Therapeutic effect effects interleukin 15. Medical search. Frequent questions

The group of common γ-chain receptor cytokines encompassing interleukin (IL)-2, IL-4, IL-9, IL-15, and IL-21 has been studied intensively over the recent years. (frontiersin.org)

Although the exact pathogenesis of FIRES has not been elucidated, a functional deficiency in the endogenous interleukin-1 receptor antagonist has been implicated in a genetic predisposition to FIRES. (annchildneurol.org)
A crucial role of interleukin-1β (IL-1β) in FIRES has been demonstrated in case reports describing the effective clinical use of anakinra, a recombinant IL-1 receptor antagonist (IL-1Ra) [ 1 , 7 ]. (annchildneurol.org)
The panel makes a conditional recommendation for interleukin (IL)-6 receptor antagonist monoclonal antibody treatment and high-flow nasal oxygen or continuous positive airway pressure in patients with hypoxaemic respiratory failure. (bvsalud.org)

Interleukin 15 (IL-15) has been evaluated as a potential treatment for solid tumors in clinical trials, but the effectiveness of systemic IL-15 administration as a monotherapy has not been realized. (frontiersin.org)
Systemic and local administration of IL-15cx shows two distinct therapeutic responses, a moderate tumor growth inhibition or heterogeneous tumor regressions with survival improvement. (frontiersin.org)
In contrast, while indomethacin treatment effectively decreased paw edema, it did not appreciably affect the systemic aberrant interleukin production. (aai.org)
Tralokinumab for Moderate-to-Severe Atopic Dermatitis in Adults Review evidence from the latest clinical trials of tralokinumab, a new systemic interleukin-13 inhibitor for moderate-to-severe atopic dermatitis. (medscape.com)

Interleukin 15 (IL-15) is a pleiotropic cytokine, which was originally discovered by Drs. Waldmann and Grabstein's groups ( 6 , 7 ). (frontiersin.org)
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. (wikipedia.org)
IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. (wikipedia.org)
Knockdown of SOX11 reduced epithelial-derived cytokine expression and MUC5AC levels in interleukin-13-treated human nasal mucosa epithelial cells. (balkanmedicaljournal.org)
Interleukin-4 (IL-4), also known as B cell-stimulatory factor-1, is a monomeric, approximately 13 kDa‑18 kDa Th2 cytokine that shows pleiotropic effects during immune responses (1‑3). (rndsystems.com)
This pilot study aimed to investigate the effect of characterized MSC-EVs on chondrogenesis in a 3D chondrocyte inflammation model with the pro-inflammatory cytokine TNFα. (bvsalud.org)
exogenous rhIL-10 has a limited effect on cytokine production and no effect on T lymphocyte proliferation or HLA expression. (cdc.gov)

New therapeutic concepts in anti-tumor therapy aim to modulate the patient's immune system to increase its aggressiveness or targeted effects toward tumor cells. (frontiersin.org)
CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
Immunocytokines (ICKs) targeting cytokines to the tumor environment using antibodies directed against a tumor-associated antigen often have a higher therapeutic index than the corresponding unconjugated cytokines. (hal.science)
Various ICKs displaying significant antitumoral effects in several murine tumor models have already been developed, and some of them, in particular interleukin (IL)-2-based ICKs, are in Phase II clinical trials. (hal.science)
These protective effects may be associated with the inhibition of apoptosis and inflammation, as reflected by less TUNEL-positive cells and lower levels of serum proinflammatory cytokines (Interleukin-1β, Interleukin-6, tumor necrosis factor-α) and cardiac troponin I in the N-CM group compared with the vehicle group. (researchsquare.com)

Ajulemic acid (AjA, 1'1'-dimethylheptyl-THC-11-oic acid) has exhibited potent anti-inflammatory and analgesic effects in several animal models. (aad.org)
AjA has a 65-fold higher affinity for CB2 than CB1, enabling it to be anti-inflammatory without significant psychoactive effects. (aad.org)
Naringin exhibits anti-inflammatory and anti-oxidation effects among others, but its specific mechanisms are not clear. (biomedcentral.com)
However, there have been no studies on the anti-inflammatory effects of GSP in human hepatic stellate cells (HSCs). (spandidos-publications.com)

4 Therefore, novel therapeutic methods and AR targets urgently need to be explored. (balkanmedicaljournal.org)

bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)

1977. Inhibition of human plasma cholinesterase by ingested dichlorvos: effect of formulation vehicle. (cdc.gov)
FOURIER has undoubtedly provided definitive evidence for PCSK9 inhibition as a therapeutic strategy in high risk patients with residual LDL-C burden despite intensive statin therapy. (eas-society.org)

Dysregulation of the interleukin-1β-interleukin-1 receptor 1 (IL-1β-IL-1R1) signaling pathway appears to be involved in the pathogenesis of FIRES. (annchildneurol.org)
However, it is unknown whether genetic susceptibility to T1D also contributes to shaping the microbial communities of high-risk individuals, and whether the enteric dysbiosis seen in T1D is a cause or effect of the disease, and the immune dysregulation associated with its development. (biomedcentral.com)

A study in mice has shown that IL-10 is also produced by mast cells, counteracting the inflammatory effect that these cells have at the site of an allergic reaction. (wikipedia.org)
Eczema, characterized by itchy, scaly, erythematous, and oozing skin, is the most common chronic inflammatory skin disorder, affecting 10-20% of children and 1-3% of adults [ 1 , 2 ]. (hindawi.com)
Allergic rhinitis is a chronic inflammatory disease of the nasal mucosa affecting the quality of life of patients. (balkanmedicaljournal.org)
Granulomatous mastitis (GM) is a rare benign inflammatory breast disease that affects mostly women of childbearing age with a history of breastfeeding. (karger.com)

In these patients, the addition of the PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor evolocumab to intensive statin therapy lowered LDL-C levels by 59% and led to a 15% reduction in major cardiovascular events and 20% reduction in the secondary 'hard outcomes' endpoint, a composite of cardiovascular death, MI and stroke. (eas-society.org)

In this chapter, we will focus on IL-21's biological effects and signaling pathways as well as discuss the potential implications and applications of IL-21 in leukemia cells. (intechopen.com)
These pathways mediate some of the effects of IL-21. (intechopen.com)
Thus, the investigation of other pathogenic pathways and relevant therapeutic strategies is worthwhile. (biomedcentral.com)
molecules by B-CLL cells, their regulation, transduction pathways and their effects on leukaemic cells. (cancer-ecosystem.com)
It will discuss the expression of these molecules by B-CLL cells, their regulation, transduction pathways and their effects on leukaemic cells. (cancer-ecosystem.com)

Yet, its active compounds and therapeutic mechanisms have not been elucidated. (hindawi.com)
However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)
To assess the therapeutic potential of naringin and the mechanisms involved, we cultured rat glomerular mesangial cells and grouped them according to different glucose concentrations, different action times, different concentrations of MCC950, and different concentrations of naringin.The cell proliferation was measured by MTT assay. (biomedcentral.com)
In the present study, we aimed to investigate the molecular mechanisms and prophylactic effects of grape seed proanthocyanidin (GSP) on lipopolysaccharide (LPS)-stimulated human hepatic stellate cells (HSCs). (spandidos-publications.com)
Taken together, these results suggest that disease-associated abnormalities in interleukin production may be mediated by different mechanisms with differential sensitivity to the effects of the disease-modifying drug auranofin. (aai.org)
In order to understand the mechanisms behind the seizures we study this type of epilepsy with the aim to develop new therapeutic strategies specially adapted for children. (lu.se)

Other immunotherapeutic strategies and combination approaches are needed to improve the therapeutic efficacy and broaden its indications for a large patient population. (frontiersin.org)

Hence, we established a two-phase expansion protocol with IL-15 to induce an early NK cell expansion, followed by short exposure to IL-21 that boosted the cytotoxic activity of NK cells against RMS cells. (frontiersin.org)
Fenugreek has been documented to have uterine stimulant effects and has been used in traditional medicine to induce childbirth. (drugs.com)

Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age. (wikipedia.org)
Furthermore, allergic rhinitis mice exhibited overproduction of epithelial-derived cytokines (thymic stromal lymphopoietin, interleukin-25, interleukin-33), C-C motif chemokine ligand 26 (CCL26), and mucin 5 AC (MUC5AC). (balkanmedicaljournal.org)
Here, we aimed to explore the effects and the related mechanism of dietary AMP supplementation on food intake, body composition, energy expenditure, and lipid metabolism in male mice. (foodandnutritionresearch.net)

Therapeutic ligands are often made dimeric as antibody Fc fusions to confer desirable pharmacokinetic benefits, with under-explored consequences on signaling. (biorxiv.org)
Here, we investigated, in the context of an ICK, the effect of associating RLI with an antibody targeting the GD2 ganglioside, a validated tumoral target expressed on many neurectodermal tumors. (hal.science)
an effect specific to this antibody. (eas-society.org)

IL-15cx shows superior in vivo bioactivity to expand CD8 T cells in comparison to an equimolar single chain IL-15. (frontiersin.org)
T-bet is partially involved in CD8 T cell expansion ex vivo and in vivo due to IL-15 or IL-15cx. (frontiersin.org)
In a proof of concept in vivo study, we also observed a therapeutic effect of adoptively transferred IL-15 expanded and IL-21 boosted NK cells in combination with image guided high precision radiation therapy using a luciferase-transduced RMS xenograft model. (frontiersin.org)
RLI showed better biological activities than IL-15 in vitro as well as higher antitumoral effects in vivo in murine and human cancer models. (hal.science)

We then utilize our model to identify the potential benefits conferred by valency engineering as an additional mechanism for cytokines with optimized therapeutic benefits. (biorxiv.org)
Our study provides an insight into the therapeutic mechanism underlying multiscale benefits of SZT for eczema and paves the way for developing new and potentially more effective eczema therapies. (hindawi.com)
The specific mechanism by which apremilast exerts it therapeutic action in psoriatic arthritis is not well defined. (medscape.com)

Myoinositol With Metformin vs Metformin Monotherapy in PCOS An RCT looked at the effects of metformin alone or combined with myoinositol in the treatment of PCOS. (medscape.com)

Bivalent Fc fusions display enhanced specificity and potency for T reg s through avidity effects toward IL-2Rα. (biorxiv.org)
Its therapeutic potency was higher than those of RLI and anti-GD2 alone or in combination. (hal.science)

The ORs at 90% sensitivity were 15 (95% CI = 3.1-140) and 10 (95% CI = 2.1-97), respectively. (lu.se)

However, direct injection of IL-2 has been shown to be accompanied by severe side effects, such as vascular leak syndrome, activation-induced cell death, and strong induction of regulatory CD4 pos T cells, which did not occur after IL-15 administration ( 15 , 16 ). (frontiersin.org)
Secondary hyperparathyroidism may occur in 10-15% of patients with Paget disease. (medscape.com)

The incubation of DSS fibroblasts with a synthetic cannabinoid receptor agonist (WIN55, 212- 2) decreased their expression in a dose-dependent manner, together with a parallel reduction in collagen production and pro- fibrotic cytokines, including transforming growth factor-beta (TGF-beta), connective tissue growth factor and interleukin-6 (IL-6). (aad.org)
A reduction in PLP availability appears to primarily affect kynureninase activity, limiting NAD production and leading to higher concentrations of kynurenine, 3-hydroxykynurenine, and xanthurenic acid in blood and urine ( Figure 2 ) (9) . (oregonstate.edu)
Prophylactic treatment of AA rats with auranofin resulted in a slight reduction in paw edema, a complete normalization of the depressed IL-2 production, and a reduction of the elevated IL-1 production, but had no effect on the depressed IL-3 production. (aai.org)

In many cases, successfully mobilization is not effected in the patient and inadequate numbers of hematopoietic stem cells are harvested from these patients using current methods. (justia.com)
In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients' survival rate. (researchsquare.com)
Although many therapeutic remedies focusing on hyperglycemia and high blood pressure have been used, many patients still suffer progressive and severe renal injury. (biomedcentral.com)
Comme nous l'avons vu dans les chapitres précédents, les directives de pratique clinique utilisent différents systèmes de classification pour guider la prise en charge de ces patients. (fullphysio.com)
Il est bon de noter que quelle que soit l'approche utilisée, les guidelines des récentes études soutiennent l'utilisation de la réassurance, des conseils et de l'éducation thérapeutique pour la plupart des patients considérés comme présentant un faible risque de chronicité en phase aigüe (Blanpied et al. (fullphysio.com)
Furthermore, patients with this comorbidity are frequently treated for a single condition in clinical settings, and the therapeutic outcome is poor. (biomedcentral.com)
We analyzed the outcomes of patients receiving high-dose IL-2 in relation to the severity of toxicity to ascertain if response or survival were adversely affected. (biomedcentral.com)
Early diagnosis and effective treatment of TB among HIV-infected patients are critical for curing TB, minimizing the negative effects of TB on the course of HIV, and interrupting the transmission of Mycobacterium tuberculosis to other persons in the community. (cdc.gov)

In this study, we addressed feeder cell-free expansion methods using common γ-chain cytokines, especially IL-15 and IL-21. (frontiersin.org)

3 However, the widespread application of AIT is still limited by its risk of side effects, high cost, and low patient compliance arising from cumbersome, lengthy treatment courses. (balkanmedicaljournal.org)

The goal of this study was to examine the activity of IL-15/IL-15Rα complex (IL-15cx) to CD8 + T cells and evaluate its potential efficacy in murine breast cancer models. (frontiersin.org)
Over the past 20 years, multiple studies have reported the efficacy of TCM for the treatment of eczema without serious adverse effects [ 9 , 10 ]. (hindawi.com)

In total, these findings represent a comprehensive analysis of how ligand properties, and their consequent effects on surface receptor-ligand interactions, translate to selective activation of immune cell populations. (biorxiv.org)
It also identifies a new route toward engineering even more selective therapeutic cytokines. (biorxiv.org)
Interestingly, this inhibitory effect was not abrogated by selective cannabinoid receptor antagonism, suggesting that it was not mediated by classical CB1 nor CB2 receptors, but possibly via other receptors, such as PPAR (peroxisome proliferator-activated receptor-gamma). (aad.org)

The design of reagents able to counteract the effects of these molecules seems to be a new promising therapeutic approach for B-CLL and is already currently developed in the treatment GSK 2334470 of autoimmune diseases. (cancer-ecosystem.com)
Effect of auranofin treatment on aberrant splenic interleukin production in adjuvant arthritic rats. (aai.org)
In this study we investigated the altered production of interleukins in arthritic rats and evaluated the effects of auranofin treatment on disease progression and aberrant interleukin production. (aai.org)
This study confirms that insulin resistance affects treatment outcome, and thus HOMA-IR testing before initiation of therapy may be a cost-effective tool. (who.int)
4 2 ( 2 0 0 6 ) 2 7 2 9 - 2 7 3 7 treatment with unnecessary side effects. (lu.se)

7 , 8 Alternatively, cisplatin (cis-Diamminedichloro-platinum(II))-based therapeutic strategy has a relatively low response rate, significant side effects, and acquired or intrinsic chemoresistance. (dovepress.com)
However, recent reports have demonstrated paracrine activities are likely implicated in the therapeutic effects of BMSCs(9) due to the relatively low long-term survival rate of implanted BMSCs(10, 11). (researchsquare.com)

IL-2 and IL-15 have similar impacts on NK cells ( 13 , 14 ). (frontiersin.org)
Moreover, exosomal miRNA-130a was transferred from CAFs to recipient NSCLC cells and knockdown of miRNA-130a reversed the effect of CAFs-derived exosomes during chemoresistance of NSCLC cells. (dovepress.com)
One of these cytokines, interleukin (IL)-2, has potential as a therapy in autoimmunity but is limited in effectiveness by its modest specificity toward regulatory T cells (T reg s). (biorxiv.org)
Interleukin-13-stimulated human nasal mucosa epithelial cells were used for in vitro studies. (balkanmedicaljournal.org)
In human nasal mucosa epithelial cells, interleukin-13 enhanced SOX11 expression in a time-dependent manner, and signal transducer and activator of transcription 6 (STAT6) was involved in the interleukin-13-mediated expression of SOX11 by regulating transcription. (balkanmedicaljournal.org)
Bone marrow mesenchymal stem cells (BMSCs) have been reported to attenuate myocardial I/R injury via their paracrine effects, which can be enhanced by hypoxic preconditioning. (researchsquare.com)
Interleukin-21 (IL-21) is produced by activated T cells and it plays many diverse roles by regulating the functions of normal and abnormal cells. (intechopen.com)
Interleukin-21 (IL-21) was first identified in 2000 through screening of a cDNA library from CD3+ human T cells [ 1 ]. (intechopen.com)
The capacity of the AA rat spleen cells to produce interleukin (IL) 2 and IL-3 was found to decrease during the development of the arthritic lesion, with maximum suppression occurring 16 to 17 days after adjuvant injection. (aai.org)
AIM: To investigate how these three platinum-based drugs affect mitochondrial function and myelination state of Schwann cells and the signalling pathway involved. (bvsalud.org)

Furthermore, IL-21 promotes differential expression of many cytokines including interleukins and chemokines. (intechopen.com)

Febrile infection-related epilepsy syndrome (FIRES) characteristically affects previously healthy children, who experience a sudden and explosive onset of super-refractory status epilepticus preceded by febrile infection and accompanied by fulminant neurogenic inflammation. (annchildneurol.org)
The histological feature of AR is typical type 2 inflammation is induced mainly by the type 2 cytokines interleukin (IL)-4, IL-15, and IL-13. (balkanmedicaljournal.org)

Cytokines that bind to the common γ-chain (γ c ) receptor, including interleukin (IL)-2, 4, 7, 9, 15, and 21, are a critical hub in modulating both innate and adaptive immune responses ( 1 ) . (biorxiv.org)

To observe and evaluate the effects of manipulation on knee osteoarthritis (KOA) using T2-mapping and magnetic resonance imaging (MRI)-based volume measurements. (jcimjournal.com)
Introduction: Osteoarthritis (OA) affects a large percentage of the population worldwide. (bvsalud.org)
Osteoarthritis (see the image below) is the most common type of joint disease, affecting more than 20 million individuals in the United States alone. (medscape.com)

Intratumoral GET with plasmid IL-15/IL-15Rα leads to a long-term survival benefit in 4T1 mammary carcinoma model. (frontiersin.org)
IL-15 is considered superior to IL-2 for cancer immunotherapy due to its strong bioactivity in improving CD8 + T and natural killer (NK) cell survival, proliferation and cytotoxic function ( 8 ). (frontiersin.org)

Being one of the most common neurological diseases, epilepsy affect 60 million people worldwide. (lu.se)
Until this day there is no cure for epilepsy, the therapies available only treat symptoms and come with severe side effects. (lu.se)

Our results demonstrated high potential of IL-15 for NK cell expansion, while IL-21 triggered NK cell maturation and functionality. (frontiersin.org)
This study indicates that CAFs-derived exosomal miRNA-130a may be a potential therapeutic target for cisplatin resistance in NSCLC. (dovepress.com)
Although sharing common biological activities with IL-2 in vitro, IL-15 is now considered as having a better potential in antitumor immunotherapeutical strategies and has been shown to be less toxic than IL-2 in preclinical studies. (hal.science)

SOX11 plays a critical role in allergic rhinitis development by regulating epithelial-derived cytokines and might be a new therapeutic target for allergic rhinitis. (balkanmedicaljournal.org)

Effects of an organophosphate (dichlorvos) on open field behavior and locomotor activity: correlation with regional brain monoamine levels. (cdc.gov)
Therapeutic administration of auranofin to AA rats with established disease resulted in normalization of IL-1 production without affecting the suppressed IL-2 and IL-3 levels. (aai.org)

The importance of these cytokines to immune homeostasis and challenges in altering their signaling toward specific therapeutic goals have inspired a variety of engineered forms. (biorxiv.org)

Using agent based modeling to assess the effect of increased Bus Rapid Transit system infrastructure on walking for transportation. (stanford.edu)
Particular relevance is given to assess the effect of the growth of the Bus Rapid Transit (BRT) system in Bogotá on walking. (stanford.edu)

High-dose interleukin-2 (IL-2) has been FDA-approved for over 20 years, but it is offered only at a small number of centers with expertise in its administration. (biomedcentral.com)

The aim of this study is to investigate the synergistic anticancer effects of melatonin and erastin on ROS modulation and subsequent RCD induction. (bvsalud.org)

Acupuncture, which has many good effects and few adverse effects, is widely recognized as an alternative therapy for depression in clinical practice. (medscimonit.com)

Subsequently, the investigators identified a specific clone as containing pro-proliferative effects that was sensitive to neutralization by the soluble IL-21R. (intechopen.com)
How should therapeutic management be approached for each specific subtype? (medscape.com)

We previously developed the fusion protein RLI, linking a soluble form of human IL-15Rα-sushi+ domain to human IL-15. (hal.science)

We investigated the expression of the NLRP3-inflammasome under high-glucose conditions, assessed the effects of naringin on that process, and further elucidated the role of naringin in the pathogenesis of diabetic kidney disease(DKD). (biomedcentral.com)
The prognosis of ADHD is poor, with some children retaining symptoms into adulthood, and a study found that the risk of premature death is twice as high in those affected with ADHD, bringing a heavy burden to society and families [ 4 ]. (biomedcentral.com)

The expression of Interleukin-1β(IL-1β) and Interleukin18 (IL-18) in the cell supernatant were detected by ELISA. (biomedcentral.com)

The ABM results are consistent with previous empirical findings, increasing BRT access does indeed increase the number of minutes that individuals walk for transportation, although this effect also depends on the availability of other transport modes. (stanford.edu)

Thus, for genetic variants to significantly affect disease severity or incidence, they must act cumulatively. (cdc.gov)

Evolving Story of JAK Inhibitors for Treating Alopecia Areata Review the introduction of Janus kinase inhibitors and their application as the first-line therapeutic option for severe alopecia areata. (medscape.com)

Anatomy38

Organisms18

Diseases21

Chemicals and Drugs92

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Psychiatry and Psychology1

Phenomena and Processes33

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture1

Humanities2

Information Science3

Health Care6

Cytokines encompassin1

Receptor antagonist3

Systemic4

Cytokine7

Tumor5

Anti-inflammatory4

Novel therapeutic1

Endogenous1

Inhibition2

Dysregulation2

Inflammatory4

Inhibitor1

Pathways5

Mechanisms6

Indications1

Induce2

Mice3

Antibody3

Vivo4

Mechanism3

Monotherapy1

Potency2

Sensitivity1

Occur2

Reduction3

Patients8

Methods1

Patient1

Efficacy2

Selective3

Treatment5

Relatively low2

Cells10

Differential1

Inflammation2

Responses1

Osteoarthritis3

Survival2

Epilepsy2

Potential3

Target1

Levels2

Immune1

Assess the effect2

Administration1

Subsequent1

Adverse effects1

Specific2

Human1

High2

Expression1

Results1

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INTRODUCTION1