• Currently, the etiology of drug-induced gingival overgrowth is not entirely understood but is clearly multifactorial. (medscape.com)
  • However, the complete etiology of drug-induced myopathies remains unclear. (degruyter.com)
  • Pazopanib therapy is commonly associated with transient elevations in serum aminotransferase during therapy and has been linked to rare, but occasionally severe and even fatal cases of clinically apparent acute liver injury. (nih.gov)
  • We report a patient who developed transient euthyroid hyperthyroxinemia within a few weeks of initiation of lithium therapy. (psychiatrist.com)
  • To our knowledge, this is the first reported case of lithium-induced transient euthyroid hyperthyroxinemia. (psychiatrist.com)
  • CMV infection has been shown to induce transient abnormalities of in vitro cellular-immune function in otherwise healthy human hosts (2,3). (cdc.gov)
  • A very similar set of genes is induced in unlesioned animals by administration of the psychostimulant cocaine or the antipsychotic eticlopride, although in distinct striatal cell populations. (jneurosci.org)
  • Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. (nih.gov)
  • Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. (nih.gov)
  • Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. (nih.gov)
  • The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. (nih.gov)
  • The Phase II clinical trial was a multi-center, double-blind, placebo-controlled study designed to evaluate the motoric tolerability, antipsychotic efficacy, and safety of ACP-103 in patients with Parkinson's disease suffering from treatment-induced psychosis. (acadia.com)
  • We propose that hypometabolism, coupled with oxidative stressors, is responsible for most Alzheimer disease (AD) and cerebrovascular accidents (CVAs) and appears to be a central initiating factor for vascular abnormalities, mitochondrial damage and an imbalance in the activity of vasoactive substances, such as different isoforms of nitric oxide synthase (NOS), endothelin-1 (ET-1), oxidative stress markers, mtDNA and mitochondrial enzymes in the vascular wall and in brain parenchymal cells. (nih.gov)
  • In addition to this, the rising incidence of several associated risk factors, such as drug abuse, traumatic brain injury, arteriovenous malformations, vascular abnormalities, use of blood-thinning medications, etc., is also propelling the market growth. (imarcgroup.com)
  • Adefovir dipivoxil (ADV)-induced renal tubular dysfunction and hypophosphatemic osteomalacia (HO) have been given great consideration in the past few years. (biomedcentral.com)
  • Early replacement therapy is recommended when proximal renal tubular abnormalities are detected to help prevent and control the severe metabolic bone disease associated with the Fanconi syndrome. (lvhn.org)
  • SCLE may occur in patients with systemic lupus erythematosus (SLE), Sjögren syndrome , deficiency of the second component of complement (C2d), or it may be drug-induced. (medscape.com)
  • In perhaps as many as 30% of patients with SCLE, drugs may exacerbate or induce their disease. (medscape.com)
  • Data is lacking on the natural history, response to therapy and survival of patients diagnosed with precapillary pulmonary hypertension (PH) with mild or borderline elevation of PVR. (ersjournals.com)
  • Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. (nih.gov)
  • In large clinical trials, abnormalities in routine liver tests were common in patients treated with pazopanib, with serum aminotransferase elevations occurring in up to half of patients and total serum bilirubin in approximately one-third. (nih.gov)
  • Heparin-induced thrombocytopenia (HIT) is a rare but important cause of morbidity and mortality in patients exposed to heparin [ 1 ]. (biomedcentral.com)
  • DESCRIPTION (provided by applicant): The objective of this project is to develop a genetic test, involving the protein, RGS9, to identify patients that are at risk for developing tardive dyskinesia (TD) or L-DOPA induced dyskinesia (LID). (sbir.gov)
  • To further determine the clinical features of ADV-induced HO in Chinese chronic hepatitis B patients, we investigated the demographics, clinical spectrum, laboratory tests, treatment and prognosis of ADV-induced HO through a comparison of Chinese and non-Chinese case series. (biomedcentral.com)
  • Can usually be discontinued after several weeks, but maintenance therapy may be necessary for some patients. (genesight.com)
  • Moreover, the emerging popularity of stem cell therapy, owing to its various benefits, such as promoting tissue regeneration, enhancing recovery, modulating inflammatory response in patients, etc., is expected to drive the brain hemorrhage market in the coming years. (imarcgroup.com)
  • The formation of therapy is asymptomatic patients who do not appear to thrive and thereby increase over 10. (eostone.com)
  • Recognition of a potential drug-induced Fanconi syndrome is important when managing pediatric oncology patients previously treated with ifosfamide. (lvhn.org)
  • Their immune-boosting quality has one major drawback, their proclivity to induce a broad array of immune-related adverse events (irAEs) affecting, among others, the liver and sharing some similarities with classic autoimmune liver diseases (AILD).We aimed to compare clinical, laboratory and histological features of patients with liver-related irAEs and AILD. (bmj.com)
  • It is also approved in over 40 countries for the treatment of adults with moderate to severe AD who are candidates for systemic therapy and approved in Japan for the treatment of certain hospitalized patients with COVID-19. (nationaleczema.org)
  • OLUMIANT ® (baricitinib) 2-mg is indicated for the treatment of adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more tumor necrosis factor (TNF) antagonist therapies. (nationaleczema.org)
  • Test patients for latent TB before initiating Olumiant and during therapy. (nationaleczema.org)
  • Carefully consider the risks and benefits of Olumiant prior to initiating therapy in patients with chronic or recurrent infection. (nationaleczema.org)
  • Closely monitor patients for the development of signs and symptoms of infection during and after treatment with Olumiant including the possible development of TB in patients who tested negative for latent TB infection prior to initiating therapy. (nationaleczema.org)
  • Patients with active infection on chest X-ray are given isoniazid combined with other antituberculous drugs . (hdkino.org)
  • SAN DIEGO, March 23 /PRNewswire-FirstCall/ - ACADIA Pharmaceuticals Inc. (Nasdaq: ACAD) today reported results from its Phase II clinical trial of ACP-103 in patients with Parkinson's disease suffering from treatment-induced psychosis. (acadia.com)
  • The trial results are encouraging and suggest that ACP-103 may provide an important advance in the therapy for patients with Parkinson's disease. (acadia.com)
  • The study involved once-daily oral administration of either ACP-103 or placebo for a 28-day period to patients who also received their stable dopamine replacement therapy. (acadia.com)
  • however, 27 % of patients who received the combination therapy developed signs of HF (16 % were in New York Heart Association [NYHA] class III-IV). (touchoncology.com)
  • or patients who have failed or are intolerant to other available osteoporosis therapy. (rxlist.com)
  • however, the septic shock in the early onset of sepsis, which induced by cytokine storm and cardiac dysfunction, is also an important cause of death for septic patients, especially for the young patients with toxic shock syndrome or meningococcemia ( 2 ). (frontiersin.org)
  • POETYK PSO-1 (N=664) and POETYK PSO-2 (N=1020) were two, 52-week, multicenter, randomized, double-blind, placebo- and active (apremilast 30 mg twice daily)-controlled, Phase 3 studies to evaluate the safety and efficacy of SOTYKTU (6 mg once daily) in adult patients with moderate-to-severe plaque psoriasis who were eligible for systemic therapy or phototherapy. (sotyktuhcp.com)
  • Patients may prefer oral therapies, and many patients and physicians are looking for additional efficacious and tolerable options. (tpmg.pro)
  • The results are particularly meaningful for dermatologists and patients who have been waiting for a more effective and convenient oral therapy to help manage this serious, chronic, immune-mediated disease. (tpmg.pro)
  • An elevated arterial or free venous serum ammonia level is the classic laboratory abnormality reported in patients with hepatic encephalopathy. (medscape.com)
  • Patients with drug-induced pulmonary eosinophilia commonly have crackles on physical examination. (medscape.com)
  • In continued therapy, gradually reduce dosage to the lowest effective maintenance level, after symptoms have been controlled for a reasonable period. (genesight.com)
  • If symptoms persist for 2 to 3 days, parenteral therapy is indicated. (genesight.com)
  • Furthermore, the inflating adoption of effective drugs, including diuretics, antihypertensive agents, antiepileptics, etc., for reducing the disease symptoms is acting as another significant growth-inducing factor. (imarcgroup.com)
  • In case presentation a role of in his symptoms included cortisol replacement therapy in the lowest. (eostone.com)
  • Our study suggests that inhibiting a certain enzyme in the brain could be an effective therapy for countering the debilitating symptoms of FXS in children, and possibly in autistic kids as well," said co-author Mansuo L. Hayashi, a former Picower Institute postdoctoral fellow currently at Merck Research Laboratories in Boston. (mit.edu)
  • From a clinical perspective, if a clinician finds elevated thyroxine levels in the absence of overt thyrotoxicosis in a patient started on lithium therapy, it would seem prudent to carefully monitor clinically for development of thyrotoxic symptoms without immediately resorting to an extensive and expensive diagnostic workup. (psychiatrist.com)
  • Specific medical therapies may be applied to many liver diseases in an effort to diminish symptoms and to prevent or forestall the development of cirrhosis. (medscape.com)
  • Symptoms may start hours after taking the medications or, more commonly, after several days of therapy. (medscape.com)
  • eg, caused by diving) or strenuous activities (eg, weightlifting) can induce a perilymphatic fistula between the middle and inner ear, causing sudden, severe symptoms. (msdmanuals.com)
  • This condition may follow certain diseases such as syphilis, or can result from fever, trauma, systemic upsets or adverse reaction to drugs. (wikipedia.org)
  • SOTYKTU is indicated for the treatment of moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy. (sotyktuhcp.com)
  • PRINCETON, N.J.-( BUSINESS WIRE )- Bristol Myers Squibb (NYSE:BMY) today announced that the European Commission has approved Sotyktu (deucravacitinib), a first-in-class, selective tyrosine kinase 2 (TYK2) inhibitor, for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy, representing a new way of treating this chronic immune-mediated disease. (tpmg.pro)
  • At presentation, the routine laboratory test results showed no abnormalities. (biomedcentral.com)
  • Moreover, we will discuss mechanisms of drug-induced SKM injury, traditional laboratory testing for SKM injury, and novel skeletal myocyte biomarkers under investigation. (degruyter.com)
  • Pazopanib is susceptible to drug-drug interactions with agents that inhibit or induce hepatic CYP 3A4 activity. (nih.gov)
  • Halting PAK's enzymatic activity reversed the structural abnormality of neuronal connections found in the FXS mice, said co-author Susumu Tonegawa, 1987 Nobel laureate and Picower Professor of Biology and Neuroscience. (mit.edu)
  • Birth defects can be defined as structural or functional abnormalities, including metabolic disorders, which are present from birth. (who.int)
  • Additional implicated agents include calcium channel blockers, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs, antifungal agents (particularly terbinafine), chemotherapy agents, immunotherapies, proton pump inhibitors, and tumor necrosis factor (TNF) antagonists. (medscape.com)
  • The use of dopamine antagonists as antipsychotics can result in tardive dyskinesia, while drugs such as cocaine that increase striatal dopamine release can cause dependency and addiction (for review, see Hyman, 1996 ). (jneurosci.org)
  • There are several hypotheses about the mechanisms by which calcium antagonists induce gingival hyperplasia, but further investigation is still needed. (medscape.com)
  • Antineoplastic therapy is frequently complicated by the development of cardiotoxicity, either as the direct effects of chemotherapy on the heart, such as left ventricular dysfunction (LVD), heart failure (HF) or ischaemia, or as indirect effects due to haemodynamic changes, thrombotic events or hypertension. (touchoncology.com)
  • The patient has been treated with 2 short courses of TMP/SMX that have been limited because of a sulfa-induced neutropenia. (cdc.gov)
  • The mechanisms of NAFLD and in particular fructose-induced lipid accumulation remain unclear, although there is evidence for a role for endoplasmic reticulum (ER) stress and oxidative stress. (aurorakinaseb.com)
  • Although the role of lithium in thyroid hormone synthesis and release has been extensively investigated and reviewed, 9 how it may induce euthyroid hyperthyroxinemia is unclear. (psychiatrist.com)
  • The following article summarises the recent data in the literature on the epidemiology and pathophysiology of cardiotoxicity induced by different target drugs, as well as strategies for patient management before, during and after antineoplastic treatment, early diagnosis of cardiovascular adverse events, with particular attention on the role of echocardiography. (touchoncology.com)
  • The pathophysiology of sepsis includes inflammation, immune dysfunction, and dysfunction of coagulation, while sepsis-induced cardiomyopathy ( SIC ), defined as a global but reversible dysfunction of both sides of the heart induced by sepsis, plays a significant role in all of the aspects above in the pathogenesis of sepsis. (frontiersin.org)
  • Phenotypic features include primary hypogonadism, renal abnormalities, and profound short stature. (sbir.gov)
  • The delicate balance between effective cancer therapy and the risk of secondary cardiovascular disease that could affect the gain of survival, requires a profound collaboration between oncologists and cardiologists, with the aim of creating a personalised therapy for the patient and their illness. (touchoncology.com)
  • Circulating Pneumolysin, another common PAMP produced by Streptococcus pneumoniae , induced cardiomyocyte injury through triggering profound calcium influx during pneumococcal infection ( 11 ). (frontiersin.org)
  • Initial hearing loss is typically unilateral (unless drug-induced) and may range in severity from mild to profound. (msdmanuals.com)
  • In addition, checkpoint inhibitors are more frequently being employed in combination with other agents (including with other checkpoint inhibitors) in clinical practice, as well in hundreds of combination drug trials with other novel biological, targeted, and immunotherapies. (degruyter.com)
  • The use of checkpoint inhibitors in combination therapy further complicates the safety monitoring of SKM injury due to the potential for drug-drug interactions. (degruyter.com)
  • Limitation of Use: Not recommended for use in combination with other JAK inhibitors, biologic disease-modifying antirheumatic drugs (DMARDs), or with potent immunosuppressants such as azathioprine and cyclosporine. (nationaleczema.org)
  • Isoniazid is used to prevent active tuberculosis in persons who have an abnormal skin test for tuberculosis (latent tuberculosis) or in combination with other drugs for the treatment of active tuberculosis. (hdkino.org)
  • 2 However, even these new target drugs have been shown to have a cardiotoxic potential, especially when used as combination therapies, by inhibition of transduction pathways in normal or non-cancerous cells. (touchoncology.com)
  • The drug treatment of Parkinson's disease produces a high incidence of hallucinations and paranoid delusions, which in turn are the most common causes for nursing home placement. (acadia.com)
  • Cell Therapy for Parkinson's Disease: What Next? (lu.se)
  • In a person with PCB-induced chloracne, the acne-like lesions arise as a result of inflammatory responses to irritants in the sebaceous glands. (cdc.gov)
  • Celecoxib is among the more potent and better clinically studied, nonsteroidal anti-inflammatory drugs (NSAID) for use as a chemoprevention agent for colorectal cancer. (bvsalud.org)
  • Phenytoin has been shown to induce gingival overgrowth by its interaction with a subpopulation of sensitive fibroblasts. (medscape.com)
  • AHS typically appears one to four weeks after the initiation of therapy with an aromatic antiepileptic drug, such as Phenytoin, Phenobarbital, or Carbamazepine. (okstate.edu)
  • These findings indicate that the colonic mucosal injury induced by FC-exposure are associated with oxidative stress generation, inflammation response and cell apoptosis, as well as the changes in gut microbes diversity and composition. (bvsalud.org)
  • Tell your doctor about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. (rxlist.com)
  • In this report, the parenteral drug used was GMP certified and produced by the US Army Medical Materiel Development Activity. (cdc.gov)
  • All 5 reported using inhalant drugs, and 1 reported parenteral drug abuse. (cdc.gov)
  • The clinical picture of drug-induced myopathies may range from asymptomatic or mild myalgias, with or without muscle weakness, which are likely underreported, to chronic myopathy with severe weakness and rarely, even to massive rhabdomyolysis with acute kidney injury (AKI) [ 1 ]. (degruyter.com)
  • While artemisinin-based therapies are well tolerated, recent studies have reported cases of severe delayed hemolysis after artesunate treatment for malaria ( 1 - 5 ). (cdc.gov)
  • INDIANAPOLIS, July 16, 2021 /PRNewswire/ - Eli Lilly and Company (NYSE: LLY) and Incyte (NASDAQ:INCY) announced today that the U.S. Food and Drug Administration (FDA) will not meet the Prescription Drug User Fee Act (PDUFA) action date for the supplemental new drug application (sNDA) for baricitinib for the treatment of adults with moderate to severe atopic dermatitis (AD). (nationaleczema.org)
  • The endotoxin-induced myocardial dysfunction probably depends on the toll-like receptor (TLR) 4-induced cytokines release as a delay in onset of myocardial depression after endotoxin administration ( 10 ). (frontiersin.org)
  • Other TLR-related genes (TLR2, 3, and 9) were demonstrated to be involved in sepsis-induced cardiac dysfunction from recent studies. (frontiersin.org)
  • Heparin-induced thrombocytopenia (HIT) is an antibody-mediated adverse drug reaction characterized by thrombocytopenia and thromboembolism. (biomedcentral.com)
  • In the past year, four antibody-drug conjugates (ADC) were approved, nearly doubling the marketed ADCs in oncology. (aacrjournals.org)
  • Trastuzumab is a humanised monoclonal antibody against the human epidermal growth factor receptor (HER2), a tyrosine kinase receptor overexpressed at the time of diagnosis in 15 % of breast cancer (BC) and up to 20-30 % of metastatic BC, 4 which is associated with more aggressive disease, poor response to therapy and survival. (touchoncology.com)
  • Until the current report, data showed that Wyeth HDCV administered intramuscularly induced acceptable antibody levels. (cdc.gov)
  • In Australia, PAH therapy could be prescribed solely on mean pulmonary arterial pressure (PAP) and pulmonary arterial wedge pressure (PAWP) criteria. (ersjournals.com)
  • Daptomycin-induced pulmonary infiltrates with eosinophilia. (medscape.com)
  • In Iceland, a single case of varenicline hepatotoxicity has been reported (Case 1), there having been an estimated 20,000 persons treated with the drug in the country since its introduction. (nih.gov)
  • The rare reports of hepatotoxicity attributed to varenicline therapy have been mild and self-limiting. (nih.gov)
  • Current therapies include topicals, orals and biologics. (tpmg.pro)
  • In clinical practice, as well as during drug development and in clinical trials, the diagnosis of SKM injury can be challenging due to the variable symptomology, reliance on patient-self reporting, and lack of highly specific biomarkers, such as those available for cardiac myocyte injury (i.e., cardiac troponins) [ 3 ]. (degruyter.com)
  • One example is dynorphin gene expression, which is progressively induced in dorsal striatum by cocaine. (jneurosci.org)
  • Moreover, the rapid rise of new therapeutics with the potential to cause SKM injury, such as immunotherapies and targeted therapies, as well as new treatments (such as gene therapy) specifically targeting muscular or neuromuscular diseases, demands an improved clinical strategy to identify myocyte injury and enable appropriate and timely clinical intervention. (degruyter.com)
  • These are intriguing findings because the expression of the gene that inhibits PAK occurs in the third week after birth, which means that the neuronal abnormalities in the fragile X mouse are reversed after they appear," said Eric Klann, a professor at New York University's Center for Neural Science. (mit.edu)
  • Financial considerations in expanded access policy for gene therapies: A tough nut to crack? (cdc.gov)
  • It is frequently associated with an internal disorder, trauma, infection, nail fungi, allergy to nail enhancement products, or side effects of drugs. (wikipedia.org)
  • Therapy should be initiated by a health care provider experienced in the management of HIV infection. (who.int)
  • Sepsis is a lethal syndrome induced by infection, which has a reported annual death of 200,000 in the United States ( 1 ). (frontiersin.org)
  • These include direct myotoxicity (caused by alcohol, cocaine, glucocorticoids, and statins, amongst others), immunologically-induced inflammatory myopathy (caused by D-penicillamine, statins, and anti-cancer drugs), and indirect SKM injury (occurs as a result of a variety of different mechanisms). (degruyter.com)
  • She had no history of liver disease, alcohol abuse, risk factors for viral hepatitis or drug allergies. (nih.gov)
  • Maternal illnesses like diabetes mellitus, conditions such as iodine and folic acid deficiency, and exposure to medicinal and recreational drugs including alcohol and tobacco, certain environmental chemicals, and high doses of radiation are other factors that cause birth defects. (who.int)
  • Although there was no significant difference in the duration of ADV therapy before ostalgia onset, the C group tended to develop adverse events earlier, by 2-3 years, while the F group developed adverse events at 4-5 years ( Z = − 1.517, P = 0.129). (biomedcentral.com)
  • 1 While lithium treatment has been associated with a wide range of adverse effects, 2 , 3 thyroid-related abnormalities, especially hypothyroidism, are the most commonly reported ones. (psychiatrist.com)
  • Therefore, mitochondrial DNA abnormalities such as overproliferation and or deletion can be used as a key marker for diseases differentiation and effectiveness of the treatment. (nih.gov)
  • Ferric citrate (FC) has been used as an iron fortifier and nutritional supplement, which is reported to induce colitis in rats, however the underlying mechanism remains to be elucidated. (bvsalud.org)
  • The mechanism of injury accounting for serum enzyme elevations during pazopanib therapy is not known. (nih.gov)
  • Varenicline has been associated with a low rate of serum enzyme elevations during therapy and, since approval and its widescale use, with rare instances of clinically apparent mild liver injury. (nih.gov)
  • Varenicline has not been associated with rates of serum enzyme elevations during therapy greater than occurs with placebo therapy, but information on these abnormalities is limited and occasional instances of asymptomatic ALT elevations leading to drug discontinuation have been reported. (nih.gov)
  • Drug-induced myopathies may result from various mechanisms. (degruyter.com)
  • At higher concentrations, ROS induces cell injury and death, which occurs during the aging process, where accelerated generation of ROS and a gradual decline in cellular antioxidant defense mechanisms, especially in the mitochondria. (nih.gov)
  • Here, we reviewed the latest literatures on the mechanisms and treatments of SIC and hope to provide further insights to researchers and create a new road for the therapy of sepsis. (frontiersin.org)
  • Isoniazid is an anti-bacterial drug that has been used to prevent and to treat tuberculosis since 1952. (hdkino.org)
  • Is isoniazid, INH available as a generic drug? (hdkino.org)
  • Isoniazid-associated hepatitis usually occurs during the first three months of treatment but can occur at any time during therapy or even many months after starting treatment. (hdkino.org)
  • Shared decision making resulted in the patient discontinuing all prescribed medications and was empirically treated for a drug-induced hypersensitivity reaction with oral Prednisone. (okstate.edu)
  • Obtain a detailed drug history, including prescription and over-the-counter medications, nutritional supplements, and illicit drugs. (medscape.com)
  • Chronic HBV carriers can be defined as those people in the immune tolerance phase who are positive for HBsAg, HBeAg, and HBV DNA and have normal liver function and no obvious abnormalities in the liver histology, and this situation might be maintained for several years or even decades [ 4 , 5 ]. (hindawi.com)
  • Active, chronic disease of the immune system (including stable disease treated with immune therapy (e.g. (who.int)
  • Similar cases have shown this clinical picture within weeks of exposure to antiepileptic drugs. (okstate.edu)
  • We herein report a rare presentation of Anticonvulsant Hypersensitivity Syndrome after 26 years of exposure to antiepileptic drugs in an 81 year old female. (okstate.edu)
  • Sufficient attention is required for middle-aged males before and during exposure to long-term ADV therapy, regardless of nationality. (biomedcentral.com)
  • Platelet count, hemoglobin level, hemorrhagic events and treatment in a patient with HIT after cardiovascular interventional therapy. (biomedcentral.com)
  • Pacerone (amiodarone HCl) is an antiarrhythmic drug indicated for treatment of recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia only when these conditions have not responded to documented adequate doses of other available antiarrhythmics or when alternative agents could not be tolerated. (rxlist.com)
  • This includes treatment practices, in-market, and pipeline drugs, share of individual therapies, market performance across the seven major markets, market performance of key companies and their drugs, etc. (imarcgroup.com)
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. (nih.gov)
  • Unfortunately, the available biomarkers for SKM injury do not fully meet the needs for satisfactory detection of drug-induced damage, both in clinical and research settings, mainly due to their low sensitivity and specificity. (degruyter.com)
  • This can be incredibly useful in both clinical practice and for de-challenge/re-challenge investigational trials where the risk of drug-induced SKM injury is present. (degruyter.com)
  • On the basis of the above researches, we hypothesized that serum miR-122 can act to evaluate conditions HBV-induced liver injury at different stages. (hindawi.com)
  • A diagnosis of artesunate-associated hemolysis was made in this case based on the temporal relationship with therapy and the absence of other identified causes of intravascular hemolysis. (cdc.gov)
  • Liver test abnormalities are frequent during pazopanib therapy and routine monitoring is recommended at 3 to 4 week intervals. (nih.gov)
  • However, drug-induced myopathy is among the most frequent causes of muscle disease. (degruyter.com)
  • Over the last 20 years, considerable progress has been made in the management of cancer due to the introduction of targeted molecular therapies. (touchoncology.com)
  • If SCLE is drug-induced, withdrawal of the culprit medication in conjunction with medical therapy is often necessary for disease control. (medscape.com)
  • Our Pacerone (Amiodarone HCl) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • However, the status of oral health prior to onset of gingival overgrowth combined with the medication are both clearly involved in the onset of drug-induced gingival hyperplasia. (medscape.com)
  • Our Prolia (denosumab) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)