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  • Drugs
  • The drugs in the tetracycline class have closely similar antimicrobial spectra, and cross-resistance among them is common. (nih.gov)
  • Up to 44 percent of strains of Streptococcus pyogenes and 74 percent of Streptococcus faecalis have been found to be resistant to tetracycline drugs. (nih.gov)
  • A tetracycline disk may be used to determine microbial susceptibility to drugs in the tetracycline class. (nih.gov)
  • The tetracyclines are inexpensive drugs that are of primary value in treating nonpregnant women who have acute urethral syndrome or endocervicitis due to Chlamydia trachomatis. (prohealth.com)
  • A very rare but dangerous reaction is Stevens-Johnson syndrome, a life-threatening condition affecting the skin, which has also been described under metronidazole and tetracycline as separate drugs. (wikipedia.org)
  • protein
  • Tetracyclines are primarily bacteriostatic and exert their antimicrobial effect by the inhibition of protein synthesis. (nih.gov)
  • The entirety of several TetO sequences with a minimal promoter is called a tetracycline response element (TRE), because it responds to binding of the tetracycline transactivator protein tTA by increased expression of the gene or genes downstream of its promoter. (wikipedia.org)
  • teeth
  • Tetracyclines are teratogens due to the likelihood of causing teeth discolouration in the fetus as they develop in infancy. (wikipedia.org)
  • Tetracycline use should be avoided in pregnant or lactating women, and in children with developing teeth because they may result in permanent staining (dark yellow-gray teeth with a darker horizontal band that goes across the top and bottom rows of teeth), and possibly affect the growth of teeth and bones. (wikipedia.org)
  • known
  • The Federal Trade Commission found that the cross-license, combined with the fact that Pfizer had withheld information that it knew or should have known was relevant to the patentability of tetracycline, constituted an attempt by Pfizer and American Cyanamid to share in an unlawful monopoly. (wikipedia.org)