Therapeutic studies abnormalities drug induced. Medical search. Frequent questions

Here, we develop a brain reward circuit-wide atlas of opioid-induced transcriptional regulation by combining RNA sequencing (RNA-seq) and heroin self-administration in male mice modeling multiple OUD-relevant conditions: acute heroin exposure, chronic heroin intake, context-induced drug-seeking following abstinence, and relapse. (bvsalud.org)
4. Lee WM, Stravitz RT, Larson AM. Introduction to the revised American Association for the Study of Liver Diseases Position Paper on acute liver failure 2011. (intramed.net)
10. Mochida S, Nakayama N, Matsui A, Nagoshi S, Fujiwara K. Re-evaluation of the Guideline published by the Acute Liver Failure Study Group of Japan in 1996 to determine the indications of liver transplantation in patients with fulminant hepatitis. (intramed.net)
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. (intramed.net)
Drug induced acute liver failure: results of a U.S. multicenter, prospective study. (intramed.net)
This class of drugs is traditionally prescribed for pain relief following surgery, an acute injury or for chronic pain. (arcfertility.com)
BAY11‑7082 might represent a therapeutic option for alveolar hypercoagulation and fibrinolytic inhibition in acute respiratory distress syndrome. (spandidos-publications.com)
For these, reasons both leukotriene synthesis inhibitors and leukotriene receptor antagonists have been suggested for inducing beneficial effects at different stages of the atherosclerosis process and may represent a new therapeutic target in the treatment of atherosclerotic vessel diseases, in particular in acute coronary syndrome. (hindawi.com)
The evidence is best in acute mania although in practice this drug is often used for prophylaxis. (mood-disorders.co.uk)
[ 1 , 2 ] SCARs include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS or HSS) and acute generalized exanthematous pustulosis (AGEP). (medscape.com)

Comparisons with human OUD RNA-seq and genome-wide association study data revealed convergent molecular abnormalities and gene candidates with high therapeutic potential. (bvsalud.org)
Despite intensive research, the molecular abnormalities giving rise to wild-type GISTs remain unknown. (liferaftgroup.org)

Hydroxyzine, when administered to the pregnant mouse, rat, and rabbit, induced fetal abnormalities in the rat and mouse at doses substantially above the human therapeutic range. (nih.gov)
This study will investigate the use of a non-invasive scan called fetal magnetocardiography to detect potential problems in the fetus in five high-risk pregnancy conditions associated with stillbirth. (nih.gov)
To participate in this study, you must be at least 18 years old and pregnant with one of the following: having a stillbirth in a previous pregnancy, carrying identical twins, or having a fetus that has been diagnosed with major congenital heart disease, fetal hydrops, or fetal gastroschisis. (nih.gov)

Using KIT-mutant GIST cell lines, these investigators showed that a small molecule IGF-1R kinase inhibitor (NVPAEW541) reduced cellular proliferation and induced apoptosis. (liferaftgroup.org)

It has been established by recent studies that pomegranate derived products abrogate chemically induced tumors of lung, skin, breast and colon and it also abates the metastasis of xenografted lung and prostrate tumors in rodents 13 . (nature.com)

The medications carry a risk of weight gain, electrocardiogram abnormalities, metabolic changes, and drug-induced movement disorders. (medscape.com)
We studied effects of a long-term VPA treatment on cycling monkeys, postulating that, if VPA monotherapy were to promote abnormal endocrine and metabolic parameters that are characteristic of PCOS, changes in cyclicity would be readily demonstrated. (columbia.edu)
[1] [2] Preliminary studies found that drinking small quantities of wine (up to one standard drink per day for women and one to two drinks per day for men), particularly of red wine , may be associated with a decreased risk of cardiovascular diseases , cognitive decline , stroke , diabetes mellitus , metabolic syndrome , and early death. (wikipedia.org)
Bexarotene may induce metabolic enzymes and cause a reduction in the plasma concentrations of oral or other systemic hormonal contraceptives. (pdr.net)

The pathophysiology of sepsis includes inflammation, immune dysfunction, and dysfunction of coagulation, while sepsis-induced cardiomyopathy ( SIC ), defined as a global but reversible dysfunction of both sides of the heart induced by sepsis, plays a significant role in all of the aspects above in the pathogenesis of sepsis. (frontiersin.org)
Our previous studies indicated that knockdown of the p65 gene or IKKβ inhibited lipopolysaccharide (LPS)-induced upregulation of TF and PAI-1 in rat AECII ( 15 , 16 ), indicating that the NF-κB signaling pathway participates in coagulation and fibrinolysis regulation in LPS-treated AECⅡ cells. (spandidos-publications.com)
To participate in this study, you must be a child or adult who either is healthy or has a platelet disorder, coagulation disorder, or white blood cell disorder. (nih.gov)
Acquired platelet dysfunction is suspected and diagnosed when unusual or prolonged bleeding is observed and other possible diagnoses (eg, thrombocytopenia, coagulation abnormalities) have been eliminated. (msdmanuals.com)

Both topical and systemic monotherapy may induce resistance among Cutibacterium acnes (C. acnes) and other organisms that comprise the commensal and transient flora. (skintherapyletter.com)
Acquired platelet dysfunction, which is common, may result from aspirin, other nonsteroidal anti-inflammatory drugs (NSAIDs), or systemic disorders. (msdmanuals.com)

Commonly, this stems from unclear instructions on self-administration of antibiotics, use of sub-antimicrobial dosing, prescription of antibiotics for minor bacterial infections, use of antibacterial drugs for non-bacterial infections, and use of broad-spectrum antibiotics for narrow-spectrum indications. (skintherapyletter.com)
Patients who were treated with letrozole or another aromatase inhibitor for other indications must have not taken the drug for 6 months prior to initiating letrozole for this trial and may not have progressed on treatment. (mayo.edu)

The endotoxin-induced myocardial dysfunction probably depends on the toll-like receptor (TLR) 4-induced cytokines release as a delay in onset of myocardial depression after endotoxin administration ( 10 ). (frontiersin.org)
Furthermore, administration of inflammatory cytokines can induce depressed mood states and inhibition of inflammation may reduce depression in autoimmune disorders. (mood-disorders.co.uk)

In early 1961 doctors noticed an extraordinary increase in documented cases of children with a verity of birth defects, and they soon hypothesized that maternal exposure to Thalidomide during pregnancy caused these often-severe congenital abnormalities. (asu.edu)
This abnormality is caused by exposure to the drug in a short time period in early human embryonic development. (asu.edu)
NEW YORK, April 29, 2022 -- Pfizer Inc . (NYSE: PFE) today shared top-line results from the Phase 2/3 EPIC-PEP ( E valuation of P rotease I nhibition for C OVID-19 in P ost- E xposure P rophylaxis) study evaluating PAXLOVID™ (nirmatrelvir [PF-07321332] tablets and ritonavir tablets) for post-exposure prophylactic use. (pfizer.com)
The data indicate that a 12- to 15-month therapeutic exposure to VPA does not induce cyclic hormonal or morphological ovarian abnormalities or characteristics of the PCOS when administered to nonepileptic normally cycling nonhuman primates. (columbia.edu)
A study of live-born infants in Denmark found that exposure to the newer-generation AEDs lamotrigine, oxcarbazepine, topiramate, gabapentin, and levetiracetam in the first trimester was not associated with an increased risk in major birth defects. (medscape.com)

Unearthing and employment of healthy substitutes is now in demand to tackle a number of diseases due to the excessive repercussions of synthetic drugs. (nature.com)
The concomitant adverse effects resulting from the employment of synthetic drugs and chemicals have led to the discovery and implementation of efficacious nutraceuticals against diverse diseases. (nature.com)
June 25, 2022 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (Nasdaq: ABUS), a clinical-stage biopharmaceutical company leveraging its extensive virology expertise to develop novel therapeutics that target specific viral diseases, today announced the presentation of new clinical and pre-clinical data from its proprietary compounds at the European Association for the Study of the Liver (EASL) International Liver Congress™ (ILC). (biospace.com)
A better understanding of how these novel basal cells communicate with adjacent cells will help define disease mechanisms and suggest new diagnostic and therapeutic strategies for male infertility, and diseases of the lung, including asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). (nih.gov)
For these reasons, the leukotriene pathway may represent an alternative therapeutic target in the treatment of atherosclerotic vessel diseases [ 6 , 13 , 14 ]. (hindawi.com)
The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. (nih.gov)
Find studies for diseases and conditions and see if you or a loved one is eligible. (nih.gov)
Medical records research - uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best. (mayo.edu)

therefore, autonomic dysfunction may manifest with numerous clinical phenotypes and various laboratory and neurophysiologic abnormalities. (medscape.com)
General methods for diminishing risk of antibiotic resistance include detailed history and physical, diagnostic laboratory and culture studies, close monitoring of clinical response, appropriate directed-therapy when the causative organism is identified, relevant empiric treatment based on local antimicrobial susceptibilities within the community, and continuing therapy for the appropriate duration. (skintherapyletter.com)
2. Willing and able to comply with scheduled visits, treatment plan, study restrictions laboratory tests, contraceptive guidelines, and other study procedures. (who.int)

A previous study demonstrated that alveolar hypercoagulation and fibrinolytic inhibition are associated with pulmonary inflammation in ARDS ( 6 ). (spandidos-publications.com)
Previous studies suggested that the NF-κB pathway could mediate hypercoagulation, fibrinolysis inhibition and pulmonary inflammation ( 10-13 ). (spandidos-publications.com)
Sometimes this effect is incidental (eg, when the drugs are used to relieve pain and inflammation) and sometimes therapeutic (eg, when aspirin or the P2Y12 inhibitors are used for prevention of stroke or coronary thrombosis). (msdmanuals.com)

It is characterized by the low endogenous GnRH-induced gonadotropin secretion, thus triggering the ovarian blockade and a hypoestrogenic condition. (researchgate.net)

In their study titled "Effect of Some Therapeutic Agents on the Developing Rat Fetus," McColl and colleagues observed in rats an increase in resorption rate but no incidences of phocomelia, the absence or abnormal development of the limbs. (asu.edu)
In this study, the researchers tested whether a drug aimed at an unrelated phenomenon, the abnormal blood vessels of tumors, used in combination with imipramine might further improve outcomes. (technologynetworks.com)

Pharmacological and clinical studies indicate that hydroxyzine in therapeutic dosage does not increase gastric secretion or acidity and in most cases has mild antisecretory activity. (nih.gov)
In clinical practice, metformin is a frequently used hypoglycemic drug that has been shown to have pharmacological effects in attenuating antipsychotic-induced HPRL ( 14 ), but the specific mechanism of action is uncertain. (frontiersin.org)

This is very exciting because it suggests that PAK inhibitors could be used for therapeutic purposes to reverse already established mental impairments in fragile X children. (mit.edu)
The main groups include sodium channel blockers, calcium current inhibitors, gamma-aminobutyric acid (GABA) enhancers, glutamate blockers, carbonic anhydrase inhibitors, hormones, and drugs with unknown mechanisms of action (see the image below). (medscape.com)
Potent inhibitors or inducers or substrates of CYP3A4 within 2 weeks before the first dose of study treatment (3 weeks for St. John's wort) or sensitive substrates of CYP3A4, CYP2C9 and/or CYP2D6 with a narrow therapeutic window within 1 week prior to the first dose of study treatment. (astrazenecaclinicaltrials.com)

It is important to understand the mechanisms of action and the pharmacokinetics of antiepileptic drugs (AEDs) so that these agents can be used effectively in clinical practice, especially in multidrug regimens (see the image below). (medscape.com)

A retrospective cohort study reported that SIC developed in 13.8% of patients with sepsis and septic shock ( 5 ), which could be used as an outcome predictor in the septic patients ( 6 ). (frontiersin.org)
23. Björnsson E, Olsson R. Outcome and prognostic markers in severe drug-induced liver disease. (intramed.net)
This study confirms that insulin resistance affects treatment outcome, and thus HOMA-IR testing before initiation of therapy may be a cost-effective tool. (who.int)
Pulmonary abnormalities in liver disease: relevance to transplantation and outcome. (cdc.gov)

CMV infection has been shown to induce transient abnormalities of in vitro cellular-immune function in otherwise healthy human hosts (2,3). (cdc.gov)
1984. Fibrogenesis by mineral fibres: An in-vitro study of the roles of the macrophage and fibre length. (cdc.gov)

Additionally, premature epiphyseal closure and growth plate abnormalities occurred in nine patients with various durations and doses of isotretinoin ranging from the lowest dose of 0.5 mg/kg/day for a few months to 3.5 mg/kg/day for years. (degruyter.com)
Sixty-five percent of the dose is recovered in the urine as unchanged drug and 11% of the dose appears as the metabolite adipic acid. (globalrph.com)
DALIRESP 250 mcg is a starting dose, for the first 4 weeks of treatment only and is not the effective (therapeutic) dose. (nih.gov)
However, 250 mcg per day is not the effective (therapeutic) dose. (nih.gov)
Nitrosourea or mitomycin C within 6 weeks of the first dose of study treatment. (astrazenecaclinicaltrials.com)
Any investigational agents or study drugs from a previous clinical study within 30 days of the first dose of study treatment. (astrazenecaclinicaltrials.com)
Any other chemotherapy, immunotherapy, immunosuppressant medication (other than corticosteroids) or anti-cancer agents within 3 weeks of the first dose of study treatment, except hormonal therapy with luteinising hormone-releasing hormone (LHRH) analogues for medical castration in patients with prostate cancer, which are permitted. (astrazenecaclinicaltrials.com)
4. Major surgery (excluding placement of vascular access) within 4 weeks of the first dose of study treatment. (astrazenecaclinicaltrials.com)
5. Radiotherapy with a wide field of radiation within 4 weeks of the first dose of study treatment. (astrazenecaclinicaltrials.com)
High-dose vitamin D versus placebo to prevent complications in COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial (CARED-TRIAL). (cdc.gov)

Given that relapse prevention is the most clinically challenging issue in treating substance use disorders, studies examining the effects of microbiome manipulations in relapse-relevant models are critical. (bvsalud.org)
8. Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease. (astrazenecaclinicaltrials.com)

Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. (intramed.net)

We conducted an exploratory epidemiologic study to investigate potential risk factors associated with LCH. (thedoctorsdoctor.com)

Other defects that occur due to a mutation of the Otx2 gene include pituitary abnormalities and mental retardation. (wikipedia.org)
These are intriguing findings because the expression of the gene that inhibits PAK occurs in the third week after birth, which means that the neuronal abnormalities in the fragile X mouse are reversed after they appear," said Eric Klann, a professor at New York University's Center for Neural Science. (mit.edu)

Many of the medical complications that arise are the direct consequence of the need to administer potent immunosuppressive agents, with their attendant risks of infection, malignancy and drug toxicity. (ersjournals.com)
The new clinical data for AB-729, our RNAi therapeutic, continues to support its development as a potential cornerstone agent for the treatment of chronic hepatitis B (cHBV) infection. (biospace.com)
Sepsis is a lethal syndrome induced by infection, which has a reported annual death of 200,000 in the United States ( 1 ). (frontiersin.org)
Circulating Pneumolysin, another common PAMP produced by Streptococcus pneumoniae , induced cardiomyocyte injury through triggering profound calcium influx during pneumococcal infection ( 11 ). (frontiersin.org)
This study will investigate how the brain regulates the body's response to stress and how infection with HIV or pre-hypertension affects regulation. (nih.gov)
Although the pathogenesis of HIV infection and the general virologic and immunologic principles underlying the use of antiretroviral therapy are similar for all HIV-infected persons, unique therapeutic and management considerations apply to HIV-infected children. (cdc.gov)

Hanahan and his colleagues have been exploring in preclinical studies whether drug combinations that target distinct growth-promoting properties of tumors might work synergistically to stall or reverse disease progression. (technologynetworks.com)

Randomized controlled trials involving larger numbers of patients and comparing treatments, as well as studying combination therapies, would be beneficial. (springer.com)
Finally, she discussed treatments for Psychotropic Induced Weight Gain (PIWG). (mood-disorders.co.uk)
Current drug treatments restore the lost dopamine, while initially efficacious, the beneficial effects wear off resulting in severe side effects. (lu.se)

These findings point towards pomegranate as a potential and efficacious therapeutic agent against liver fibrosis. (nature.com)

Rats were trained to self-administer cocaine and subjected to either within-session threshold testing to evaluate motivation for cocaine or 21 days of abstinence followed by a cue-induced cocaine-seeking task to model relapse behavior. (bvsalud.org)
Similarly, microbiome depletion increased cue-induced cocaine-seeking following prolonged abstinence and altered transcriptional regulation in the nucleus accumbens. (bvsalud.org)

It "may be a safe and effective treatment of Tourette syndrome with advantages over other currently approved therapeutic agents," the authors wrote. (medscape.com)
Neonatal treatment using hypervolemic hemodilution and induced arterial hypertension pah. (elastizell.com)
The U.S. Food and Drug Administration (FDA) has received reports of premature epiphyseal closure in patients treated with isotretinoin retinoids, which are commonly prescribed by primary care providers as a treatment for acne. (degruyter.com)
There have been reported cases of premature epiphyseal closure in individuals receiving therapeutic doses of isotretinoin for acne treatment, which are much lower compared to the high doses utilized for neuroblastoma. (degruyter.com)
Although melasma has been studied, its pathogenesis remains largely unknown and its treatment is still met with difficulty. (springer.com)
TB389 trade name] is indicated in combination with other tuberculosis medicines for the treatment of drug- resistant tuberculosis caused by Mycobacterium tuberculosis . (who.int)
EAST HANOVER, N.J., Feb. 19 -- (Healthcare Sales & Marketing Network) -- Novartis announced today that Tasigna (nilotinib) 200 mg capsules has been granted priority review by the US Food and Drug Administration (FDA) for the treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase. (salesandmarketingnetwork.com)
Recently presented data showed that Tasigna surpassed Gleevec in every measure of treatment efficacy designated in the study including prevention of disease progression at 12 months," said David Epstein, CEO of the Novartis Pharmaceuticals Division. (salesandmarketingnetwork.com)
In order to decrease the risk of adverse events and accidents in psychiatric patients and to promote patient compliance with treatment, it is vital for psychiatrists to find effective ways to diminish or neutralize antipsychotic-induced HPRL. (frontiersin.org)
In 1940, phenytoin (PHT) was found to be an effective drug for the treatment of epilepsy, and since then it has become a major first-line antiepileptic drug (AED) in the treatment of partial and secondarily generalized seizures. (medscape.com)
Ethosuximide has been used since 1958 as a first-choice drug for the treatment of absence seizures without generalized tonic-clonic seizures. (medscape.com)
It became the drug of choice in primary generalized epilepsies and in the mid 1990s was approved for treatment of partial seizures. (medscape.com)
In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. (mayo.edu)
The purpose of this study is to evaluate the response to treatment with Ribociclib and Letrozole in patients with low-grade serous cancer of the ovary, fallopian tube or peritoneum. (mayo.edu)
Patients should use barrier contraception (ie, condoms) from the time of screening until 16 weeks after discontinuation of study treatment. (astrazenecaclinicaltrials.com)
Therefore, if patients wish to father children they should be advised to arrange for collection of sperm samples prior to the start of study treatment. (astrazenecaclinicaltrials.com)
7. Spinal cord compression or brain metastases unless asymptomatic, treated and stable and not requiring steroids for at least 4 weeks prior to start of study treatment. (astrazenecaclinicaltrials.com)

A retrospective study noted that sodium bicarbonate administration was associated with better survival in adult cardiac arrests with nonshockable rhythms and asystole. (medlink.com)

Donald L. Gilbert, MD, MS, with the division of neurology at Cincinnati Children's Hospital, and colleagues noted that all Food and Drug Administration-approved medications for Tourette syndrome are antipsychotics. (medscape.com)
Other inherited disordersqualitative abnormalities of dna the blueprint of an overdose, the hepatic veins in budd-chiari syndrome. (elastizell.com)
however, the septic shock in the early onset of sepsis, which induced by cytokine storm and cardiac dysfunction, is also an important cause of death for septic patients, especially for the young patients with toxic shock syndrome or meningococcemia ( 2 ). (frontiersin.org)
Serum amyloid A-A potential therapeutic target for hyper-inflammatory syndrome associated with COVID-19. (cdc.gov)

Thus, innovative therapeutic strategies to ameliorate the prognosis of NBL patients need to be developed. (biomedcentral.com)

Otx2 mutations have also been associated with seizures, developmental delays, short stature, structural abnormalities of the pituitary gland, and an early onset of degeneration of the retina. (wikipedia.org)
Langer cj, mehta mp therapeutic advances in clotting factor needed x can be supported by current techniques use reflected sound to measure latency to sleep onset and to if patients are treated as a result of slowing of cardiac output to the fall in ph can also assist in developing countries and is the preferred study. (elastizell.com)

Hepatic fibrosis in rats was induced by the intra-peritoneal injection of NDEA (10 mlkg −1 b.wt. (nature.com)

While offering a vital therapeutic option for patients with advanced lung disease, LTx remains fraught with complications that threaten both the quality and duration of the recipient's life. (ersjournals.com)

it can lead to significant developmental abnormalities and disorders. (wikipedia.org)
It is necessary to identify any stressed situation induced by loss, family or working problems, weight loss or eating disorders, or physical training or agonist activity. (researchgate.net)
This study is looking at people who have platelet or other blood disorders. (nih.gov)

In April 2021, we searched the FDA's "Drug Data and Adverse Event Report System" utilizing the terms "isotretinoin" and "epiphysis premature fusion. (degruyter.com)

Describes the nature of a clinical study. (mayo.edu)
3. Subject has an APOL1 genotype of G1/G1, G2/G2, or G1/G2 obtained with a Vertex designated investigational clinical study assay. (who.int)

Biochemical, histopathological and ultra-structural studies were carried out on control, fibrotic and treated rats. (nature.com)
Halting PAK's enzymatic activity reversed the structural abnormality of neuronal connections found in the FXS mice, said co-author Susumu Tonegawa, 1987 Nobel laureate and Picower Professor of Biology and Neuroscience. (mit.edu)

These findings suggest that gut bacteria, via their metabolites, are key regulators of drug-seeking behaviors, positioning the microbiome as a potential translational research target. (bvsalud.org)
In 1965, J.D. McColl and colleagues in Canada further illustrated the limitations of animal studies for the use of predicting human responses to potential teratogens. (asu.edu)
Despite various documented roles of PGJ, there are no studies on antifibrotic potential in NDEA-induced mammalian liver fibrotic model. (nature.com)
Our 8-MOP (methoxsalen) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
Hopefully, the greatly increased attention to the potential dangers of opioids has altered all physician prescribing patterns to find alternatives or sharply limit the time frame for use and amount of drug prescribed. (arcfertility.com)
identified the Insulinlike growth factor 1 receptor (IGF-1R) as a potential therapeutic target in GIST. (liferaftgroup.org)
Antiepileptic drugs should be used carefully, with consideration of medication interactions and potential side effects. (medscape.com)
Contact the study team to discuss study eligibility and potential participation. (mayo.edu)
Our investigation illustrates the great potential of drug repurposing for cancer therapy," said Hanahan, distinguished scholar at the Ludwig Institute for Cancer Research Lausanne Branch. (technologynetworks.com)

Whether this association can be attributed to epilepsy itself or is related to antiepileptic drug therapy, in particular valproate (VPA), remains controversial. (columbia.edu)
Pearls of antiepileptic drug use and management. (medscape.com)

Understanding the role of MPDs may lead to development of new therapeutic and diagnostic targets. (nih.gov)

Bevacizumab is known to quasi-normalize leaky tumor blood vessels, whose abnormalities also compromise both chemotherapy and immunotherapy. (technologynetworks.com)

Other TLR-related genes (TLR2, 3, and 9) were demonstrated to be involved in sepsis-induced cardiac dysfunction from recent studies. (frontiersin.org)
Therapeutic hypothermia increases the chances of survival and reduces the risk of neurologic damage following cardiac arrest. (medlink.com)

They explore how abnormalities in these molecules could interfere with an animal's behavior. (mit.edu)
All these stressors act on hypothalamic and extra hypothalamic areas inducing specific defensive behavior in the many hypothalamic centers such as those controlling reproduction, body temperature, food intake, sleep regulation [4, 15]. (researchgate.net)

Researchers led by Ludwig Lausanne's Douglas Hanahan report in the current issue of Cancer Cell how the drugs used in the combination-an antidepressant, an immune checkpoint blockade antibody and a mouse analog of a cancer therapy that by themselves provide no survival benefit against GBM-synergize to unleash potently therapeutic immune responses against the tumor. (technologynetworks.com)
We've shown here that three extensively characterized drugs already in use in the clinic can be newly combined to lift the tumor's immunosuppressive barrier and induce a therapeutic immune response that significantly extends survival in mouse models of GBM, a cancer that has so far evaded every therapy used to treat it. (technologynetworks.com)

Out of 29 liver tissue sections examined, 14 had a low level of expression of insulin receptor type 1 by immunohistochemical studies. (who.int)

The current study employed Bayesian networks to a longitudinal proteomic dataset generated from Caco-2 cells transfected with SARS-CoV-2 (isolated from patients returning from Wuhan to Frankfurt). (mdpi.com)
Holter ECG confirmed the conduction abnormalities in 3 of the 4 patients (SAB, AVB, and ventricular hyperexcitability in 2 patients). (cdc.gov)
Since drowsiness may occur with use of the drug, patients should be warned of this possibility and cautioned against driving a car or operating dangerous machinery while taking hydroxyzine pamoate. (nih.gov)
Patients should be advised against the simultaneous use of other CNS depressant drugs, and cautioned that the effect of alcohol may be increased. (nih.gov)
The majority of reports occurred in patients with other risk factors for QT prolongation/TdP (pre-existing heart disease, electrolyte imbalances or concomitant arrhythmogenic drug use). (nih.gov)
All filings are based on data showing superior efficacy for Tasigna in the first head-to-head comparison of the drug against the standard of care Gleevec in newly diagnosed Ph+ CML patients. (salesandmarketingnetwork.com)
If approved for the first-line indication, Tasigna will be the first drug for newly diagnosed patients to become available since the approval of Gleevec in 2002. (salesandmarketingnetwork.com)
Fewer patients discontinued due to adverse events from the Tasigna 300 mg twice daily arm of the study compared to the Gleevec 400 mg once daily arm. (salesandmarketingnetwork.com)
No patients in the study had a prolongation of the QT interval >500 milliseconds(1). (salesandmarketingnetwork.com)
Almost all patients with CML have an abnormality known as the Philadelphia chromosome, which produces a protein called Bcr-Abl. (salesandmarketingnetwork.com)
Lymphocyte studies were not performed on the other 2 patients. (cdc.gov)
However, whether either of the two drugs can reduce PRL levels in patients with long-term hospitalized chronic schizophrenia with co-morbid type 2 diabetes (T2DM) has not been adequately reported. (frontiersin.org)
In our study, long-term hospitalized chronic schizophrenia patients with co-T2DM who were prescribed olanzapine or risperidone as the primary antipsychotic medication were enrolled. (frontiersin.org)
According to a significant Chinese study, the prevalence of HPRL in hospitalized schizophrenia patients is up to 61.3% and is similar in men and women ( 3 ). (frontiersin.org)
What's more, risperidone and olanzapine are two of the top-ranked antipsychotic drugs in terms of prescription rates, according to reports of prescribing patterns for psychiatric patients from around the world, including China ( 5 - 8 ). (frontiersin.org)
Phase 2/3 Study of VX 147 in Patients With APOL1-mediated Kidney Disease. (who.int)
Sixteen patients (ten with one or more intestinal fistula) developed abdominal wall dehiscence were included in this study. (who.int)

A 1962 study titled "Thalidomide and Congenital Abnormalities," by Victor Knapp, George Christie, and Mary Seller, all working in the UK, looked at the teratogenic effects of Thalidomide on rats, mice, and rabbits, and the study reported no abnormalities in the offspring of these animals after researchers had exposed the pregnant females to the drug. (asu.edu)
In humans limb truncation in offspring is a common congenital abnormality arising from Thalidomide use by pregnant women. (asu.edu)

Strikingly, PAK inhibition also restored electrical communication between neurons in the brains of the FXS mice, correcting their behavioral abnormalities in the process," he said. (mit.edu)
However, whether TNF‑α‑induced alveolar hypercoagulation and fibrinolysis inhibition is also associated with the NF‑κB pathway remains to be determined. (spandidos-publications.com)
These findings suggest that BAY11‑7082 improves the hypercoagulation and fibrinolytic inhibition induced by TNF‑α in alveolar epithelial cells via the NF‑κB signaling pathway. (spandidos-publications.com)

By 1962, researchers across scientific disciplines began studies on Thalidomide's teratogenic effects in various organisms. (asu.edu)
From these studies, and many others, the scientists formed a consensus about the key feature of rodent embryos that grants them the resistance to Thalidomide's teratogenic effects. (asu.edu)
Drug interactionsadditive stimulant effects are present in hf. (elastizell.com)
Less common side effects of isotretinoin include hearing loss, pseudotumor cerebri, anaphylaxis, and skeletal abnormalities including growth arrest. (degruyter.com)
Studies published in English between 1980 and 2020 were also included, as well as background sources relating to an isotretinoin profile with side effects and dosing. (degruyter.com)
Nursing Mothers: DALIRESP should not be used by women who are nursing as excretion of roflumilast and/or its metabolites into human milk is probable and there are no human studies that have investigated effects of DALIRESP on breast-fed infants. (nih.gov)
Other studies found no such effects. (wikipedia.org)
Yet though this drug combination extended survival, its effects were not very durable. (technologynetworks.com)

Weight gain was larger in the placebo group than in the ecopipam group: 17.1% in the ecopipam group and 20.3% of those who got a placebo had a weight gain of more than 7% over the study period. (medscape.com)

This chapter aims to elucidate that isotretinoin, given at various doses and durations, has been associated with growth plate abnormalities, which can lead to premature epiphyseal closure. (degruyter.com)
Isotretinoin-induced premature epiphyseal closure and growth plate deformities seem to be linked to higher doses of isotretinoin for the duration of months to years. (degruyter.com)
Studies show that the time to the next depressive episode is delayed at doses of 100 to 400mg/day, and it may be as good as lithium at achieving this. (mood-disorders.co.uk)

To reduce the development of drug-resistant bacteria and maintain the effectiveness of CIPRO® XR and other antibacterial drugs, CIPRO XR should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (theodora.com)

To investigate the regulatory effect of electroacupuncture (EA) at Zusanli (ST36) on tumor necrosis factor-alpha (TNF-α) in rats with ulcerative colitis (UC), and further elucidate the therapeutic mechanism of EA on UC. (wjgnet.com)
Antiepileptic drugs can be grouped according to their major mechanism of action. (medscape.com)
Some antiepileptic drugs work by acting on combination of channels or through some unknown mechanism of action. (medscape.com)

The dire need for therapeutic strategies to mitigate and successfully treat COVID-19 is now a public health crisis with national security implications for many countries. (mdpi.com)
This chapter aims to give insights into diagnosis and putative therapeutic strategies. (researchgate.net)

It was stressed that therapeutic levels tend to be higher than when valproate is used as an anticonvulsant (suggestive levels of more than 80). (mood-disorders.co.uk)
Suggestive biomarkers for valproate response include mixed episodes, rapid cycling and mania post head injury or with EEG abnormalities. (mood-disorders.co.uk)

That outrage motivated a scientific debate over the efficacy of using model organisms, like mice and rats, in drug development. (asu.edu)
Hyperactivation of autophagy by these drugs modestly extended survival of mice with GBM. (technologynetworks.com)

The findings will help to identify drugs that cure otherwise lethal infections. (nih.gov)
A Ludwig Cancer Research study has identified a combination of three existing drugs that significantly extends survival in mouse models of the lethal brain cancer glioblastoma multiforme (GBM). (technologynetworks.com)

The binding of ciprofloxacin to serum proteins is 20% to 40%, which is not likely to be high enough to cause significant protein binding interactions with other drugs. (theodora.com)

MAC was also found to induce the nuclear factor-κB (NF-κB) p65 activation by phosphorylation and its translocation into the nucleus. (biomedcentral.com)
A study from the Chinese province of Taiwan found that olanzapine can cause high levels of PRL (up to 51.6%) ( 4 ). (frontiersin.org)
In 1910, phenobarbital (PHB), which then was used to induce sleep, was found to have antiseizure activity and became the drug of choice for many years. (medscape.com)
A population-based study in Massachusetts found the minimum incidence of PCP during the first year of life to be 2.3% among all infants born to seropositive mothers, or an estimated 7.7% among HIV-infected infants (7). (cdc.gov)

The study identifies a key enzyme-a chemical reaction-inducing protein-as a possible target for an FXS drug. (mit.edu)

Anatomy29

Organisms5

Diseases84

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment98

Psychiatry and Psychology5

Phenomena and Processes39

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture4

Humanities2

Information Science8

Named Groups1

Health Care25

Acute10

Molecular abnormalities2

Fetal3

Apoptosis1

Chemically1

Metabolic4

Coagulation4

Systemic2

Indications2

Cytokines2

Exposure5

Diseases8

Laboratory3

Inflammation3

Ovarian1

Abnormal2

Pharmacological2

Inhibitors3

Mechanisms1

Outcome4

Vitro2

Dose10

Clinically2

Liver injury1

Exploratory1

Gene2

Infection6

Tumors1

Treatments3

Efficacious1

Abstinence2

Treatment17

Adult1

Syndrome4

Prognosis1

Onset2

Hepatic1

Lung1

Disorders3

20211

Clinical study2

Structural2

Potential9

Antiepileptic drug2

Diagnostic1

Chemotherapy1

Cardiac2

Behavior2

Immune2

Receptor1

Patients17

Pregnant2

Inhibition3

Effects8

Weight gain1

Doses3

Antibacterial drugs1

Mechanism3

Strategies2

Valproate2

Mice2

Lethal2

Serum1

Found4

Target1