Therapeutic drug carriers. Medical search. Frequent questions

Strategies have been advised that nanoparticles can be used to deliver drug/gene to targeted tissues [ 4 ]. (hindawi.com)
Nanoparticles (NPs) frequently are selected to deliver therapeutic agents due to their unique properties, which improve systemic delivery. (sbir.gov)
Niosoms are nanoparticles used in drug delivery systems. (scialert.net)
Recently there has been a wide concern on inorganic nanoparticles as drug delivery carriers. (scirp.org)
G. F. Paciotti, D. G. I. Kingston and L. Tamarkin, "Colloidal Gold Nanoparticles: A Novel Nanoparticle Platform for Developing Multifunctional Tumor-Targeted Drug Delivery Vectors," Nanobiotechnology, Drug Development Research, Vol. 67, No. 1, 2006, pp. 47-54. (scirp.org)
The MSN nanoparticles used have the potential for carrying and delivering therapeutic agents to highly specific target sites of the respiratory tract. (cdc.gov)
In this article, the authors described the design of mesoporous silica nanoparticles which could act as carriers for drugs. (cdc.gov)
It has been reported that bovine serum albumin (BSA) nanoparticles (NPs) serve as carriers for anticancer drugs, which have been extensively explored for their therapeutic efficacy against cancers. (jefferson.edu)
Both the size of nanoparticles and the additional ability of drug delivery systems to release the active compound in a controlled manner play key roles in successful medical treatment. (europa.eu)
Solid lipid nanoparticles (SLN) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. (banglajol.info)
Drug and gene delivery carriers such as hydrogels and metallic nanoparticles have shown remarkable promise as programmable platforms in the targeted delivery of their payload. (auburn.edu)
One of the most important applications of nanotechnology in medicine involves use of nanoparticles to deliver drugs, and other therapeutic substances to specific types of cells (such as cancer cells). (trialx.com)
Due to their small size, nanoparticles can also penetrate the blood-brain barrier which is impervious to most therapeutic and imaging agents. (trialx.com)
To be suitable as a drug carrier, the size of nanoparticles should be small enough to avoid elimination from the body by Mononuclear phagocytic system (MPS) and big enough to avoid rapid renal filtration. (trialx.com)
Nanoparticles have the ability to encapsulate the water insoluble drugs within them and protect it from hydrolytic and enzymatic degradation in the gastrointestinal tract. (trialx.com)
The bioavailability of drugs is increased due to the specialized uptake of nanoparticles by absorptive endocytosis. (trialx.com)
Due to their small size nanoparticles are able to avoid opsonization by MPS and remain in the blood circulation for a longer duration of time as compared to microparticles and other traditional drug delivery systems. (trialx.com)
Through the chemical modifications the properties of nanoparticles can be manipulated and drug release can be controlled to achieve the desired therapeutic concentration for the desired duration of time. (trialx.com)
Protein nanoparticles are promising targeted drug delivery carriers due to their low toxicity, biodegradability, and abundance of proteins in natural sources. (bvsalud.org)

However, clinical researchers continually find that the involvement of drug carriers may lead to poor biocompatibility and biodegradability, low loading efficacy, and potential side effects. (nature.com)
The hydrogels are expected to be capable of superior solubility, optimal therapeutic efficacy, and almost no cytotoxicity. (nature.com)
More importantly, the hybrid NPs can absorb and convert near-infrared (NIR) light to heat due to the existence of CDs, and thus, can realise NIR-controlled drug release and combined photothermo/chemotherapy for high therapeutic efficacy. (rsc.org)
MAL to assess the therapeutic efficacy of chloroquine against uncomplicated falciparum malaria in Yemen. (who.int)

Using established molecular biology techniques, Rubius's scientists can engineer progenitor cells taken from human bone marrow and grow blood cells that produce specific therapeutic proteins on their surface or inside the cell. (technologyreview.com)
The agents such as nucleic acids, therapeutic enzymes, proteins and certain antibiotics cannot cross the cell membrane and, therefore such problems can be overcome by using nano delivery systems. (europa.eu)
Proteins and antigens intended for therapeutic purposes may be incorporated or adsorbed onto SLN, and further administered by parenteral routes or be alternative routes such as oral, nasal and pulmonary. (banglajol.info)
Protein drugs are a critically important therapeutic modality due to the sophisticated binding recognition, catalytic properties, and disease relevance of proteins. (bvsalud.org)
Recombinant elastin-based proteins (ELPs) are used in applications that include therapeutics, drug delivery, and tissue engineering due to their biocompatibility and unique ability to undergo simple coacervation. (bvsalud.org)

In Dry Power Inhalation treatment known as DPI, the active ingredient is routed through the respiratory pathway to the site of action i.e the lungs to exert the desired therapeutic effect. (lankabusinessonline.com)

Many anticancer drugs require intracellular delivery to be effective. (europa.eu)
These results indicate that in addition to systemic chemotherapy, an adjuvant nHA could be used as a carrier for intracellular delivery of DOX for prevention of tumor recurrence after surgical resection in an osteosarcoma. (lu.se)

The anticancer drug methotrexate (MTX) shows affinity for solute carrier (SLC) and ATP-binding cassette (ABC) transporters. (frontiersin.org)
This study investigated relationships between accumulation of methotrexate and gene expression levels of solute carrier and ATP-binding cassette transporters in cancer cells after a single and high-dose X-ray irradiation. (frontiersin.org)
We examined expression levels of organic anion-transporting polypeptide (OATP)1B1, OATP1B3, OATP1B7, and organic anion transporter (OAT)1 as solute carrier transporters and multidrug resistance-associated protein (MRP)1 and MRP2 as ATP-binding cassette transporters, using real-time polymerase chain reaction and accumulation of 3 H-MTX in cancer cells after 10-Gy irradiation, assuming stereotactic body radiotherapy. (frontiersin.org)
Irradiation of cancer cells thus alters gene expression levels of both solute carrier transporters (OATP1B1/1B3/1B7) and ABC transporters (MRP1/2) and decreases accumulation of 3 H-MTX in cancer cells over time due to elevated expression of MRP1/2. (frontiersin.org)
The company is building the first drug discovery platform dedicated to targeting the solute carrier (SLC) family of transporters, the cell's metabolic gates. (businesswire.com)
Jnana is committed to discovering and developing medicines that will make a transformative difference for patients using the first drug discovery platform dedicated to targeting the solute carrier (SLC) family of transporters. (businesswire.com)
In addition, validation of preliminary findings of solute carrier molecules (usually used for drug-delivery) selectively expressed in tumor cells with the aim to develop imaging-led theranostic approaches of personalized treatment will be performed. (lu.se)

They are not really cages or boxes but large molecules that are attached to a drug. (rug.nl)
Prodrugs are derivatives of drug molecules that are pharmacologically inactive but require either chemical or enzymatic transformation to release the active drug in vivo in order to exert a pharmacological effect. (ijpsonline.com)
Demonstrate a critical understanding of receptors, ion channels, enzymes and carrier molecules as drug targets. (kent.ac.uk)
Nanoformulations have been an important drug delivery platform for the anticancer molecules like Hsp90 inhibitors. (jefferson.edu)
However, the chemical PEGylation may hamper the therapeutic effects of the BF-30 or other peptides because the increased steric hindrance prevents the binding of targeting molecules [ 6 ]. (jcancer.org)
In traditional drug delivery systems such as oral or intravascular delivery, the drug or therapeutic molecules are distributed throughout the body through the systemic blood circulation. (trialx.com)
The drug and therapeutic molecules have short plasma half-life, poor stability in serum and potential immunogenicity, and insolubility in water which results in their rapid clearance by MPS and limits their efficiency. (trialx.com)
The 2 primary types of transporters are influx, which translocate molecules into the liver, and efflux, which mediate excretion of drugs into the blood or bile. (msdmanuals.com)

Drug resistance is a main obstacle for curative cancer chemotherapy. (hindawi.com)
Chemoradiotherapy combines chemotherapy with anticancer drugs and radiotherapy to treat cancer. (frontiersin.org)
Drug targeting is important in chemotherapy, a drug delivery system should target only the cancer cells while shielding the healthy cells from the drug. (trialx.com)

The potential approach is to develop particular carriers which can facilitate the release of the payload locally in tissue by internal or external stimuli (such as heat, light, ultrasound, etc. (hindawi.com)
Ultrasonic drug and gene delivery from nanocarriers have tremendous potential because of the wide variety of drugs and genes that could be delivered to targeted tissues by fairly noninvasive means [ 7 ]. (hindawi.com)
UCAs are known as microbubbles (MBs), which can be chemically and physically manipulated to improve their therapeutic potential. (benthamscience.com)
Thus, MBs can be used as vehicles for localized drug delivery and gene therapy allowing us to further develop the potential of curing cancer and other diseases. (benthamscience.com)
CaCO 3 particles have shown promising potential for the development of carriers for drugs, but little research had been performed regarding their safe dosage for maximizing the therapeutic activity without harming biosystems. (scirp.org)
The company is remaining tight-lipped about what additional therapies might be in the pipeline, but Kahvejian says the potential for new drugs based on red blood cells is "only limited by your imagination. (technologyreview.com)
Drugs targeting heat shock protein 90 (Hsp90) have been extensively explored for their anticancer potential in advanced clinical trials. (jefferson.edu)
Identification of SLC38A7 as a Prognostic Marker and Potential Therapeutic Target of Lung Squamous Cell Carcinoma. (nih.gov)
We aim to understand their pathophysiological relevance in a variety of tissues and therapeutic potential in differentdiseaseschronic inflammatory diseaseswith secretory dysfunction. (fu-berlin.de)
Drug delivery systems seem to be a new method for improving drug targeting and release into cells, bringing new opportunities for improving drug efficiency and avoiding potential side effects. (frontiersin.org)
Based on the literature, the present investigation was carried out to reveal the effect of RGF and MTF, with an expectation that MTF can synergize therapeutic potential as well reduce chances of resistance. (cancerindex.org)
Allopregnanolone, a first-in-class regenerative therapeutic, has the potential to delay neurodegeneration in early Alzheimer's disease (AD) by promoting endogenous systems of renewal and repair, early clinical data show. (medscape.com)
Furthermore, we demonstrate that nHA particles are pivotal in this approach but a combination of nHA with mHA could increase the safety associated with particulate nanomaterials while maintaining similar therapeutic potential. (lu.se)

Jnana's founding team includes recognized leaders at the forefront of chemistry, drug discovery and development, translational medicine and company building. (businesswire.com)

Researchers identified a grade of lactose mimicking the ideal surface properties for this purpose.In the second aspect, the invention focused on a method to mix the active drug with an aerodynamic diameter of 1-5 µm with the carrier particles. (lankabusinessonline.com)

CYROLITE ® with balanced optical transmission and mechanical robustness offers chemical resistance to IPA, lipids, blood, disinfectants, and oncology drugs, necessary for safe BPA-free, infusion therapy applications such as filter housings. (medicaldesignbriefs.com)
BACKGROUND Regorafenib (RGF) is the drug of choice for treating hepatic carcinoma (HCC), but the drug has drawbacks due to resistance and associated adverse effects. (cancerindex.org)
Previous researches revealed that BF-30 is a phenylalanine- and lysine-rich polypeptide exhibiting broad spectrum and strong antibacterial properties without drug resistance. (jcancer.org)
Most malaria epidemics follow abnormal weather conditions, often in combination with other causes, including increased resistance of the parasite to antimalarial drugs, population movement due to seasonal labor and civil unrest, and reduced malaria control operations, in particular, the cessation of regular vector control ( 1 ). (cdc.gov)
resistance to antimicrobial drugs. (who.int)
Use additional code (U85) , if desired, to identify resistance, non-responsiveness and refractive properties of the neoplasm to antineoplastic drugs. (who.int)

Jnana's proprietary small molecule platform allows the company to address therapeutic targets rapidly and comprehensively across the SLC transporter family. (businesswire.com)
This book covers different therapeutic targets for angiogenesis interventions with emphasis on clinical development of antiangiogenic drugs that target antiangiogenic cascade in different forms of cancers like breast cancer, multiple myeloma, renal carcinoma, gastrointestinal, prostate and lung cancer. (benthamscience.com)
Nav channels serve as the primary targets for several classes of widely used and investigational drugs, including local anesthetics, antiepileptic drugs, antiarrhythmics, and analgesics. (bvsalud.org)
Lamotrigine (Ltg), an anticonvulsant drug, targets initiation factor 2 (IF2), compromises ribosome biogenesis and causes toxicity to Escherichia coli. (bvsalud.org)
Pharmacotherapy for SARS-CoV-2 and Seizures for drug repurposing presumed on Mechanistic Targets. (cdc.gov)

Nanoparticle, used as a drug/gene delivery vehicle, can not only target specific cells and tissues, but also retain the biological activity of the drug/gene during transport. (hindawi.com)
Besides, nanocarriers decorated with targeting moiety can adhere to targeted tissues, which can promote intracellular uptake of drug delivery vehicles. (hindawi.com)
If you want to treat a tumour, the chemotherapeutic drug has to travel through the patient's entire body, potentially causing many side effects in healthy tissues. (rug.nl)
Its proprietary therapeutic delivery platform can deliver RNA, gene editing, and other therapeutic options to hard-to-penetrate tissues such as cartilage, kidney, brain, and some solid tumors. (massbio.org)
MBs can be tailored to bind to specific diseased tissues and act as carriers of different chemo-drugs and genetic materials. (benthamscience.com)

Multiple Linear Regression Modeling To Predict the Stability of Polymer-Drug Solid Dispersions: Comparison of the Effects of Polymers and Manufacturing Methods on Solid Dispersion Stability MOLECULAR PHARMACEUTICS. (nottingham.ac.uk)
Niosomes entrap soluble material as do liposomes but the former is more stable at laboratory's atmosphere so they can increase the stability of the drugs. (scialert.net)
Meanwhile, the mesoporous carbon shell and hydrophilic surface functional groups endow the hybrid NPs with high loading capacity (835 mg g −1 ) for the anti-cancer drug doxorubicin and excellent stability in aqueous solutions. (rsc.org)
Core-shell microspheres have shown particular advantages in drug delivery application as drug carriers, such as preventing burst release of drug, improving drug stability and achieving synergistic therapeutic effects. (confex.com)
Moreover, common targeted therapeutic drug formulations have weak stability in malignant tumor leukemia, and their application effects are limited. (frontiersin.org)

With the development of nanotechnology, nanocarriers have been increasingly used for curative drug/gene delivery. (hindawi.com)
Recent advances in nanotechnology have made possible the site specific treatments of animals and human diseases by lowering the drugs adverse effects ( Mozafari, 2006 ). (scialert.net)
Nanotechnology and materials innovation are utilized together for making improvements in drug delivery. (cede.ch)
This drug-carrier inhalation nanotechnology should potentially be useful in human clinical setting in the future. (cdc.gov)

Current research in pharmacology and drug discovery 2021 0 0. (cdc.gov)
Critical reviews in therapeutic drug carrier systems 2021 0 0. (cdc.gov)

These interactions allow cationic liposomes to condense and encapsulate various therapeutic and diagnostic agents in their aqueous compartment or in their lipid bilayer. (wikipedia.org)
Nanocarriers, with the properties of smaller particle size, and long circulation time, would be advantageous in diagnostic and therapeutic applications. (hindawi.com)
Templated polymer systems have unique 'trained' binding characteristics that make them of high interest within chromatography, sensors, diagnostic devices, and drug delivery carriers. (auburn.edu)

They primarily focus on facilitating penetration of drugs through the BBB, delivery of recombinant enzyme to the brain by gene therapy, or direct CNS administration. (nih.gov)
Successful aerosol therapy depends mainly on targeting an adequate dose of drug to the appropriate receptors in the respiratory tract ( 3 ). (snmjournals.org)
Therefore, knowledge of the lung dose, its regional distribution, and the manner in which pulmonary drug targeting may be affected by large and small airway obstruction in bronchiolitis is very important if aerosol therapy is to be optimized. (snmjournals.org)
These effects may induce transient membrane permeabilization (sonoporation) on a single cell level, cell death, and disruption of tissue structure, ensuring noninvasive, targeted, and efficient drug/gene delivery and therapy. (hindawi.com)
In recent years, tumor-targeted therapy has been appearing as a promising therapeutic choice for cancer treatment. (hindawi.com)
They can pass through blood capillary walls and cell membrane walls to deliver drugs [ 8 ], thereby reducing the side effect and enhancing the curative effect of cancer therapy [ 9 ]. (hindawi.com)
Thermo-responsive Fibrinogen Nanogels: a Viable Thermo-responsive Drug Delivery Agent for Breast Cancer Therapy? (amrita.edu)
Experimental analysis was also conducted on the characterization ability, drug release, and targeted therapy of nanomedicine. (frontiersin.org)
Its drug release characteristics perform well in photothermal therapy, indicating that black phosphorus nano drugs can improve the biological safety and applicability of drugs in new tumor targeted therapy. (frontiersin.org)
Targeted therapy uses targeted drugs to maintain a high concentration of the drug in the tumor area, improving the killing efficiency of cancer cells while avoiding damage to other normal cells. (frontiersin.org)
By actively targeting nanoscale drug delivery systems it is possible to minimize the uptake of anticancer agent by normal cells thus minimizing the side effects of therapy. (trialx.com)

As such, γ-scintigraphy answers important questions regarding the pulmonary dose and the distribution within the lung and has been successfully applied in the evaluation of drug delivery in infantile pulmonary diseases such as bronchopulmonary dysplasia (BPD), cystic fibrosis (CF), and asthma ( 9 - 11 ). (snmjournals.org)
Systems pharmacology: the biological basis of diseases states affecting different physiological systems, therapeutic approaches to treating these diseases, and the cellular/molecular mode of action of drugs used. (kent.ac.uk)
The approach provides a critical foundation for developing therapeutic treatment protocols for a wide range of diseases where aerosol delivery to the respiratory system would be desirable. (cdc.gov)
Risk of Underlying Diseases and Effectiveness of Drugs on COVID-19 Inpatients Assessed Using Medical Claims in Japan: Retrospective Observational Study. (cdc.gov)

An inactive carrier molecule facilitates the passage of the active drug and an inhalation device aids the process. (lankabusinessonline.com)
Prodrugs have better delivery properties that surpass the parent drug molecule [ 1 ]. (ijpsonline.com)
Hence, search for new lead molecule/bioactive and rational delivery of the existing drug (for better therapeutic effect) to the site of action is the need of the hour. (hindawi.com)

Tezcat Biosciences is developing a portfolio of protein-drug conjugates to provide therapeutic options for patients harboring mutant RAS cancers. (massbio.org)

Ultrasound is a noninvasive and visual theranostic modality that can be used to track drug carriers, trigger drug release, and improve local drug sediment with high spatial precision [ 5 , 6 ]. (hindawi.com)

A common application for cationic liposomes is cancer drug delivery. (wikipedia.org)
The information obtained within these methods will lead to better understanding of formulations, designed for peptide, DNA and anti-cancer drugs delivery. (europa.eu)
The strategy used to identify new therapeutic markers on leukemia stem cells will also be explored in other tumor types studied within the MAD for Cancer Program. (lu.se)

Liver Injury Caused by Drugs Many medications (eg, statins) commonly cause asymptomatic elevation of hepatic enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase). (msdmanuals.com)

Carriers injection at nano scale are used with the aim of passing through biological barriers, drug protection and release of optimum dose of drugs ( Costantino and Boraschi, 2012 ). (scialert.net)
Additionally, these biological materials from drug carriers require complex syntheses and are relatively expensive 12 , which create great obstacles for effective clinical application. (nature.com)

Herein, we review findings supporting the applications of and research on heavy water in monitoring of bacterial metabolism, rapid detection of drug sensitivity, identification of tumor cells, precision medicine, and evaluation of skin barrier function and promote the use of heavy water as a suitable marker for the development of detection and treatment methodologies. (medsci.org)
Although metabolism typically inactivates drugs, some drug metabolites are pharmacologically active-sometimes even. (msdmanuals.com)
Although metabolism typically inactivates drugs, some drug metabolites are pharmacologically active-sometimes even more so than the parent compound. (msdmanuals.com)
Drug metabolism rates vary among patients. (msdmanuals.com)
Individual drug metabolism rates are influenced by genetic factors, coexisting disorders (particularly chronic liver disorders and advanced heart failure), and drug interactions (especially those involving induction or inhibition of metabolism). (msdmanuals.com)
For many drugs, metabolism occurs in 2 phases. (msdmanuals.com)

Their vesicular system can be used as carriers of lipophilic and amphiphilic drugs. (scialert.net)
Recently, increasing attention has been focused on these SLN as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs. (banglajol.info)

The prodrug approach using various carriers has evolved as a significant tool in surmounting different obstacles in relation to drug formulation and targeting. (ijpsonline.com)
This text book is a guide for pharmaceutical academics (students and teachers) as well as industry professionals learning about drug delivery and formulation. (benthamscience.com)

The results implied that porous spherical calcium carbonate microparticles could be applied as relatively safe drug vehicles, but with the caveat that the effect of high dosages should not be ignored when attempting to maximize therapeutic activity by increasing the concentration. (scirp.org)
Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2. (nih.gov)
Efficient systemic pharmacological treatment of solid tumors is hampered by inadequate tumor concentration of cytostatics necessitating development of smart local drug delivery systems. (lu.se)

This study supports the use of exosomes as biomimetic nanovesicles that may be useful in future therapeutic approaches against tumours. (nature.com)

Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. (nature.com)
Subsequently, rhein hydrogels alleviate neuroinflammation with a long-lasting effect and little cytotoxicity compared to the equivalent free-drug in vitro. (nature.com)

The country maintained all basic health services and immunization programmes and supported all proposals for COVID-19 drugs and vaccines. (who.int)

Since the molecular weight of conventional drugs is only a few hundred Daltons, they easily escape from tumours. (europa.eu)

Consequently, plenty of strategies were developed to increase the therapeutic duration of BF-30 in vivo including enlarging the molecular size via PEGylation to prevent from the rapid renal filtration and enzymatic degradation [ 6 ]. (jcancer.org)

Cite this: First-in-Class Regenerative Therapeutic for Alzheimer's Promising - Medscape - Oct 30, 2023. (medscape.com)

These prodrugs subsequently undergo enzymatic or non-enzymatic cleavage to release the active drug moiety (figure 1) [ 12 , 13 ]. (ijpsonline.com)

Demonstrate a critical understanding of systems pharmacology - e.g. cardiovascular and central nervous systems - and the action of therapeutic agents in diseased states. (kent.ac.uk)
To overcome this, we demonstrate that doxorubicin (DOX), a cornerstone drug used for osteosarcoma treatment, shows reversible accretion to hydroxyapatite (HA) of both nano (nHA) and micro (mHA) size. (lu.se)

Prodrug concept is justified because it enables the active drug to overcome the barrier that would impede it from reaching the site of action to exert the required pharmacological activity. (ijpsonline.com)

The platforms were able to released anticancer drug doxorubicin (DOX) in response to an ambient pH drop from 7.4 to 5.5. (europa.eu)

In this review, we explore the research progress and application of ultrasound-mediated local drug/gene delivery with nanocarriers. (hindawi.com)
This Ebook describes the applicability of diverse natural and synthetic biopolymers and their blends in drugs, vaccines and gene delivery. (benthamscience.com)

Drug delivery refers to the formulations, storage systems, methods, production processes and technologies used to transport a pharmaceutical compound to its target site for achieving intended therapeutic effect. (cede.ch)
This method does not alter the cell composition or rely on cell culture and thus allows the rapid, quantitative, and nondestructive evaluation of the effect of drugs on the real-time metabolic activity of microorganisms at the single-cell level [ 8 - 10 ]. (medsci.org)
The two-dimensional nano drug carrier has high safety and effectiveness in drug delivery, and its targeted treatment effect on acute T lymphoblastic leukemia cells is obvious. (frontiersin.org)

The amount of released drug (48 h) from pegylated and non pegylated formulations in the presence of Spans 60 and 20 were 8, 10, 6, 7%, respectively. (scialert.net)

Of the total 6-min nebulized dose (i.e., drug aerosol dose leaving the nebulizer [not the nebulizer charge]), 1.5% ± 0.7% reached the right lung, with only approximately one third of that (0.6%) penetrating to the peripheral lung zone. (snmjournals.org)

Its low toxicity, high efficiency, and controllable drug release advantages make it have good application effects. (frontiersin.org)
Fast dissolution results in greater bio-availability, small drug doses and less toxicity. (trialx.com)

The synthesis and design of effective drug delivery systems (DDS) is critical for healthcare and medicine. (cede.ch)
M. P. Ginebra, T. Traykova and J. A. Planell, "Calcium Phosphate Cements as Bone Drug Delivery Systems: A Review," Journal of Controlled Release, Vol. 113, No. 2, 2006, pp. 102-110. (scirp.org)
Furthermore, delivery systems exhibit intracellular pH-response (demonstrating endosomal escape), as changes in cell morphology and drug release was observed within 24 h. (europa.eu)
Readers will learn about the types of self-emulsifying drug delivery systems, evaluation parameters and digestion models, among other topics. (benthamscience.com)
The development of bioinformatics technology has enabled nanomedicine to play a significant role in drug delivery systems. (frontiersin.org)
Some examples of targeting ligands used in nanoscale drug delivery systems include folate, transferrin. (trialx.com)

Treatment of these neurological manifestations remains challenging due to the blood-brain barrier (BBB) that limits delivery of therapeutic agents to the central nervous system (CNS). (nih.gov)
The field of ultrasound has expanded since the discovery of ultrasound contrast agents (UCAs) from diagnostics to therapeutic use. (benthamscience.com)

Despite their clinical benefits, these drugs are limited by systemic side-effects. (imperial.ac.uk)

While bound to a cage, the drug is inactive. (rug.nl)

Photo cages are molecular tools that are used to deliver drugs. (rug.nl)
The molecular structure of the in silico-designed photocage Cy7-PPG, showing the location where drugs can be attached. (rug.nl)
Around 10 % of marketed medicines can be categorized as prodrugs currently, and also that during 2008, 33 % of approved small molecular weight drugs were prodrugs [ 5 - 7 ]. (ijpsonline.com)
Describe drug-receptor interactions at the molecular level. (kent.ac.uk)

The results suggest that luminespib interacts by non-covalent reversible interactions with BSA to form drug-loaded BSA NPs (DNPs). (jefferson.edu)
Due to system maintenance, the drug interactions feature you are attempting to access is temporarily unavailable. (medscape.com)

The biodistribution of drug carriers is monitored by imaging, so that the optimal timing for the application of external stimuli can be achieved [ 2 ]. (hindawi.com)
Hence, the development of different stimuli-responsive platforms to control the release of drugs upon applying external stimuli has attracted a lot of interest. (europa.eu)

This book provides comprehensive insights into materials design and clinical perspectives in drug delivery. (cede.ch)
Hence, most of the products that are in advanced-phase clinical trials are derivatives of hemoglobin and are known as hemoglobin-based oxygen carriers (HBOCs). (medscape.com)
FROM THE CLINICAL EDITOR: Delivery of drugs via the respiratory tract is an attractive route of administration. (cdc.gov)
The company has so far tested the PKU drug in animals and in human blood in the lab, and it aims to begin clinical testing next year. (technologyreview.com)
In this study, we present cryogenic electron microscopy (cryo-EM) structures of human Nav1.7 bound to two clinical drugs, riluzole (RLZ) and lamotrigine (LTG), at resolutions of 2.9 Å and 2.7 Å, respectively. (bvsalud.org)

Adverse drug events in the prevention and treatment of COVID-19: A data mining study on the FDA adverse event reporting system. (cdc.gov)

Though several studies have been carried out on various prodrugs, surprisingly very few reviews on different carriers, which can be used for prodrug synthesis were published to date. (ijpsonline.com)
Carrier-linked prodrugs are for drugs with major drawbacks, which are linked to a nontoxic carrier or promoiety through covalent linkage to change or get rid of their undesirable physicochemical properties. (ijpsonline.com)

It aims to change the specificity and pharmacokinetics of the drug by combining it with various drug carriers, excipients and medical devices. (cede.ch)
Overview of Pharmacokinetics Pharmacokinetics, sometimes described as what the body does to a drug, refers to the movement of drug into, through, and out of the body-the time course of its absorption, bioavailability, distribution. (msdmanuals.com)

nanoMIL-89) as a carrier for the PAH-drug sildenafil, which we have previously shown to be relatively non-toxic in vitro and well-tolerated in vivo. (imperial.ac.uk)

The inhalation device and the powder inhalation mix inside the capsule constitute the drug delivery system. (lankabusinessonline.com)

A lack of knowledge about natural drug gels limits there current application. (nature.com)

Anatomy4

Organisms3

Diseases8

Chemicals and Drugs86

Analytical, Diagnostic and Therapeutic Techniques and Equipment60

Phenomena and Processes30

Disciplines and Occupations10

Technology, Industry, Agriculture17

Information Science2

Health Care11

Nanoparticles19

Efficacy4

Proteins5

Desired therapeutic effect1

Intracellular delivery2

Solute7

Molecules8

Chemotherapy3

Potential13

Chemistry1

Particles1

Resistance6

Targets5

Tissues5

Stability5

Nanotechnology4

20212

Diagnostic3

Therapy11

Diseases4

Molecule3

Cancers1

Modality1

Cancer3

Enzymes1

Biological2

Metabolism6

Lipophilic2

Formulation2

Concentration3

Approaches1

Hydrogels2

Immunization1

Tumours1

Degradation1

20231

Moiety1

Demonstrate2

Exert1

Anticancer drug1

Gene delivery2

Effect3

Formulations1

Aerosol1

Toxicity2

Delivery systems6

Agents2

Systemic1

Inactive1

Molecular4

Interactions2

External stimuli2

Clinical5

Adverse1

Prodrugs2

Pharmacokinetics2

Vivo1

Inhalation1

Limits1