• Agonists
  • METHOD AND THERAPEUTIC/COSMETIC TOPICAL COMPOSITIONS FOR THE TREATMENT OF ROSACEA AND SKIN ERYTHEMA USING A1-ADRENOCEPTOR AGONISTS - The present invention is directed to the treatment of skin erythema as exhibited in rosacea and other conditions characterized by increased erythema (redness) of the skin. (patentsencyclopedia.com)
  • molecular
  • 19:20H FIA8 Patrício P, Pinheiro A, Alves ND, Morais M, Santos AR, Bessa J, Irmler M, Beckers J, Sousa N, Pinto L. Genome-wide characterization of the adult hippocampal neurogenic niche regulators in depression and by antidepressant drugs: Cellular and molecular. (docplayer.net)
  • Targets
  • Our ATTR program is the lead effort in our Genetic Medicine Strategic Therapeutic Area (STAr) product development and commercialization strategy, which is focused on advancing innovative RNAi therapeutics toward genetically defined targets for the treatment of rare diseases with high unmet medical need. (pharmaceuticalintelligence.com)
  • This review summarizes evidence for these interactions in the CNS and in cancer, and is organized according to the cellular targets involved. (frontiersin.org)
  • gene
  • Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder , schizophrenia and the personality trait of novelty seeking . (wikipedia.org)
  • stimulation
  • The serotonin is secreted luminally and basolaterally which leads to increased serotonin uptake by circulating platelets and activation after stimulation, which gives increased stimulation of myenteric neurons and gastrointestinal motility. (wikipedia.org)
  • stomach
  • In human duodenum and stomach, for example, 5-HT3C and 5-HT3E mRNA might be greater than for 5-HT3A and 5-HT3B. (wikipedia.org)
  • Connection to the central nervous system also means that signals from outside of the digestive system can be relayed to the digestive system: for instance, the sight of appealing food stimulates secretion in the stomach. (wikipedia.org)
  • gastrointestinal
  • Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract (GI tract), blood platelets, and the central nervous system (CNS) of animals, including humans. (wikipedia.org)
  • A part of the enteric nervous system, the myenteric plexus exists between the longitudinal and circular layers of muscularis externa in the gastrointestinal tract. (wikipedia.org)
  • vascular
  • The results showed that pretreatment with red wine has preventive effects on the acute vascular and systemic inflammation, together with other indicators of cellular aging process induced by smoking. (genscript.com)
  • cannabinoids
  • Cannabinoids produce many of their cellular and organ system effects by interacting with the well-characterized CB1 and CB2 receptors. (frontiersin.org)
  • synthetic and other types of cannabinoids (many developed seeking modulators of other signaling systems, but found to interact with the classic CB1 and/or CB2 receptors). (frontiersin.org)
  • human
  • In this study, the smartphone used is iPhone 5 and human interleukin-6 (IL-6), (a well-known biomarker for lung, prostate, liver, breast, and epithelial cancers) is used to demonstrate this potential application. (genscript.com)
  • 2-Ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT) WAY-181,187 WAY-208,466 N-(inden-5-yl)imidazothiazole-5-sulfonamide (43): Ki = 4.5nM, EC50 = 0.9nM, Emax = 98% E-6837 - Full agonist at human 5HT6 receptors E-6801 E-6837 - partial agonist at rat 5-HT6 receptors. (wikipedia.org)
  • Serotonin is produced by pathogenic amoebae, and its effect in the human gut is diarrhea. (wikipedia.org)
  • central
  • The enteric nervous system can and does function autonomously, but normal digestive function requires communication links between this intrinsic system and the central nervous system. (wikipedia.org)
  • bind
  • When the platelets bind to a clot, they release serotonin, where it can serve as a vasoconstrictor and/or a vasodilator while regulating hemostasis and blood clotting. (wikipedia.org)
  • effects
  • In high concentrations, serotonin acts as a vasoconstrictor by contracting endothelial smooth muscle directly or by potentiating the effects of other vasoconstrictors (e.g. angiotensin II, norepinephrine). (wikipedia.org)
  • However, it has become clear that not all effects of cannabinoid drugs are attributable to their interaction with CB1 and CB2 receptors. (frontiersin.org)
  • patients
  • We reported data from our ongoing Phase 2 open-label extension (OLE) study of patisiran, an investigational RNAi therapeutic targeting transthyretin (TTR) for the treatment of TTR-mediated amyloidosis (ATTR amyloidosis) patients with familial amyloidotic polyneuropathy (FAP). (pharmaceuticalintelligence.com)
  • Patients have a life expectancy of 5 to 15 years from symptom onset, and the only treatment options for early stage disease are liver transplantation and TTR stabilizers such as tafamidis (approved in Europe) and diflunisal. (pharmaceuticalintelligence.com)
  • channels
  • It appears that only the 5-HT3A subunits form functional homopentameric channels. (wikipedia.org)
  • All other subunit subtypes must heteropentamerize with 5-HT3A subunits to form functional channels. (wikipedia.org)
  • HTR3C and HTR3E do not seem to form functional homomeric channels, but when co-expressed with HTR3A they form heteromeric complex with decreased or increased 5-HT efficacies. (wikipedia.org)
  • years
  • Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also known as familial amyloidotic polyneuropathy (FAP), is an inherited, progressive disease leading to death within 5 to 15 years. (pharmaceuticalintelligence.com)
  • memory
  • The neurosteroids pregnenolone sulfate (PREGS), dehydroepiandrosterone sulfate (DHEAS) and allopregnanolone (3α,5α THPROG) have been implicated as powerful modulators of memory processes and sleep states in young and aged subjects with memory impairment. (springer.com)
  • Serotonin also has some cognitive functions, including memory and learning. (wikipedia.org)
  • agents
  • We highlight UML's lack of expressive ability concerning cyclic feedbacks in cellular networks, and the compounding concurrency arising from huge numbers of stochastic, interacting agents. (jove.com)
  • interactions
  • This protocol describes how to pharmacologically characterize specific GPCR-ligand interactions by monitoring the binding of the radio-labeled GTP analog, [ 35 S]guanosine-5'-O-(3-thio)triphosphate ([ 35 S]GTPγS), in response to a ligand of interest. (jove.com)
  • evidence
  • Since NNTTR is pathogenic in ATTR amyloidosis and the level of NNTTR reduction correlated with total TTR knockdown, these results provide direct mechanistic evidence supporting the therapeutic hypothesis that TTR knockdown has the potential to result in clinical benefit. (pharmaceuticalintelligence.com)
  • found
  • Since many of the same neurotransmitters are found in the ENS as the brain, it follows that myenteric neurons can express receptors for both peptide and non-peptide (amines, amino acids, purines) neurotransmitters. (wikipedia.org)
  • second
  • Pubmed ID: 11823862 Phospholipase C gamma 1 (PLC-gamma 1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. (jove.com)