Therapies cell line tumor. Medical search. Frequent questions

Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. (nature.com)
Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes. (harvard.edu)
Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. (hindawi.com)
Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
My lab's work has pursued how multiple discrete subpopulations of malignant cells within these tumors cooperatively resist therapy via both tumor cell autonomous mechanisms and crosstalk with the stromal microenvironment. (upenn.edu)
The fourth generation of CAR-T design attempts to deliver cytokines to modulate the tumor microenvironment either by activating host effector T cells or hampering host suppressors and reinforcing memory T cells. (bdbiosciences.com)
Preclinical tests show that the inhibitor can change the microenvironment of a tumor by increasing populations of antitumor immune cells in the area. (genengnews.com)

Bispecific CAR T cells target two tumor antigens at once and have been explored as a strategy to reduce the risk of relapse. (aacr.org)
1 T cells are engineered to express CARs through viral vectors, enabling them to recognize specific target antigens. (bdbiosciences.com)
Immunocytochemistry is a technique which is able to determine the cell of origin by detecting various membrane and cytoplasmic antigens. (vin.com)
The specific set of antigens expressed by a cell population constitutes a unique phenotype. (vin.com)
4SC-202 also appears to increase the expression of tumor-associated antigens and immunomodulatory molecules in cancer cell lines. (genengnews.com)
Cellular therapies produce mainly effector CD8-positive T cells that are fully differentiated to attack cells bearing specific antigens. (newswise.com)
Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)

Interleukin 15 (IL-15) has been evaluated as a potential treatment for solid tumors in clinical trials, but the effectiveness of systemic IL-15 administration as a monotherapy has not been realized. (frontiersin.org)
Solid tumors, autoimmune diseases, graft versus host disease (GvHD), genetic diseases and neurodegenerative diseases are investigated using many types of autologous and allogeneic cells with rapidly evolving cell engineering and editing approaches. (bdbiosciences.com)
I think the future of oncology, in terms of treating solid tumors , will be these combination therapies," Dr. Hermann says. (genengnews.com)
Photodynamic therapy (PDT) is a new treatment modality for solid tumors as well as for flat lesions of the gastrointestinal tract. (bioone.org)

EGFR-ERK signaling act downstream of berberine/pro-inflammatory cytokines axis to regulate CACRC cell proliferation. (nih.gov)
IL-15 is considered superior to IL-2 for cancer immunotherapy due to its strong bioactivity in improving CD8 + T and natural killer (NK) cell survival, proliferation and cytotoxic function ( 8 ). (frontiersin.org)
AKAP12 knockdown in benign meningioma cells SF4433 increases proliferation, cell cycle, migration, invasion, and confers an anaplastic profile. (nature.com)
Down-regulation of EIF5B significantly decreased proliferation and invasiveness of the HCC cells. (techscience.com)
In each category, studies related to growth control genes, cell proliferation, apoptosis, DNA repair genes, antioxidant and drug detoxification genes, genes of drug metabolizing enzymes, tissue remodeling genes and genes of antibody-dependent cellular cytotoxicity were discussed separately. (researchsquare.com)
It is now known that new blood vessels originate from preexisting vessels by activation, proliferation and migration of endothelial cells through a process named "angiogenesis" [ 4 ]. (hindawi.com)
Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
A hallmark of the disease is the proliferation of cells that have not completely matured. (genengnews.com)
Fabricated by 3D laser lithography, the microrobots' porous structure facilitates the attachment, proliferation and differentiation of various stem cells. (physicsworld.com)
For example, a subset of astrocytoma cells with ultra-long, thin, and highly dynamic membrane protrusions named tumor microtubes are able to extend in the surrounding tissue for tumor cell invasion, proliferation, and connection between tumor cells ( 11 ). (frontiersin.org)
At the same time, a subpopulation of highly tumorigenic glioma stem cells (GSCs) with high plasticity and self-renewal properties contribute to tumor malignancy through their sustained proliferation, invasion, stimulation of angiogenesis, suppression of anti-tumor immune responses and chemo-resistance ( 12 ). (frontiersin.org)
We have already acquired proof-of-principle showing that reprogramming towards astrocytic fate causes morphological changes, reduces proliferation and bestow astrocytic function in human GBM cell lines. (lu.se)

If this damage cannot be repaired, particularly to DNA, cells will self-destruct to protect the surrounding tissue and organism as a whole. (sciencedaily.com)
Liquid biopsy is a new and noninvasive alternative to tumor tissue sequencing, and it is intended to specifically detect and sequence tumor DNA circulating in patients' blood. (hopkinsmedicine.org)
Limited access to tissue samples and patient-derived cell lines has been a significant barrier to understanding the differences between pediatric brain tumors at a molecular level. (chop.edu)
A renewable, tissue culture source of human cells capable of differentiating into a wide variety of cell types would have broad applications in basic research and therapeutic techniques. (spiked-online.com)
Current screening of potential new drugs is done using cell lines derived from animals or 'abnormal' human tissue such as tumor cells. (spiked-online.com)
The exact process of differentiation is not yet understood and although embryonic stem cells can, in principle, provide for all human tissue, scientists are some way from controlling the process. (spiked-online.com)
Real-time PCR was performed for Brachyury on lung tumor tissue cDNA from 80 lung cancer patients of the indicated stages of disease. (jci.org)
In the adult brain, the Tlx protein is responsible for generating new neurons from tissue stem cells. (dkfz.de)
It is what is called the subventricular zone, a tissue structure lining the lateral ventricles. (dkfz.de)
As a result, cell division activity in the subventricular zone increased, the cells left their habitual environment called stem cell niche, and started forming glioblastoma-like tissue lesions. (dkfz.de)
A C 60 -PEG conjugate irradiated by light strongly induced tumor necrosis without any damage to the overlying normal tissue [ 684 , 2576 ], with complete cure achieved by a C 60 -PEG dose of 0.424 mg/kg and irradiation power of 10 11 J/m 2 , making this and similar materials [ 5237 ] excellent candidates for photodynamic tumor therapy. (nanomedicine.com)
Almac sought to identify new biomarkers and drug targets by performing DNA microarray analysis of high Gleason score prostate tumour samples and normal prostate tissue samples. (almacgroup.com)
It can be used to cut out tumors without damaging other tissue. (medlineplus.gov)
These lasers remove thin layers of tissue from the surface of the body and the lining of organs inside the body. (medlineplus.gov)
Firstly, the anatomical location and size of the tumor impact the extent of resection, as a fine balance must be achieved between the maximal removal of malignant tissue and minimal operative risk ( 6 ). (frontiersin.org)
While the pathophysiology underlying peritoneal endometriosis lesion formation is still unclear, the interaction between invading endometrial tissue and the peritoneal mesothelial lining is an essential step in lesion formation. (bvsalud.org)
Tissue from both primary surgery and reoperations from the same patients, allows in depth analysis of the evolution of glioblastoma over time with the goal of development of diagnostic monitoring and identification of druggable GBM stromal targets in recurrent brain tumors. (lu.se)
The applicant is responsible for a brain tumor tissue biobank which provides the basis for the studies on human GBM tumor cells and stroma. (lu.se)
The cancer cells begin in the ducts and then grow outside the ducts into other parts of the breast tissue. (cdc.gov)

Furthermore, the Food & Drug Administration (FDA)-approved mIDH1 inhibitor ivosidenib (AG-120) dramatically inhibited tumor growth in preclinical models of pancreatic cancer, highlighting this approach as a potential therapeutic strategy against wild-type IDH1 cancers. (nature.com)

An in vitro study on cell lines identified that berberine treatment of Raw 264.7 macrophages resulted in conditioned media with fewer proliferative effects on a cell line with a heterozygous Apc mutation (Immorto-Min colonic epithelium, IMCE). (nih.gov)
Fetal bovine serum is the most widely used serum-supplement for the in vitro cell culture of eukaryotic cells. (wikipedia.org)
Fetal bovine serum is commercially available from many manufacturers, and because cells grown in vitro are highly sensitive, customers usually test specific batches to check for suitability for their specific cell type. (wikipedia.org)
Subsequent studies described a VEGFR2 and AC133 expressing subpopulation of these CD34 positive circulating cells that could form endothelial colonies in vitro [ 14 , 15 ]. (hindawi.com)
In vitro cytotoxicity against the HeLa S3 cell line has been evaluated by studying the inhibited growth rate [ 922 ], and some C 60 derivatives have shown promise as anti-cancer agents [ 1090 - 1092 ]. (nanomedicine.com)
Researchers from South Korea and Switzerland have developed magnetically actuated microrobots and used them for precise stem cell delivery and transplantation in vitro , ex vivo and in vivo . (physicsworld.com)
Producing more central memory T cells in vitro can address this persistence challenge and increase the effectiveness of cellular therapies," Yee notes. (newswise.com)
Three human colon carcinoma cell lines with variable degrees of differentiation and a normal colon fibroblast cell line were used to generate a suitable in vitro model for investigation of photosensitizer concentration as well as the applied light dose. (bioone.org)
As a third major line of research, we explore, in collaboration with associate professor Henrik Ahlénius group if GBM cells can be reprogrammed to neuron like cells in vitro and in vivo. (lu.se)

Notably, the findings suggest new strategies to improve combination therapies for cancer. (sciencedaily.com)
The promising preclinical results seen with our bimodal ASO, IM-T9P1, pave the way for the development of combination therapies targeting TLR9 and PD-L1 for the treatment of cancer. (izb-online.de)
Like the developers of LSD1 combination therapies, 4SC AG researchers are pairing an epigenetic drug, in this case an HDAC inhibitor, with immunotherapies. (genengnews.com)

PHILADELPHIA - Bispecific anti-CD19/CD20 chimeric antigen receptor (CAR) T-cell therapy was well tolerated and showed signs of clinical efficacy in patients with relapsed/refractory B-cell lymphoma, according to phase I clinical trial data presented during Week 1 of the virtual AACR Annual Meeting 2021 , held April 10-15. (aacr.org)
Engineered chimeric antigen receptor (CAR) T cell therapies (CAR-T) are now commercially available to treat certain leukemias and lymphomas. (bdbiosciences.com)
The company and Conkwest, Inc., a privately-held immuno-oncology company developing proprietary Neukoplast®, a Natural Killer (NK) cell-line based therapy, also entered into an agreement to jointly develop next generation CAR.TNK™ (Chimeric Antigen Receptor Tumor-attacking Neukoplast) immunotherapies for the treatment of cancer. (prnewswire.com)
Present cellular therapies include chimeric antigen receptor T cells - genetically modified to attack a specific target and used to treat B cell blood cancers - and tumor-infiltrating leukocytes harvested from tumors used to treat melanoma. (newswise.com)

Low AKAP12 expression in a larger cohort of patients (75) characterized tumor invasiveness, recurrence, and progression, indicating its potential as a prognostic biomarker. (nature.com)
Both EMT and CSC phenotypic changes are associated with tumor recurrence. (techscience.com)
Therefore, EMT-targeted therapy is necessary to effectively overcome tumor drug resistance and recurrence. (techscience.com)
The findings could significantly delay tumor recurrence resulting from chemoresistance and prolong survival in glioblastoma patients, according to Sheng. (eurekalert.org)
One major research line is to clarify changes in the glioblastoma (GBM) stroma between primary surgery and tumor recurrence. (lu.se)

Human cell cultures: glioblastoma (U87), colorectal human adenocarcinoma (SW-620), human melanoma (SK-Mel28) and primary embryonic cell lines were irradiated with a neutron flux at the presence of BPA, BSH and liposomal BSH with a concentration of10B 40 μg/ml. (isnct.net)
The data obtained indicate that the accelerator-based BNCT using boron delivery drugs, such as borphenylalanine, borcaptate and liposomal borcaptat, has a positive effect on tumor lines of glioblastoma, colorectal adenocarcinoma and melanoma. (isnct.net)
While a few studies have attempted reprogramming of glioblastoma (GBM) cells toward a neuronal fate, this approach has not yet been used to induce differentiation into other lineages and in vivo data on reduction in tumorigenicity are limited. (lu.se)
Therefore, the discovery of Tlx might provide the first target for a specific therapy against deadly glioblastoma. (dkfz.de)
For many years now, the subventricular zone has been suspected to be the origin of specific malignant brain tumors called gliomas, the most deadly type of which is glioblastoma. (dkfz.de)
Glioblastoma (GBM) is a very aggressive primary malignant brain tumor and finding effective therapies is a pharmaceutical challenge and an unmet medical need. (frontiersin.org)
image: Glioblastoma cells, pictured above, are notoriously aggressive and evade front-line cancer treatments. (eurekalert.org)
Glioblastoma often resists front-line chemotherapies, including temozolomide, a drug that damages DNA and triggers tumor cell death. (eurekalert.org)
Sheng's research team used glioblastoma cell lines and primary glioblastoma cells derived from patient tumor specimens to discover that inhibiting two specific proteins when combined with temozolomide, produced an effective "triple combinational therapy" that overcame chemoresistance. (eurekalert.org)
To me, the most novel finding in this study is that we discovered connexin 43 selectively binds to the PIK3CB/p110beta protein, enabling certain glioblastoma cells to gain chemoresistant traits," Sheng said. (eurekalert.org)
Direct cellular reprogramming of glioblastoma might provide proof of concept for a GBM therapy based on delivery of reprogramming factors. (lu.se)

miR-101-5p has shown tumor-suppressive properties in multiple cancer forms, and we assessed the effect and mechanism of action of this miRNA in HER2+ breast cancer. (nih.gov)
The ability of miR-101-5p to sensitize for treatment with lapatinib, tucatinib and trastuzumab was explored in HER2+ breast cancer cells responding poorly to such targeted drugs. (nih.gov)
miR-101-5p acts as a tumor suppressor by inducing apoptosis in HER2+ breast cancer and sensitizes cells with initially poor response to lapatinib and trastuzumab. (nih.gov)
However, whether the anti-inflammatory effect of berberine contributes to its anti-tumor effect on colitis-associated colorectal cancer (CACRC) remains unknown. (nih.gov)
ISNCT promotes widespread interest on neutron capture therapy and related forms of cancer management. (isnct.net)
Previously, Lahav and colleagues revealed the dynamic behavior of p53 over time and how it affects cancer drug efficacy, cell fate, and more. (sciencedaily.com)
So, the team explored whether manipulating p53 dynamics could increase tumor vulnerability, focusing on human colon cancer cell lines with unmutated, functional p53. (sciencedaily.com)
Direct cellular reprogramming has recently gained attention of cancer researchers for the possibility to convert undifferentiated cancer cells into more differentiated, postmitotic cell types. (lu.se)
We take advantage of the similarity between neural developmental processes and cancer hierarchy to mitigate, if not completely abolish, the malignant nature of tumor cells and pave the way for new intervention strategies. (lu.se)
In pancreatic cancer cells a cytosolic metabolic enzyme, wild-type isocitrate dehydrogenase 1 (wtIDH1), enables adaptation to these conditions. (nature.com)
We demonstrate that low magnesium levels facilitate allosteric inhibition of wtIDH1, which is lethal to cancer cells when nutrients are limited. (nature.com)
These same adaptive survival pathways protect pancreatic cancer cells against chemotherapy 7 . (nature.com)
Herein, we also demonstrate that compounds developed to target mutant IDH1 can be repurposed as wild-type IDH1 inhibitors, because these drugs surprisingly become potent inhibitors of wtIDH1 in cancer cells under conditions present in tumors: specifically, we found that wtIDH1 is critical for PDAC cell survival under low-glucose conditions, and allosteric IDH inhibitors effectively block wtIDH1 activity under low magnesium. (nature.com)
Therapeutic inhibition of Sp1 expression in growing tumors by mithramycin a correlates directly with potent antiangiogenic effects on human pancreatic cancer. (scienceblog.com)
Since epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, including gefitinib (GEF) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of GEF are further enhanced under amino acid starvation (AAS) culture conditions. (spandidos-publications.com)
Although the LAT family plays important roles in the development and function of normal tissues, they are frequently increased in cancer cells ( 3 ). (spandidos-publications.com)
Johns Hopkins Kimmel Cancer Center researchers demonstrated that mice with ovarian cancer that received drugs to reactivate dormant genes along with other drugs that activate the immune system had a greater reduction of tumor burden and significantly longer survival than those that received any of the drugs alone. (hopkinsmedicine.org)
Downregulation of endogenous TRAIL and its effect on the human cancer cell line KELLY. (uni-muenchen.de)
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. (cancerindex.org)
Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective therapies are urgently needed. (cancerindex.org)
The activity of IM-T9P1 was tested in cancer cell lines and tumor models. (izb-online.de)
The goal of this study was to examine the activity of IL-15/IL-15Rα complex (IL-15cx) to CD8 + T cells and evaluate its potential efficacy in murine breast cancer models. (frontiersin.org)
Intraperitoneal administration of IL-15cx results in a moderate inhibition of breast cancer growth that is associated with an increase in the frequency of cytotoxic CD8 T cells and the improvement of their function. (frontiersin.org)
The depletion of myeloid-derived suppressor cells (MDSCs) has no impact on mouse breast cancer growth. (frontiersin.org)
A major breakthrough in cancer therapy is immune checkpoint inhibitor (CPI)-based immunotherapy which has been approved by the FDA for the treatment of multiple types of cancers ( 1 ). (frontiersin.org)
One of these poorly immunogenic tumors is breast cancer with response rates of only 0%-18.5% to CPI therapy alone ( 2 - 4 ). (frontiersin.org)
PD-L1 is expressed mainly on tumor-infiltrating immune cells in roughly 41% of patients with triple negative breast cancer ( 5 ). (frontiersin.org)
Considering these two percentages together, there are only a small subset of breast cancer patients who would benefit from this combination therapy. (frontiersin.org)
Researchers from Children's Hospital of Philadelphia (CHOP), the Alex's Lemonade Stand Foundation Childhood Cancer Data Lab , the Children's Brain Tumor Network (CBTN) , the Pacific Pediatric Neuro-Oncology Consortium (PNOC) , and more than 20 additional institutions have partnered to create a first-of-its-kind open-source, reproducible analysis platform for pediatric brain tumors. (chop.edu)
Pediatric brain tumors are collectively the leading cause of cancer-related death in children in the United States. (chop.edu)
With the help of the Alex's Lemonade Stand Foundation Childhood Cancer Data Lab, the team of researchers was able to build an open-source version of this atlas, the Open Pediatric Brain Tumor Atlas (OpenPBTA), to analyze these data. (chop.edu)
Hepatocellular carcinoma, known as liver cancer, is the most common life-killing tumors in the world. (usda.gov)
Newcastle disease virus (NDV), an avian disease pathogen, has been proved to be an efficient cancer cells killing, or oncolytic, agent. (usda.gov)
The results showed that the NDV Anhinga strain was effective in killing liver cancer cells. (usda.gov)
There was no obvious difference of the growth capability between the recombinant NDV and the parental virus in the cancer cells. (usda.gov)
NDV/Anh-EGFP significantly inhibited liver cancer development both in cancer cell lines and in mice. (usda.gov)
Our results suggest that NDV Anhinga strain could become a potent candidate for clinical carcinoma therapy especially for liver cancer. (usda.gov)
Furthermore, EIF5B knockdown suppressed epithelial-mesenchymal transition (EMT) and the cancer stem cell (CSC) phenotype. (techscience.com)
These data suggest that EIF5B functions as an oncogene that promotes cancer cell growth, survival, and progression. (techscience.com)
Epithelial-mesenchymal transition (EMT) is a dynamic process involved in cancer metastasis wherein cancer cells with epithelial characteristics acquire mesenchymal characteristics such as increased motility, invasion, and survival [ 6 ]. (techscience.com)
Furthermore, cancer cells undergoing EMT phenotypic changes also acquire drug resistance [ 7 ]. (techscience.com)
A subset of cancer cells undergoing EMT acquire characteristics of stem cells and are designated as cancer stem cells (CSCs) [ 8 ]. (techscience.com)
The selective expression of Brachyury in tumor cells and its role in EMT and cancer progression suggest that Brachyury may be an attractive target for antitumor therapies. (jci.org)
It has been suggested that radiation sensitivity and chemosensitivity of cancer cells may play an important role in the local control of the tumor following these therapies. (researchsquare.com)
Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now shown for the first time that malignant brain tumors arise directly from brain stem cells. (dkfz.de)
Scientists from the divisions of Professor Dr. G nther Sch tz and Professor Dr. Peter Lichter at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have recently shown in mouse brains that brain stem cells in the subventricular zone are characterized by a specific molecule: Protein Tlx, a transcription factor, which stimulates the activity of various genes. (dkfz.de)
UK-headquartered Clinigen announced the divestment of global rights for four of its cancer therapies from its portfolio, as per a 10 August press release. (pharmaceutical-technology.com)
Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
3) Tumor/Anti-Cancer Therapy . (nanomedicine.com)
In the process, we have developed the ability to analyze heterogeneity and phenotypic plasticity within cancer cell lines, patient-derived xenografts, and primary human cancer samples based on molecular and functional criteria. (upenn.edu)
As a result, rapid compensation to targeting these pathways occurs not only at the level of signaling networks in individual cells but also through dynamics among diverse cell states cooperatively sustaining cancer progression. (upenn.edu)
We are presently exploiting such intra-tumor diversity as a basis to improve the marginal efficacy of current targeted agents in head and neck cancer therapy with new drug combinations. (upenn.edu)
My NIH-funded research enterprise brings a cutting edge molecular perspective to surgical cancer care while optimizing use of tumors that I remove from patients to advance the science of cancer therapy. (upenn.edu)
This may provide a therapeutic rationale for immune-checkpoint targeted therapies in the context of DNA damage response deficiency in cancer. (almacgroup.com)
To further these goals we developed a specific array platform, this array was based upon extensive sequencing of prostate tumour samples and contains approximately 90,000 probesets, many of which are specific to prostate cancer. (almacgroup.com)
Data to be presented include studies on the significant reduction in tumor burden and enhanced survival following Cynviloq intraperitoneal therapy, compared to albumin-bound paclitaxel* intravenous therapy in a metastatic model of ovarian cancer, successful development of anti-cancer antibody drug conjugates using novel C- and K-lock linker technology, and significant efficacy of its c-Met/EGFR Bispecific Targeting ADC in a non-small cell lung cancer model. (prnewswire.com)
The talks highlighted a promising trend-epigenetic modification could be the next wave in cancer therapy, especially when exploited in tandem with the administration of other medications, 4SC AG's Chief Development Officer Frank Hermann, M.D., told GEN . (genengnews.com)
Preclinical studies also suggest INCB059872 could help combat small-cell lung cancer and Ewing Sarcoma, and clinical trials are currently underway to test the drug's efficacy in patients with sickle-cell disease, as well as its safety in patients with advanced malignancies. (genengnews.com)
Together, the one-two punch could spur the body's own immune system to attack cancer cells. (genengnews.com)
Together, the drugs appear to prevent cancer cells from evading detection. (genengnews.com)
Laser therapy uses a very narrow, focused beam of light to shrink or destroy cancer cells. (medlineplus.gov)
Thin fibers at the end of the tube direct the light at the cancer cells. (medlineplus.gov)
They can treat basal cell skin cancer and cancers of the cervix, vagina, and vulva. (medlineplus.gov)
These lasers can treat skin cancer and are also used with light-sensitive drugs in a treatment called photodynamic therapy . (medlineplus.gov)
The laser-emitting fibers are put inside a tumor to heat up and damage the cancer cells. (medlineplus.gov)
Stem cell therapy is an emerging method for restoring damaged tissues or treating a variety of diseases, from cancer to degenerative neural disorders like Alzheimer's disease. (physicsworld.com)
Next, Jeon and colleagues established the feasibility of targeted cell delivery using microrobots loaded with human colon cancer cells in a body-on-a-chip microfluidic cell culture platform that mimics parts of a liver tumour network. (physicsworld.com)
BUSINESS WIRE )--Positive results from the pivotal TROPION-Lung01 Phase III trial showed that datopotamab deruxtecan (Dato-DXd) demonstrated a statistically significant improvement for the primary endpoint of progression-free survival (PFS) compared to docetaxel, the current standard of care, in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) treated with at least one prior line of therapy. (businesswire.com)
For patients with advanced non-small cell lung cancer, current standard of care second-line docetaxel is associated with limited benefit and substantial toxicity. (businesswire.com)
The improvement in progression-free survival observed with datopotamab deruxtecan, particularly in patients with non-squamous tumors, and the improved tolerability of this antibody drug conjugate compared to docetaxel, represent a meaningful advance for patients with lung cancer. (businesswire.com)
The TROPION-Lung01 results demonstrate for the first time that an antibody drug conjugate can delay disease progression or death for longer than conventional chemotherapy in patients with advanced non-small cell lung cancer. (businesswire.com)
The benefit seen in patients with non-squamous tumors is particularly impressive and, coupled with the data from TROPION-Lung05, provides promising evidence that datopotamab deruxtecan may play an important role in treating patients with non-small cell lung cancer who currently have limited effective options following initial treatment. (businesswire.com)
Newswise - HOUSTON -- Treating T cells harvested from a patient with a combination of an epigenetic drug and a cytokine while expanding the cells in the lab re-programs them into a stronger T cell type that persists longer than its comrades, researchers at The University of Texas MD Anderson Cancer Center report in Cancer Immunology Research, a journal of the American Association for Cancer Research. (newswise.com)
The combination of panobinostat and interleukin-21 converts the less vigorously expanding effector T cells that attack cancer cells to a more proliferative and enduring central memory T cell type capable of self-renewal, the team found. (newswise.com)
Lack of persistence is one major reason cellular therapies that involve harvesting, expanding, and in some instances, genetically modifying, a patient's T cells before returning them to attack cancer fail, Yee says. (newswise.com)
Merkel cell carcinoma, a rare type of skin cancer, is an aggressive and fast-growing disease that has been associated with mortality rates higher than other types of skin cancer, including melanoma," said Dr. (merck.com)
Merkel cell carcinoma is an aggressive and rare form of skin cancer that is often caused by a Merkel cell associated polyomavirus. (merck.com)
Merkel cell carcinoma is more likely to spread to other parts of the body than most types of skin cancer. (merck.com)
KEYTRUDA, as a single agent, is indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have high PD-L1 expression [Tumor Proportion Score (TPS) ≥50%] as determined by an FDA-approved test, with no EGFR or ALK genomic tumor aberrations. (merck.com)
The new study, in combination with the Sheng Lab's 2015 study published in Cancer Research , is the first to depict a specific channel protein and its enzymatic interactions with signaling molecules driving tumor growth that may underlie chemotherapy resistance in glioblastomas that don't express the DNA-repairing protein MGMT - as well as a novel therapeutic approach. (eurekalert.org)
Sheng's team applied two molecules that blocked downstream chemical reactions, curbing the production of Akt - a key protein kinase that the cancer cells need to metabolize food, move, proliferate, and survive. (eurekalert.org)
After surgery, my PSA was at 0.1, and with eight(8) lymph nodes dissected during surgery all were negative for microscopic cancer cells. (cancer.org)
The International Germ Cell Cancer Consensus Group (IGCCCG) developed a classification system based on identifying clinically independent prognostic features, including extent of disease and levels of serum tumor markers. (medscape.com)
National Comprehensive Cancer Network guidelines strongly prefer surveillance for stage IA or IB pT1-3 tumors. (medscape.com)
Recent studies demonstrated that the tumor suppressor gene programmed cell death 4 (PDCD4) and its upstream regulator miR-21 have been considered as oncogenes for novel cancer prevention or anticancer therapies. (cdc.gov)
While macrophage phagocytosis is an immune defense mechanism against invading cellular organisms, cancer cells expressing the CD47 ligand send forward signals to repel this engulfment. (bvsalud.org)
Here we report that the reverse signaling using CD47 as a receptor additionally enhances a pro-survival function of prostate cancer cells under phagocytic attack. (bvsalud.org)
Although low CD47-expressing cancer cells still allow phagocytosis, the reverse signaling delays the process, leading to incomplete digestion of the entrapped cells and subsequent tumor hybrid cell (THC) formation. (bvsalud.org)
Viable THCs acquire c-Myc from parental cancer cells to upregulate both M1- and M2-like macrophage polarization genes. (bvsalud.org)
Furthermore, these cells intrinsically express low levels of androgen receptor and its targets, resembling an adenocarcinoma-immune subtype of metastatic castration-resistant prostate cancer. (bvsalud.org)
Here, we report that concordant AXL-STAT3 signaling in TAMs is triggered by lung cancer cells or cancer-associated fibroblasts in the cytokine milieu. (bvsalud.org)
Although cell diversification fosters tumor evolution and therapy resistance, upstream mechanisms that regulate the stability and plasticity of the cancer epigenome remain elusive. (bvsalud.org)
Further, ascorbate-2-phosphate (A2P) eradicates heterogeneity and impairs growth of high 2HG-producing breast cancer cells. (bvsalud.org)
These findings suggest 2HG as a key determinant of cancer plasticity and provide a rational strategy to counteract tumor cell evolution. (bvsalud.org)
We performed a first-of-kind evaluation of two transcriptome-based precision cancer medicine methodologies to predict tumor sensitivity to a comprehensive repertoire of clinically relevant oncology drugs, whose mechanism of action we experimentally assessed in cognate cell lines. (cdc.gov)
diagnostic prediction of small round blue cell tumors (SRBCT) of childhood and determining the estrogen receptor (ER) status of sporadic breast cancer. (lu.se)
Treatment protocols for nonseminoma testicular cancer are provided below, including recommendations for treatment of stage I-III disease, second-line recommendations for metastatic disease, and recommendations for persistent or recurrent disease. (medscape.com)
Renal cell carcinoma (RCC) is the most common renal cancer. (msdmanuals.com)
Wilms Tumor Wilms tumor is an embryonal cancer of the kidney composed of blastemal, stromal, and epithelial elements. (msdmanuals.com)
Clinical Impact of Adherence to NCCN Guidelines for Biomarker Testing and First-Line Treatment in Advanced Non-Small Cell Lung Cancer (aNSCLC) Using Real-World Electronic Health Record Data. (cdc.gov)
Family history of prostate cancer and prostate tumor aggressiveness in black and non-black men;results from an equal access biopsy study. (cdc.gov)
Invasive cancer cells can also spread, or metastasize, to other parts of the body. (cdc.gov)
The cancer cells are only in the lining of the ducts, and have not spread to other tissues in the breast. (cdc.gov)
Men who had radiation therapy to the chest have a higher risk of getting breast cancer. (cdc.gov)
As in women, treatment for breast cancer in men depends on how big the tumor is and how far it has spread. (cdc.gov)

Cell survival 96 hours after irradiation was determined using MTT test, and survival fraction was evaluated using the clonogenic test. (isnct.net)
A new study now finds that cellular survival after radiation exposure depends on behavior of the tumor-suppressor protein p53 over time. (sciencedaily.com)
In the intestine, which is normally more resistant to radiation, the addition of the drug reduced cell viability and survival. (sciencedaily.com)
Chemotherapy can be used as adjuvant therapy in patients with advanced or recurrent disease and has been effective in improving disease-free survival. (medscape.com)
In this study, BAVENCIO plus best supportive care (BSC) as first-line maintenance therapy significantly extended the survival of patients with previously untreated locally advanced or metastatic UC whose disease did not progress on induction chemotherapy, compared with BSC only. (emdserono.com)
BAVENCIO is the first immunotherapy to demonstrate a statistically significant improvement in overall survival in a Phase III clinical trial in the first-line setting for patients with locally advanced or metastatic urothelial carcinoma,' said Chris Boshoff, M.D., Ph.D., Chief Development Officer, Oncology, Pfizer Global Product Development. (emdserono.com)
Treatment with IM-T9P1 resulted in the sustained activation of a specific type of tumor infiltrating cell, dendritic cells 3 (DC3s), which can promote antitumor immunity by supporting T cells with survival signals and enabling them to perform their effector functions. (izb-online.de)
Systemic and local administration of IL-15cx shows two distinct therapeutic responses, a moderate tumor growth inhibition or heterogeneous tumor regressions with survival improvement. (frontiersin.org)
However, the severity of pediatric brain tumors varies wildly, with some having an almost universally fatal prognosis while others have relatively strong long-term survival rates, though all brain tumors negatively impact these children and their families to at least some degree. (chop.edu)
In this study, researchers found that the loss of the tumor suppressor gene TP53 is a significant marker for poor overall survival in fast-growing brain and spinal cord tumors called ependymomas and certain diffuse midline gliomas, and dysregulation of the gene was also implicated in hypermutant high-grade gliomas. (chop.edu)
In the glioma cells, EIF5B promotes cell survival by enhancing the translation of several IRES-containing mRNAs including those encoding anti-apoptotic proteins such as XIAP and Bcl-xL [ 4 ]. (techscience.com)
Mammalian cells require oxygen and nutrients for their survival and are therefore located within 100 to 200 m of blood vessels, the diffusion limit of oxygen. (hindawi.com)
Median progression-free and overall survival were not reached at the time of follow-up, and all responding patients continued to have CAR T-cell persistence at the time of data cutoff. (aacr.org)

Thus, the best available treatments against PDAC (that is, chemotherapy) are less effective under tumor-associated conditions. (nature.com)
Advanced head and neck squamous cell carcinoma (HNSCC) is treated with radiotherapy, chemotherapy, targeted therapy or a combination of these treatments. (researchsquare.com)
Findings were categorized by type of treatment (radiotherapy, chemotherapy, targeted therapy, or combination therapy). (researchsquare.com)
The standard of care therapy for GBM consists in surgical resection of the tumor, followed by radiotherapy and adjuvant plus concomitant chemotherapy with Temozolomide (TMZ) (Stupp protocol) ( 3 ). (frontiersin.org)
KEYTRUDA, in combination with pemetrexed and platinum chemotherapy, is indicated for the first-line treatment of patients with metastatic nonsquamous NSCLC, with no EGFR or ALK genomic tumor aberrations. (merck.com)
KEYTRUDA, as a single agent, is also indicated for the treatment of patients with metastatic NSCLC whose tumors express PD-L1 (TPS ≥1%) as determined by an FDA-approved test, with disease progression on or after platinum-containing chemotherapy. (merck.com)
1 line of systemic therapy in case of participants ineligible for high-dose chemotherapy and autologous Hematopoietic stem cell transplantation (HSCT). (who.int)

For the primary transplanted embryonic line, high toxicity was revealed when BNCT was performed with borphenylalanine and borcaptate. (isnct.net)
For each cell line, the toxicity of each compound in the DTP database was compared with the FLCN expression level. (scienceblog.com)
Variations in toxicity and response to therapy are observed among patients despite similar clinicopathologic characteristics which are attributed to single nucleotide polymorphisms (SNPs). (researchsquare.com)
The aim of this review was to evaluate the impact of SNPs on toxicity and response to therapy in HNSCCs. (researchsquare.com)
A web-based search of all original articles about the impact of gene polymorphisms on toxicity and response to therapy in HNSCCs was done until September 2021 using international English language databases including Google Scholar, Scopus, PubMed and Web of science. (researchsquare.com)
2004 ). One problem with cancers, especially HNSCCs, is the unpredictability of treatment outcomes, both in terms of tumor response and host toxicity. (researchsquare.com)
As a surgeon-scientist, my overall goal is to improve our ability cure the most aggressive head and neck cancers while also abating treatment toxicity for ones readily curable by existing therapies. (upenn.edu)
Well-differentiated tumor cells showed higher toxicity than less-differentiated cells. (bioone.org)

This review summarizes the most relevant data relating to the potential role of melatonin (pineal secretory product) as an adjuvant therapy of tumors. (unboundmedicine.com)
A meta-analysis of clinical studies in which melatonin was applied as an adjuvant drug in the therapy of various tumors pointed to some effects of its administration. (unboundmedicine.com)
Dziegiel P, Podhorska-Okolow M, Zabel M. Melatonin: adjuvant therapy of malignant tumors. (unboundmedicine.com)
Radiation is used as adjuvant to treat progressive tumors since there are no efficient chemotherapies for the management of high-grade tumors that fail treatments. (nature.com)

Most importantly, forced differentiation substantially reduces tumorigenicity of GBM cells in an in vivo xenotransplantation model. (lu.se)
The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells. (harvard.edu)
This report details the diagnosis of lymphoblastic leukemia with suspected B-cell differentiation in a diamondback terrapin ( Malaclemys terrapin ). (vin.com)
Research has shown that lysine-specific histone demethylase 1 (LSD1) plays an essential role in the self-renewal of these "leukemic stem cells," Incyte principal investigator Sang Hyun Lee, Ph.D., tells GEN . Building on this finding, Dr. Lee and colleagues developed an LSD1 inhibitor called INCB059872, which spurs myeloid cell differentiation. (genengnews.com)
Fluorescent microscopy images of neural stem cells and their differentiation into astrocytes, oligodendrocytes and neurons on a lab dish, a helical microrobot and a spherical microrobot. (physicsworld.com)
This paracrine action drives TAM differentiation toward a tumor-promoting "M2-like" phenotype with upregulation of CD163 and putative mesenchymal markers, contributing to TAM heterogeneity and diverse cellular functions. (bvsalud.org)
First, we screened 513 natural compounds on primary AML cells and identified a novel diterpene (H4) that preferentially induced differentiation of FLT3 wild-type AMLs, while FLT3-ITD/mutations conferred resistance. (lu.se)
By combinatorial screening using H4 and molecules with defined targets, we demonstrated that H4 induces differentiation by the activation of protein kinase C (PKC) signaling pathway, and in line with this, activates PKC phosphorylation and translocation of PKC to the cell membrane. (lu.se)

Another important aspect of BHD research is developing therapeutic treatments for BHD syndrome, and in particular for renal cell carcinoma (RCC). (scienceblog.com)
An understanding of the biological properties of MM may provide insights into useful therapeutic strategies, and MM cell lines and animal models have been major contributors to our current knowledge of this tumour. (ersjournals.com)
Photoabsorbing agents such as nanoparticles need to reach the tumor site at therapeutic concentrations, crossing the blood-brain barrier upon systemic administration. (frontiersin.org)
Additionally, GBM is characterized by high inter-tumor and intra-tumor heterogeneity at a cellular, molecular, histological, and clinical level leading to very different responses to therapeutic agents and failure of targeted therapies ( 9 , 10 ). (frontiersin.org)

Anti-CD19 CAR T-cell therapy has revolutionized the management of this disease in recent years, but it still has several limitations," she noted, explaining that approximately half of patients relapse within six months of starting the treatment due to a lack of CAR T-cell persistence and/or downregulation of the target antigen, CD19, on the tumor. (aacr.org)
We hypothesized that this approach might increase CAR T-cell persistence and expansion in the patient, while limiting relapses due to loss of the tumor antigen. (aacr.org)
The presented analysis included five patients with B-cell malignancies that were positive for both CD19 and CD20 tumor antigen expression. (aacr.org)
The technique has also shown preliminarily promising outcomes in B cell acute lymphoblastic leukemia (B-ALL), B cell non-Hodgkin's lymphoma (B-NHL), chronic lymphocytic leukemia (CLL), Hodgkin's lymphoma and multiple myeloma in clinical trials targeting CD19, CD20, CD22, CD30 and B-cell maturation antigen (BCMA), with many more under investigation. (bdbiosciences.com)
5 The BLA.36 antigen is known to stain a subset of B-cells in humans and has been shown to stain cells in many mammals which correspond to CD79a positive cells, a component of the B-cell receptor. (vin.com)
Results of immunocytochemical staining revealed that the neoplastic cells were positive for the BLA.36 antigen, demonstrating a 3-4+ membrane stain. (vin.com)
The neoplastic cells were negative for CD3 antigen, although few circulating small well-differentiated lymphocytes were positive for this marker. (vin.com)
Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
and T-cell epitopes, and the heavily glycosylated portion of Reports of P. jirovecii colonization detected by molecular the antigen plays a central role in the interaction of the probes in persons ranging from healthy young children to organism with the host ( 6 - 10 , 20 ). (cdc.gov)

Collectively, these data show that IM-T9P1 leads to long-lasting, adaptive antitumor immunity that can be further improved when combined with T cell-targeting immune checkpoint inhibitors and can have efficacy against large, established tumors in preclinical tumor models. (izb-online.de)
The antitumor efficacy was studied in mouse mammary carcinoma models (Her2/neu transgenic and 4T1-luc mammary cancers) treated with systemic recombinant protein with/without the depletion of myeloid-derived suppressor cells or intra-tumoral gene electrotransfer (GET). (frontiersin.org)
NDV tumor killing efficacy is not only depending on the NDV strain but also the type of tumor targeted. (usda.gov)
The antitumor efficacy of the recombinant virus on hepatoma was examined both in cell cultures and in mice. (usda.gov)
In this study, Ghafouri and colleagues evaluated the safety and efficacy of anti-CD19/CD20 bispecific CAR T-cells using naïve memory cells. (aacr.org)

EIF5B (Eukaryotic Translation Initiation Factor 5B) is a conserved eukaryotic translation factor that mediates association of the 40S and 60S ribosomal subunits during eukaryotic translation initiation, and modulates the cell cycle progression by regulating the translation of upstream open reading frames (uORF)-containing mRNAs such as p27 and p21 [ 3 ]. (techscience.com)
Here we show that the T-box transcription factor Brachyury induces in tumor cells epithelial-mesenchymal transition (EMT), an important step in the progression of primary tumors toward metastasis. (jci.org)
We also determined that the percentage of human lung tumor tissues positive for Brachyury expression increased with the stage of the tumor, indicating a potential association between Brachyury and tumor progression. (jci.org)
Angiogenesis, the growth of new blood vessels, occurs at different stages during embryonic development, physiological processes such as wound healing and reproduction, and numerous diseases, including inflammation, tumor progression, and metastasis [ 1 ]. (hindawi.com)
When safe and gross cytoreduction is achieved, residual infiltrating GBM cells undetectable by advanced imaging techniques still remain in the peritumoral area leading to disease progression and inevitable patient's death ( 7 , 8 ). (frontiersin.org)
Bridging therapy: For participants who are at high risk to experience disease progression during the manufacture of JNJ-90009530 drug product and before lymphodepletion, a bridging therapy is allowed at the investigator's discretion and Sponsor's approval. (who.int)

Theca cell tumors almost always are benign and carry an excellent prognosis. (medscape.com)
The World Health Organization (WHO) histologically classifies tumors into three grades: benign (I), atypical (II) and anaplastic (III) 2 . (nature.com)
PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
Von Hippel-Lindau Disease (VHL) Von Hippel-Lindau disease is a rare hereditary neurocutaneous disorder characterized by benign and malignant tumors in multiple organs. (msdmanuals.com)

Molecularly targeted therapy on a new preclinical mouse model for gastric neuroendocrine tumors. (uni-muenchen.de)

The mechanism behind malignancy and tumor genesis is unknown, limiting development of alternative therapies. (nature.com)
This strategy was used to better understand the underlying mechanisms of meningioma malignancy, aid in the development of novel therapies and markers of poor prognosis. (nature.com)

Secarna Pharmaceuticals, an IZB-based biopharmaceutical company focusing on the discovery and development of next-generation antisense oligonucleotide (ASO) therapies to address challenging or previously undruggable targets via its LNAplus™ platform, announced the publication of striking new preclinical data demonstrating that bimodal ASOs can enable efficacious long-term antitumor immunity in tumor models compared to current immune checkpoint inhibitors. (izb-online.de)
The publication describes the preclinical activity of Secarna's high-affinity bimodal LNAplus™-based ASO, IM-T9P1, that simultaneously triggers toll-like receptor 9 (TLR9) signaling and downregulates programmed cell death ligand 1 (PD-L1) expression, a protein involved in the suppression of the adaptive immune system, in one molecular entity. (izb-online.de)
TLR9 signaling is an important innate immune pathway that is relevant as a first-line defense mechanism against pathogens. (izb-online.de)
The innate immune system is mainly composed of myeloid lineage cells, such as macrophages, neutrophils, and mast cells [ 2 ]. (hindawi.com)
No dose-limiting toxicities or immune effector cell-associated neurotoxicity were observed in any of the patients. (aacr.org)
A number of growth factors, including platelet derived growth factors A and B (PDGF-A and -B), insulin-like growth factor I and transforming growth factor-beta (TGF-beta), and some of their receptors, have been reported to be expressed by MM cells, and each has the potential to play a role as a growth stimulant for MM or to modify immune responses to the tumour. (ersjournals.com)
Some data support an autocrine role for PDGF-A. MM cell lines are susceptible to lysis by a variety of immune effector cells, and their growth can often be inhibited by cytokines. (ersjournals.com)
The possibility of stimulating an immune response to MM by genetic manipulation of the tumour cells has been investigated using a murine model. (ersjournals.com)
What could be truly exciting, Dr. Lee notes, is the combination of LSD1 inhibitors with antibodies that block programmed cell death-1 (PD-1), a cell surface receptor that keeps the immune system in check. (genengnews.com)
Specifically, CD8+ cells, also known as cytotoxic T cells, burst onto the scene, while other immune system suppressor cells drop off, Dr. Hermann tells GEN . (genengnews.com)
Inactivating immune system checkpoints such as PD-1 and treating cells with 4SC-202 can inhibit tumor growth. (genengnews.com)
KEYTRUDA is an anti-PD-1 therapy that works by increasing the ability of the body's immune system to help detect and fight tumor cells. (merck.com)

Notably, IM-T9P1 triggered complete tumor regression in 39% (7/18) of MC38 tumor-bearing mice (compared with the 0% regression rate following PD-L1 monoclonal antibody treatment), and in 77% (30/39) of EMT6 tumor-bearing mice (compared with the 28% response rate following PD-L1 monoclonal antibody treatment). (izb-online.de)
An early increase of local cytotoxic cells correlates with GET treatment and an increase of long-term memory T cells results from animals with complete tumor regression. (frontiersin.org)

The anti-inflammatory and anti-tumor effects of berberine, a traditional Chinese medicine, were separately discovered in pathological intestinal tissues. (nih.gov)
Boron neutron capture therapy (BNCT) is a promising method for treating tumors, in particular, infiltrative malignant tumors, due to the selective destruction of tumor cells without damaging the surrounding normal tissues. (isnct.net)
Exposure to radiation can wreak indiscriminate havoc on cells, tissues, and organs. (sciencedaily.com)
In vulnerable tissues, p53 levels go up and remain high, leading to cell death. (sciencedaily.com)
Blastocytes obtained through nuclear transfers would be used to generate the embryonic stem cells that could be differentiated to specific tissues or organs for transfer to the nuclear donor. (spiked-online.com)
In the present study, we investigated the expression profile and prognostic potential of EIF5B in HCC tissues and cell lines. (techscience.com)
Furthermore, we found Brachyury to be overexpressed in various human tumor tissues and tumor cell lines compared with normal tissues. (jci.org)
Brachyury expression in human lung tumor tissues. (jci.org)
Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
Photothermal therapy may be a promising strategy for the treatment of GBM, as it allows the destruction of the tumor using heat as a non-chemical treatment for disease bypassing the GBM heterogeneity limitations, conventional drug resistance mechanisms and side effects on peripheral healthy tissues. (frontiersin.org)
C. Peterson, M. Ringne´r / Artificial Intelligence in Medicine 28 (2003) 59-74 structure and function, cellular metabolism, development of cells and tissues, and response of organisms to their environments. (lu.se)
Since genes are composed of a given alphabet (A, T, C, G) with fixed pairing properties A-T and C-G, probes can be constructed that attract gene transcripts extracted from cell tissues and cultures. (lu.se)

Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
In this review, we discuss the role of myeloid cells in promoting tumor angiogenesis. (hindawi.com)
These observations stimulated an intensive search for the mechanisms regulating tumor angiogenesis. (hindawi.com)
Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)

Submission of a supplemental Biologics License Application (sBLA) for BAVENCIO® (avelumab)* for first-line maintenance treatment of patients with locally advanced or metastatic urothelial carcinoma (UC). (emdserono.com)
ROCKLAND, Mass. and NEW YORK, April 9, 2020 / PRNewswire / -- EMD Serono, the biopharmaceutical business of Merck KGaA, Darmstadt, Germany in the US and Canada, and Pfizer Inc. (NYSE: PFE) today announced completion of the submission of a supplemental Biologics License Application (sBLA) to the US Food and Drug Administration (FDA) for BAVENCIO ® (avelumab)* for first-line maintenance treatment of patients with locally advanced or metastatic urothelial carcinoma (UC). (emdserono.com)
License Application (sBLA) seeking accelerated approval for KEYTRUDA, Merck's anti-PD-1 therapy, for the treatment of adult and pediatric patients with recurrent locally advanced or metastatic Merkel cell carcinoma (MCC). (merck.com)
Symptoms usually do not appear until late, when the tumor may already be large and metastatic. (msdmanuals.com)

Overproduction of Tlx in mice stimulates the development of malignant brain tumors from brain stem cells. (dkfz.de)

Targeting melanoma with front-line therapy does not abrogate Nodal-expressing tumor cells. (harvard.edu)
Proleukin uses interleukin-2 to induce T cell-mediated tumour regression in advanced melanoma. (pharmaceutical-technology.com)
Central memory T cells do almost all the things you want - they persist because they have high replicative and proliferative capacity, and they have inducible cell-killing capacity so what they see they kill very well," says senior author Cassian Yee, M.D., professor of Melanoma Medical Oncology . (newswise.com)
Yee, first author Junmei Wang, Ph.D., instructor in Melanoma Medical Oncology, and colleagues showed that the combination therapy re-programs these effector T cells into central memory cells. (newswise.com)
The "melanoma-enriched" microRNA miR-4731-5p acts as a tumour suppressor. (nih.gov)

In a whole-genome sequencing in 17 Esophageal Squamous Cell Carcinoma cases and whole-exome sequencing in 71 cases, Song (2014), reported ASH1L alterations. (cancerindex.org)

More than 1,000 of these tumors were sequenced to form the initial release of the Pediatric Brain Tumor Atlas (PTBA) in 2018, and data were made available without embargo so that researchers could study what variants might be driving certain types of brain tumors. (chop.edu)

Tumors treated this way shrunk significantly more than when given either radiation alone or the drug alone. (sciencedaily.com)
In the HCC cells, activation of the NF-kappa B signaling pathway and IkB phosphorylation was significantly reduced by EIF5B silencing. (techscience.com)

Human epidermal growth factor receptor 2 positive (HER2+) breast cancers responding poorly to targeted therapy need improved treatment options. (nih.gov)
The protein is also a famous tumor suppressor -- around half of human cancers have p53 mutations that render it defective or suboptimal. (sciencedaily.com)
Some cancers can become resistant to radiation therapy. (sciencedaily.com)
CNX is developing lifileucel as a cell therapy for various cancers. (pharmaceutical-technology.com)

Patient PBMCs are collected by leukapheresis followed by enrichment approaches to isolate T cells while removing other cells such as B cells, monocytes, neutrophils, dendritic cells and contaminating tumor cells. (bdbiosciences.com)

Expression levels of miR-101-5p in two clinical datasets, TCGA and METABRIC, were compared between tumor and normal adjacent samples, and across molecular subtypes and HER2 status. (nih.gov)
When cells are exposed to ionizing radiation, high-energy atomic particles haphazardly assault the delicate molecular machinery inside. (sciencedaily.com)
In a study using genetically engineered mice, Johns Hopkins researchers have uncovered some new molecular details that appear to explain how electroconvulsive therapy (ECT) rapidly relieves severe depression in mammals, presumably including people. (hopkinsmedicine.org)
Identifying molecular markers that are effective in responding to treatment is important in order to optimize therapies (Ansell et al. (researchsquare.com)
Using a molecular-biological trick, the investigators induced an overproduction of Tlx by the brain stem cells of mice. (dkfz.de)
My group seeks precise molecular definition of the epigenetic plasticity that promotes homeostasis of tumor cells that retain malignant potential in the face of standard therapy. (upenn.edu)

A mechanistic study identified that these inhibitory effects of berberine occurred through blocking interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) expression in colonic macrophages. (nih.gov)
Fullerene-treated mice had less tumor necrosis factor alpha and less interleukin-1beta production compared to the production levels for nontreated mice. (nanomedicine.com)
After irradiation, cell lines with cytosolic or mitochondrial PPIX localization indicate a loss of mitochondrial transmembrane potential resulting in growth arrest, whereas membrane-bound PPIX induces a loss of membrane integrity and consequent necrosis. (bioone.org)

Therefore, the use of melatonin could offer hope in future antitumor therapy. (unboundmedicine.com)
The combined downregulation of PD-L1 expression in a single-molecule approach resulted in exceptional antitumor activity in different tumor models. (izb-online.de)

RCC, an adenocarcinoma, accounts for 90 to 95% of primary malignant renal tumors. (msdmanuals.com)

Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)

A common theme in cell therapy is the need to characterize and understand cell phenotypes and heterogeneity at every step of the process. (bdbiosciences.com)
Breast tumors with high 2HG exhibit enhanced heterogeneity with undifferentiated epigenomic signatures linked to adverse prognosis. (bvsalud.org)

In previous studies of gliomas, increased levels of the connexin 43 protein suppressed tumor growth. (eurekalert.org)

We were able to connect differences in temporal p53 expression with radiation response, and these insights allowed us to 'coax' radioresistant tumors into more radiosensitive ones," said co-corresponding author Ralph Weissleder, the Thrall Family Professor of Radiology and HMS professor of systems biology at Mass General. (sciencedaily.com)
Building off experience in hematopoietic stem cell transplant and exploiting advances in genetic engineering, genome editing, immunology, immunotherapy, stem cell biology, understanding disease mechanisms and cell therapy manufacturing, considerable progress has been made with hundreds of clinical trials underway. (bdbiosciences.com)

Certificates of Analysis vary between commercial suppliers, but each usually includes the following details: filtration statement, country of blood collection, country of manufacture, cell growth performance testing, microbial sterility testing, as well as screening for mycoplasma and virus, endotoxin, hemoglobin, IgG gamma glutamyl transferase and total protein assays. (wikipedia.org)
Scientists have known these differences involve the protein p53, a well-studied tumor-suppressor protein that initiates a cell's auto-destruct programs. (sciencedaily.com)
Functioning of the stem cells thus appears to depend on the presence of this protein. (dkfz.de)
Their research confirmed that IL-21 activates STAT3, a protein that then connects with the promoter region of the gene encoding the T cell stimulatory protein CD28, firing up CD28. (newswise.com)

Morphogen and community effects determine cell fates in response to BMP4 signaling in human embryonic stem cells. (harvard.edu)
Embryonic stem cells are derived from early embryos and have the ability to differentiate into any cell type. (spiked-online.com)
In his original report, Thompson demonstrated that human embryonic stem cells could be coaxed into developing gut-like structures, bone, cartilage and muscle (1). (spiked-online.com)
Mouse embryonic stem cells are known to be tumorigenic - that is, they can grow uncontrollably and become cancerous. (spiked-online.com)

Alternatively, transgenesis and gene targeting techniques can be used to introduce the patient's genes into the stem cell line. (spiked-online.com)
Similarly, there is no evidence of activation or over-expression of a known oncogene, or of the inactivation of currently identified tumour suppressor genes. (ersjournals.com)
To further confirm the central memory properties of treated cells, the team assessed expression of genes involved in differentiating T cells and found expression of central-memory differentiating genes to be highly expressed on the identified central memory cells generated by the combination. (newswise.com)

Resistance is typically related to the immunogenicity of the tumor. (frontiersin.org)
Our studies integrate known drug resistance mechanisms into a conceptual framework where oncogenic signal dependence is regulated by flux between distinct cell states. (upenn.edu)
Targeted inhibition of PDGFR (using TKI or siRNA knockdown) reverses platinum therapy resistance in EOC. (almacgroup.com)
This clinical and pre-clinical data supports the use of anti-angiogenic agents in the first and second line setting in patients with innate and acquired resistance to platinum therapy, respectively. (almacgroup.com)

The prognosis of patients who relapse after CAR T-cell therapy is dismal," Ghafouri added. (aacr.org)

Malignant mesothelioma (MM) is an aggressive tumour, which is strongly associated with previous asbestos exposure and is resistant to all conventional anticancer therapies. (ersjournals.com)
Hematologic parameters of anticancer therapy in a diamondback terrapin. (vin.com)

Results of studies on cell lines of various tumors showed that the anti-proliferative effect of melatonin might involve a receptor-mediated mechanism. (unboundmedicine.com)
CAR-T cells, which incorporate an antibody-derived extracellular receptor and T cell derived intracellular signaling domains, have shown convincing outcomes in certain types of leukemia and lymphoma, including commercial licensure of CD19 CAR-Ts for the treatment of relapsed/ refractory large B cell lymphoma and acute lymphoblastic leukemia. (bdbiosciences.com)

Citing uncertainties about the risks and benefits of an experimental therapy for fetuses whose kidneys do not develop, bioethicists at Johns Hopkins and a team of medical experts are calling for rigorous clinical trials in the use of a potential treatment, known as amnioinfusion. (hopkinsmedicine.org)
IL-15cx treatment diminishes MDSCs in murine tumors. (frontiersin.org)
Unfortunately there is no effective treatment of the tumor disease. (usda.gov)
Patients with relapsed/refractory B-cell lymphoma tend to have a more aggressive disease trajectory and limited treatment options," said presenting author Sanaz Ghafouri, MD , a fellow of hematology and oncology at University of California Los Angeles Medical Center. (aacr.org)
The white blood cell (WBC) estimate underwent a steady decline during the first 24 days of treatment. (vin.com)
This treatment has been used to shrink liver tumors. (medlineplus.gov)
In this review, we report and discuss recent advances in nanoparticle-mediated plasmonic photothermal therapy for GBM treatment and discuss the preclinical challenges commonly faced by researchers to develop and test such systems. (frontiersin.org)
My next step is to under go Radiation Treatment with Hormonal Treatment (total of 39 treatments and 6 mos of hormonal therapy. (cancer.org)
Treatment is with surgery for early disease and targeted therapy, an experimental protocol, or palliative therapy for advanced disease. (msdmanuals.com)
Combination treatment has proven effective for patients with acute promyelocytic leukemia, exemplifying the importance of therapy targeting multiple components of oncogenic regulation for a successful outcome. (lu.se)
Radiation therapy treatment. (cdc.gov)
Hormone therapy treatment. (cdc.gov)

The team found certain types of tumors in mice were more vulnerable to radiation after being given a drug that blocks p53 levels from declining and oscillating. (sciencedaily.com)

Banking of multiple cell lines with varying genetic spectrum that can be matched to patients is one possibility. (spiked-online.com)
Here, the stem cell line is created using the genetic properties of the prospective recipient via somatic cell nuclear transfer. (spiked-online.com)
Tuberous Sclerosis Complex (TSC) Tuberous sclerosis complex is a dominantly inherited genetic disorder in which tumors (usually hamartomas) develop in multiple organs. (msdmanuals.com)

Tumor-associated macrophages (TAMs) are integral to the development of complex tumor microenvironments (TMEs) and can execute disparate cellular programs in response to extracellular cues. (bvsalud.org)

Germ cell tumors occur less frequently (20%), while sex cord-stromal tumors make up the smallest proportion, accounting for approximately 8% of all ovarian neoplasms. (medscape.com)
pathologic diagnosis may show pure seminoma or nonseminoma germ cell tumors. (medscape.com)

To this end, we overexpressed key transcriptional regulators of astroglial development in human GBM and GBM stem cell lines. (lu.se)
Cell Stem Cell. (harvard.edu)
Scientists anticipate that in the future stem cell lines will provide a virtually unending supply of pancreatic cells for diabetic patients, neuronal cells for patients with neural disorders such as Parkinson's or Alzheimer's disease, and a host of heart cells that may treat a variety of cardiac problems. (spiked-online.com)
Dr Thomas Okarma, who heads up the Geron Corporation, claims to have heart cells that 'beat' in laboratory dishes developed from stem cells (2). (spiked-online.com)
Not only might stem cell technology obviate the need for cadaver donation - it could also resolve the problem of rejection. (spiked-online.com)
There are major obstacles to overcome before a stem cell line is liable to reach clinical trials. (spiked-online.com)
It is likely that human stem cells will have similar properties. (spiked-online.com)
This is where neural or brain stem cells reside, which are responsible for generating new neurons if needed. (dkfz.de)
In the adult animal, Tlx is expressed exclusively in brain stem cells. (dkfz.de)
When the scientists switched off Tlx, there were no more detectable stem cells in the brain and the formation of new neurons ceased. (dkfz.de)
Moreover, the scientists discovered that stem cells with increased Tlx production stimulate the formation of new vessels. (dkfz.de)
13 ] isolated mononuclear cells from human peripheral blood that were enriched for expression of the hematopoietic stem cell marker CD34 [ 13 ]. (hindawi.com)
Instead, they stay in a stem cell−like state. (genengnews.com)
Precise delivery of stem cells to the desired target is, however, crucial for the success of transplantation. (physicsworld.com)
Small, minimally invasive and wirelessly controlled, magnetic microrobots have ideal qualities for use in stem cell therapy, but must be further improved before application in the clinic, the authors say. (physicsworld.com)
Upon application of a rotating magnetic field, the spherical and helical microrobots respectively exhibited rolling and corkscrew motions that propelled them through 3D spaces - such as a blood vessel isolated from a rat brain and a ventricle within a slice of mouse brain - enabling precise targeting of transplanted stem cells. (physicsworld.com)
The researchers examined hippocampal neural stem cells (NSCs) grown on the microrobots. (physicsworld.com)
Finally, the team demonstrated in vivo stem cell transportation using the microrobots in a live nude mouse. (physicsworld.com)
They cultured mesenchymal stem cells derived from the human nose on spherical microrobots for transplantation in the mouse, and showed that an externally applied magnetic field could manipulate the cell-loaded microrobots within the animal's hollow abdominal cavity. (physicsworld.com)
These results confirm the feasibility of using microrobots for targeted stem cell transportation and transplantation in various physiological fluidic environments. (physicsworld.com)

Granulosa-theca cell tumors, also known as granulosa cell tumors (GCTs), represent about 2% of all ovarian tumors. (medscape.com)
GCTs account for approximately 2% of all ovarian tumors and can be divided into adult (95%) and juvenile (5%) types based on histologic findings. (medscape.com)

Cells use a number of mechanisms to sense and maintain their homeostatic levels. (spandidos-publications.com)

The rich variety of proteins in fetal bovine serum maintains cultured cells in a medium in which they can survive, grow, and divide. (wikipedia.org)
However, the effectiveness of serum-free media is limited as many cell lines still require serum in order to grow, and many serum-free media formulations can only support the growth of narrowly-defined types of cells. (wikipedia.org)
FBS, as with the vast majority of animal serum used in cell culture, is produced from blood collected at commercial slaughterhouses from cattle that also supply meat intended for human consumption. (wikipedia.org)
It is then centrifuged to remove the fibrin clot and the remaining blood cells from the clear yellow (straw) colored serum. (wikipedia.org)
The serum is frozen prior to further processing that is necessary to make it suitable for cell culture. (wikipedia.org)
When changing from batch to batch it is usual to adapt the cells to the new batch of material, for example, by mixing 50% of the old serum with 50% of the new serum and allowing the cells to acclimatize to the new material. (wikipedia.org)
The transport of serum amino acids into cells is an active process that is facilitated by plasma membrane-localized amino acid transporters. (spandidos-publications.com)
The diagnostic procedures performed were a complete blood count (CBC), serum chemistry, routine blood films, a bone marrow biopsy, radiographs, immunocytochemistry to type the leukemic cell line, magnetic resonance imaging (MRI), and computed tomography (CT). (vin.com)

2 prior lines of anti-neoplastic systemic therapy. (who.int)

Our findings raise the possibility of a lasting long-term remission with bispecific CAR T-cell therapy in patients with this aggressive disease. (aacr.org)
Up to 12 adult participants with r/r aggressive B-cell NHL may be enrolled into a Run In dose level. (who.int)

T cell-targeted immunomodulators such as monoclonal antibodies against PD-1 or CTLA4 may be used in combination with CAR-T cells in clinical trials. (bdbiosciences.com)

At the time of this study, OpenPBTA contained genomic and clinical data from more than 1,000 pediatric brain tumors and 22 patient-derived cell lines from the CBTN and PNOC. (chop.edu)
It is the first large-scale, collaborative, open analysis of genomic data and provides a cloud-based resource for researchers looking for more comprehensive data on pediatric brain tumors. (chop.edu)

Clinical trials will be required to advance his team's findings in human T cell lines. (newswise.com)

Extra sinusoidal myeloid cells and intrasinusoidal erythroid cells were scant. (vin.com)

2011) set about identifying compounds that selectively inhibit tumour growth in RCC cell lines that have FLCN inactivation. (scienceblog.com)
Researchers have begun to home in on these proteins, looking for drugs that inhibit their actions in the cell. (genengnews.com)

In July 2017, KEYTRUDA was granted Breakthrough Therapy Designation by the FDA for this indication. (merck.com)

Anatomy23

Organisms12

Diseases68

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes58

Disciplines and Occupations1

Information Science4

Health Care4

Microenvironment7

Antigens7

Solid tumors4

Proliferation12

Tissue19

Inhibited tumor growth1

Vitro9

Combination therapies3

Chimeric antigen receptor4

Recurrence5

Glioblastoma11

Cancer105

Survival13

Chemotherapy7

Toxicity8

Adjuvant4

Differentiation8

Therapeutic4

Antigen10

Efficacy5

Progression6

Benign4

Neuroendocrine tumors1

Malignancy2

Immune12

Complete tumor regression2

Tissues12

Angiogenesis5

Metastatic4

Malignant brain1

Melanoma5

Squamous Cell Carc1

Brain tumor1

Significantly2

Cancers4

Dendritic cells1

Molecular6

Necrosis3

Antitumor2

Primary malignant1

Metastasis1

Heterogeneity2

Gliomas1

Biology2

Protein4

Embryonic4

Genes3

Resistance4

Prognosis1

Anticancer2

Receptor2

Treatment12

Mice1

Genetic3

Cellular1

Germ2

Stem20

Ovarian2

Mechanisms1

Serum8

Systemic1

Aggressive2

Monoclonal1

Genomic2

Clinical trials1

Myeloid1

Inhibit2

20171