Therapy dose response relationship radiation. Medical search. Frequent questions

Low-dose cisplatin and 5-fluorouracil (LDPF) chemotherapy with daily radiotherapy (RT) is used as an alternative chemoradiotherapy regimen for locally advanced esophageal carcinoma. (nih.gov)
BACKGROUND AND PURPOSE: The apparent diffusion coefficient (ADC), a potential imaging biomarker for radiotherapy response, needs to be reproducible before translation into clinical use. (bvsalud.org)
However, after adjustment for age, PS, radiotherapy dose, and logarithmic GTV, CACs did not have a statistically significant impact on OS with hazard ratios of 1.04 (95% CI 0.85-1.28), 1.11 (95%CI 0.89-1.43), and 1.16 (95%CI 0.92-1.47) for CACs 1-99, CACs 100-399 and ≥400, respectively. (bvsalud.org)
Biological basis for fractionation of radiotherapy and dose-response relationships in the clinic as well as other approaches to improve radiotherapy will be covered in depth, which include treatment interruption and retreatment issues, targeting hypoxia, biological modifiers and combined radiotherapy/chemotherapy. (seafomp.org)
The calculation of the absorbed dose in molecular radiotherapy based on the MIRD scheme relies on the determination of the time-integrated activity coefficients (TIACs) and S-values. (seafomp.org)
Hall EJ: Time, dose, and fractionation in radiotherapy. (smallanimaloncology.com)
Dynamic trajectory radiotherapy (DTRT) extends volumetric modulated arc therapy (VMAT) with dynamic table and collimator rotation during beam-on. (biomedcentral.com)
The introduction of intensity-modulated radiotherapy (IMRT) has enabled clinically significant toxicity reduction through better dosimetric sparing of OARs [ 1 ] while volumetric modulated arc therapy (VMAT) improved delivery efficiency with dynamic gantry rotation [ 2 ]. (biomedcentral.com)
From "Can rational combination of ultra-high dose rate FLASH radiotherapy with immunotherapy provide a novel approach to cancer treatment? (varian.com)
Objective: The MEDIRAD EARLY HEART study aims to identify and validate new cardiac imaging and circulating biomarkers of radiation-induced cardiovascular changes arising within first 2 years of breast cancer radiotherapy and to develop risk models integrating these biomarkers combined with precise dose metrics of cardiac structures based on three-dimensional dosimetry. (rug.nl)
Dose escalation has been proposed to improve local control [2] -[5] and capitalize on the therapeutic ratio of thoracic radiotherapy, which is mainly limited by the potential toxicity to organs at risk (OARs). (scirp.org)
Real-time dose-guidance in radiotherapy: Proof of principle. (au.dk)
Multiple studies have examined the issue of the optimal dose of radiotherapy in NSCLC but are complicated by the heterogeneity of the disease itself in terms of size and location of the primary tumor, number and size of involved lymph nodes, and the patient's comorbidities, all of which limit the treatment tolerability and risks. (frontiersin.org)
Long- and well-established cancer treatment experience in radiotherapy has provided ample evidence that absorbed dose may be used to predict biologic response ( 1 ). (snmjournals.org)
As has been recognized in radiotherapy and is beginning to be appreciated in radionuclide therapy, the rate at which the absorbed dose is delivered, the manner by which it is delivered (β-particles, α-particles, or Auger electrons), the radiobiologic characteristics of the tumor or normal organ, and the treatment history of the patient all affect response to a specific total absorbed dose ( 2 ). (snmjournals.org)
PURPOSE: To investigate estimated delivered dose distributions using weekly cone-beam computed tomography (CBCT) scans for pelvic organs at risk (OARs) in salvage radiotherapy (SRT) after radical prostatectomy. (lu.se)
In addition, the rate of recurrence increases and the response to radiotherapy decreases. (medscape.com)

6 Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado. (nih.gov)

SVC112 alone inhibited the growth of patient-derived xenografts (PDX), and SVC112 combined with radiation resulted in tumor regression in HPV-positive and HPV-negative HNSCC PDXs. (nih.gov)
Notably, CSC depletion after SVC112 correlated with tumor response. (nih.gov)
SIGNIFICANCE: Inhibiting protein elongation with SVC112 reduces tumor growth in head and neck squamous cell carcinoma and increases the effects of radiation by targeting the cancer stem cell pool. (nih.gov)
In such organoids, we can also mimic brain tumor initiation and growth and examine the interaction between normal tissue and tumor tissue upon treatment with ionizing radiation alone or in combination with other treatment modalities such as chemotherapies. (gsi.de)
With current multimodality therapy, approximately 80-90% of children with a diagnosis of Wilms tumor survive. (medscape.com)
However, the effects of radiation on the tumor and on organs at risk (OARs) are also influenced by the applied dose and volume of irradiated tissues. (maastrichtuniversity.nl)
A holistic model will allow for determination of an individual dose-response relationship for each organ at risk for each tumor in each individual patient for the complete oncological treatment package. (maastrichtuniversity.nl)
Mean, median, and D70 (minimum dose to 70% of tumor volume) values determined from dose maps were correlated with change in tumor volume and volumetric RECIST response using linear and logistic regression, respectively. (ox.ac.uk)
Results: Mean administered radioactivity was 1,469 ± 428 MBq (range, 847-2,185 MBq), achieving a mean absorbed radiation dose to tumor of 35.5 ± 9.4 Gy and mean normal liver dose of 26.4 ± 6.8 Gy. (ox.ac.uk)
Eligibility criteria include unresectable/unablatable HCC, Barcelona Clinic Liver Cancer stage A, B1, B2, or C with a maximal single tumor diameter of ≤ 8 cm, and a sum of maximal tumor diameters of ≤ 12 cm, and at least one tumor ≥ 2 cm (long axis) per localized, modified Response Evaluation Criteria in Solid Tumors. (biomedcentral.com)
the target mean dose to tumor is ≥ 150 Gy. (biomedcentral.com)
Post-treatment dosimetry is used to assess dose delivered to tumor and consider if retreatment is necessary. (biomedcentral.com)
SIRT is a technique that selectively deposits yttrium-90 ( 90 Y) microspheres into the hepatic vasculature to deliver a lethal dose of radiation to the tumor(s). (biomedcentral.com)
Although chemotherapy (CT) and traditional fractionated radiation have been described as immunosuppressive ( 2 ), recent data suggests that RT can modulate anti-tumor immune responses ( 3 ), modifying tumor and its microenvironment ( 4 ). (amegroups.org)
Besides the direct effects of radiation in reducing viable cancer cells, RT may induce modifications on the local microenvironment that can affect tumor development ( 5 ). (amegroups.org)
As a consequence, they cannot directly activate the specific CD4+ T cell-mediated tumor immunity, which is essential for the development of adaptive immune responses. (amegroups.org)
The percentage differences of the average absorbed dose rates calculated by this methodology and the MIRD S-values were 9.1% for liver, 13.7% for spleen, and 0.9% for the tumor. (tmc.edu)
More accurate estimates of the 3-D distribution of absorbed dose can be used as a guide in specifying the minimum activity to be administered to patients to deliver a prescribed absorbed dose to tumor without exceeding the toxicity limits of normal tissues. (tmc.edu)
The DVHs for the PTV and organs at risk were analyzed using a Biosuite algorithm to calculate the equivalent uniform dose (EUD), tumor control probability (TCP) via a Poisson model, and normal tissue complication probability (NTCP) via an LKB model. (scirp.org)
Stereotactic body radiation therapy (SBRT) is a technique that can attain a high cumulative biologically effective dose (BED) inside the tumor with a steep gradient outside the tumor, preventing dose to OARs. (scirp.org)
Tumor vascular perfusion parameters obtained by using CT or MR perfusion have been used for tumor grading, prognosis, and treatment response in addition to differentiating treatment/radiation effects and non-neoplastic lesions from neoplasms. (ajnr.org)
Perfusion imaging has been used to assess tumor grade and prognosis and, recently, to assess treatment response, which has attracted more attention due to the advent of newer therapeutic options, including antiangiogenic agents. (ajnr.org)
3 - 5 However, PCT, which has also been used recently for glioma grading, 6 , 7 provides a linear relationship between tissue attenuation and tissue concentration of a contrast agent, unlike perfusion MR imaging, and, hence, probably provides a more robust and less biased estimation of hemodynamic (tumor blood volume) and physiologic (tumor vascular leakiness) parameters. (ajnr.org)
Thus, the target, either the cavity of the tumor or the tumor itself, receives a full dose while the surrounding healthy tissue is spared. (utswmed.org)
and a single-arm study to assess patient-level adverse-event and tumor outcomes after receiving a post-lumpectomy tumor bed boost with the GammaPod followed by whole breast radiation ( NCT03562273 ). (utswmed.org)
Other advantages are that we might be able to deliver an ablative dose and eliminate the tumor with a single fraction of radiation. (utswmed.org)
Furthermore, in collaboration with our Radiology, Translational Medicine, and Physics departments, we are exploring the relationships between imaging techniques and predictions for patient and tumor responses. (utswmed.org)
Delivery of tumoricidal doses to the primary tumor and involved lymph nodes is balanced by treatment-related toxicities, namely esophagitis, pneumonitis, and cardiac injury. (frontiersin.org)
Throughout this review, response is defined as an acute, deterministic response, such as toxicity or tumor shrinkage, rather than a stochastic or carcinogenic effect, such as leukemia. (snmjournals.org)

We evaluated whether RT plus LDPF chemotherapy had an advantage in terms of survival and/or toxicity over RT plus standard-dose cisplatin and 5-fluorouracil (SDPF) chemotherapy in this study. (nih.gov)
Patients were randomly assigned to receive RT (2 Gy/fraction, total dose of 60 Gy) with SDPF (arm A) or LDPF (arm B) chemotherapy. (nih.gov)
Over the decades Dr. Morrison has been involved in trials of fractionation, radiation protectors, induction and concurrent chemotherapy, and proton beam therapy. (mdanderson.org)
The standard of care in locally advanced non-small cell lung cancer (NSCLC) includes concurrent chemotherapy and radiation therapy (RT). (appliedradiationoncology.com)
However, for patients with more locally advanced NSCLC, 5-year OS after treatment with definitive radiation therapy and concurrent chemotherapy remains modest, at approximately 15-20% ( 4 ). (frontiersin.org)
Prior to the advent of cytotoxic chemotherapy, lung cancer at all stages was treated surgically or by radiation alone ( 5 , 6 ). (frontiersin.org)
Presently, stage III lung cancer is managed with a combination of chemotherapy, radiation therapy, and sometimes surgery but the two major challenges in improving outcomes of the treatment of this disease remain local control and metastatic spread. (frontiersin.org)

Image-guided robotic stereotactic body radiation therapy for liver metastases: is there a dose response relationship? (google.fr)
7. Is There a Dose Response Relationship for Pulmonary Function Changes After Stereotactic Body Radiation Therapy for Early-stage Non-small Cell Lung Cancer? (rainerklement.com)
Does HCC Etiology Impact the Efficacy of Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma? (hku.hk)
Purpose: Stereotactic body radiation therapy (SBRT) has emerged as a standard treatment moda- lity for medically inoperable early-stage lung cancer patients. (scirp.org)
GammaPod is a Food and Drug Administration-approved stereotactic radiation machine that allows practitioners to pinpoint and treat breast cancer. (utswmed.org)
Unlike any other stereotactic body radiation therapy (SBRT) machine, GammaPod is equipped with a vacuum-assisted breast immobilization cup with an embedded fiducial wire that keeps the target centered during treatment. (utswmed.org)
Over the last 17 years, stereotactic body radiation therapy (SBRT) has shown a high degree of safety and local control for stage I lung cancers and other localized malignancies. (frontiersin.org)

Individualized dose-response curves will allow for consideration of different doses of radiation and combinations with other drugs to plan for both optimal toxicity and complete response. (maastrichtuniversity.nl)
LaDue T, Klein MK: Toxicity criteria of the veterinary radiation therapy oncology group, Vet Rad Ultrasound 42:475, 2001. (smallanimaloncology.com)
Response and toxicity prediction is essential to rational implementation of cancer therapy. (snmjournals.org)
We identified statistically significant associations between QUANTEC-recommended dose-volume constraints and acute bowel toxicity, as well as late urinary patient-reported symptoms, for both the estimated delivered and planned dose distributions. (lu.se)
More commonly, multidrug regimens incorporating drugs with different mechanisms of action and different toxicities are used to increase efficacy, reduce dose-related toxicity, and decrease the probability of drug resistance. (msdmanuals.com)

Patients were predominantly treated on 2 prospective institutional protocols assessing dose escalation. (appliedradiationoncology.com)
However, SBRT confronts several issues including patient positioning, breathing patterns, and high dose escalation. (scirp.org)
Local and distant failure remains high in this group of patients, so dose escalation has been studied in both single institution and national clinical trials. (frontiersin.org)
Though initial studies showed a benefit to dose escalation, phase III studies examining dose escalation using standard fractionation or hyperfractionation have failed to show a benefit. (frontiersin.org)
More recently, phase I/II studies using SBRT for dose escalation after conventional chemoradiation in locally advanced NSCLC have been promising with good apparent safety. (frontiersin.org)

In summary, these data demonstrate that SVC112 suppresses CSC-related proteins, enhances the effects of radiation, and blocks growth of HNSCC PDXs by inhibiting CSCs. (nih.gov)
hES cells also serve as a basis for cerebral organoid models (Figure C) to better understand e.g. the mechanisms of cognitive impairment and radiation necrosis as severe side effects of radiation therapies. (gsi.de)
1986. Carcinogenic effects of radiation on the human skin. (cdc.gov)
Individual susceptibility to the harmful effects of radiation can vary. (fortunefavorsthebravenyc.com)
In addition to the direct effects of radiation, the ensuing immune response promotes the expression of inflammatory and immunostimulatory mediators, which act on neighboring, non-irradiated, cells. (amegroups.org)

The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other chemicals are present. (cdc.gov)
This public health statement tells you about ionizing radiation and the effects of exposure. (cdc.gov)
Exposure to ionizing radiation can come from many sources. (cdc.gov)
You can learn when and where you may be exposed to sources of ionizing radiation in the exposure section below. (cdc.gov)
This information is important because exposure to ionizing radiation may harm you and because these sites may be sources of exposure. (cdc.gov)
Even in the event that you are exposed, it does not necessarily mean you will be harmed or suffer longterm health effects from exposure to ionizing radiation. (cdc.gov)
For example, in a study from Fukushima, intensive thyroid screening predicted that the thyroid cancer incidence would increase sevenfold and that 5 to 10 % of the incidence would be attributable to radiation exposure among all screened cancers [ 5 ]. (eaht.org)
Multivariate analysis found that radiation therapy was the only treatment-related exposure, but markers of sensitivity to UV radiation, such as light skin and hair color, were also associated with a higher risk of basal cell carcinoma. (ascopost.com)
Medical imaging procedures that use ionizing radiation, like CT scans and some types of X-rays, contribute to cumulative radiation exposure over time. (fortunefavorsthebravenyc.com)
Prolonged exposure to UV radiation damages the DNA within skin cells and can lead to the development of skin cancer, including melanoma, the most deadly form of skin cancer. (fortunefavorsthebravenyc.com)
Factors such as age, genetics, and overall health can influence how our bodies respond to radiation exposure. (fortunefavorsthebravenyc.com)
It is essential to consider these individual differences when assessing the overall cancer risk posed by radiation exposure. (fortunefavorsthebravenyc.com)
The radiation used in therapy is carefully targeted to minimize damage to healthy tissues, but some exposure to nearby healthy cells is inevitable. (fortunefavorsthebravenyc.com)
Such effects on wildlife following acute radiation exposure are reasonably well understood. (uchicago.edu)
But the effects of long-term exposure of lower levels of radiation, as seen currently within the CEZ are still being debated. (uchicago.edu)
However, at the moment there is little data on how bees respond to chronic radiation exposure. (uchicago.edu)
Ionising radiation is a human carcinogen, but the evidence is less clear that exposure to low-dose ionising radiation (LDIR) increases the risk of adverse cardiovascular outcomes. (bmj.com)
There is a growing recognition that exposure to low-dose ionising radiation (LDIR) may increase the risk of cardiovascular disease and reduce longevity. (bmj.com)
The scientific literature concerning cytogenetic biodosimetry has been reviewed to identify the range of scenarios of radiation exposure where biodosimetry has been carried out. (bioone.org)
Characterisation of exposure was highly with solar UV radiation, but there are wide varia- variable across reports. (who.int)
This platform allows us to minimize the number of trips to the radiation oncology suite and thus minimize potential virus exposure for patients, while striving to improve their outcomes. (utswmed.org)
The prevalence of thyroid nodules within a given population depends on a variety of factors that include age, sex, diet, iodine deficiency, and therapeutic and environmental radiation exposure. (medscape.com)
Exposure of the head and neck to ionizing radiation increases the incidence of thyroid nodules. (medscape.com)

This course also includes current understanding of radiobiology in radionuclide therapy, latest development of the biomarkers and its clinical applications in precision medicine. (seafomp.org)
It should be noted that the dose rates at which we exposed bumblebees are well above those seen in the environment from practices such as nuclear energy generation and radionuclide therapy used in medical treatment for cancer. (uchicago.edu)
Giap, Huan Bosco, "Development of a SPECT-based three-dimensional treatment planner for radionuclide therapy with iodine-131" (1994). (tmc.edu)
The biologic effects of radionuclide therapy are mediated via a well-defined physical quantity, the absorbed dose, which is defined as the energy absorbed per unit mass of tissue. (snmjournals.org)
A treatment planning approach to radionuclide therapy will eventually require incorporation of biologic and radiobiologic considerations. (snmjournals.org)
Unlike most other systemic treatments, the biologic effects of radionuclide therapy are mediated via a well-defined physical quantity, the absorbed dose, which is defined as the energy absorbed per unit mass of tissue. (snmjournals.org)

BED allows conclusions to be drawn about the biological response of TARE by putting it in conversation with what is known about the biological response of other treatment modalities, namely external beam radiation therapy (EBRT). (claremont.edu)
BACKGROUND AND PURPOSE: To perform a systematic review of the predictive ability of various dose-volume histogram (DVH) parameters (V(dose), mean lung dose (MLD), and normal tissue complication probability (NTCP)) in the incidence of radiation pneumonitis (RP) caused by external-beam radiation therapy. (uwo.ca)

Radiation therapy plays an important role in the management of head and neck (HN) cancer but is often challenging, especially for target volumes with complex shapes overlapping with organs-at-risk (OARs). (biomedcentral.com)
Differences in dose-volume metrics between the planned and estimated delivered doses for the examined OARs were mostly modest, although generally statistically significant. (lu.se)
CONCLUSION: We found small but statistically significant differences between estimated delivered and planned doses to OARs. (lu.se)

The purpose of this study was to establish the dose-response relationship of selective internal radiation therapy (SIRT) in patients with metastatic colorectal cancer (mCRC), when informed by radiobiological sensitivity parameters derived from mCRC cell lines exposed to 90Y. (ox.ac.uk)
Selective internal radiation therapy (SIRT) with yttrium-90 ( 90 Y) resin microspheres is an established locoregional treatment option for unresectable hepatocellular carcinoma (HCC), which delivers a lethal dose of radiation to hepatic tumors, while sparing surrounding healthy tissue. (biomedcentral.com)
One such strategy is selective internal radiation therapy (SIRT), also referred to as radioembolization. (biomedcentral.com)

Relating in vitro to in vivo exposures with physiologically-based tissue dosimetry and tissue response models. (cdc.gov)
This study suggests the need for patient-specific TARE dosimetry which considers biological response, such as BED or another adaptive model. (claremont.edu)
It is unique in that it is the first study with resin microspheres to utilize a personalized 90 Y dosimetry approach, and independent review for treatment planning and response assessment. (biomedcentral.com)
This study investigated a methodology for 3-D internal dosimetry, which integrates the 3-D biodistribution of the radionuclide acquired from SPECT with a dose-point kernel convolution technique to provide the 3-D distribution of absorbed dose. (tmc.edu)
Ongoing efforts to improve the accuracy of dosimetry calculations are discussed, as well as studies examining the relationship between absorbed dose and response. (snmjournals.org)
The term "dose" does not have a precise meaning in radionuclide dosimetry. (snmjournals.org)

While TARE has been shown to be a clinically effective and safe treatment, there is little understanding of the radiobiological relationship between absorbed dose and tissue response, and thus there is no dosimetric standard for treatment planning. (claremont.edu)
SIRT exploits the tumor's hypervascularity relative to healthy tissue, delivering safe levels of radiation to normal tissue while achieving a selective tumoricidal dose. (biomedcentral.com)
1,2 Major improvements in radiation technology have led to significant changes in radiation delivery for NSCLC, including 3D-conformal radiation treatment (3DCRT) and intensity-modulated radiation therapy (IMRT).These technologies have enabled the delivery of more conformal radiation to spare normal surrounding tissue. (appliedradiationoncology.com)
Preoperative radiation can minimize the amount of tissue that is ultimately irradiated, in comparison to radiation after surgery. (utswmed.org)

An early dose-finding study by the Radiation Therapy Oncology Group (RTOG) 7301 study was conducted from 1973 to 1978 and studied four different doses and schedules: 40 Gy split course, 40 Gy continuously, 50 Gy, and 60 Gy. (frontiersin.org)

Aggressive tumors typically demonstrate a high glycolytic rate, which results in resistance to radiation therapy and cancer progression via several molecular and physiologic mechanisms. (springer.com)
Possible causes of the failures to radiation therapy, the dose-response relationship, association with the second malignant tumors, and some recommendations for better treatment outcome are analyzed and discussed. (e-roj.org)
Lattimer JC, Corwin LA Jr, Stapleton J, et al: Clinical and clinicopathologic response of canine bone tumors patients to treatment with Samarium-153-EDTMP, J Nucl Med 31:1316, 1990. (smallanimaloncology.com)
Ionizing radiation (IR) is used as a main treatment for many types of localized solid tumors where radiation therapy (RT) is considered the primary non-surgical modality in the curative treatment of cancer ( 1 , 2 ). (amegroups.org)
Accurate calculation of absorbed dose to target tumors and normal tissues in the body is an important requirement for establishing fundamental dose-response relationships for radioimmunotherapy. (tmc.edu)
We calculate dose volume histograms (DVHs) of targeted tumors and organs at risk for 39 patients. (scirp.org)

Thames HD Jr, Withers WR, Peters LJ, et al: Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships, Int J Radiat Oncol Biol Phys 8:219, 1982. (smallanimaloncology.com)

Trans-arterial radioembolization (TARE) is a protracted modality of radiation therapy where radionuclides labeled with Yttrium-90 ( 90 Y) are inserted inside a patient's hepatic artery to treat hepatocellular carcinoma (HCC). (claremont.edu)

Several authors have carried out studies on lung SBRT, examining the impacts of beam arrangement, image guidance, radiation dose constraints, dose prescription, and treatment planning algorithm on patient outcomes. (scirp.org)
They established that SBRT treatment can be a new standard therapy for inoperable lung cancer. (scirp.org)
By building on the proven concept of conventional chemoradiation for patients with locally advanced NSCLC with a subsequent radiation dose intensification to residual disease with SBRT concurrent with immunotherapy, we hope address the issues of metastatic and local failures. (frontiersin.org)

From 1967, the year of licensure of live mumps vaccine, until 1978, the number of doses of killed mumps vaccine administered is unknown, but appears to have been limited. (cdc.gov)

At the Stem Cell Differentiation and Cytogenetics Group, we are interested in the effects of ionizing radiation on organs such as the brain, the heart, and the lung trying to elucidate the risks for patients treated with ionizing radiation as well as for astronauts, who are inevitably exposed to ionizing radiation on their missions into space. (gsi.de)
Although amplification of the DNA damage signal through multifactorial protein complex formation of DNA damage checkpoint factors is crucial for proper DNA damage response in two-dimensionally cultured cells, the dynamics of the DNA damage response in three-dimensional tissues or organs remained to be determined. (bioone.org)
Particular attention is placed on the marrow and kidney as dose-limiting organs. (snmjournals.org)

Soon after the discovery of X-rays by Wilhelm Conrad Röntgen in 1895, ionizing radiation was utilized for cancer treatment. (springer.com)
This Public Health Statement is the summary chapter from the Toxicological Profile for ionizing radiation . (cdc.gov)
It does not tell you about non-ionizing radiation, such as microwaves, ultrasound, or ultraviolet radiation. (cdc.gov)
However, it's unknown how many of the 1,467 current or former NPL sites have been evaluated for the presence of ionizing radiation sources. (cdc.gov)
As more sites are evaluated, the sites with ionizing radiation may increase. (cdc.gov)
If you are exposed to ionizing radiation, many factors determine whether you'll be harmed. (cdc.gov)
What is ionizing radiation? (cdc.gov)
To explain what ionizing radiation is, we will start with a discussion of atoms, how they come to be radioactive, and how they give off ionizing radiation. (cdc.gov)
Of the different types and sources of ionizing radiation, this profile will discuss the three main types: alpha, beta, and gamma radiation. (cdc.gov)
Before defining ionizing radiation, it is useful to first describe an atom. (cdc.gov)
Ionizing radiation is energy that is carried by several types of particles and rays given off by radioactive material, x ray machines, and fuel elements in nuclear reactors. (cdc.gov)
1998. Food preservation using ionizing radiation. (cdc.gov)
This study provides new information on the role of ionizing radiation in the development of [basal cell carcinomas] by defining the dose-dependent relationship between the amount of radiation to the skin and subsequent risk of developing a [basal cell carcinoma]," CCSS researchers stated. (ascopost.com)
Ionizing radiation, such as X-rays and gamma rays, has higher energy levels and can penetrate deeply into our bodies. (fortunefavorsthebravenyc.com)
Q: Can non-ionizing radiation, such as radiofrequency radiation from cell phones, cause cancer? (fortunefavorsthebravenyc.com)
A: The potential link between non-ionizing radiation, such as radiofrequency radiation from cell phones, and cancer is still being studied. (fortunefavorsthebravenyc.com)
The ATM-dependent DNA damage checkpoint plays a pivotal role in cellular response to ionizing radiation. (bioone.org)
Ionizing radiation therapy (RT), either alone or in combination with additional immune stimulators, can render cancer cells visible to the immune system. (amegroups.org)
Smoking, ionizing radiation, occupational risks, environment, indoor air pollution and diseases as risk factors for lung cancer are the ultimate causes and risk factors. (scirp.org)
This study provides a detailed characterization of the dose-dependent impact of ionizing radiation on skin cells (45, 60, or 80 grays). (mdpi.com)

The Biologically Effective Dose (BED) formalism, derived from the Linear-Quadratic model of radiobiology, is used to weigh the absorbed dose by the time pattern of delivery. (claremont.edu)
6 MV photons) were used in biologically effective dose (BED) calculations. (ox.ac.uk)

Cancer stem cells (CSC) drive growth, therapy resistance, and recurrence in head and neck squamous cell carcinoma (HNSCC). (nih.gov)
Dr. William Morrison is a Professor of Radiation Oncology at M.D. Anderson Cancer Center, with 31 years of clinical experience treating patients with head and neck cancer. (mdanderson.org)
He has personally treated 3200 head and neck patients, and gained leading technical expertise and judgement in the formulation and delivery of radiation therapy. (mdanderson.org)
A direct dose-response relationship between thyroid nodularity and radiation to the head and neck region also exists. (medscape.com)

At low doses, the risk of cancer is relatively low, but as the dose increases, so does the risk. (fortunefavorsthebravenyc.com)
Previous attempts to characterise cardiovascular risks in cohorts suggests ionising radiation increases the risk of cardiovascular disease. (bmj.com)
PUVA therapy increases the risk ship was scanty. (who.int)
The prevalence rate of thyroid nodules in radiation-exposed patients increases significantly, ie, 16-31% relative to the general population. (medscape.com)

All research areas are substantiated by analyses (Figure D) monitoring the acute radiation-induced cytogenetic damage and the long-term genetic stability of cells. (gsi.de)

A Python program was developed to calculate BED from absorbed dose distributions of six HCC patients treated at Massachusetts General Hospital, and optimized treatment activity levels with respect to biological response were determined. (claremont.edu)
The results show there is a disconnect between the current clinical treatment planning standard for TARE and the tissue's biological response. (claremont.edu)
This will allow the investigator to take a probabilistic approach to analysis of cytogenetic data, which can be considered highly appropriate for biological dose estimation. (bioone.org)
Bystander effects induced by radiation are characterized by biological responses, which are observed in non-irradiated cells that are in the vicinity of irradiated cells. (amegroups.org)
related chemical compounds, physical agents (such as radiation) and biological factors (such as viruses). (who.int)

Guptill L, Scott-Moncrieff CR, Janovitz EB, et al: Response to high-dose radioactive iodine administration in cats with thyroid carcinoma that had previously undergone surgery, J Am Vet Med Assoc 207:1055, 1995. (smallanimaloncology.com)
Previously, it was reported that the slope of the dose-response relationship between radiation and thyroid cancer did not differ significantly before and after screening among patients who had received radiation therapy, indicating that the association between radiation and thyroid cancer may not be changed by intensive screening [ 2 ]. (eaht.org)
A study from the Chernobyl accident also reported screening to be a weak confounder for radiation dose and thyroid cancer [ 3 ]. (eaht.org)
Screening detects many small cancers but occult thyroid cancer could also be radiation related. (eaht.org)
Even if non-radiationrelated cancers make up the majority, it does not change the causal relation between radiation and thyroid cancer. (eaht.org)
Based on International Agency for Research on Cancer classification ( http://www.iarc.fr ), radiation is the only confirmed carcinogen for the thyroid. (eaht.org)
It is important to acknowledge that screening also detected radiation-related thyroid cancers that were not diagnosed during routine medical care [ 6 ]. (eaht.org)
For a laryngeal carcinoma, DTRT resulted in higher dose than VMAT to the pharynx and brachial plexus but lower dose to the upper oesophagus, thyroid gland and contralateral carotid artery. (biomedcentral.com)

We conclude that CR and KDs may act synergistically with radiation therapy for the treatment of cancer patients and provide some guidelines for implementing these dietary interventions into clinical practice. (springer.com)
The course aims to provide basic understanding of radiobiology principles, its clinical applications and implementations in radiation therapy. (seafomp.org)
This course will advance the knowledge of medical physicists, radiation oncologists, nuclear medicine physicians and other related professionals with radiobiology key points that might be useful and practical in their clinical routine while bridges the gap for the application of radiobiology principles in state-of-art theranostic procedures. (seafomp.org)
The Impact of Radiobiologically Informed Dose Prescription on the Clinical Benefit of 90Y SIRT in Colorectal Cancer Patients. (ox.ac.uk)
From advanced imaging and radiation therapy, to comprehensive software and services, to interventional radiology, we are harnessing the power of our perspective while also pursuing clinical research to create a more efficient, and more personalized care pathway. (varian.com)
pursue developing statistical methods with real applications in heterogeneity in CLINICAL STUDIES, threshold DOSE-RESPONSE models, SURVIVAL ANALYSIS with incomplete and correlated data, efficient estimation in MIXED effects (REPEATED measure) models, robust estimation in high-dimension data (BIOINFORMATICS), effects of SAMPLING weights in log-linear models, and characterization and estimation of POPULATION RISK. (louisville.edu)
The concepts, basic definitions, and different approaches to the clinical implementation of absorbed dose estimation are reviewed in this article. (snmjournals.org)

Despite these advancements, several cancer types continue to elude modern treatment techniques with radiation therapy (RT). (springer.com)
OBJECTIVE: Breast cancer and breast cancer-directed radiation therapy (RT) may increase the risk of late effects, such as hypothyroidism. (bvsalud.org)
Invited talk at the 3rd International Workshop No-Cancer 2018 -Understanding Cancer Cell Biology to Improve Diagnosis and Therapy. (rainerklement.com)
Retrospective analyses were done of 48 patients with early glottic cancer, 31 with T1NOMO and 17 with T2NOMO, who received radiation therapy from March 1979 to August 1984 at Seoul National University Hospital with the prescribed full dosage. (e-roj.org)
Fewer than 30% of childhood cancer survivors seek appropriate medical care, either because they are not aware of their initial diagnosis or, more frequently, because they do not know the risks associated with the therapy they received," the authors concluded. (ascopost.com)
An understanding of the radiation dose-dependent nature of [basal cell carcinoma] risk may facilitate the development of improved surveillance and treatment guidelines for physicians who care for cancer survivors," they added. (ascopost.com)
1. Watt TC, Inskip TC, Stratton K, et al: Radiation-related risk of basal cell carcinoma: A Report From the Childhood Cancer Survivor Study. (ascopost.com)
Are you curious about how radiation causes cancer? (fortunefavorsthebravenyc.com)
As someone with experience in understanding the connection between radiation and cancer, I'm excited to share valuable insights with you. (fortunefavorsthebravenyc.com)
Let's delve into the fascinating world of radiation and its relationship with cancer. (fortunefavorsthebravenyc.com)
When exposed to radiation, our cells can be damaged, and this damage has the potential to lead to cancer. (fortunefavorsthebravenyc.com)
UV radiation, mainly from the sun and tanning beds, is another form of radiation that can cause cancer. (fortunefavorsthebravenyc.com)
When it comes to radiation and cancer, it's crucial to consider the dose. (fortunefavorsthebravenyc.com)
However, even low doses of radiation can contribute to long-term cancer risk over time. (fortunefavorsthebravenyc.com)
Some individuals may be more sensitive to radiation and have a higher risk of developing cancer even at lower doses. (fortunefavorsthebravenyc.com)
Q: Can radiation therapy for cancer cause new cancers to develop? (fortunefavorsthebravenyc.com)
A: While radiation therapy is an effective treatment for cancer, it can occasionally lead to the development of second cancers in certain individuals. (fortunefavorsthebravenyc.com)
Current scientific evidence does not conclusively establish a direct causal relationship between cell phone use and cancer. (fortunefavorsthebravenyc.com)
Note: This table provides a concise overview of the health effects of different types of radiation in relation to cancer. (fortunefavorsthebravenyc.com)
Studies using 3-dimensional conformal radiation therapy (3DCRT) show that elective nodal (EN) areas receive substantial incidental irradiation in non-small cell lung cancer (NSCLC) treated with involved-field radiation therapy (IFRT). (appliedradiationoncology.com)
Therefore, identifying breast cancer patients at the highest risk for radiation-induced cardiac complications is crucial for developing strategies for primary and secondary prevention, which may contribute to healthy aging. (rug.nl)
Current practice in proton therapy delivery in adult cancer patients across Europe. (au.dk)
Spot-scanning proton therapy for targets with adjacent cardiac implantable electronic devices - Strategies for breast and head & neck cancer. (au.dk)
Broadband UVB has been used for many years these facilities, or use more than 15 to 20 years and, more recently, narrow-band UVB, but there prior to diagnosis of melanoma, was weak, and are few data on which to base estimates of risk evidence regarding a dose-response relation- for skin cancer. (who.int)
METHODS AND MATERIALS: Studies assessing the relationship between CT-based DVH reduction parameters and RP rate in radically treated lung cancer were eligible for the review. (uwo.ca)
Smoking and alcohol consumption have a linear dose-specific relationship with oral cancer. (medscape.com)
These risk factors and the underlying pathogenesis do not disappear following surgical excision or radiation therapy for the cancer. (medscape.com)
The number of approved cancer therapies is increasing rapidly. (msdmanuals.com)
In contrast, other drugs (eg, DNA cross-linkers, also known as alkylating agents) have a linear dose-response relationship, killing more cancer cells at higher doses. (msdmanuals.com)

This is an important aspect to discuss with your doctor when weighing the benefits and risks of radiation therapy. (fortunefavorsthebravenyc.com)

Community-led vaccine promotion and education are needed to encourage uptake of both vaccine doses, including vaccination clinics at community spaces and events. (umn.edu)
Evaluation of immune response to single dose of quadrivalent HPV vaccine at 10-year post-vaccination. (who.int)
Comparing one dose of HPV vaccine in girls aged 9-14 years in Tanzania (DoRIS) with one dose of HPV vaccine in historical cohorts: an immunobridging analysis of a randomised controlled trial. (who.int)

Outcomes after radiation therapy for T2N0/stage II glottic squamous cell carcinoma. (mdanderson.org)

Since it has not been possible to quantify cytosolic amounts of delivered siRNA at therapeutic doses, determining delivery bottlenecks and total efficiency has been difficult. (lu.se)

Enhanced registration methods and imaging techniques could potentially further enhance the assessment of truly delivered doses and yield more reliable dose-volume constraints for future therapies. (lu.se)

Within the limits of the BED analysis, none of the patients had originally received the optimal dose, with some patients having been overdosed and some having been underdosed. (claremont.edu)
Patients are assessed at baseline and at regular intervals up until 12 months of treatment for response rates, safety, and quality of life (QoL). (biomedcentral.com)
It has been reported that patients experiencing side effects of amiodarone (AM) therapy, such as amiodarone-induced thyrotoxoco. (nel.edu)
The influence of radioiodine therapy on ocular changes and their relation to urine cotinine level in patients with Graves' Ophthalmopathy. (nel.edu)
Radioiodine therapy (RIT) is frequently used as the definitive treatment in patients with Graves' hyperthyroidism when remissi. (nel.edu)
Twenty-three stage IIIA NSCLC patients treated with curative intent IMRT (median dose 72 Gy) were studied. (appliedradiationoncology.com)
At a median follow up of 21 months, 6 patients (26%) had isolated locoregional recurrences, with only 1 patient (4%) having an isolated EN failure (station 5, supraclavicular) without intrathoracic progression. (appliedradiationoncology.com)
Inclusion criteria consisted of patients with histologically proven NSCLC, stages IIIA-IIIB, curative intent treatment, and radiation prescription doses ≥ 50 Gy. (appliedradiationoncology.com)
When patients are treated with GammaPod, they are situated on a patient-loading couch in a prone position, which helps limit the dose of radiation to the skin, heart, and lungs. (utswmed.org)
Treatment was personalised based on PSA response during SRT, classifying patients as PSA responders or non-responders. (lu.se)
Dose modification or exclusion of certain drugs may be necessary in patients with lung disease (eg, bleomycin), kidney failure (eg, methotrexate), liver dysfunction (eg, taxanes) or heart disease (daunorubicin, cyclophosphamide). (msdmanuals.com)

It will address the molecular and cellular responses to radiation-induced damage and factors that affect cell survival curve. (seafomp.org)
At a cellular level, radiation can disrupt the DNA within our cells. (fortunefavorsthebravenyc.com)

8,9,11,12 However, studies on EN failure patterns to date have primarily utilized 3DCRT, and it is unclear whether these data are applicable to more advanced modalities like IMRT. (appliedradiationoncology.com)
The major modalities of therapy are Surgery (for local and local-regional disease) Radiation. (msdmanuals.com)

The dose refers to the amount of radiation our bodies receive. (fortunefavorsthebravenyc.com)

1993. Protective effects of chlorogenic acid, curcumin and beta-carotene against gamma-radiation-induced in vivo chromosomal damage. (cdc.gov)
At high doses, DNA cross-linkers damage the bone marrow. (msdmanuals.com)

For three locoregionally advanced oropharyngeal carcinomas and one adenoid cystic carcinoma, mean dose to the contralateral salivary glands, pharynx and oral cavity was reduced by 2.5, 1.7 and 3.1 Gy respectively on average with DTRT compared to VMAT. (biomedcentral.com)
Mean dose, V40, V50 and V60 were compared for each station. (appliedradiationoncology.com)

Particularly, human embryonic stem cells (hES cells), which can give rise to all tissues of an organism (Figure A), are used to generate mature cells of the heart (Figure B) allowing us to study radiation/microgravity-induced cardiovascular alterations, which may occur during long-term space missions. (gsi.de)
Although multiple mechanisms are possible, the relationship between exercise as measured by accelerometer data and cardiovascular mortality is strong (inverse, non-linear). (wikipedia.org)

In addition, the guidelines for surgical treatment and the role of radiation therapy are better defined now than ever before. (medscape.com)
The course would benefit attendance by all the professionals involved in the treatment chain: oncologist: medical physicists and radiation therapist. (seafomp.org)
After treatment with localized radiation, systemic effects in non-irradiated area (out-of-field) may also occur. (amegroups.org)
3,4 More recently, treatment has evolved to involved-field radiation therapy (IFRT), in which EN regions are omitted to deliver higher doses of radiation to gross disease while decreasing subclinical treatment volumes to reduce toxicities to the esophagus, lung and heart. (appliedradiationoncology.com)
Advancements in imaging and radiation treatment delivery systems have provided radiation oncologists with better target definition. (scirp.org)
While standard whole breast irradiation can require daily treatments for three to six weeks, partial breast radiation treatment with GammaPod can be as short as one to five days. (utswmed.org)
This system uses 25 cobalt sources of radiation that continuously rotate during treatment, creating thousands of beam angles that converge at the target to create an intense focal spot. (utswmed.org)
This means we can achieve reduced treatment margins (2-3 mm) compared with those required by conventional radiation therapy (10-15 mm). (utswmed.org)
In our preoperative single-fraction radiation trial ( NCT04040569 ), we will give one treatment of radiation prior to surgery. (utswmed.org)

Investigation of the association between responses, changes in lymphocyte populations, indoor tanning and skin cancers poses challeng- and depression of NK cell activity. (who.int)

All plans were delivered successfully on the phantom and dosimetric validation resulted in gamma passing rates of 93.9% and 95.8% (2%/2 mm criteria, 10% dose threshold). (biomedcentral.com)

This methodology can provide heterogeneous distributions of absorbed dose in volumes of any size and shape with nonuniform distributions of activity. (tmc.edu)
Estimated radiation dose distributions were obtained using deformable image registration from weekly CBCT scans. (lu.se)
These differences showed trends toward improved associations for estimated delivered dose distributions with side effects. (lu.se)

The results of this trial should provide further information on the potential use of SIRT with 90 Y resin microspheres as first-line therapy for unresectable HCC. (biomedcentral.com)

These factors include the dose (how much), the duration (how long), and the type of radiation. (cdc.gov)

A number of difficulties also stem from limitations of the classical statistical methodology, which requires that chromosome aberration yields be considered as something "fixed" and thus provides a deterministic estimate of radiation dose and associated confidence limits (because an assignment of a probability to an event is based solely on the observed frequency of occurrence of the event). (bioone.org)

Relationships between vancomycin accumulation in the kidney and urinary kidney injury biomarkers were explored. (authorea.com)

From its introduction in December 1967, through 1981, more than 55 million doses have been distributed in the United States. (cdc.gov)

5-(3,3-dimethyle-1-triazeno) imidazole-4-carboxamide and interleukin-2 adjuvant therapy in resected high-risk primary and regionally metastatic m elanoma. (louisville.edu)

With GammaPod, we can administer higher doses of radiation in a more controlled and patient-friendly manner compared with conventional treatments. (utswmed.org)

IMRT is being increasingly used for NSCLC with the potential for more conformal radiation, with one study demonstrating an increase in IMRT from 2% in 2002 to 25% in 2009. (appliedradiationoncology.com)
This "quadmodality" approach is still in its infancy but appears to be a safe and rational approach to the improving the outcome of NSCLC therapy. (frontiersin.org)

Organisms1

Diseases3

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes9

Disciplines and Occupations1

Health Care7

Radiotherapy17

Department of Radiation Oncology1

Tumor29

Chemotherapy7

Stereotactic7

Toxicity5

Escalation5

Effects of radiation5

Exposure23

Radionuclide therapy6

Beam radiation therapy2

OARs3

Selective interna3

Dosimetry6

Tissue4

Different doses1

Tumors6

Fractionation1

Hepatocellular carcinoma1

SBRT3

19781

Organs3

Ionizing Radiation20

Biologically effective2

Head and neck4

Increases4

Acute1

Biological5

Thyroid8

Clinical7

Cancer29

Risks1

Vaccine3

Squamous1

Therapeutic1

Constraints1

Patients11

Cellular2

Modalities2

Amount of radiation1

Damage2

Mean dose2

Cardiovascular2

Treatment9

Cancers1

Threshold1

Distributions3

Unresectable1

Type of radiation1

Deterministic1

Biomarkers1

19811

Metastatic1

Higher1

NSCLC2