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  • systemic
  • The Food and Drug Administration (FDA) approved Benlysta® (belimumab), a new biologic therapy developed to treat patients suffering from active, autoantibody-positive systemic lupus erythematosus (SLE). (medicalnewstoday.com)
  • Variants in this gene have been associated with insulin-dependent diabetes mellitus, Graves' disease, Hashimoto's thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, primary biliary cirrhosis and other autoimmune diseases. (wikipedia.org)
  • Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (wikipedia.org)
  • Systemic therapy is often used in conjunction with other modalities that constitute local therapy (i.e. treatments whose efficacy is confined to the anatomic area where they are applied) for cancer such as radiation therapy, surgery or hyperthermia therapy. (wikipedia.org)
  • Belimumab (Benlysta) is a monoclonal antibody developed by Human Genome Sciences and GlaxoSmithKline, with significant discovery input by Cambridge Antibody Technology, which specifically recognizes and inhibits the biological activity of B-Lymphocyte stimulator (BLyS) and is in clinical trials for treatment of Systemic lupus erythematosus and other autoimmune diseases. (wikipedia.org)
  • Tissues
  • 23 million Americans have these diseases, where the body attacks its own tissues. (healthline.com)
  • Autoimmune diseases are conditions in which the patient's immune system generates cellular and antibody responses to substances and tissues normally present in the body. (cellmedicine.com)
  • Besides healing damaged tissues, stem cells have the unique ability to modulate the immune system so as to shut off pathological responses while preserving its ability to fight off disease. (cellmedicine.com)
  • We describe and discuss novel therapeutic strategies that directly interfere with the production and regulation of pathogenic autoantibodies (rituximab), their catabolism (intravenous immunoglobulins), and their presence in the circulation and extravascular tissues such as the skin (immunoadsorption), leading to a significant amelioration of disease. (springer.com)
  • Rather than looking at overall gene expression in all cells, we focused on how these genes upregulated gene expression in specific cell types and tissues, and found patterns that were directly relevant to specific diseases. (technologynetworks.com)
  • By understanding cell signaling, diseases may be treated more effectively and, theoretically, artificial tissues may be created. (wikipedia.org)
  • chronic inflammatory
  • RR-MS is a chronic inflammatory demyelinating disease of the central nervous system (CNS) associated with an accumulation of immune cells at lesion sites. (rupress.org)
  • These conditions include primary immunodeficiency, idiopathic thrombocytopenic purpura, chronic inflammatory demyelinating polyneuropathy, Kawasaki disease, certain cases of HIV/AIDS and measles, Guillain-Barré syndrome, and in certain other infections when a more specific immunoglobulin is not available. (wikipedia.org)
  • rituximab
  • Rituximab treatment combined with monthly IV immunoglobulin infusions has resulted in long-term remission with no recurrence of disease in 10 years after treatment was halted. (wikipedia.org)
  • complications
  • With any unrelated health complications, including autoimmune responses," Step back, give yourself care and permission to be felt by palpating the thyroid is the same genetic predispositions. (autoimmunediseaseaid.com)
  • The National Advisory Committee on Blood and Blood Products of Canada (NAC) and Canadian Blood Services have also developed their own separate set of guidelines for the appropriate use of immunoglobulin therapy, which strongly support the use of immunoglobulin therapy in primary immunodeficiencies and some complications of HIV, while remaining silent on the issues of sepsis, multiple sclerosis, and chronic fatigue syndrome. (wikipedia.org)
  • inflammatory
  • Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. (springer.com)
  • Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. (springer.com)
  • concluded that pig whipworm seemed to help inflammatory bowel disease. (healthline.com)
  • TxCell and Ferring are collaborating on the development of TxCell's lead product Ovasave for inflammatory bowel diseases under an option, development and license agreement potentially worth up to EUR 76 million plus royalties. (technologynetworks.com)
  • In June 2015 Celgene announced it had licensed Lyceras RORgamma agonist portfolio for up to $105 million and continue to develop its Phase I lead compound LYC-30937 for the treatment of inflammatory bowel disease. (wikipedia.org)
  • hepatitis
  • According to Virginia T. Ladd, President and Executive Director of the American Autoimmune Related Diseases Association (AARDA), "The FDA's approval of Benlysta is momentous not only for the new hope it brings to the 300,000 to 1.5 million Americans suffering with lupus but also for the millions of Americans who suffer from many other autoimmune diseases such as autoimmune hemolytic anemia and autoimmune hepatitis . (medicalnewstoday.com)
  • Wistar researchers are collaborating with leading scientists worldwide to develop vaccines for hepatitis C, malaria, and other potentially deadly diseases. (wikipedia.org)
  • antibody
  • Some cases of reactivation of the disease have been reported Alemtuzumab is a recombinant DNA-derived humanized IgG1 kappa monoclonal antibody that is directed against the 21-28 kDa cell surface glycoprotein CD52. (wikipedia.org)
  • Immunology
  • The Wistar Institute is an international leader in biomedical science, with special expertise in oncology, immunology, infectious disease and vaccine research. (wikipedia.org)
  • genes
  • We identified genes with a biological relevance to these diseases, acting along gene networks and pathways that may offer very useful targets for therapy. (technologynetworks.com)
  • In August 2000, Celgene acquired Signal Pharmaceuticals, Inc., a privately held company that searches for and develops pharmaceuticals that regulate disease-related genes. (wikipedia.org)
  • treatments
  • These diseases, along with lupus, have not seen the development of specific new treatments since the 1950s. (medicalnewstoday.com)
  • Benlysta exemplifies a welcomed interest by today's biotechnology and pharmaceutical companies to investigate and develop new treatments for orphan and less common diseases. (medicalnewstoday.com)
  • infectious
  • Each mother has her medical history screened and is tested for infectious diseases. (cellmedicine.com)
  • The Use of the Developing Egg in Virus Research (Special Report No, 220), London: Medical Research Council, 1936 Biological Aspects of Infectious Disease Cambridge: Cambridge University Press, 1940. (wikipedia.org)
  • Later editions of the book were published as The Natural History of Infectious Disease in 1953, 1962 and in 1973 with D.O. White. (wikipedia.org)
  • The Background of Infectious Diseases in Man. (wikipedia.org)
  • cancer
  • A new discovery by an international research team-co-led by UBC Canada 150 Research Chair Josef Penninger and Harvard Medical School neurobiologist Clifford Woolf-could have implications for therapies for cancer and autoimmune diseases. (ubc.ca)
  • The basic CAR T cell concept was first described in the late 1980s, principally as an anti-cancer strategy, but technical challenges delayed its translation into successful therapies. (medicalxpress.com)
  • Following her time at the JDRF, Hehenberger served as the Executive Vice President of Scientific Affairs and Chief Medical Officer at Coronado Biosciences, Inc., a publicly traded biopharmaceutical company that develops immunotherapy biologic agents for autoimmune diseases and cancer. (wikipedia.org)
  • human
  • Human immunoglobulin therapy first occurred in the 1930s and a formulation for injection into a vein was approved for medical use in the United States in 1981. (wikipedia.org)
  • Melbourne: Macmillam, 1942 Virus as Organism: evolutionary and ecological aspects of some human virus diseases. (wikipedia.org)
  • adults
  • Discoveries at Wistar have led to the creation of vaccines that protect children and adults from widespread, debilitating, and life-threatening diseases. (wikipedia.org)
  • genetic
  • Our approach did more than finding genetic associations among a group of diseases," said study leader, Hakon Hakonarson, M.D., Ph.D., director of the Center for Applied Genomics at The Children's Hospital of Philadelphia (CHOP). (technologynetworks.com)