• nitric oxide
  • The Wall Street Journal describes that "Although the company knew when it began work on treating acne that nitric oxide has a beneficial effect on hypertension, it didn't expect to see such a strong reduction of blood pressure in the [acne] study. (wikipedia.org)
  • Dermatology
  • Realm's lead drug development programs utilize the Company's proprietary immunomodulatory technology for the treatment of Allergic Conjunctivitis (PR013) and Atopic Dermatitis (PR022) and Realm is exploring its efficacy in Acne and additional Dermatology and Ophthalmology indications as well as other disease areas. (medindia.net)
  • SB204
  • Novan's Phase 2 results of SB204 were very impressive, having demonstrated a rapid and clear dose response in subjects with severe acne," commented Dr. Hilary Baldwin, dermatologist at SUNY Downstate Medical Center University Hospital of Brooklyn. (novan.com)
  • Importantly, with advanced clinical testing, I believe SB204 has the potential to be used as a first-line monotherapy, or in combination with existing drugs, providing an exciting new solution for patients with acne. (novan.com)
  • novel
  • It is a novel compound not related to other anti-acne drugs. (bmj.com)
  • focused on developing novel therapeutics in immune-mediated diseases, today provided a clinical and business update. (medindia.net)
  • Realm Therapeutics is a clinical-stage biopharmaceutical company focused on developing novel therapeutics that target the intersection between innate and adaptive immunity, to influence immune signaling and to change the course of immune-mediated diseases in adults and children. (medindia.net)
  • The company is developing a novel class of therapeutics to improve skin health, hypertension, and other systemic conditions. (wikipedia.org)
  • inflammation
  • Acne vulgaris is a chronic skin disease involving blockage and inflammation of pilosebaceous follicles. (researchandmarkets.com)
  • Acne scars are caused by inflammation within the dermal layer of skin and are estimated to affect 95% of people with acne vulgaris. (wikipedia.org)
  • Acne scars are classified based on whether the abnormal healing response following dermal inflammation leads to excess collagen deposition or loss at the site of the acne lesion. (wikipedia.org)
  • People of recent African descent may experience more inflammation in comedones, more comedonal acne, and earlier onset of inflammation. (wikipedia.org)
  • growth
  • The market intelligence report is a comprehensive review of the growth trail in terms of current, historical, and future scenarios of the global acne vulgaris market. (tmrresearch.com)
  • Currently, mounting concerns and awareness among people across the globe over the harmful effects of this kind of skin disease will further aid in the growth of the acne vulgaris market. (tmrresearch.com)
  • phase
  • The Company plans to file an Investigation New Drug Application (IND) for Acne Vulgaris in Q4 and, pending FDA allowance, commence a Phase 2 proof of concept study shortly thereafter. (medindia.net)
  • AOBiome started its Phase 2 clinical trial for adult acne in 2015. (wikipedia.org)
  • therapies
  • They have since performed in-vitro studies, in-vivo studies, and two human studies in acne vulgaris, the results of which have led the company to now additionally explore systemic therapies for conditions such as hypertension. (wikipedia.org)
  • patients
  • Successful management of the disease requires a better understanding of various pathogenetic factors and identifying the etiology of the acne in patients. (tmrresearch.com)
  • There currently remains a need for new agents to treat the growing number of patients suffering from acne vulgaris. (novan.com)
  • clog
  • Although HS shares certain common features with acne vulgaris, such as a tendency to clog skin follicles with skin cell debris, the condition otherwise lacks the defining features of acne and is therefore considered a distinct skin disorder. (wikipedia.org)
  • development
  • The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. (researchandmarkets.com)
  • A review of the Acne Vulgaris products under development by companies and universities/research institutes based on information derived from company and industry-specific sources. (sbwire.com)
  • Identify and understand important and diverse types of therapeutics under development for Acne Vulgaris. (sbwire.com)
  • This data enables us to move forward with late stage clinical development for a fast acting, first-in-class new drug for acne. (novan.com)
  • P. acnes plays a role in the development of acne. (wikipedia.org)
  • It is not clear what effect shaving has on the development of comedones or acne. (wikipedia.org)
  • Study
  • We are also delighted to confirm our progress in our Acne program as we plan to submit an IND in the fourth quarter and initiate a clinical study shortly thereafter. (medindia.net)
  • puberty
  • During puberty, in both sexes, acne is often brought on by an increase in hormones such as testosterone. (wikipedia.org)
  • Oil production in the sebaceous glands increases during puberty, causing comedones and acne to be common in adolescents. (wikipedia.org)
  • sebum
  • It can proliferate in sebum and cause inflamed pustules (pimples) characteristic of acne. (wikipedia.org)
  • Globally
  • In 2015, acne was estimated to affect 633 million people globally, making it the 8th most common disease worldwide. (wikipedia.org)
  • skin disease
  • Acne is a skin disease that affects more than fifty million people in the United States. (novan.com)
  • Acne, also known as acne vulgaris, is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin. (wikipedia.org)
  • people
  • The gel is used on the skin to treat light to medium acne vulgaris in people 12 years and older. (wikipedia.org)
  • Although acne becomes less common in adulthood, it persists in nearly half of affected people into their twenties and thirties and a smaller group continue to have difficulties into their forties. (wikipedia.org)
  • rosacea
  • Acne inversa (L. invertō, "upside down") and acne rosacea (rosa, "rose-colored" + -āceus, "forming") are not true forms of acne and respectively refer to the skin conditions hidradenitis suppurativa (HS) and rosacea. (wikipedia.org)
  • affects
  • Acne commonly occurs in adolescence and affects an estimated 80-90% of teenagers in the Western world. (wikipedia.org)