Therapeutic staurosporine protein kinase inhibitors. Medical search. Frequent questions

Targeting the ATP binding site of c-Met by small molecules inhibitors is one strategy for inhibition of the tyrosine kinase. (wikipedia.org)
Stress granules, are membrane-less ribonucleoprotein-based condensates, could enhance chemoresistance by sequestering proapoptotic proteins inhibition of cell death upon exposure to drug-induced oxidative stress. (bvsalud.org)
Therefore, the authors concluded that LRRK2 inhibition may not represent a suitable therapeutic strategy for the treatment of PD.54 Another research group created inducible transgenic rats expressing LRRK2 with G2019S substitution and recapitulated the initiation process of dopaminergic dysfunction. (campaignfornonviolentschools.org)
Thus, the inhibition of LRRK2 kinase activity may hold potential to protect against LRRK2 toxicity and consequently for the treatment of neurodegeneration in PD.58 Hence, LRRK2 kinase inhibition holds potential PEPCK-C for the treatment of PD. (campaignfornonviolentschools.org)
The inhibition effect of ROCOLRRK2 fragments will not be discussed.59 Small Molecule Kinase Inhibitors for LRRK2 LRRK2 is a large protein with several discrete domains. (campaignfornonviolentschools.org)
Tellingly, we demonstrate that the metabolic stabilization of the cleaved fragment of PKC-theta or inhibition of the N-end rule augments the apoptosis-inducing effect of staurosporine in Jurkat cells. (qxmd.com)
In addition, the increase in the P3/P0 density ratio induced by a high glucose level was restored to the control level by both staurosporine and calphostin C. These results suggest that the high glucose level induced the inhibition of GJIC activity in cultured VSMCs through excessive phosphorylation of Cx43, mediated by PKC activation. (elsevierpure.com)
Similar findings were made in bone marrow cells from gene-targeted mice lacking Bim and/or Puma infected with FLT3-ITD and treated with inhibitor, where loss of Puma only provided transient protection from apoptosis, but loss of Bim preserved clonal survival upon FLT3-ITD inhibition. (ashpublications.org)
Since FTS is a non toxic drug we hypothesized that FTS and chloroquine (an autophagy inhibitor) will synergize in cell growth inhibition and cell death. (oncotarget.com)
Considering the fact that Stat3 inhibition also blocks VEGF expression in tumours characterized by aberrant activation of Src, therapeutic focusing on of Stat3 may well inhibit neovascularisation in tumours associ ated with extreme signaling through epidermal development issue receptor. (mirnaarray.com)

c-Met inhibitors are a class of small molecules that inhibit the enzymatic activity of the c-Met tyrosine kinase, the receptor of hepatocyte growth factor/scatter factor (HGF/SF). (wikipedia.org)
c-Met is a receptor tyrosine kinase, which can cause a wide variety of different cancers, such as renal, gastric and small cell lung carcinomas, central nervous system tumours, as well as several sarcomas when its activity is dysregulated. (wikipedia.org)
Receptor tyrosine kinases (RTKs) are a vital element in regulating many intracellular signal transduction pathways. (wikipedia.org)
Met tyrosine kinase is the receptor for hepatocyte growth factor (HGF), also known as scatter factor (SF). (wikipedia.org)
The beta chain contains the intracellular tyrosine kinase domain and a tail on the C-terminal which is vital for the docking of substrates and downstream signalling. (wikipedia.org)
The injection of the LRRK2 kinase inhibitors can attenuate the loss of tyrosine hydroxylase-positive neurons induced by HSV-G2019S. (campaignfornonviolentschools.org)
Since epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, including gefitinib (GEF) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of GEF are further enhanced under amino acid starvation (AAS) culture conditions. (spandidos-publications.com)
Constitutively activating internal tandem duplications (ITD) of FLT3 (FMS-like tyrosine kinase 3) are the most common mutations in acute myeloid leukemia (AML) and correlate with poor prognosis. (ashpublications.org)
Receptor tyrosine kinase inhibitors targeting FLT3 have developed as attractive treatment options. (ashpublications.org)
FLT3 (FMS-like tyrosine kinase 3) is a type III receptor tyrosine kinase (RTK) closely related to the platelet-derived growth factor (PDGF) receptor and c-Kit with important functions in the regulation of early hematopoietic cells. (ashpublications.org)
Upon cytokine activation receptor chain- bound STATs are then phosphorylated on the tyrosine residues, which results in dimerisation of STAT proteins that translocate to the nucleus and activate gene transcription. (openrheumatologyjournal.com)
GSK3 is inactivated by other growth factors or hormones that, like insulin, signal through receptor tyrosine kinases. (justia.com)

Here, we found that galectin-7 promotes cisplatin (CDDP) induced apoptosis and associates with stress granule-nucleating protein G3BP1 degradation. (bvsalud.org)
Importantly, the mitochondrial association of n-cofilin and ADF had no impact on apoptosis signaling because ablation of either n-cofilin, ADF, or both proteins together did not change cell death progression. (nature.com)
UCN-01, a kinase inhibitor/mitochondrial uncoupler that has been shown to lead to Puma-induced mitochondrial apoptosis as well as ATP synthase inhibitor oligomycin, demonstrated effectiveness against spheroids, whereas spheroids were refractory to cisplatin and paclitaxel. (duke.edu)
Apoptosis regulatory proteins are delicately balanced. (bmj.com)
The key regulator of this process, hypoxia inducible factor 1 (HIF-1), can initiate apoptosis by inducing high concentrations of proapoptotic proteins, such as BNIP3, and can cause stabilisation of p53. (bmj.com)

Glioblastoma (GBM), a very aggressive and incurable tumor, often results from constitutive activation of EGFR (epidermal growth factor receptor) and of phosphoinositide 3-kinase (PI3K). (sdbonline.org)

Phosphorylation occurs in tyrosines close to the C-terminus, creating a multi-functional docking site which recruits adaptor proteins and leads to downstream signalling. (wikipedia.org)
However, we could not detect any phosphorylation of RIPK-1 and mixed lineage kinase domain like pseudokinase (MLKL), as well as any necrosome formation. (spandidos-publications.com)
Phosphorylation of these dual tyrosines leads to the conformational changes in the JAK protein to facilitate binding of substrate. (jaksignaling.com)
instead cytokines function through binding to a cognate receptor proteins, which trigger phosphorylation and activation of intracellular signaling proteins. (openrheumatologyjournal.com)
Formation of the cytokine receptor / JAK signaling complex and activation of JAK kinases leads to the phosphorylation of receptor chains, which creates docking sites for STAT ( S ignal T ransducers and A ctivators of T ranscription) transcription factors. (openrheumatologyjournal.com)

LKB1 itself is a constitutively active kinase, which is regulated by posttranslational modifications and direct binding to phospholipids of the plasma membrane. (sdbonline.org)
Therefore, cellular stresses induced during cell isolation cause dedifferentiation and transition to duct-like cells through activation of p38 MAP kinase and constitutively active Src kinases. (sykinhibitors.com)

Next, we observed that Acanthamoeba specifically activates phosphatidylinositol 3-kinase. (asm.org)
Acanthamoeba -mediated brain endothelial cell death was abolished using LY294002, a phosphatidylinositol 3-kinase inhibitor. (asm.org)
These results were further confirmed using brain microvascular endothelial cells expressing dominant negative forms of phosphatidylinositol 3-kinase. (asm.org)
This is the first demonstration that Acanthamoeba -mediated brain microvascular endothelial cell death is dependent on phosphatidylinositol 3-kinase. (asm.org)

Autophagy is generally considered as a cell survival/protection mechanism because it removes toxic or obsolete proteins and organelles and recycles the degradation products for use as sources for energy and metabolites in anabolic pathways 3 . (nature.com)
N-degron-mediated degradation of the proteolytically activated form of PKC-theta kinase attenuates its pro-apoptotic function. (qxmd.com)
Mounting number of studies reveal that the activity of these proteolytically activated protein fragments can be counteracted via their selective degradation by the N-degron degradation pathways. (qxmd.com)
Our results expand the functional scope of mammalian N-degron pathway, and support the notion that targeting N-degron degradation machinery may have promising therapeutic implications in cancer cells. (qxmd.com)
In contrast to the influx of amino acids, the degradation of proteins is also the important intracellular mechanism for releasing free amino acids both under steady-state conditions and during cellular stresses. (spandidos-publications.com)
Autophagy is a process that regulates the balance between protein synthesis and protein degradation. (oncotarget.com)
FTS acts as a functional Ras antagonist in cells, affecting Ras-membrane interactions by dislodging the protein from its anchorage domains, facilitating its degradation and, thus, reducing cellular active Ras content [ 8 , 9 ]. (oncotarget.com)

The reversal of the antisecretory activity of the inhibitors in dogs is suggested to be due to the action of endogenous extracellular GSH, in addition to de novo synthesis of the proton pump, because bullfrog gastric mucosae were found in the present study to secrete GSH into the mucosal solution at the rate of about 0.25 nmol/min/g tissue. (shengsci.com)
The epitope has been successfully located in region 122-195 of extracellular domain I. These findings could lead to the identification of novel epitopes on ErbB2 that could be used as potential therapeutic targets to mitigate anti-ErbB2-associated cardiotoxicity and eventually overcome resistance. (cnr.it)

Its N-terminal region binds to Met and receptor dimerization as well as autophosphorylation of two tyrosines occur in the activation loop (A-loop) in the kinase domain of Met. (wikipedia.org)
More specifically, substrates with certain FYVE domains (named after the first four proteins in this motif, Fab1, YotB, Vac1p, and EEA1) bind PIP, and these pathways have been implicated in vesicular trafficking or receptor-mediated endocytosis ( 5 ). (asm.org)
The presence of necrostatin-1, an inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK‑1), but not that of Z-VAD-fmk, attenuated the cytotoxic effects of GEF under AAS culture conditions. (spandidos-publications.com)
The biofilm proteome showed major variations in the composition of outer membrane proteins and receptor or transport proteins. (hdac-inhibitors.com)

This is why targeting the HGF/c-MET signalling pathway has been untaken as a treatment for cancer, and several different therapeutic approaches are being clinically tested. (wikipedia.org)
Inactivation of the PI3-kinase pathway, but not of Ras-mitogen-activated protein (MAP) kinase signaling, was essential to elicit cytotoxic responses. (ashpublications.org)
This tumor cell characteristic demonstrates, partly, a dysregulation of the total amount between pro-apoptotic and anti-apoptotic BCL-2 protein [7] that regulate the intrinsic mitochondrial apoptotic pathway. (islamophobiacon.com)
Functional assays confirmed impaired DNA binding of mutated RBPJ, placing it among other notch-pathway Selleckchem Galardin proteins altered in human genetic syndromes. (phosphorylase-signal.com)

Altogether, these data suggest that autophagy is repressed during glial tumorigenesis and that V-ATPase and MTORC1 components acting at lysosomes could represent therapeutic targets against GBM. (sdbonline.org)

Later, series of more selective c-Met inhibitors were designed, where an indolin-2-one core (encircled in figure 1) was present in several kinase inhibitors. (wikipedia.org)
Using information from the co-crystal structure of PHA-66752 and c-Met, the selective inhibitor PF-2341066 was designed. (wikipedia.org)
Development of RTK inhibitors selective for FLT3 has emerged as attractive drugs for treatment of AML patients. (ashpublications.org)
The invention provides materials and methods relating to identification and optimization of selective inhibitors of glycogen synthase kinase 3 (GSK3), and also relates to methods of treating a condition mediated by GSK3 activity. (justia.com)

Provided these multiple activities, the primary system where gossypol induces cell loss of life in virtually any particular tumor type will probably vary, with regards to the known degrees of anti-apoptotic BCL-2 proteins as well as other tumor cell-specific elements. (islamophobiacon.com)

Glucose has been reported to increase the de novo synthesis of diacylglycerol (DAG) and translocate and activate protein kinase C (PKC) in rat adipocytes. (jci.org)

Interestingly, some proteins related to energy production, such as ATP-synthase were down-regulated selleck kinase inhibitor in biofilms. (hdac-inhibitors.com)

Phosphatidylinositol 3-kinases (PI3Ks) are important signaling molecules that phosphorylate the 3′ OH position of the inositol ring of phosphoinositides (PIs), generating the second messengers PI(3)P, PI(3,4)P 2 , and PI(3,4,5)P 3 ( 4 , 17 ). (asm.org)

This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. (thermofisher.com)
It phosphorylates and activates several downstream kinases, including AMP-dependent kinase, AMPK . (sdbonline.org)

Despite data supporting the transcriptional activity of p53 protein in differentiation, few genetic targets have been described and fewer still within a neuronal context. (biomedcentral.com)
For this reason, Ras and its effectors serve as important targets for therapeutic intervention. (oncotarget.com)

Both compounds induced up-regulation of proapoptotic BH3-only proteins Bim and Puma, and subsequent cell death. (ashpublications.org)

A variety of approaches have been used to target c-Met, each focusing on one of the serial steps that regulate c-Met activation by antibodies, peptide agonists, decoy receptors and other biologic inhibitors or small molecules inhibitors. (wikipedia.org)
Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (De Novo phospholipid synthesis) of rat adipocytes. (jci.org)
Cellular signalling cues lead to the initiation of apoptotic pathways and often result in the activation of caspases which in turn cause the generation of proteolytically generated protein fragments with new or altered functions. (qxmd.com)
3 Pro-apoptotic proteins, such as cytochrome c and second mitochondria-derived activator of caspase (SMAC), are released from mitochondria into the cytosol where they participate in the activation of execution caspases. (nature.com)
Activation of p38 MAP kinase occurs during cell isolation from the parotid glands and is retained up to 6 h after the isolation. (sykinhibitors.com)
In contrast, activation of Src kinases does not increase during the cell isolation. (sykinhibitors.com)
The Src inhibitor PP1 suppresses the activation of p38 MAP kinase. (sykinhibitors.com)

Discovery of non-genotoxic mechanisms through which p53 protein may be activated within tumor cells harboring wild-type p53 remains an important therapeutic objective, both in effort to alleviate traditional off-target chemotherapeutic side-effects and to prevent the unpredictable mutagenicity characteristic of these therapies. (biomedcentral.com)

Cellular proteins and organelles are engulfed into a double-membrane vesicle to form an autophagosome. (spandidos-publications.com)
As a transcription factor, many of the functional cellular roles of the p53 protein are elicited through direct DNA binding to sequence-specific cis-regulatory elements [ 3 ] leading to the transactivation or transrepression of target genes. (biomedcentral.com)
The master kinase LKB1 is a key regulator of several cellular processes, including cell proliferation, cell polarity and cellular metabolism. (sdbonline.org)

Following our observation that erythrosine B (FD&C Red No. 3) is a relatively potent inhibitor of the TNF-R-TNFα and CD40-CD154 protein-protein interactions, we investigated whether this inhibitory activity extends to any other protein-protein interactions (PPI) as well as whether any other approved food colors posses. (shengsci.com)
Rapamycin may be a potent and specified inhibitor of mTOR, a crucial effector of activated PIK3CA/AKT signaling and it is currently used in the clinic. (pafr-inhibitor.com)

Positive Control: Staurosporine-treated HeLa or Jurkat cell lysate. (thermofisher.com)

Similar patterns are found in other European countries, with different therapeutic options offered to patients. (mdmsignaling.com)

Stat3 could possibly also advertise neovascularisa tion by mediating endothelial cell responses to other development variables, including granulocyte macrophage purchase Staurosporine stim ulating issue. (mirnaarray.com)
Figure 5 shows that the levels of the CCR5 ligands macrophage inflammatory protein (MIP)-1α and MIP-1β dropped significantly from week 12. (ikk-signal.com)

It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. (thermofisher.com)

Glycogen synthase kinase 3 (GSK3) is a proline-directed serine/threonine kinase originally identified as an activity that phosphorylates glycogen synthase as described in Woodgett, Trends Biochem Sci 16:177-181 (1991). (justia.com)

PKC412 is one of several FLT3 inhibitors that is currently evaluated in late-stage clinical trials in AML patients carrying FLT3 mutations. (ashpublications.org)
We noticed that rapamycin can reactivate senescence in mouse tumors haboring mutations in both RAS and PTEN, pointing to doable therapeutic exercise against human tumors of this, or equivalent, genotype. (pafr-inhibitor.com)
Through exome resequencing, we identified two unique mutations in recombination signal binding protein for immunoglobulin kappa J (RBPJ) in two independent families affected by Adams-Oliver syndrome (AOS), a rare multiple-malformation disorder consisting primarily of aplasia cutis congenita of the vertex scalp and transverse terminal limb defects. (phosphorylase-signal.com)
Scope includes mutations and abnormal protein expression. (cancer-genetics.org)

Convection enhanced delivery (CED), an innovative technique that directly infuses a therapeutic agent into a brain tumor through a cannula, bypassing the blood-brain barrier (BBB), is safe and feasible for treating diffuse intrinsic pontine glioma (DIPG), according to our experience to date in an ongoing phase I clinical trial at Memorial Sloan Kettering Cancer Center (MSK). (mskcc.org)
Growth factor cytokine receptors typically have intrinsic kinase activity. (openrheumatologyjournal.com)
In contrast, classical immune (type I/ II) cytokine receptors do not have intrinsic protein kinase activity but associate with the Janus family of kinases (JAKs). (openrheumatologyjournal.com)

To reveal the details of the variables that were significant predictors in the multivariate analyses, we conducted a posteriori univariate analyses using all species that were included in each continuous and discrete variable Staurosporine molecular weight category. (bcl2signaling.com)

Provided these limited treatment plans and the intense behavior of MPNSTs, brand-new therapeutic approaches are expected. (islamophobiacon.com)

Outer mitochondrial membrane permeabilization and cytochrome c release are typically achieved by pro-apoptotic Bcl-2 proteins, such as Bax and Bak. (nature.com)
Taken together, our findings suggest that genes involved in mitochondrial function in spheroids may be an important therapeutic target in preventing disease recurrence. (duke.edu)

Rutin caused attenuation of streptozotocin-induced inflammation by decreasing the activity of the glial fibrillary acidic protein, interleukin-8, cyclooxygenase-2, inducible nitric oxide synthase and nuclear factor-kB and thereby prevented gross anatomical changes in rat hippocampus. (fuqna.com)

Acanthamoeba binding to HBMEC is mediated by a mannose-binding protein expressed on the surface of Acanthamoeba cells ( 2 ). (asm.org)
In addition, treatment of the cells with calphostin C, a specific PKC inhibitor, for 3 h completely restored the GJIC activity inhibited by the high glucose level. (elsevierpure.com)
The protein kinase C inhibitor UCN-01 (7-hydroxystaurosporine) has shown higher efficacy against slow proliferating and/or quiescent ovarian cancer cells. (duke.edu)
ApoVs are rich in proteins, RNA (microRNAs, mRNAs, ncRNAs, etc.) and lipids, and are a key intercellular communication mediator that can exert different regulatory effects on recipient cells. (biomedcentral.com)
Here, we have determined the growth-inhibitory and proapototic mechanisms of 2 small molecule inhibitors of FLT3, AG1295 or PKC412, in hematopoietic progenitor cells, human leukemic cell lines, and primary AML cells expressing FLT3-ITD. (ashpublications.org)
Several inhibitors have been described, such as AG1295, CEP701, PKC412, and SU-11 248, with cytotoxic effects to cell lines and primary AML cells in vitro expressing mutant FLT3. (ashpublications.org)
After 15-oxo-ETE treatment, Human umbilical vein endothelial cells (HUVECs) showed more attractive to monocytes, whereas monocyte adhesion is suppressed when treated with PKC inhibitor. (biomedcentral.com)
The data show p53 protein was transcriptionally activated and contributed to NGF-mediated neurite outgrowth during differentiation of PC12 cells. (biomedcentral.com)

However, the application of a calcaneal plate via an extensile lateral approach is at risk for a substantial rate of complications including delayed healing, skin necrosis, www.selleckchem.com/products/Staurosporine.html or infection. (hdac-inhibitors.com)

Use of other contrast media, such as water-soluble iodinated contrast, normal Epigenetics inhibitor saline, or air, is recommended under either fluoroscopic or sonographic guidance. (phosphorylase-signal.com)

The R1441C mutation could represent pathogenic precursors preceding dopaminergic degeneration in PD brains.53 A novel herpes simplex virus (HSV) amplicon-based mouse model of LRRK2 dopaminergic neurotoxicity was developed to determine the efficacy of several LRRK2 kinase inhibitors. (campaignfornonviolentschools.org)

We present that AT101 induces appearance of BCL-2/E1B-19K-interacting proteins 3 (BNIP3), an atypical BH3-just proteins, which promotes AT101-induced cell loss of life. (islamophobiacon.com)

The invention meets this need by providing crystallizable GSK3 polypeptides useful for design and optimization of GSK3 inhibitors. (justia.com)

This study reports that LKB1 binds to Phosphoinositide-dependent kinase (PDK1) by a conserved binding motif. (sdbonline.org)
Furthermore, a PDK1-consensus motif is located within the kinase domain of LKB1 and LKB1 gets phosphorylated by PDK1 in vitro. (sdbonline.org)

The food colorant erythrosine is a promiscuous protein-protein interaction inhibitor. (shengsci.com)
Activated Ras transmits signals through its interaction with multiple effectors, including mitogen activated kinase (MAPK), phosphoinositide-3-kinase (PI3K) and Ral-GEF [ 1 , 2 ]. (oncotarget.com)

SU-11274 was evolved by substitution at the 5-position of the indolinone and by adding a 3,5-dimethyl pyrrole group, PHA-665752 was evolved - a second-generation inhibitor with better potency and activity. (wikipedia.org)
It surfaced as a therapeutic target when the kinase activity and the most common LRRK2 mutation, G2019S, were associated with neurotoxicity and PD. (campaignfornonviolentschools.org)
Quite a few research of VEGFR multikinase inhibitors have already established that this class of targeted agents has activity in MTC.Motesanib was studied inside a phase II trial in which 81 patients with progressive or symptomatic MTCwere treated.14 ThePRrate was 2%, and81%of patients had SD. (ikk-signal.com)

Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer. (sagepub.com)

The majority of inositol lipids reside in membranes and serve as substrates for kinases, phosphatases, and phospholipases. (asm.org)
ApoVs are rich in protein, RNAs and lipids, and they are a key intercellular communication medium [ 27 ]. (biomedcentral.com)

At that time, DLT was also mentioned in schedule B with the dose of 34 mg/m2, wherever two patients had grade 3 dyspnea secondary to STAT inhibitor pneumonitis. (ikk-signal.com)

Other chemokines, such as monocyte chemotactic protein (MCP)-1 and MIG, also dropped (Fig. 5), and their levels correlated positively with VL (P=0.02 and 0. (ikk-signal.com)

The protein encoded by this gene represents the beta subunit and is a type I membrane protein. (cancer-genetics.org)

Because relapses occur after initial responses, identification of FLT3-ITD-mediated signaling events are important to facilitate novel therapeutic interventions. (ashpublications.org)
This true point is important since it suggests a therapeutic margin. (colinsbraincancer.com)

2] Common symptoms Staurosporine of active UC and CD are diarrhoea, with stools filled with bloodstream and mucous, and stomach pain. (monossabios.com)

20 crystal structures with and without ligands have been published and in 2010 nearly a dozen small molecule c-Met inhibitors have been tested clinically. (wikipedia.org)
In the following, we will give a summary of small molecule LRRK2 kinase inhibitors. (campaignfornonviolentschools.org)
Small molecule Jak inhibitors as therapeutic agents have become a reality and the palette of such inhibitors will likely expand. (openrheumatologyjournal.com)

K252a was the first structure to be solved in complex with the unphosphorylated MET kinase domain. (wikipedia.org)
The kinase domain usually consists of a bi-lobed structure, where the lobes are connected with a hinge region, adjacent to the very conserved ATP binding site. (wikipedia.org)

LRRK2-induced neurodegeneration.43 The blockage of zebrafish LRRK2 protein by morpholinos caused embryonic lethality and severe development problems such as growth retardation and loss of neurons. (campaignfornonviolentschools.org)
5] Although population-based research found an eternity require of steroids in 50% from the patients,[6] IBD patients frequently develop Staurosporine severe complications regardless of the right administration of conventional medical therapy. (monossabios.com)

Risk of thrombosis with mechanical valves is very high in patients with hypereosinophilic syndrome despite therapeutic anticoagulation. (medscape.com)

Anatomy19

Organisms7

Chemicals and Drugs169

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes43

Information Science3

Inhibition10

Tyrosine12

Apoptosis5

Epidermal growth f1

Phosphorylation5

Constitutively active2

Phosphatidylinositol 3-kina4

Degradation7

Extracellular2

Receptor4

Pathway4

Autophagy1

Selective4

Anti-apoptotic1

Translocate1

Selleck1

Signaling molecules1

Activates2

Targets2

Proapoptotic1

Activation7

Tumor cells1

Cellular3

Potent2

Jurkat1

Different therapeutic1

Macrophage2

Neuronal1

Phosphorylates1

Mutations4

Intrinsic3

Molecular weight1

Approaches1

Mitochondrial2

Interleukin1

Cells8

Infection1

Iodinated contrast1

Efficacy1

BNIP31

Optimization1

Motif2

Interaction2

Activity3

Cancer1

Lipids2

STAT1

Monocyte1

Membrane1

Important2

Active1

Small3

Domain2

Severe2

Patients1