• In this review we discuss the current understanding of the signaling mechanisms used by TGF-beta to elicit its effects on target genes, focusing primarily on Smad proteins and their role in the transcriptional regulation of ECM gene expression. (nih.gov)
  • Thus LFY may need to interact with additional proteins to function in transcriptional regulation. (oboolo.com)
  • Post-transcriptional regulation of AG. (oboolo.com)
  • The mechanisms include DES-induced transcriptional regulation of Fas and FasL genes involving ER-mediated signaling and the participation of ERE and/or NF-κB motifs present on their promoters. (diethylstilbestrol.co.uk)
  • Overall, our data suggest that butyrate can reduce the expression of inflammatory genes not only by transcriptional regulation, but also by post-transcriptional regulation via inhibition of mRNA stabilizing proteins. (metu.edu.tr)
  • Transcriptional regulation of aquaporins in accessions of Arabidopsis in response to drought stress. (lu.se)
  • Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental stimuli, or adapt to new food sources. (wikipedia.org)
  • Developmental regulation of lck gene expression in T lymphocytes. (rupress.org)
  • It is essential to have a better understanding on inter-individual variation of gene expression, methylation and genetic effects specific to liver, and on different conditions, e.g. developmental stages. (biomedcentral.com)
  • Gene Expression Regulation, Developmental" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
  • Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. (jefferson.edu)
  • This graph shows the total number of publications written about "Gene Expression Regulation, Developmental" by people in this website by year, and whether "Gene Expression Regulation, Developmental" was a major or minor topic of these publications. (jefferson.edu)
  • Below are the most recent publications written about "Gene Expression Regulation, Developmental" by people in Profiles. (jefferson.edu)
  • In this study, using polyoma middle T antigen (PyMT) mice, a widely used luminal B breast cancer model, we profiled microRNA (miRNA) expression at four time points that represent different key developmental stages of cancer progression. (biomedcentral.com)
  • To determine whether developmental regulation results from stage-specific enhancers, the capacity of the AFP enhancers is tested to direct the expression of albumin. (princeton.edu)
  • Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage. (figshare.com)
  • The Zhx2 gene was originally characterized in our lab based on its ability to control the developmental repression of several hepatic genes, including AFP (PNAS, 102:401). (uky.edu)
  • Specifically, TGF-beta isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhibitors that prevent enzymatic breakdown of the ECM. (nih.gov)
  • Maintenance of class B gene expression The maintenance of AP3 and PI expression in flowers requires the activity of both AP3 and PI indicating that these two proteins function in a positive autoregulatory loop. (oboolo.com)
  • Our project offers a unique opportunity for Master's student to gain hands-on experience focused on transcriptional regulators with importance in expression of genes of outer membrane proteins that are essential in host-pathogen interaction. (lu.se)
  • What remain unknown are the mechanisms whereby Polycomb proteins regulate gene expression during spermatogenesis. (grantome.com)
  • Our central hypothesis is that Polycomb proteins cooperate to preprogram the epigenome in undifferentiated spermatogonia, thus regulating the subsequent dynamic genome-wide expression profile and programmed differentiation necessary for spermatogenesis. (grantome.com)
  • These studies will reveal novel epigenetic mechanisms by which interplay between Polycomb proteins regulates the dynamic gene expression during spermatogenesis. (grantome.com)
  • Enhancers are Cis DNA elements that facilitate or enhance initiation of transcription at the promoter, they interact with gene regulatory proteins or trans-factors (so termed because they are produced by other genes ) and increase the rate of expression. (online-sciences.com)
  • These proteins all contain two zinc fingers and four homeodomains, suggesting that they function as regulators of gene expression. (uky.edu)
  • Genes encoding disrupted complementary interactors tend to be risk genes, and an interaction network built from these proteins is enriched for ASD proteins. (springer.com)
  • RafK carries a C-terminal regulatory domain present in a subset of ATP-binding proteins that has been involved in both direct regulation of transporter activity (inducer exclusion) and transcription of transporter genes. (lu.se)
  • Often, one gene regulator controls another, and so on, in a gene regulatory network. (wikipedia.org)
  • The role of the putative transcriptional regulator GlyR2 in the regulation of cel5D expression was investigated. (nottingham.ac.uk)
  • The plant hormone gibberellin appears to be an important regulator of homeotic gene expression in later stages of flower development (Yu et al. (oboolo.com)
  • SCML2 is a germline-specific subunit of the Polycomb repressive complex 1 (PRC1), a regulator of heritable gene repression during development. (grantome.com)
  • RpoS is a major regulator of genes required for adaptation to stationary phase in E. coli. (mcmaster.ca)
  • The expression of RpoS-dependent genes osmY, tnaA and malK was controlled by Crl, a transcriptional regulator that modulates RpoS activity. (mcmaster.ca)
  • These data indicate that the 5MT resistance of TR-68 may be caused by mutation of a regulator of the expression of the AS genes. (elsevierpure.com)
  • Similarly to the cip-cel operon, cel5A and cel5I expressions are regulated by a carbon catabolite repression mechanism, whereas cel44O and cel5D expressions do not seem to be submitted to this regulation. (nottingham.ac.uk)
  • No physical interaction or cooperation of binding was observed in gel shift experiments Transcriptional repression of AG The lack of AG expression in vegetative tissues and the outer two floral whorls is a consequence of both the absence of AG activators and the activity of AG repressors. (oboolo.com)
  • Translational repression of AP2 The only floral organ-identity gene that does not encode a MADS-domain protein is the class A gene AP2. (oboolo.com)
  • We have discovered that Polycomb complexes determine the gene expression profile by programming genes for both repression and activation. (grantome.com)
  • are the genes which their products decrease in concentration in response to molecular signals, the process of decreasing their expression is called repression, i.e. (online-sciences.com)
  • Regulation of gene expression, or gene regulation, includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). (wikipedia.org)
  • Transcription of a gene by RNA polymerase can be regulated by several mechanisms. (wikipedia.org)
  • This review focuses primarily on the mechanisms underlying Smad modulation of gene expression and how they relate to wound healing. (nih.gov)
  • We have investigated potential mechanisms of regulation of rotavirus gene expression by functional evaluation of two differentially expressed viral mRNAs. (microbiologyresearch.org)
  • In particular, such mechanisms can influence the expression of hepatic ADME genes. (biomedcentral.com)
  • LFY can directly regulate the transcription of at least one representative of each of the class A, B and C genes but uses distinct mechanisms to activate expression of each of these genes in a region-specific manner. (oboolo.com)
  • The goal of this study is to elucidate the epigenetic mechanisms underlying dynamic genome-wide gene expression during spermatogenesis. (grantome.com)
  • The study potentially identifies fundamental mechanisms for dynamic and coordinated regulation of genome-wide gene expression necessary for spermatogenesis. (grantome.com)
  • The aim of the present study was to elucidate the molecular mechanisms of DES-mediated regulation of Fas and FasL gene expression during the development of the immune system and examine the role of ERE and NF-κB motifs in the regulation of these genes. (diethylstilbestrol.co.uk)
  • Culture conditions were chosen that measure the transient, phytohemagglutinin-induced expression of IL-2 and IFN-γ messenger RNA (mRNA), as well the intactness of post-transcriptional and suppressor T cell-dependent mechanisms that control this expression. (biu.ac.il)
  • Here, we study gene body DNA methylation (gbM) and gene expression patterns in ecotypes from contrasting thermal environments of two marine plants with contrasting life history strategies in order to explore the potential role epigenetic mechanisms could play in gene plasticity and responsiveness to heat stress. (nature.com)
  • Although we cannot discern whether gbM regulates gene expression or vice versa, or if other molecular mechanisms play a role in facilitating transcriptome responsiveness, our findings point to the existence of a relationship between gene responsiveness and gbM patterns in marine plants. (nature.com)
  • The mechanisms by which gene expression, and thus phenotypic plasticity, are influenced and regulated remain poorly understood in most organisms. (nature.com)
  • 5) in 1978 put forth a the- on exposed surfaces led to studies that revealed surface-associ- ory of biofilms that explained the mechanisms whereby micro- ated microorganisms (biofilms) exhibited a distinct phenotype organisms adhere to living and nonliving materials and the with respect to gene transcription and growth rate. (cdc.gov)
  • Stephan Sanders and his colleagues have previously shown that spontaneous, or de novo , mutations (seen only in the child and not in either parent) are important risk factors for autism and can be used to find the genes involved in causing autism. (sfari.org)
  • To find these mutations, they plan to build a map of the differences in gene expression between males and females in multiple brain regions and across multiple stages of brain development. (sfari.org)
  • They hope to look for a group of genes that have mutations in girls with autism and that also show a difference in brain expression between the sexes. (sfari.org)
  • Mutations in the CHD7 gene cause CHARGE syndrome, a disorder that affects many areas of the body. (medlineplus.gov)
  • More than 600 mutations that can cause CHARGE syndrome have been identified, and they occur throughout the CHD7 gene. (medlineplus.gov)
  • More than 50 mutations in the CHD7 gene have been identified in people with Kallmann syndrome, a disorder characterized by the combination of hypogonadotropic hypogonadism (a condition affecting the production of hormones that direct sexual development) and an impaired sense of smell. (medlineplus.gov)
  • Mutations in this gene account for 5 to 10 percent of all cases of Kallmann syndrome. (medlineplus.gov)
  • Most of the CHD7 gene mutations that cause Kallmann syndrome alter single protein building blocks (amino acids) in the CHD7 protein. (medlineplus.gov)
  • Mutations and gene deletions causing the thalassemia genotype have arisen independently in different populations but have subsequently propagated by means of natural selection. (medscape.com)
  • More than 20 different genetic mutations resulting in the functional deletion of both pairs of alpha-globin genes (--/--) have been identified. (medscape.com)
  • There are more than 15 different genetic mutations that result in decreased production of alpha globin, usually through functional deletion of 1 or more of the 4 alpha-globin genes. (medscape.com)
  • Detailed investigation of a few specialized mammalian genes, including the genes controlling the synthesis of hemoglobin, provide important models to understand how such long-range regulatory elements act. (ox.ac.uk)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (nih.gov)
  • By integrating miRNA and mRNA expression profiles, we identified differentially expressed miRNAs and their target genes involved in several hallmarks of cancer. (biomedcentral.com)
  • Further, gene length analysis of the differentially expressed genes showed that the loss of Elp1 mainly impacts the expression of long genes and that by gradually restoring Elongator their expression is progressively rescued. (figshare.com)
  • Unlike the cip-cel operon, these genes are transcribed as monocistronic units of transcription, except cel5D. (nottingham.ac.uk)
  • Genes responsible for carbon source transport (the mal operon for maltose), protein folding (dnaK and mopAB), and iron acquisition (fepBD, entCBA, fecI, and exbBD) were positively controlled by RpoS. (mcmaster.ca)
  • Pneumococci lacking RafK showed a 50- to 80-fold reduction in expression of the raf operon genes aga (alpha-galactosidase) and rafEFG (raffinose substrate binding and permease genes), and both glucose and sucrose inhibited raffinose uptake through inducer exclusion. (lu.se)
  • Like RafK, the presence of DLDH also activated the expression of raf operon genes, as DLDH-negative pneumococci showed a significantly decreased expression of aga and rafEFG, but DLDH did not regulate rafK or the putative regulatory genes rafR and rafS. (lu.se)
  • These observations suggest genetic variants can decrease mRNA expression levels by increasing usage of intronic PAS. (elifesciences.org)
  • We also identified 24 apaQTLs associated with protein levels, but not mRNA expression. (elifesciences.org)
  • FSS also caused a time-dependent increase in the expression of miR-124a, a microRNA known to reduce GR mRNA expression, which was inversely correlated with a reduction in GR mRNA levels 30 min after FSS. (karger.com)
  • Acute stress results in decreased GR mRNA expression specifically in the dentate gyrus. (karger.com)
  • The present study was designed to examine the underlying mechanism(s) by which CKS-17 down-regulates the TNF-alpha mRNA expression using a human acute monocytic leukemia cell line THP-1 stimulated with the superantigen staphylococcal enterotoxin E. A cyclooxygenase inhibitor indomethacin does not reverse the inhibition of TNF-alpha mRNA expression by CKS-17, suggesting that prostaglandins are not responsible for the suppressive action of CKS-17. (duke.edu)
  • Taken together, these results suggest that the synthetic retroviral peptide CKS-17 down-regulates TNF-alpha mRNA expression through inhibition of transcriptional activation of the TNF-alpha gene, which requires de novo synthesis of a transcriptional repressor protein(s). (duke.edu)
  • Using the Caco-2 cell line, which undergoes spontaneous re-differentiation when grown past confluency, we observed a loss of VCAM-1 (vascular cell adhesion molecule 1) mRNA expression, while ICAM-1 (intercellular cell adhesion m. (metu.edu.tr)
  • Moreover, the ability of IL-10 to induce de novo synthesis of SOCS-3 in monocytes correlates with its ability to inhibit expression of many genes in these cells, including endotoxin-inducible cytokines such as tumor necrosis factor-alpha (TNF-alpha) and IL-1. (nih.gov)
  • Thus, the ability of IL-10 to inhibit gene expression in monocytes is associated with its ability to rapidly induce synthesis of SOCS-3. (nih.gov)
  • There, he chose to tackle what was, at the time, a little-known form of translational control: the regulation of ribosomal protein synthesis by the nascent polypeptide. (u-bordeaux.fr)
  • Given the substantial inter-individual variation seen in metabolism, regulation of nutrients, protein synthesis, and detoxification of xenobiotics. (biomedcentral.com)
  • Static and dynamic biomechanical forces of high magnitudes induce proinflammatory genes and inhibit matrix synthesis. (usuhs.edu)
  • Contrarily, dynamic biomechanical signals of low/physiologic magnitudes are potent antiinflammatory signals that inhibit interleukin-1β (IL-1β)-induced proinflammatory gene transcription and abrogate IL-1β/tumor necrosis factor-α-induced inhibition of matrix synthesis. (usuhs.edu)
  • Genes that regulate both the synthesis and the structure of different globins are organized into 2 separate clusters. (medscape.com)
  • Alpha thalassemia syndromes are caused by deficient expression of 1 or more of the 4 alpha-globin genes on chromosome 16 and are characterized by absent or reduced synthesis of alpha-globin chains. (medscape.com)
  • Repressors bind to the Operator, coding sequences on the DNA strand that are close to or overlapping the promoter region, impeding RNA polymerase's progress along the strand, thus impeding the expression of the gene. (wikipedia.org)
  • This was related to an increased DNMT3a protein association with a discreet region of the Nr3c1 (GR gene) promoter, shown here to undergo increased DNA methylation after FSS. (karger.com)
  • The proximal promoter lies just 5' to the coding region for the gene and is active only in thymocytes. (rupress.org)
  • As previously reported, transgenic mice bearing functional proximal promoter sequence juxtaposed with the SV40 large T antigen gene invariably develop lymphoid tumors confined to the thymus. (rupress.org)
  • In the current work, transgenic mice bearing a 2.6-kb fragment of the human distal promoter fused to the SV40 large T antigen gene express large T antigen in thymocytes and in peripheral lymphoid cells, and develop tumors of both the thymus and the peripheral lymphoid organs. (rupress.org)
  • Hence, developmentally regulated, lineage-specific transcription of the lck gene is mediated by distinct promoter sequences that appear to be capable of functioning independently. (rupress.org)
  • The recombinant protein GlyR2 was produced and was shown to bind in vitro to the cel5D and glyR2 promoter regions, suggesting that besides regulating its own expression, GlyR2 may regulate cel5D expression. (nottingham.ac.uk)
  • fusion gene was constructed, with the clpQ + Y + promoter fused to a lacZ reporter gene. (openmicrobiologyjournal.com)
  • In a widely used mouse model of breast cancer, mammary gland-specific expression of the polyoma middle T (PyMT) oncoprotein under the control of the MMTV promoter/enhancer in transgenic mice (MMTV-PyMT) results in widespread transformation of the mammary epithelium and subsequent development of multifocal mammary adenocarcinomas and metastatic lesions in the lymph nodes and in the lungs [ 2 ]. (biomedcentral.com)
  • In turn, we have addressed how, during this process, the upstream elements control the correct spatial and temporal expression from the alpha-gene promoter which lies approximately 60 kb downstream of these elements. (ox.ac.uk)
  • A GA substitution located at -119 of the human AFP promoter is associated with hereditary persistence of AFP (HPAFP) expression in the adult liver (Hum Molec Genet, 1993, 2:379). (uky.edu)
  • Long-range regulation of alpha-globin gene expression. (ox.ac.uk)
  • The alpha-globin genes are encoded on chromosome 16, and the gamma-, delta-, and beta-globin genes are encoded on chromosome 11. (medscape.com)
  • however, their phenotypic expression may be described in simplified clinical terms related to the number of inherited alpha-globin genes. (medscape.com)
  • Alpha thalassemias may be broadly classified according to whether the loss of alpha-globin genes is complete or partial-that is, alpha(0) thalassemia or alpha(+) thalassemia. (medscape.com)
  • Persons who inherit 3 normal alpha-globin genes (-α/αα) are referred to clinically as silent carriers. (medscape.com)
  • Finally, they aim to test the top two gene candidates in mouse models or induced pluripotent stem cells to ensure that they show the predicted expression pattern and to learn whether they exaggerate phenotypes of known autism genes in females but not males. (sfari.org)
  • These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)
  • Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)
  • Some of these modifications that regulate gene expression are inheritable and are referred to as epigenetic regulation. (wikipedia.org)
  • We have hypothesized that butyrate may regulate gene expression post-transcriptionally through global effects on the expression or cytoplasmic trans location of RBPs. (metu.edu.tr)
  • It then homodimerizes and translocates to the nucleus where it binds with high affinity to STAT-binding elements (SBE) in the promoters of various IL-10-responsive genes. (nih.gov)
  • LFY encodes a novel plant-specific DNA-binding protein that can bind in vitro to the promoters of several floral organ-identity genes. (oboolo.com)
  • To examine the mechanism underlying DES-mediated regulation of Fas and FasL, we performed luciferase assays using T cells transfected with luciferase reporter constructs containing full-length Fas or FasL promoters. (diethylstilbestrol.co.uk)
  • In general, these elements contain a high density of evolutionarily conserved, transcription factor-binding sites and in many ways resemble the upstream regulatory elements found adjacent to the promoters of genes in simpler organisms, differing only in the distance over which they act. (ox.ac.uk)
  • In 10 of 14 tumors investigated the breakpoints on the myc carrying chromosome were clustered in a 1.5 kb region 5' of the intact gene, proximal to the myc promoters. (lu.se)
  • One of these genes, SOCS-3 (Suppressor of Cytokine Signaling-3) is a member of a newly identified family of genes that inhibit JAK/STAT-dependent signaling. (nih.gov)
  • We identified SCML2 as the suppressor of somatic/progenitor genes. (grantome.com)
  • Our recent RNA-seq analysis showed that about three thousand spermatogenesis-specific genes are activated, while approximately three thousand genes expressed in both somatic lineages and progenitor cells of the male germline (termed somatic/progenitor genes) are largely suppressed during late spermatogenesis, i.e., in meiosis and in postmeiotic spermatids. (grantome.com)
  • Biofilm-associated cells can be differentiated from their suspended counterparts by generation of an extracellular polymeric substance (EPS) matrix, reduced growth rates, and the up- and down-regulation of specific genes. (cdc.gov)
  • In particular, exposure to CAS resulted in the upregulation of hypha-specific genes known to play a role in biofilm formation, such as ALS3 and HWP1. (who.int)
  • Among 82 newly discovered breast-cancer-related miRNAs, 35 can potentially regulate 271 protein-coding genes based on their sequence complementarity and expression profiles. (biomedcentral.com)
  • In addition to numerous protein-coding genes, many microRNAs (miRNAs) also play important roles in breast cancer. (biomedcentral.com)
  • Light-stimulated transcription of genes for two chloroplast polypeptides in isolated pea leaf nuclei. (wikidata.org)
  • Cis-acting DNA sequences which can increase transcription of genes. (bvsalud.org)
  • Gene regulation is essential for viruses, prokaryotes and eukaryotes as it increases the versatility and adaptability of an organism by allowing the cell to express protein when needed. (wikipedia.org)
  • Gene expression is a mechanism at the molecular level by which a gene is able to express itself in the phenotype of an organism. (qforquestions.in)
  • The molecular steps in the replication pathway that regulate the levels of viral gene expression are not well defined. (microbiologyresearch.org)
  • There will be involved gene engineering and molecular biology methods such as PCR, SDS-PAGE, qPCR, western blot, DNA-protein interaction assays, flow cytometry etc. (lu.se)
  • Depending on the expression status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), it can be classified into four molecular subtypes: luminal A, luminal B, HER2-positive, and basal-like (or triple-negative) breast cancer. (biomedcentral.com)
  • Recent molecular approaches have revealed that specific biomechanical stimuli and cell interactions generate intracellular signals that are powerful inducers or suppressors of proinflammatory and reparative genes in chondrocytes. (usuhs.edu)
  • Regulated gene expression is the expression of genes in which the cellular level of their products varies in response to molecular signals, they are called inducible genes or repressible genes . (online-sciences.com)
  • This approach may be useful for inferring kinetic constants related to expression of antimetastatic genes or oncogenes and on the design of multi-drug therapeutic strategies targeting master regulatory genes. (preprints.org)
  • Taken together, these findings provide insight into how biomechanical signals regulate inflammatory and reparative gene transcription, underscoring their potential in enhancing the ability of chondrocytes to curb inflammation in diseased joints. (usuhs.edu)
  • The inflammatory process in asthma involves the increased expression of various pro-inflammatory chemokines, cytokines, growth factors, lipid mediators, adhesion molecules, enzymes, and receptors for the same inflammatory mediators 21 . (ersjournals.com)
  • The anti-inflammatory actions of corticosteroids occur with a considerable delay (within hours or days) because of the multiple steps of cellular actions required to change protein expression. (ersjournals.com)
  • Butyrate is a SCFA that was reported to alter the mRNA stability of inflammatory genes by increasiing the expression of the RNA binding protein (RBP) Tristetraprolin (TTP). (metu.edu.tr)
  • As a proof of concept, we show butyrate-mediated inhibition in binding of HuR to the 3'UTR of COX-2 mRNA resulting in reduced mRNA and protein levels of the inflammatory gene. (metu.edu.tr)
  • Here we describe how telomere length regulates gene expression long before telomeres become short enough to produce a DNA damage response (senescence). (hal.science)
  • A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. (wikidata.org)
  • A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. (wikidata.org)
  • Immunoglobulin gene transcription is activated by downstream sequence elements. (wikidata.org)
  • Run-on analysis showed transcriptional attenuation in the normal rat myc gene, similar to the situation in mice and humans. (lu.se)
  • Over the past 20 years, there has been an increasing awareness that gene expression can be regulated by multiple cis-acting sequences located at considerable distances (10-1000 kb) from the genes they control. (ox.ac.uk)
  • It has been the albumin and AFP genes contain a number of regulatory sequences important for their expression. (princeton.edu)
  • We determined the nucleotide sequences of a part of rice AS gene (OASA1) corresponding to the site of mutation in 5MT resistant mutant in Arabidopsis and to the site of naturally feedback insensitive AS in Nicotiana tabacum and Ruta graveolens, however, there were no differences in these regions between TR-68 and wild-type. (elsevierpure.com)
  • We investigate the functional relevance of de novo missense variants, specifically whether they are likely to disrupt protein interactions, and nominate novel genes in risk for ASD through integrated genomic, transcriptomic, and proteomic analyses. (springer.com)
  • Thus, arrest peptides are used for metabolite-dependent gene regulation in both prokaryotes and eukaryotes. (u-bordeaux.fr)
  • However, there is substantial inter-individual variation in hepatic gene expression, and although numerous genetic factors have been identified, less is known about the epigenetic factors. (biomedcentral.com)
  • Our analyses generated a comprehensive resource of factors involved in the regulation of hepatic gene expression, and allowed us to estimate the proportion of variation in gene expression that could be attributed to genetic and epigenetic variation, both crucial to understanding differences in drug response and the etiology of liver diseases. (biomedcentral.com)
  • FSS did not affect GR binding to a putative negative glucocorticoid response element within the Nr3c1 gene. (karger.com)
  • 3) used scanning and transmission electron microscopy to ated organisms also differ from their planktonic (freely examine biofilms on trickling filters in a wastewater treatment suspended) counterparts with respect to the genes that are tran- plant and showed them to be composed of a variety of organ- scribed. (cdc.gov)
  • In AMB-exposed biofilms, 2.7% of the genes showed altered expression, while in CAS-exposed biofilms, 13.0% of the genes had their expression modified. (who.int)
  • There was little overlap between AMB- or CAS-responsive genes in biofilms and those that have been identified as AMB, FLU, or CAS responsive in C. albicans planktonic cultures. (who.int)
  • We demonstrate that chromosome looping brings the telomere close to genes up to 10 Mb away from the telomere when telomeres are long and that the same loci become separated when telomeres are short. (hal.science)
  • Alpha-chain genes in duplication on chromosome 16 pairing with non-alpha chains to produce various normal hemoglobins. (medscape.com)
  • Genomic actions involve the regulation of target genes, and suppress most of the vascular elements of inflammation and angiogenesis in the airway. (ersjournals.com)
  • Virtually any step of gene expression can be modulated, from transcriptional initiation, to RNA processing, and to the post-translational modification of a protein. (wikipedia.org)
  • Any step of gene expression may be modulated, from signaling to transcription to post-translational modification of a protein. (wikipedia.org)
  • These data define a regulatory mechanism for the difference in amounts of VP6 and NSP1 and provide evidence for post-transcriptional control of rotavirus gene expression mediated by the translational efficiency of individual viral mRNAs. (microbiologyresearch.org)
  • A possible model for AP2 regulation by miRNA172 can be envisioned in which expression of miRNA172 in the inner two floral whorls causes' translational inhibition of AP2 mRNA in these whorls. (oboolo.com)
  • These signals intercept multiple steps in the NF-κB signaling cascade to regulate cytokine gene expression. (usuhs.edu)
  • Cloning and nucleotide sequence of the simian rotavirus gene 6 that codes for the major inner capsid protein. (microbiologyresearch.org)
  • Ramos, A.F. A Stochastic Binary Model for the Regulation of Gene Expression to Investigate Responses to Gene Therapy. (preprints.org)
  • In this manuscript we use an exactly solvable stochastic binary model for regulation of gene expression to analyse the dynamics of response to a treatment aiming to modulate the number of transcripts of RKIP gene. (preprints.org)
  • Stochastic models of gene transcription with upstream drives: exact solution and sample path characterization. (crossref.org)
  • both for subsequent genome-wide gene silencing and activation during spermatogenesis (termed ?programmed differentiation? (grantome.com)
  • Finally, through evaluation of co-expression modules, we identified gene sets with unique expression patterns that depended on ELP1 expression. (figshare.com)
  • For genes encoding the disrupted interactions, we evaluate their expression patterns across developing brains and within specific cell types, using both bulk and inferred cell-type-specific brain transcriptomes. (springer.com)
  • Using the newly released and larger ASC dataset, we confirm these observations and take them in several new directions: (1) By defining a set of genes encoding these disrupted protein interactors in ASD subjects and another for their siblings, we evaluate their expression patterns in developing brain from fetal to early postnatal development and within general cell types of brain tissue. (springer.com)
  • In multicellular organisms, gene regulation drives cellular differentiation and morphogenesis in the embryo, leading to the creation of different cell types that possess different gene expression profiles from the same genome sequence. (wikipedia.org)
  • Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate. (broadinstitute.org)
  • Together, these developments suggest great potential for the wide applicability of these platforms for better-performing eukaryotic gene regulation, and more sophisticated, customizable reprogramming of cellular activity. (caltech.edu)
  • not unique for the embryonic system but are shared by other ogenesis regulation must consider different scales of multi-cellular modeling areas. (lu.se)
  • Nucleus-specific expression in the multinuclear mushroom-forming fungus reveals different nuclear regulatory programs. (broadinstitute.org)
  • Thus, our work demonstrates that APA links genetic variation to variation in gene expression, protein expression, and disease risk, and reveals uncharted modes of genetic regulation. (elifesciences.org)
  • Furthermore, expression array analysis reveals that many loci, including noncoding RNAs, may be regulated by telomere length. (hal.science)
  • In summary, the identification of a group of exponential phase genes controlled by RpoS reveals a novel aspect of RpoS function. (mcmaster.ca)
  • While riboswitches have generally allowed for versatile and modular regulation, so far their dynamic ranges of output gene modulation have been modest, generally at most 10-fold. (caltech.edu)
  • Negative transcriptional modulation and silencing of the bi-exonic Rnf35 gene in the preimplantation embryo. (nih.gov)
  • Consistent with other studies, genes identified by disrupted protein interactions are expressed early in development and in excitatory and inhibitory neuronal lineages. (springer.com)
  • Using inferred gene co-expression for three neuronal cell types-excitatory, inhibitory, and neural progenitor-we implicate several hundred genes in risk (FDR \(\le \hspace{0.17em}\) 0.05), ~ 60% novel, with characteristics of genuine ASD genes. (springer.com)
  • Across cell types, these genes affect neuronal morphogenesis and neuronal communication, while neural progenitor cells show strong enrichment for development of the limbic system. (springer.com)
  • Given that FD is caused by a reduction, not loss, of ELP1, we generated two new mouse models by introducing different copy numbers of the human FD ELP1 transgene into the Elp1 knockout mouse (Elp1-/-) and observed that human ELP1 expression rescues embryonic development in a dose dependent manner. (figshare.com)
  • In PD subjects, by contrast, expression of IL-2 mRNA was as vigorous as in normal donors, while IFN-γ mRNA was even more strongly inducible. (biu.ac.il)
  • All elements required for proper spatial and temporal regulation of AG expression are contained within this intron. (oboolo.com)
  • By combining gene functional and pathway annotation with miRNA-mRNA interactions, we created a PyMT-specific tripartite miRNA-mRNA-pathway network and identified novel functional regulatory programs (FRPs). (biomedcentral.com)
  • By analyzing the methylomes and transcriptomes of 14 fetal and 181 adult livers, we identified 657 differentially methylated genes with adult-specific expression, these genes were enriched for transcription factor binding sites of HNF1A and HNF4A. (biomedcentral.com)
  • In three separate lines of transgenic mice, expression in fetal livers was high, and this level persisted into adulthood. (princeton.edu)
  • In addition, I show that Elovl3 expression is reduced in liver tumors, fibrotic livers and fatty livers, raising the possibility that Elovl3 can serve as a marker for HCC and liver damage. (uky.edu)
  • The change in distribution of gene 5 mRNA in polyribosome gradients in response to treatment with low concentrations of cycloheximide suggested that gene 5 is a poor translation initiation template compared with gene 6 mRNA. (microbiologyresearch.org)
  • Initiation of B class gene expression by LFY, UFO and AP1. (oboolo.com)
  • Initiation of AG expression by LFY and WUS. (oboolo.com)
  • In contrast, sedimentation of more than half of the gene 5 mRNA was subpolysomal. (microbiologyresearch.org)
  • In contrast, an AFP gene activated by the albumin enhancer was repressed after birth. (princeton.edu)
  • In contrast, 5MT did not affect the expression of AS genes in TR-68. (elsevierpure.com)
  • We then conducted a comprehensive transcriptome analysis in mouse embryos to identify genes and pathways whose expression correlates with the amount of ELP1. (figshare.com)
  • Heukelekian and genes involved in cell adhesion and biofilm formation. (cdc.gov)
  • This platform can potentially be employed to regulate the expression of any transgene or any endogenous gene by 3' UTR replacement, allowing for more complex cell state-specific reprogramming. (caltech.edu)