroides thetaiotaomicron, to deconstruct and to ferment this complex carbohydrate into host absorbable products. (uleth.ca)
  • Lactobacilli and the commensal bacteria Escherichia coli Nissle and Bacteroides thetaiotaomicron only degraded the F2 compound α-D-Glc p -(1 → 2)-[β-D-Gal p -(1 → 4)-]D-Glc p , constituting around 30% w / w of GL34. (springer.com)
  • Two were bacteria, Desulfovibrio piger and Bacteroides thetaiotaomicron, and the third was an archaean called Methanobrevibacter smithii. (vetscite.org)
  • But animals that got the archaean M. smithii and the bacterium B. thetaiotaomicron were about 54% fatter than mice given the bacteria alone. (vetscite.org)
  • By analyzing more carefully how the microbes interacted in the lab, researchers found that the archaeans actually changed the behavior of B. thetaiotaomicron, so that the bacteria would covet the more plentiful polysaccharides in the diet known as fructans, the pair report online this week in the Proceedings of the National Academy of Sciences. (vetscite.org)
  • Yet common gut bacteria called Bacteroides thetaiotaomicron are able to munch their way through a complex carbohydrate, called alpha-mannan, that appears in the cell walls of bread and brewer's yeast, researchers have found. (popsci.com)
  • Groisman and colleagues studied the effects of a high sucrose/glucose diet in mice on one of those beneficial bacteria , Bacteroides thetaiotaomicron, a species associated with the ability to process healthy foods such as vegetables. (medicalxpress.com)
Species4
  • Bacteroides thetaiotaomicron (formerly Bacillus thetaiotaomicron) is a species of bacterium of the genus Bacteroides. (wikipedia.org)
  • We expanded our analysis to other sequenced were noted on computed tomographic scan images, and Bacteroides species and observed similar results (Figure). (cdc.gov)
  • Francisella tularensis, Bartonella bacilliformis, Bacteroides species, Vibrio cholerae and Campylobacte fetus, Brucella species (in conjunction with streptomycin). (rxlist.com)
  • Cefoxitin and cefotetan have increasing rates of resistance in Bacteroides species and would not be used as monotherapy. (hopkinsguides.com)
Bacterium3
  • The study, published in Cell Host & Microbe, demonstrates how quickly Bacteroides thetaiotaomicron ( B. theta ), a prevalent bacterium in the human gut, acquires adaptive mutations in response to dietary changes. (gulbenkian.pt)
  • Landing a spot in The Koropatkin Lab at the University of Michigan, which studies the degradation of fiber and polysaccharides by the gut microbiome, Pollet's work centered on characterizing polysaccharide transporter proteins ( TonB-dependent transporters ) in the gut bacterium, Bacteroides thetaiotaomicron . (asm.org)
  • The enzyme isolated from the anaerobic bacterium Bacteroides thetaiotaomicron is involved in the degradation of host-derived N-glycans. (expasy.org)
Microbe Bacteroides thetaiotaomicron1
  • How GAGs are metabolized by the HGM is therefore of interest and has been extensively investigated in the model human gut microbe Bacteroides thetaiotaomicron. (hal.science)
Commensal1
  • B. thetaiotaomicron is considered commensal or symbiotic. (wikipedia.org)
Intestinal3
  • The fact that the genus Bacteroides and proteins involved in iron acquisition and metabolism, cell wall, capsule, virulence and mucin degradation were enriched at the end of HBR suggest that both constipation and EC decreased intestinal metal availability leading to modified expression of co-regulated genes in Bacteroides genomes. (frontiersin.org)
  • against intestinal infections, Bacteroides -derived metabolites can also be utilized by pathogens," Westermann explains. (helmholtz-hzi.de)
  • Bacteroides are typical components of intestinal, oral and vaginal flora. (hopkinsguides.com)
Genus4
  • Bacteroides thetaiotaomicron was first described in 1912 under the name Bacillus thetaiotaomicron and moved to the genus Bacteroides in 1919. (wikipedia.org)
  • Inactivity and hypoxia resulted in a significant increase in the genus Bacteroides in HBR, in genes coding for proteins involved in iron acquisition and metabolism, cell wall, capsule, virulence, defense and mucin degradation, such as beta-galactosidase (EC3.2.1.23), α-L-fucosidase (EC3.2.1.51), Sialidase (EC3.2.1.18), and α-N-acetylglucosaminidase (EC3.2.1.50). (frontiersin.org)
  • [ 1 ] group and other anaerobic gram-negative bacilli (AGNB) that were previously included in the Bacteroides genus but are now included in the Prevotella and Porphyromonas genera. (medscape.com)
  • of the genus Bacteroides . (helmholtz-hzi.de)
Anaerobe1
  • Although it is considered an obligate anaerobe, B. thetaiotaomicron is aerotolerant and can survive, but not grow, when exposed to oxygen. (wikipedia.org)
Characterization2
  • By taking advantage of an acapsular mutant of B. thetaiotaomicron, here we describe the characterization of the structure of the rough-type LPS produced by this gut mutualist. (unina.it)
  • Construction and characterization of a genome-scale ordered mutant collection of Bacteroides thetaiotaomicron. (nih.gov)
Enzymes1
  • B. thetaiotaomicron contains over 300 predicted carbohydrate active enzymes within its genome that are primarily organized into sugar-selective metabolic pathways called Polysaccharide Utilization Loci PULs (PULs). (uleth.ca)
Microbiota1
  • My team and I plan to investigate RNA -based regulations of the metabolism of Bacteroides thetaiotaomicron , a key member of the human gut microbiota. (helmholtz-hzi.de)
Coli2
  • Similar interactions can cause B. thetaiotaomicron to exacerbate pathogenic E. coli infection. (wikipedia.org)
  • Whole-genome sequencing identified the organism as a mentase and then end-repaired and A-tailed by using E. coli novel Bacteroides genomospecies. (cdc.gov)
Genome3
  • The genome of B. thetaiotaomicron was sequenced in 2003. (wikipedia.org)
  • The B. thetaiotaomicron genome also encodes a large number of small non-coding RNAs, though few have been characterized to date. (wikipedia.org)
  • Such GH family expansion is exemplified by the 23 family GH92 glycosidases encoded by the B. thetaiotaomicron genome. (rcsb.org)
Prevotella1
Utilization1
  • Here, we investigated a gene of unknown function (BT_3328) from the chondroitin sulfate (CS) utilization locus of B. thetaiotaomicron. (hal.science)
Encodes1
  • NMR and UV spectroscopic assays revealed that it encodes a novel polysaccharide lyase (PL), hereafter referred to as BtCDH, reflecting its source (B. thetaiotaomicron (Bt)) and its ability to degrade the GAGs CS, dermatan sulfate (DS), and hyaluronic acid (HA). (hal.science)
Mice1
Degradation1
  • A combination of genetic and biochemical assays revealed that BtCDH localizes to the cell surface of B. thetaiotaomicron where it enables extracellular GAG degradation. (hal.science)
Resistant1
Human2
  • Bacteroides thetaiotaomicron is one of the most common components of the human gut flora. (wikipedia.org)
  • Bacteroides thetaiotaomicron is one of the most extensively studied symbionts of the human gut. (unina.it)
Bacteria5
  • Bacteria of the genus Bacteroides are common members of the human intestinal microbiota and important degraders of polysaccharides in the gut. (nature.com)
  • Bacteroides thetaiotaomicron has emerged as a model representative of the gut microbiota, due to its widespread distribution among human populations and the relative ease of studying these bacteria under laboratory conditions 1 . (nature.com)
  • Bacteroides thetaiotaomicron (white) living on mammalian cells in the gut (large pink cells coated in microvilli) and being activated by exogenously added compounds (small green dots) to express specific genes, such as those encoding light-generating luciferase proteins (glowing bacteria). (nih.gov)
  • One of the most common bacteria in the human gut, Bacteroides thetaiotaomicron , can now be engineered with new functions and re-introduced into the intestinal tract of a mouse. (eurekalert.org)
  • In early studies, patients more likely to respond to anti-CD19 CAR T-cell therapy were found to have a relative abundance of Ruminococcus , Bacteroides , and Faecalibacterium pretreatment gut bacteria. (oncohemakey.com)
Organism3
  • Among them, the species Bacteroides thetaiotaomicron has emerged as the model organism for functional microbiota research. (nature.com)
  • Metronidazole- and carbapenem-resistant Bacteroides jected the organism to whole-genome sequencing by using fragilis are rare in the United States. (cdc.gov)
  • Whole-genome sequencing identified the organism as a mentase and then end-repaired and A-tailed by using E. coli novel Bacteroides genomospecies. (cdc.gov)
Germ-free mice2
  • Interestingly, S. Tm propionate-mediated intestinal expansion is restored when germ-free mice are monocolonized with Bacteroides thetaiotaomicron (B. theta), a prominent propionate producer in the gut, but not when mice are monocolonized with a propionate-production-deficient B. theta strain. (nih.gov)
  • We colonized germ-free mice with Bacteroides thetaiotaomicron . (cdc.gov)
Fragilis str1
Infections1
Molecule1
  • We havedeveloped methods for single-molecule investigations of live bacterialcells, and have used these techniques to investigate three importantprokaryotic systems: membrane-bound transcription activation in Vibriocholerae, carbohydrate catabolism in Bacteroides thetaiotaomicron, and DNA mismatch repair inBacillus subtilis. (brown.edu)
Obligate1
  • Although it is considered an obligate anaerobe, B. thetaiotaomicron is aerotolerant and can survive, but not grow, when exposed to oxygen. (wikipedia.org)
Gene2
  • An online browser, called 'Theta-Base' ( www.helmholtz-hiri.de/en/datasets/bacteroides ), is launched to interrogate the obtained gene expression data and annotations of ~4500 transcription start sites, untranslated regions, operon structures, and 269 noncoding RNA elements. (nature.com)
  • showed that by knocking out the tryptophanase gene in Bacteroides thetaiotaomicron , the production of indoxyl sulfate was eliminated in mice. (renalfellow.org)
Carbon2
  • Here, we analyze the proteome response of B. thetaiotaomicron cultivated on two different carbon sources, glucose and sucrose. (mitarget.org)
  • The data show that B. thetaiotaomicron widely maintains its intracellular proteome upon change of the carbohydrates and that major changes are observed solely in the machinery necessary to make use of the carbon sources provided. (mitarget.org)
Responses1
  • Diet modulates colonic T cell responses by regulating the expression of a Bacteroides thetaiotaomicron antigen. (ccf.org)
Group1
  • The MIT group, led by synthetic biologists Timothy K. Lu and Christopher Voigt, saw that Bacteroides had the potential to express genes on demand. (eurekalert.org)
Study2
  • We took a lot of the tools that people are already using in other organisms, (e.g., promoters, ribosome-binding sequences, memory switches, CRISPR interference) and demonstrated that you could port all of these over into Bacteroides and get them working," says Lu, study senior author and a biological and electrical engineer at MIT. (eurekalert.org)
  • He has included themes like Feces, Enterococcus and Bacteroides in his Antibiotic resistance study. (research.com)
Resolution1
  • Here, we use differential RNA sequencing (dRNA-seq) to generate a single-nucleotide resolution transcriptome map of B . thetaiotaomicron grown under defined laboratory conditions. (nature.com)