Therapies drug combinations. Medical search. Frequent questions

The goal of this trial was to evaluate the safety and efficacy of the combination of amlodipine/benazepril, compared with hydrochlorothiazide (HCTZ)/benazepril in reducing cardiovascular morbidity and mortality in high-risk patients with systolic hypertension. (acc.org)
Combination therapy has gained momentum in oncology in recent years, with various studies demonstrating higher response rates with combinations of drugs compared to monotherapies, and the FDA recently approving therapeutic combination regimens that demonstrated superior safety and efficacy to monotherapies. (wikipedia.org)
We investigated the efficacy of combination therapy with probiotics and mosapride for non-diarrheal-type IBS. (nih.gov)
Among the advantages of multitarget drugs vs drug combinations are the more predictable pharmacokinetic (PK) and pharmacodynamic (PD) relationship of the components of a single medicine, the possibility that one motif might improve the bioavailability of the second entity, the greater efficacy against advanced-stage diseases, the lower toxicities, the simultaneous presence of the chemical entities in multiple tissues, and the improved patient compliance [ 2 ]. (biomedcentral.com)
In terms of treatment for myositis-associated ILD, systemic corticosteroid therapy is usually combined with immunosuppressive agents, such as azathioprine, cyclophosphamide, mycophenolate mofetil, methotrexate, cyclosporine, tacrolimus, and/or rituximab, although there is little evidence to support the efficacy of these individual agents ( 4 ). (frontiersin.org)
Our objective was to evaluate the efficacy of monotherapy versus combination therapy in patients with systemic sclerosis (SSc)-associated PAH. (jrheum.org)
Our study was designed to evaluate the longterm efficacy and safety of combination therapy with PDE5 inhibitors and ERA versus monotherapy in a large Spanish nationwide SSc-related PAH cohort. (jrheum.org)
Methods This non-randomized, multicohort, phase II study evaluated the efficacy and safety of the anti-PD-1 antibody nivolumab 240 mg administered every 2 weeks in combination with the CDK4/6 inhibitor abemaciclib 150 mg twice daily and either fulvestrant (FUL) or letrozole (LET) as a first-line or second-line treatment for HR-positive HER2-negative metastatic breast cancer. (bmj.com)
The BET and GSK3 inhibitor combination shows remarkable efficacy but also no increase in toxicity because the GSK3 and BET inhibitors synergize, but on its own, the GSK3 inhibitor doesn't seem to have an effect. (medicalxpress.com)
An important step is to monitor the efficacy of this drug. (cdc.gov)
The support we provide can include financial support, training in how to do efficacy monitoring, providing quality assured drug, and reviewing the data. (cdc.gov)

The cluster model was further applied to 283 patients who received conventional regimens consisting of corticosteroids with or without a single immunosuppressive agent (dual-combo therapy or monotherapy). (frontiersin.org)
Previous studies have reached conflicting conclusions on this issue, some supporting our findings and others not, but an Editorial by Peter Sklar & Henry Mazur says taken in aggregate, the weight of the evidence suggests that HIV-infected patients treated with combination antiretroviral regimens are at increased risk for the development of premature atherosclerotic complications. (natap.org)
Results from a three year double-blinded trial which compared antiretroviral therapies show that the combination regimens of tenofovir DF and stavudine, are equally effective, though tenofovir DF has more favorable outcomes with respect to cholesterol levels and the nervous system. (news-medical.net)
Five H. pylori treatment regimens have been approved by the Food and Drug Administration. (cdc.gov)

combination antiretroviral therapy was associated with a 26 percent relative increase in the rate of myocardial infarction per year of exposure during the first four to six years of use. (natap.org)
This finding is plausible because combination antiretroviral therapy can cause adverse metabolic changes that are known risk factors for cardiovascular disease. (natap.org)
In addition, the relative increase in the risk of myocardial infarction per year cannot be extrapolated beyond the duration of follow-up in the study…… …….the annual rate of myocardial infarction, even among those exposed to therapy for four to six years, was less than 0.6 percent, and only a portion of the apparent excess risk could be attributed to combination antiretroviral therapy. (natap.org)
Hence, the substantial benefits of combination antiretroviral therapy continue clearly to outweigh the increased risk of myocardial infarction associated with this therapy. (natap.org)
It is hard to isolate specific causal effects, but it seems reasonable to suppose that the intensity of focus (and investment) has been a key driver of innovation, enabling the scale-up of new interventions, such as antiretroviral therapy, long-lasting insecticide-treated bednets, artemisinin-based combination therapy, vaccines against pneumonia and diarrhoeal disease, and new and better diagnostic tests for multiple diseases. (who.int)
Combination antiretroviral therapy is the most effective pharmacotherapy for HIV treatment. (cdc.gov)
Abacavir hypersensitivity reaction affects 5 to 8% of patients and can be observed during the first 6 weeks of antiretroviral therapy. (cdc.gov)

Monotherapy, or the use of a single therapy, can be applied to any therapeutic approach, but it is most commonly used to describe the use of a single medication. (wikipedia.org)
A single-pill combination promotes less therapeutic inertia, more patient adherence and monetary savings. (escardio.org)
Traditionally, recommendations have advised against the use of combination therapy with two drugs from the same therapeutic class. (medscape.com)
The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. (rxreasoner.com)
Approved and experimental epigenetic drugs are undergoing clinical trials in combination with other therapeutic agents via fused or linked pharmacophores in order to benefit from synergistic effects of polypharmacology. (biomedcentral.com)
Another current trend in therapy is drug repurposing or the re-discovery of a new therapeutic area for a drug used traditionally to treat a given pathology, either through the ability to modulate an additional target or by the involvement of the primary target in multiple pathologies. (biomedcentral.com)
Trametinib plus dabrafenib combined therapy demonstrated a clear therapeutic benefit in children with BRAF-mutated low- and high-grade gliomas. (medindia.net)
With the invention and development of laser technology, photo-based therapeutic modalities such as photodynamic therapy (PDT) and photothermal therapy (PTT) have become prospective minimally invasive approaches for cancer treatment [ 1 - 5 ]. (thno.org)
nied by a rise in multidrug-resistant TB (MDR TB), which is defined as TB that is resistant to the two most effective first-line therapeutic drugs, isoniazid and rifampin. (cdc.gov)
Extensively drug-resistant (XDR) TB is defined as MDR TB that also is resistant to the most effective second-line therapeutic drugs used commonly to treat MDR TB: fluoroquinolones and at least one of three injectable second-line drugs used to treat TB (amikacin, kanamycin, or capreomycin). (cdc.gov)

1 Additionally, the daratumumab combination regimen resulted in an ORR of 82 percent vs. 62 percent (p=0.2028), with very good partial response (VGPR) or better achieved in 64 percent vs. 35 percent of patients, and CR or better achieved in 34 percent vs. 9 percent of patients. (jnj.com)
0.0001).1 Additionally, the daratumumab combination regimen resulted in an ORR of 85 percent vs. 64 percent (p=0.0001), with VGPR or better achieved in 64 percent vs. 26 percent of patients, and CR or better achieved in 28 percent vs. 8 percent of patients treated with DVd vs. Vd, respectively. (jnj.com)
1 Additionally, the daratumumab combination regimen resulted in an ORR of 85 percent vs. 67 percent (p=0.0435), with VGPR or better achieved in 64 percent vs. 31 percent of patients, and CR or better achieved in 38 percent vs. 6 percent of patients. (jnj.com)
The duration of treatment should be individualized to the patient depending on baseline disease characteristics, response to therapy, and tolerability of the regimen [see Indications and Usage (1.1) , Adverse Reactions (6.1) , and Clinical Studies (14) ]. (drugs.com)
The study may support a regimen to produce complete remission with front-line therapy, without the increased risks associated with systemic chemotherapy or a stem cell transplant. (mdanderson.org)
However, adding a low concentration of navitoclax, a BCL2-family inhibitor, to the MEK-PI3K regimen in previously untreated cells resulted in improved synergistic interaction between the therapies and blocked the acquisition of resistance. (pharmaceutical-journal.com)
It is possible that the addition of a third agent may be tolerated clinically in such a dosing regimen and provide the opportunity to overcome, or ameliorate, the major clinical problem of resistance to targeted therapies," they concluded. (pharmaceutical-journal.com)
To stratify patients with polymyositis/dermatomyositis-associated interstitial lung disease (ILD) who were initially treated with an intensive regimen consisting of high-dose corticosteroids, a calcineurin inhibitor, and intravenous cyclophosphamide (triple-combo therapy) into subgroups based on mortality outcomes by a cluster analysis using a large-scale multicenter retrospective cohort of Japanese patients with myositis-associated ILD (JAMI). (frontiersin.org)
Our findings led us to a combination regimen that can reverse resistance to BET inhibition. (medicalxpress.com)
cure rates for established therapies range from approximately 70% to 90%, depending on the specific regimen (8). (cdc.gov)
In a phase III study, Vogelzang et al showed the superior benefits of a regimen using pemetrexed in combination with cisplatin over administration of cisplatin alone. (medscape.com)

The fixed dose combination of amlodipine/benazepril would be superior to HCTZ/benazepril in reducing cardiovascular mortality and morbidity in high-risk patients with hypertension. (acc.org)
After a screening phase, patients with hypertension were randomized to either fixed dose combination of amlodipine 5 mg/benazepril 20 mg or HCTZ 12.5 mg/benazepril 20 mg. (acc.org)
Pharmaceutical' combination therapy may be achieved by prescribing/administering separate drugs, or, where available, dosage forms that contain more than one active ingredient (such as fixed-dose combinations). (wikipedia.org)
A fixed-dose combination of the long-acting muscarinic antagonist (LAMA) aclidinium bromide (400 mcg) and long-acting beta-agonist (LABA) formoterol fumarate (12 mcg) has been approved by the FDA for the maintenance treatment of chronic obstructive pulmonary disease (COPD). (pharmacytimes.com)

After finding that triple-combination therapy may help to prevent resistance acquisition in colorectal cancer cells, the researchers said that future studies should look into questions of timing, dosage and tolerability. (pharmaceutical-journal.com)
Treating colorectal cancer with a trio of targeted drugs reduces the acquisition of drug resistance, in vitro research published in Oncogene shows (25 March 2019) [1] . (pharmaceutical-journal.com)
Researchers treated a panel of 47 human colorectal cancer cell lines with combinations of MEK- PI3K- and ERK-inhibitors. (pharmaceutical-journal.com)
Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer. (pharmaceutical-journal.com)
According to the results, the combination provided superior colorectal cancer protection with less gastrointestinal bleeding. (medindia.net)
It is indicated for the reduction of cytotoxicity when used in combination with 5-fluorouracil in the treatment of colorectal cancer and for the treatment of megaloblastic anemia due to folic acid deficiency when folic acid cannot be replaced orally. (janusinfo.se)

The aclidinium bromide/formoterol fumarate therapy is on track to launch in the United States in the second half of 2019, according to Circassia. (pharmacytimes.com)

The main issue with these triplet trials is on the one hand that the comparator arm of BRAF/MEK inhibition is not the recommended first-line therapy for unresectable metastatic melanoma in major guidelines. (springermedizin.at)

An expert shares her take on emerging strategies for combination treatment for NAFLD and NASH with GLP-1 receptor agonists plus SGLT2 inhibitors. (clinicaloptions.com)
The combination of Cytotoxic T-Lymphozyte Antigen-4 (CTLA‑4) and Programmed death-1 (PD‑1) antibodies and the combination of BRAF and MEK inhibitors are the current clinical standards for combination immune and targeted therapy for melanoma, respectively. (springermedizin.at)
Recent data from pivotal studies have demonstrated that roughly up to 35% (for BRAF/MEK inhibitors) and 50% (for Ipi/Nivo) of first-line patients treated with these combinations are still alive after 5 years. (springermedizin.at)
Currently several alternative immune check points like Tim‑3, Tigit, Vista LAG‑3 and others are tested, mostly in combination with PD1 inhibitors in clinical trials. (springermedizin.at)
Polymerases theta and delta assist in the development of new cancer drugs known as polymerase theta inhibitors, currently undergoing clinical trials. (medindia.net)
Monotherapy remains an option for PAH treatment 14 , 15 , 16 recommended in guidelines 17 as first-line therapy for World Health Organization functional class (FC) II-III patients, with the same grade of evidence and recommendation (IA-IB) for endothelin receptor antagonists (ERA) and phosphodiesterase-5 (PDE5) inhibitors. (jrheum.org)
Background Hormone receptor (HR)-positive breast cancer is a disease for which no immune checkpoint inhibitors have shown promise as effective therapies. (bmj.com)
Armed with this information, the researchers developed a combination therapy approach that uses both BET and GSK3 inhibitors against KMT2A mutated leukemia. (medicalxpress.com)
He emphasized that cost limits the use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and small-interfering (si)RNA drugs, "so there is a huge unmet need globally in order to get patients to goal. (medscape.com)
After that," Catapano said, there will be combination therapy, starting with bempedoic acid and ezetimibe, followed by PCSK9 inhibitors, siRNA drugs, and CETP inhibitors, all competing for the same space. (medscape.com)

Multidrug therapy against leprosy : development and implementation over the past 25 years / [editor]: H. Sansarricq. (who.int)

APG-115-US-002 is an open-label, multi-center, Phase Ib/II study in U.S. , which was designed to assess safety, toxicity, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of APG-115 in combination with pembrolizumab in patients with advanced solid tumors. (pharmiweb.com)
More than 600 drugs are known to cause pulmonary toxicity, and illicit drugs are well-known to result in pulmonary toxicities. (medscape.com)
A list of drugs that are reported to cause pulmonary toxicity is available on the continually updated Website PNEUMOTOX online . (medscape.com)
Drug-induced pulmonary toxicity is a diagnosis of exclusion. (medscape.com)
Patients who develop drug toxicity should be advised to avoid the drug in the future. (medscape.com)
The diagnosis of drug-mediated pulmonary toxicity is usually established based on clinical findings. (medscape.com)
Radiologic patterns observed in drug-induced pulmonary toxicity are highly variable and depend on the type of adverse reaction the patient is experiencing. (medscape.com)
If the drug-induced pulmonary toxicity causes airway obstruction, then the FEV 1 /FVC ratio and FEV 1 will be reduced. (medscape.com)
In general, bronchoscopy with transbronchial biopsy is not helpful in establishing the diagnosis of drug-induced pulmonary toxicity. (medscape.com)
The approach overcomes the cancer's drug resistance, without adding toxicity. (medicalxpress.com)
Dosage and duration of calcium folinate rescue primarily depend on the type and dosage of methotrexate therapy, the occurrence of toxicity symptoms, and the individual excretion capacity for methotrexate. (janusinfo.se)

In April 2009, a new treatment option for second-stage T. b. gambiense HAT, nifurtimox-eflornithine combination therapy (NECT), was added to the WHO Essential Medicines List (EML). (dndi.org)
spironolactone is an effective treatment for primary hyperaldosteronism (defined as an elevated plasma aldosterone-to-renin ratio) - thus if a patient is uncontrolled despite triple therapy then a plasma renin should be measured off beta-blockade (which suppresses renin) as part of consideration of secondary causes of hypertension (2). (gpnotebook.com)
Combination therapy may seem costlier than monotherapy in the short term, but when it is used appropriately, it causes significant savings: lower treatment failure rate, lower case-fatality ratios, fewer side-effects than monotherapy, slower development of resistance, and thus less money needed for the development of new drugs. (wikipedia.org)
Artemisinin-based drugs are the mainstay of current antimalarial treatment and play a key role in the World Health Organization (WHO) global strategy to reduce malaria illness and death caused by malaria. (cdc.gov)
Artemisinin-based combination therapies (ACTs) are the recommended first-line treatment for uncomplicated malaria in most countries ( 1 ). (cdc.gov)
Given the key role of artemisinins in malaria treatment, WHO calls for prospective clinical studies and further research to improve the understanding of delayed hemolysis after artemisinin therapy ( 10 ). (cdc.gov)
Especially since Trilogy had only a bit more than 30% of patients with elevated LDH and thus a rather positively skewed population, this raises the question whether it would be really an advantage to use both the immunotherapy and the targeted therapy option in first-line rather than saving targeted therapy as an ideal second-line treatment in the case of CPI failure. (springermedizin.at)
For patients with active RA in its early stages, combination therapy with MTX and infliximab provides greater clinical, radiographic, and functional benefits than treatment with MTX alone. (nih.gov)
These data represent the first assessment of daratumumab in combination with a next generation proteasome inhibitor (PI) and an immunomodulatory agent earlier in the treatment paradigm for multiple myeloma. (jnj.com)
Daratumumab appeared to improve poor outcomes associated with high risk cytogenetics, and these data support its consistent clinical benefit in combination with two of the most widely used treatment classes. (jnj.com)
treatment options for mesothelioma patients, including a recently-approved combination drug therapy. (nolo.com)
While there is no cure for malignant mesothelioma, a number of treatment methods-especially when used in combination-can be effective in managing the disease and prolonging life. (nolo.com)
Keep in mind that doctors who specialize in the treatment of mesothelioma patients typically use a combination of the therapies described below (called a "multimodal" approach). (nolo.com)
The treatment duration for patients who previously failed therapy is 48 weeks, regardless of HCV genotype. (drugs.com)
The universal agreement on initiating two-drug therapy in hypertensives with blood pressure ≥140/90 mmHg has not been sufficiently translated into real-world practice, leading to treatment failure. (escardio.org)
However, the latest trend shifts the focus to precision medicine, with a single-pill combination (SPC) being at the forefront of the treatment algorithm. (escardio.org)
This article will elaborate the pros and cons of a two-drug regime at the start of treatment in newly diagnosed hypertensive patients, and whether the benefits outweigh the potential risks. (escardio.org)
This protection is not short-lived, as fewer cardiovascular events were observed after one year in hypertensive patients started with combination treatment compared to those with monotherapy [7]. (escardio.org)
The treatment options for hypertension are numerous, and the number of possible combinations large. (medscape.com)
In the treatment of either hypertension or angina, combination CCB therapy can prove uniquely successful. (medscape.com)
Long-acting CCBs are now the preferred mode of therapy in the treatment of hypertension and/or angina when a CCB is opted for (Table 1). (medscape.com)
Cite this: Combination Calcium Channel Blocker Therapy in the Treatment of Hypertension - Medscape - Sep 01, 2001. (medscape.com)
Treatment for extensive stage small cell lung cancer (SCLC) usually involves combination treatment. (healthline.com)
Let's take a closer look at combination therapy for extensive stage SCLC, how it works, and things to consider before choosing a treatment. (healthline.com)
The first-line treatment for extensive stage SCLC is combination chemotherapy. (healthline.com)
This treatment combination is very attractive since it minimizes the risk of treatment-related complications for the patient, especially for older patients who have existing medical comorbidities and typically have a poor prognosis. (mdanderson.org)
After 8 weeks of oral dosing in mice, treatment with the combination did not alter prednisolone-induced reduction in osteocalcin and mid-femur bone density, which are markers of steroid-induced osteoporosis. (biomedcentral.com)
Epigenetic drug discovery is a rapidly advancing field, and drugs targeting epigenetic enzymes are in the clinic for the treatment of hematological cancers. (biomedcentral.com)
People with obsessions and compulsions experience considerable benefit from a combined treatment of drugs and behavioural therapy. (scienceblog.com)
Treatment with drugs alone is less effective. (scienceblog.com)
The combination treatment (Duaklir, Circassia) is designed to be administered twice-daily via AstraZeneca's breath-actuated inhaler (Pressair). (pharmacytimes.com)
With guidelines recommending combined LAMA and LABA therapy for a number of COPD patient groups, we believe Duaklir® will make an important contribution to the treatment of this debilitating disease," said Michael Asmus, Circassia's Vice President, US Medical Affairs, Circassia. (pharmacytimes.com)
Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/432835/all/Tenofovir_or_zidovudine_in_three_drug_combination_therapy_with_one_nucleoside_reverse_transcriptase_inhibitor_and_one_non_nucleoside_reverse_transcriptase_inhibitor_for_initial_treatment_of_HIV_infection_in_antiretroviral_na��ve_individuals:_Cochrane_systematic_review. (unboundmedicine.com)
Low-dose growth hormone treatment reduced abdominal fat deposits and improved blood pressure and triglyceride levels in a group of patients with HIV lipodystrophy, a condition involving the redistribution of fat and other metabolic changes in patients receiving combination drug therapy for HIV infection. (news-medical.net)
Increasing the body's production of growth hormone may be an effective treatment for HIV lipodystrophy, a syndrome involving the redistribution of fat and other metabolic changes in those receiving combination drug therapy for HIV infection. (news-medical.net)
that he therefore believes that there is hope for the drug, although where it will fit into the treatment pathway is "a different story. (medscape.com)
However, efforts to improve access to treatment are hampered by development of HIV, TB and malaria drug resistance. (who.int)
Following widespread resistance to chloroquine and sulphadoxine-pyrimethamine all malaria- endemic countries except two in the Region have changed the treatment policy to artemisinin-based combination therapy (ACT). (who.int)
Health Organization, about drug resistant malaria treatment in Vietnam. (cdc.gov)
For the treatment of falciparum malaria, WHO is recommending the use of a type of drug called artemisinin-based combination therapy, or ACTs. (cdc.gov)

As the cost of "potent but expensive" injectable therapies has limited their uptake, he noted, "there remains a high unmet need for new effective, safe therapies. (medscape.com)

Scientists at St. Jude Children's Research Hospital developed a novel combination therapy approach for a leukemia subtype harboring rearrangements in the KMT2A gene. (medicalxpress.com)

Recent precision medicine approaches have focused on targeting multiple biomarkers found in individual tumors by using combinations of drugs. (wikipedia.org)

This study reports on programmatic coverage and compliance of MDA using artemisinin-based combination therapy (ACT) in four shehias (smallest administration unit) that had been identified as hotspots through Zanzibar's malaria case notification surveillance system. (biomedcentral.com)
We performed a prospective observational study of patients with uncomplicated malaria to investigate whether posttreatment hemolysis also occurs after oral artemisinin-based combination therapy. (cdc.gov)
Eight of 20 patients with uncomplicated malaria who were given oral artemisinin-based combination therapy met the definition of posttreatment hemolysis (low haptoglobin level and increased lactate dehydrogenase level on day 14). (cdc.gov)
The pathophysiology of hemolysis after artemisinin therapy is not fully understood. (cdc.gov)
The currently recommended ACTs are a combination of the drug artemisinin and one of five different partner drugs. (cdc.gov)
Unfortunately, in parts of Southeast Asia, we've seen resistance to both artemisinin and to most of the ACT partner drugs. (cdc.gov)
Resistance to partner drugs used together with an artemisinin is a particularly big problem in Cambodia. (cdc.gov)

One major benefit of combination therapies is that they reduce development of drug resistance since a pathogen or tumor is less likely to have resistance to multiple drugs simultaneously. (wikipedia.org)
Chemotherapy drugs don't target a specific tumor or a specific part of the body. (healthline.com)
In this study, the calcium carbonate worked not only a drug keeper to entrap ICG on the surface of GNSs in the form of a stable aggregate which was protected from blood clearance, but also as the a pH-responder to achieve highly effective tumor-triggered drug release locally. (thno.org)
Meanwhile, the distinct pH-triggered drug release performance of GNS@CaCO 3 /ICG implemented the tumor-targeted NIR fluorescence imaging. (thno.org)
In addition, we monitored the bio-distribution and excretion pathway of GNS@CaCO 3 /ICG based on the NIR fluorescence from ICG and two-photon fluorescence and photoacoustic signal from GNSs, and the results proved that GNS@CaCO 3 /ICG had a great ability for tumor-specific and tumor-triggered drug release. (thno.org)
We therefore conclude that the GNS@CaCO 3 /ICG holds great promise for clinical applications in anti-tumor therapy with tumor imaging or drug tracing. (thno.org)

Charlotte Rasmussen] The resistance to antimalarial drugs has long been a challenge in Southeast Asia. (cdc.gov)
Charlotte Rasmussen] I work for WHO which supports countries in monitoring that the antimalarial drug that is recommended by a country continues to work in that country. (cdc.gov)

In a recent study about solid cancers, Martin Nowak, Bert Vogelstein, and colleagues showed that in most clinical cases, combination therapies are needed to avoid the evolution of resistance to targeted drugs. (wikipedia.org)

Yielding both antihypertensive and non-hypertensive mediated protection, combination therapy is recommended in the first instance for most patients. (escardio.org)
Since hypertension is multifactorial in genesis, combining drug classes augments the antihypertensive effect by approximately five times, thereby increasing the control rate. (escardio.org)
Epidemiologic studies of high blood pressure, antihypertensive therapies, and the risk of AMD thus far have been inconclusive. (cdc.gov)
However, few studies evaluated risks according to the use of different classes of antihypertensive drugs or took combinations of use into account. (cdc.gov)
History of high blood pressure, regular use of antihypertensive medications, and comprehensive risk factor information was collected via self-administered questionnaires at baseline in 1995-1996, and information on specific classes of antihypertensive drugs was provided by a subsample of CTS participants who completed a follow-up questionnaire in 2000. (cdc.gov)
In women treated with a combination of antihypertensive drugs, we observed no increased risk of AMD for any individual class of drugs. (cdc.gov)

Although in guidelines 17 the grade of evidence and recommendation for combination therapy is the same as for monotherapy, more recent reports, including the AMBITION trial 18 and its posthoc analysis 19 , which focused on CTD-PAH patients, suggest combination therapy as a better option to treat PAH, demonstrating its superiority regarding morbidity and mortality. (jrheum.org)
To minimize the potential morbidity and mortality from drug-induced respiratory diseases, healthcare providers should be familiar with the possible adverse effects of the medications they prescribe. (medscape.com)
The authors add it can take decades to progress to a clinically detectable degree, and thus further follow-up of our cohort is necessary to determine whether a substantial absolute increase in morbidity and mortality from therapy-related cardiovascular disease will emerge. (natap.org)

Various systems biology methods must be used to discover combination therapies to overcome drug resistance in select cancer types. (wikipedia.org)
However, with 300 FDA-approved cancer drugs on the market, there almost 45,000 possible two-drug combinations and almost 4.5 million three-drug combinations for to choose from. (wikipedia.org)
These powerful drugs can stop cancer cells from growing and reproducing. (healthline.com)
A combination of ponatinib and blinatumomab was found to be safe and highly effective in patients with newly diagnosed or relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL), according to researchers at The University of Texas MD Anderson Cancer Center . (mdanderson.org)
However, the use of cocktails or multicomponent drugs to address several targets simultaneously is also popular to treat multifactorial diseases such as cancer and neurological disorders. (biomedcentral.com)
Lecithin found in soybeans in combination with a non-steroidal anti-inflammatory drug (NSAID), can prevent cancer and its side effects. (medindia.net)
The anti-inflammatory drugs also have the potential use for cancer therapy. (medindia.net)
Combining anticancer drugs with osteoprotective agents in prostate cancer-A contemporary update. (cristiansurcel.ro)
Abstract Recently, a plethora of life-prolonging cytotoxic, next-generation hormonal, immunotherapeutical as well as radionuclide therapies has emerged as a standard care for metastasized castration-resistant prostate cancer. (cristiansurcel.ro)
Being strikingly effective in cancer control, these novel therapies might in fact exert a beneficial impact on skeletal events. (cristiansurcel.ro)
Support our research today to unlock new combination treatments, so more people will survive cancer. (icr.ac.uk)
The primary challenge of the photo-based anti-cancer therapy is to define a method that ensures the specific killing effect of malignant tissues, while minimizing the side-effect to normal tissues or organs. (thno.org)
My PhD project is to determine if the cellular protein dynamin II (dynII) is a potential anti-cancer drug target. (edu.au)

The results of this large, randomized trial indicate that a single combination therapy of amlodipine/benazepril is superior to HCTZ/benazepril in the reduction in blood pressure as well as cardiovascular endpoints in patients with high-risk hypertension. (acc.org)
Monotherapy is an option as first-line therapy for pulmonary arterial hypertension (PAH). (jrheum.org)
Conversely, significant contributions from diabetes, hypertension, and lipodystrophy were not identified…… we found no evidence to suggest that the duration of HIV-1 infection, the level of prior immunodeficiency, or the degree of HIV-1 RNA replication affected the association between exposure to therapy and the risk of myocardial infarction. (natap.org)

The performance of the clustering was generally replicated in patients who received initial dual-combo therapy or monotherapy. (frontiersin.org)
Survival benefits of triple-combo therapy over dual-combo therapy or monotherapy were not observed in any of the clusters. (frontiersin.org)
We successfully developed a cluster model that stratified patients with myositis-associated ILD who were treated with initial triple-combo therapy into subgroups with different prognoses, although this model failed to identify a patient subgroup that showed survival benefits from triple-combo therapy over dual-combo therapy or monotherapy. (frontiersin.org)
Patients were split into 3 groups: monotherapy versus sequential combination versus upfront combination therapy. (jrheum.org)
Survival from PAH diagnosis among monotherapy, sequential, and upfront combination groups was 78% versus 95.8% versus 94.1% at 1 year, 40.7% versus 81.5% versus 51.8% at 3 years, and 31.6% versus 56.5% versus 34.5% at 5 years (p = 0.007), respectively. (jrheum.org)

Mass drug administration (MDA) appears to be effective in reducing the risk of malaria parasitaemia. (biomedcentral.com)
Mass drug administration for malaria was well accepted by communities at high risk of malaria in Zanzibar, with high participation and completion rates. (biomedcentral.com)
One potential strategy for targeted interventions in a malaria elimination setting is focal mass drug administration (MDA) in high-risk populations. (biomedcentral.com)

Combination therapy with probiotics and mosapride is effective for relief of symptoms in patients with non-diarrheal-type IBS. (nih.gov)
Out protocol was effective in our ICU and may be valuable for determining future therapies of COVID-19. (fortunejournals.com)
How effective is combination therapy? (healthline.com)
The drug's label also includes clinical data from the phase IV ASCENT study, which shows aclidinium therapy is effective at reducing COPD exacerbations. (pharmacytimes.com)

Additionally, data from the Phase 1b MMY1001 study will show the potential of daratumumab in combination with carfilzomib, lenalidomide and dexamethasone (KRd) for newly diagnosed patients with multiple myeloma. (jnj.com)

Thus, the aim is to provide an overview of the most important combination strategies in late stage clinical development and an outlook on drug combinations in early development that might enter larger clinical trials within the next few years. (springermedizin.at)
Clinical trials studying immunotherapy with combination chemotherapy are ongoing. (healthline.com)
In addition, the regulatory requirements are more complex when the agents are used in combination, since the safety profile of each drug needs to be demonstrated before clinical trials, and this can be further delayed due to regulatory and IP issues, in particular if the two drugs are being developed by different companies [ 1 ]. (biomedcentral.com)
While two clinical trials of SCID-X1 gene therapy have shown success, some infants developed leukaemia as a result of the integrating virus used for gene delivery, a risk previously estimated as insignificant. (edu.au)
Currently, cisplatin as a single drug has been used as the standard drug for phase III clinical trials. (medscape.com)

It may be a combination of chemotherapy drugs or chemotherapy plus immunotherapy. (healthline.com)
The immunotherapy drug atezolizumab (Tecentriq) can be given along with combination chemotherapy. (healthline.com)
Once you're finished with chemotherapy, you can stay on atezolizumab as a maintenance therapy. (healthline.com)
Combination chemotherapy for extensive stage SCLC can slow disease progression and provide some relief from symptoms. (healthline.com)
Chemotherapy drugs target cells that divide quickly. (healthline.com)
Side effects of chemotherapy vary based on the particular drugs, dosage, and how often you get it. (healthline.com)
As first-line chemotherapy for patients with peritoneal mesothelioma, the combination of pemetrexed plus gemcitabine is active and can be an option for patients who cannot take cisplatin. (medscape.com)

They found that treating cells with a MEK-PI3K-inhibitor combination led to a synergistic effect in cell growth inhibition. (pharmaceutical-journal.com)

The combination of prednisolone and the antithrombotic drug dipyridamole was profiled using in vitro and in vivo models of anti-inflammatory activity and glucocorticoid-induced adverse effects to demonstrate a dissociated activity profile. (biomedcentral.com)
To benefit from those effects, it is required that the multitarget drug exhibit balanced in vitro and in vivo activities to match potency for the corresponding targets, as well as optimized PK and safety profiles. (biomedcentral.com)
The application of GNS@CaCO 3 /ICG for in vitro and in vivo therapy achieved the combined antitumor effects upon the NIR irradiation, which was superior to the single PDT or PTT. (thno.org)

Helicobacter pylori eradication in adult patients to reduce the risk of duodenal ulcer recurrence in combination with amoxicillin and clarithromycin. (nih.gov)

The combination of vemurafenib and cobimetinib with the PD-L1 blocking antibody atezolizumab (NCT02908672, Trilogy) as well as the combination of dabrafenib and trametinib with the PD‑1 blocking antibody spartalizumab (NCT02967692, Combi-I) are currently being tested in phase III trials in patients with BRAF mutations and in comparison to the respective BRAF/MEK inhibitor combination. (springermedizin.at)

However, monotherapies may also be used because of unwanted side effects or dangerous drug interactions. (wikipedia.org)
These multiple ligands should in principle have a lower risk of drug-drug interactions and drug resistance compared to cocktails or multicomponent drugs. (biomedcentral.com)
Interactions between Chinese herbal medicinal products and orthodox drugs / Kelvin Chang and Lily Cheung. (who.int)
However, that combination has a number of drug-drug interactions and negative side effects that prevent some people from using it. (nationaljewish.org)

Combination therapy, targeting several of the main pathways that contribute to physiopathology of PAH (endothelin-1, prostacyclin, and nitric oxide), is gaining evidence. (jrheum.org)

The success of these therapies has stimulated research into novel drug combinations for melanoma, of which a large majority are based on combination with PD‑1 or PD-Ligand 1 (PD-L1) blocking drugs. (springermedizin.at)

Immunotherapy, also known as biologic therapy, provides a boost to the immune system. (healthline.com)
Developed at SMART, the therapy stimulates the host immune system to more effectively clear bacterial infections and accelerate infected wound healing. (mit.edu)

The researchers said the findings indicated that triple-combination therapy may help to prevent resistance acquisition, rather than overcoming pre-existing resistance. (pharmaceutical-journal.com)
SMART researchers find the enzyme RlmN, which directly senses chemical and environmental stresses, can be targeted in drug development. (mit.edu)
There is no syndrome that causes increased belly fat and decreased facial and limb fat among HIV-positive men who take antiretroviral drugs, according to a study by researchers at the San Francisco VA Medical Center and the University of California, San Francisco. (news-medical.net)
Denver - Researchers at National Jewish Health and around the world report in the New England Journal of Medicine that a novel combination of medications improves lung function and reduces disease exacerbations in cystic fibrosis patients with the most common form of the disease. (nationaljewish.org)

Use of an oral antidiabetes medication produced significant improvement in a group of patients with HIV lipodsytrophy, a syndrome involving the redistribution of fat and other metabolic changes in those receiving combination drug therapy for HIV infection. (news-medical.net)

Typically, the term refers to using multiple therapies to treat a single disease, and often all the therapies are pharmaceutical (although it can also involve non-medical therapy, such as the combination of medications and talk therapy to treat depression). (wikipedia.org)
The intended applications of pharmacogenomics research include identifying responders and non-responders to medications, avoiding adverse events, optimizing drug dose and avoiding unnecessary healthcare costs. (cdc.gov)

Combination therapy with two or more antibiotics are often used in an effort to treat multi-drug resistant Gram-negative bacteria. (wikipedia.org)

The findings suggest that the combination of BET and GSK3 inhibition holds promise for further development in KMT2A-rearranged leukemias. (medicalxpress.com)
Moreover, although anacetrapib "showed that LDL lowering via CETP inhibition worked," retention of the drug in fat tissue meant it had an extended half-life. (medscape.com)

The initial data with our drug candidates, including MDM2-p53 inhibitor APG-115, novel Bcl-2/Bcl-xL dual inhibitor palcitoclax or APG-1252, and IAP inhibitor APG-1387, support further study with great potential in combination therapies," said Dr. Dajun Yang, Chairman & CEO of Ascentage Pharma. (pharmiweb.com)

Lecithin, a chemical found in soybeans when added to a non-steroidal anti-inflammatory drug (NSAID), increased its anticancer properties and reduced its side effects, finds a study by scientists at The University of Texas Health Science Center at Houston (UTHealth). (medindia.net)
Risk reduction of nonsteroidal anti-inflammatory drugs (NSAID)-associated gastric ulcer in adults at risk for developing gastric ulcers due to age (60 years and older) and/or documented history of gastric ulcers. (nih.gov)

Control medicines for asthma are drugs you take to control your asthma symptoms. (medlineplus.gov)
Normally, you use these medicines only when you are using an inhaled steroid drug and you still have symptoms. (medlineplus.gov)
This condition can be suspected if the patient has been exposed to a likely causative drug, develops new signs and symptoms, and has a remittence of these symptoms once the drug is withheld. (medscape.com)

Now, a trial comparing two doses of obicetrapib with placebo in 120 patients already on high-intensity statin therapy has shown that it significantly reduces low-density-lipoprotein (LDL) cholesterol by up to 51% over baseline and improves many other lipid parameters. (medscape.com)

As of April 1, 2020, in the Phase Ib study, 19 patients were treated with APG-115 in 4 alternate-day (QOD) dose cohorts (50 mg, 100 mg, 150 mg, and 200 mg) in combination with pembrolizumab. (pharmiweb.com)
APG-115 in combination with pembrolizumab was generally tolerated. (pharmiweb.com)

Patients taking the ivacaftor-tezacaftor combination also experienced fewer respiratory adverse events, including respiratory infections, cough, headache and fatigue, than did those taking placebo. (nationaljewish.org)

The European Society of Cardiology and the American College of Cardiology, two of the most renowned associations in the cardiovascular field, have reached a consensus on initial two-drug therapy for most patients with persistent blood pressure ≥140/90 mmHg [5]. (escardio.org)

CHICAGO and RARITAN, NJ, June 4, 2017 - Janssen Research & Development, LLC today announced new data from updated analyses of the pivotal Phase 3 CASTOR and POLLUX clinical studies, demonstrating that DARZALEX ® (daratumumab) in combination with bortezomib and dexamethasone, or lenalidomide and dexamethasone, improved progression-free survival (PFS) and the overall response rate (ORR) for previously-treated patients with multiple myeloma, regardless of cytogenetic risk. (jnj.com)
There is a need to develop neuroprotective drugs which slow or stop the progression of the disease. (edu.au)

Anatomy5

Organisms7

Diseases19

Chemicals and Drugs109

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Psychiatry and Psychology1

Phenomena and Processes26

Disciplines and Occupations5

Technology, Industry, Agriculture2

Information Science2

Health Care10

Geographicals1

Efficacy11

Regimens4

Antiretroviral therapy7

Therapeutic10

Regimen11

Fixed-dose4

Colorectal cancer6

20191

Metastatic1

Inhibitors10

Leprosy1

Toxicity11

Treatment40

Injectable1

Novel Combination Therapy1

Tumors1

Artemisinin7

Tumor6

Antimalarial2

Cancers1

Antihypertensive6

Morbidity and morta3

Cancer13

Hypertension3

Monotherapy5

Malaria3

Effective4

Newly diagnosed1

Clinical trials5

Chemotherapy7

Synergistic1

Vitro3

Recurrence1

Inhibitor combination1

Interactions4

Pathways1

Melanoma1

Immune2

Researchers4

Metabolic changes1

Medications2

Resistant1

Inhibition2

Yang1

NSAID2

Symptoms3

Improves1

Pembrolizumab2

Adverse Events1

MmHg1

Progression2