• immunological
  • The exact genesis of immunological tolerance is still elusive, but several theories have been proposed since the mid-twentieth century to explain its origin. (wikipedia.org)
  • The conceptualization of immunological self is amongst the most important theories of modern biology, representing a sort of theoretical guideline for experimental immunologists, in order to understand how host constituents are ignored by the immune system (IS). (blogspot.com)
  • A consistent advancement in this field has been represented by the danger/damage theory and its subsequent refinements, which at present represents the most comprehensive conceptualization of immunological self. (blogspot.com)
  • Along these lines, Metchnikoff and Ehrlich gave a pivotal contribution in underpinning the "biological individuality" on specific immunological level, the former by proposing cell theory of phagocytosis as a pathogen-engulfing mechanism able to maintain organismal identity ( 7 ), the latter by suggesting the concept of " horror autotoxicus " to explain how immune system (IS) avoids toxic reactions against the endogenous constituents. (blogspot.com)
  • previously
  • This theory was previously conceptualized as a safeguard to protect against the development of autoimmune disorders, such as multiple sclerosis , rheumatoid arthritis, and systemic lupus erythematous (SLE). (greenmedinfo.com)
  • system
  • In fact, over a century ago, Ilya Ilyich Metchnikoff incorporated Darwinian logic into a theory suggesting that the objective of the immune system is not war against non-self, but rather ""harmonization of self," or even ontogenetic creation of multi-cellular organism" in the face of environmental and internal challenges (1, p. 221). (greenmedinfo.com)