Testes germ cell tumor sertoli leydig cell tumor. Medical search. Frequent questions

Through their hormonal balance, these cells play an important role in the development of secondary male characteristics and spermatogenesis. (medscape.com)
The intratesticular testosterone is needed for spermatogenesis from the sertoli cells. (bearcreekbb.net)
While sperm production has classically been the focus of adult reproductive function, somatic cells are crucial for the maintenance of spermatogenesis and gamete production. (biomedcentral.com)
Sertoli cells not only regulate the inflow of external substances, but also produce several substances which are critical to the proper progression of spermatogenesis [ 4 ]. (biomedcentral.com)
This compromised testicular antioxidant status might have contributed to poor growth and development by affecting the spermatogenesis and steroidogenesis in rats before puberty as indicated by reduced germ cell number, complete absence of round spermatids, decreased seminiferous tubule diameter, and decreased testosterone level. (hindawi.com)
particularly the Sertoli cells, which play a major role in spermatogenesis and are the main cell type in the testis which expresses T 3 receptors [ 16 ]. (hindawi.com)
In vitro spermatogenesis could indeed be proposed to patients with testicular localization of residual tumor cells, for whom testicular tissue autografting is not indicated (about 30% of patients with acute leukemia). (elifesciences.org)
A decline in intratesticular testosterone levels has been highlighted in vitro in 35- to 49-day cultures of 5 d pp mouse testes, i.e. after the end of the first wave of spermatogenesis ( 9 ). (elifesciences.org)
Spermatogenesis in testis and ovotestis is rare given the high circulating estrogen levels. (medscape.com)
The immunohistological and ultrastructural features of the human testis with emphasis upon the process of spermatogenesis and the cytology of the Leydig cells were reviewed in this study. (ac.ir)
Spermatogenesis takes place on the male reproductive system, initially in the testes then proceeds to the epididymis then the gametes are stored and readied for ejaculation. (superbgrade.com)
Spermatogenesis provides cell multiplication and cell differentiation. (superbgrade.com)
However, in male species spermatogenesis occurs at puberty due to the interactions of the Leydig cells, hypothalamus, and the pituitary glands. (superbgrade.com)
Piperine stimulates pubertal Leydig cell development by increasing Leydig cell number and promoting its maturation while it inhibits spermatogenesis in the rat. (frontiersin.org)
In order to examine whether PIP affected spermatogenesis by interfering with Leydig cell testosterone production, in the current study we evaluated the effects of PIP on pubertal Leydig cell development. (frontiersin.org)
I. FSH: FSH stimulates spermatogenesis and Sertoli cell function . (online-sciences.com)
It is also essential for the maturation phase of spermatogenesis particularly spermatid maturation in the Sertoli cell . (online-sciences.com)
This decreases the local androgen concentration in the testes resulting in depression or spermatogenesis, so treatment with exogenous androgens can be used as a method of contraception in males. (online-sciences.com)
Estrogens formed from testosterone by the Sertoli cells when they are stimulated by follicle-stimulating hormone, are probably also essential for spermiogenesis, Inhibin depresses spermatogenesis by inhibiting FSH secretion. (online-sciences.com)
Growth hormone and most of the other hormones: For controlling metabolic functions of the testes, GH specifically promotes early division of the spermatogonia, In its absence, spermatogenesis is severely deficient or entirely absent. (online-sciences.com)
Spermatogenesis is also depressed at lower temperatures than 32 °C. For this reason, the dartos muscle contracts in cold weather to draw the testes upwards (in order to be warmed by the abdominal temperature). (online-sciences.com)

Non-germ cell testicular cancers come from the Sertoli cells or the Leydig cells which can secrete excess sex hormones . (osmosis.org)
Sertoli cell tumors come from the Sertoli cells that support normal sperm growth. (horizonhospital.org)

Their five main subtypes include seminomas, teratomas , yolk sac tumors or endodermal sinus tumors, choriocarcinoma or placental tissue tumors, and embryonal carcinomas. (osmosis.org)
Non-seminomas - There are a few types of non-seminomas: choriocarcinoma, embryonal carcinoma, teratoma and yolk sac tumors. (horizonhospital.org)
The germ cell tumours include dysgerminoma, endodermal sinus tumour, embryonal carcinoma, malignant teratoma and choriocarcinoma. (cancertame.com)

An ovarian Leydig cell tumor stained intensely, whereas granulosa cell tumors were negative. (elsevierpure.com)
Ovarian cancer is the most common cause of cancer death from gynecologic tumors in the United States. (medscape.com)
Epithelial ovarian tumors are the most common tumor subtype. (amboss.com)
About 85 per cent of the ovarian tumours are carcinomas, which include mucinous cystadenocarcinoma, serous cystadenocarcinoma, clear cell cystadenocarcinoma, endometrioid adenocarcinoma and undifferentiated carcinoma. (cancertame.com)
The remaining 15 per cent of the ovarian tumours are germ cell tumours, stromal tumours and the borderline tumours. (cancertame.com)
In stage I of the ovarian carcinoma, the tumour is localised in one or both of the ovaries. (cancertame.com)
Ovarian germ cell tumours and stromal tumours constitute about 10 per cent of the ovarian tumours. (cancertame.com)
Germ cell ovarian tumour arises from the germ cells (the cells that give rise to ovaries during the foetal development). (cancertame.com)
Ovarian germ cell tumours and stromal tumours affect young women usually below 20 years of age. (cancertame.com)
Ovarian germ cell tumours and stromal tumours remain asymptomatic during initial stages of the disease. (cancertame.com)
Common presenting symptoms of the ovarian germ cell tumours and stromal tumours include mass in the abdomen and vaginal bleeding. (cancertame.com)
In stage I, a germ cell ovarian tumour is localised to one or both ovaries. (cancertame.com)
Recurrent germ cell ovarian tumour is the one that reappears after an apparent recovery in response to the initial treatment. (cancertame.com)
Procedures used in the diagnosis and evaluation of a germ cell ovarian tumour include pelvic examination, ultrasound, CT scan and biopsy. (cancertame.com)
Additionally, testicular and ovarian tissue may develop on the same side of the pelvis as a separate ovary and testis. (medscape.com)
The ovotestis can be anatomically located in an ovarian position, or along the anatomical path of the testes in the labioscrotal fold, the inguinal canal, or at the internal inguinal ring. (medscape.com)
Ovarian tumors include luteoma of pregnancy, arrhenoblastoma, hilar-cell tumor, masculinizing ovarian stromal cell tumor, and Krukenberg tumor. (health.am)

GCTs account for about 1 in 5 tumors in the ovary. (proprofs.com)
Mature teratomas (aka dermoid cysts) are germ cell tumors of the ovary that are both common and benign. (proprofs.com)
Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
These discrepancies can be manifested in different gonadal combinations, including ovotestis with ovary, ovary and testis, bilateral ovotestis, and ovotestis and tesis. (medscape.com)
The gonads present may be bilateral ovotestes, or they may be a combination of a unilateral ovary or testis with an ovotestis on the contralateral side. (medscape.com)
Cen C # , Chen M # , Zhou J, Zhang L, Duo S, Jiang L, Hou X, Gao F. Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development. (cas.cn)
In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)

The deformity leads to inadequate posterior fixation of the testis to the epididymis and scrotal wall. (aafp.org)
Detailed histopathological examination of testis and epididymis were performed, as well. (europa.eu)
However, in the 200 and 800 mg/kg groups the relative and absolute weights of testis and epididymis were significantly decreased.The results of sperm analysesshowedsignificantlyreduced ofsperm motility, viability, survivability and the number of sperms in the left epididymis in the group treated with 50 mg/kg or more of the test chemical compared with controls. (europa.eu)
The histopathological examination of the gonads revealed atrophy of seminiferous tubule of testis and the epididymis in the two highest dose groups (200 and 800 mg/kg). (europa.eu)

Testicular cancer is a condition in which the unusual cell grows out of control in the tissue of one or both of the testes. (planetayurveda.net)
Outside the tubule, there's connective tissue with capillaries , as well as Leydig cells - another supportive cell which produces testosterone , which is a hormone necessary for the proper development of sperm . (osmosis.org)
In the interstitial tissue, Leydig cells synthesize androgens and the insulin-like factor 3 (INSL3) [ 3 ], whereas in the seminiferous tubules, Sertoli cells regulate the nutrients and factors that reach the germ cells by means of the blood-testis barrier. (biomedcentral.com)
Depending on the molecules and testis age, highly deleterious effects of phytocannabinoid exposure were observed on testis tissue after 14 days, including Sertoli and germ cell death. (biomedcentral.com)
The testis was considered to be a thyroid hormone unresponsive tissue [ 3 ]. (hindawi.com)
The ovaries consist of different types of tissue ( epithelial , germ cells, and sex cord tissue), which may give rise to benign or malignant tumors . (amboss.com)
Aydiner A, Aytekin Y, Topuz E. Effects of Cisplatin on Testicular Tissue and the Leydig Cell-Pituitary Axis. (ijmhr.org)
In conclusion, this study reports the failure of adult Leydig cell development and altered steroid production and signaling in tissue cultures. (elifesciences.org)
This study reports useful information on the limits of the organotypic culture of neonatal mouse testes, which has been regarded as an experimental strategy that can be extended to humans in the clinical setting for the conservation and subsequent re-use of testicular tissue. (elifesciences.org)
The organotypic culture procedure, which preserves testicular tissue architecture, microenvironment and cell interactions, has been used successfully to obtain spermatozoa from fresh or frozen/thawed mouse prepubertal testicular tissues ( 3 - 6 ). (elifesciences.org)
The present study also has its future implications in staging of cancer metastasis in the patients with Seminoma Testis and Leydig Cell Tumors and also in future xenografting of testicular tissue from an infant human donor. (ac.ir)
The testis tissue samples from aborted human fetuses of various weeks of gestation were taken and then subjected to immunohistochemistry by Ki-67 antibodies and also to Scanning Electron Microscopy and Transmission Electron Microscopy. (ac.ir)
12. Richardson LL, Kleinman HK, Dym M. Altered basement membrane synthesis in the testis after tissue injury. (ac.ir)
Hodgkin Lymphoma Hodgkin lymphoma is a localized or disseminated malignant proliferation of cells of the lymphoreticular system, primarily involving lymph node tissue, spleen, liver, and bone marrow. (msdmanuals.com)
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. (lookformedical.com)

They increase the tumor marker protein called alpha fetoprotein as well as HCG. (planetayurveda.net)
This type also increases the alpha fetoprotein levels in tumors. (planetayurveda.net)

Testicular cancers are malignant tumors that form in one or both testes . (osmosis.org)
Cisplatin is an organic metal co-ordination complex and is a widely used chemotherapeutic agent against a variety of malignant tumors, like sarcomas and carcinomas. (ijmhr.org)

The stromal tumours include granulosa cell tumour and Sertoli-Leydig tumour. (cancertame.com)

Seminomas and testicular germ cell tumors were negative. (elsevierpure.com)
These germ cell tumors are divided into seminomas and nonseminomas. (planetayurveda.net)

Testicular germ cell cancers in young adult men derive from a precursor lesion called carcinoma in situ (CIS) of the testis. (ku.dk)
These cancers grow from germ cells, the cells that make sperm. (medlineplus.gov)
The disease-free survival rate for Stage II and III cancers is slightly lower, depending on the size of the tumor and when treatment is begun. (medlineplus.gov)
Most of the testicular cancers arise from germinal cell tumors and spread rapidly. (planetayurveda.net)
Greater than 95%of testicular cancers start with germ cells. (planetayurveda.net)
These Are the less developed cancers with cells that appear like embryos in their early stages. (planetayurveda.net)
Germ cell testicular cancers come from germ cells that normally develop into sperm . (osmosis.org)
There are also rare testicular cancers from cells that support other roles. (horizonhospital.org)
Tumors or cancers of the KIDNEY. (lookformedical.com)

During puberty, testosterone induces Sertoli cell maturation, and prevails over FSH on AMH regulation. (biomedcentral.com)
The objective of the present study is to investigate the modulation of antioxidant defence status in neonatal persistent hypothyroid rats before their sexual maturation and also to identify the specific testicular cell populations vulnerable to degeneration during neonatal hypothyroidism in immature rats. (hindawi.com)

The wall of the tubule is made up of two kinds of cells: at the periphery , there's the germ cells known as spermatogonia, which are the primordial sperm cells that begin dividing over and over in puberty , and give rise to male gametes. (osmosis.org)
AMH is secreted in high amounts by Sertoli cells from fetal life until the onset of puberty. (biomedcentral.com)
In all documented biopsied cases, there is a significant decline in germ cell development and an increase in tubular sclerosis by puberty. (medscape.com)
Recent evidence suggests that children withKlinefelter syndrome are born with spermatogonia and lose large numbers of germ cellsduring puberty. (health-abstracts.com)

Leydig cell tumors (see the image below) are rare testicular tumors of the gonadal interstitium that may be hormonally active and lead to feminizing or virilizing syndromes. (medscape.com)
Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)

The peak incidence is in the third decade of life for non-seminomatous germ cell tumour (NSGCT) and mixed GCT patients, and in the fourth decade for seminoma testis (ST) patients. (uroweb.org)

Other GCTs include the dysgerminoma and yolk sac tumor. (proprofs.com)
These tumors look like a yolk sac of early human embryos. (planetayurveda.net)

Previous studies on the role of thyroid hormone in testis are mainly focused on histological and physiological aspects resulting into reproductive failure [ 6 , 8 , 12 - 14 ]. (hindawi.com)
Effects of cisplatin on testes and chromosome of rats: A histological and chromosomal study. (ijmhr.org)
Quantitative histological analysis and ultrastructure of the aging human testis. (ac.ir)
Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. (philarchive.org)

We speculate that disturbed development of somatic cells in the fetal testis may play a role in allowing undifferentiated cells to survive in the postnatal testes. (ku.dk)
The further development of CIS into invasive germ cell tumors may depend on signals from their postpubertal niche of somatic cells, including hormones and growth factors from Leydig and Sertoli cells. (ku.dk)
Using single-cell RNA sequencing (RNAseq), we studied the development of ProSG, their SG descendants and testicular somatic cells during the perinatal period in mice. (biologists.com)
The lining of seminiferous epithelium is unique in the complexity of its arrangement which consists of supporting somatic cells, a proliferating population of germ cells that are displaced centripetally from the spermatogonia to the base of spermatozoa in the central compartment. (superbgrade.com)

It has many synonyms like endodermal sinus tumor, infantile embryonal carcinoma and orchid blastoma. (planetayurveda.net)

We conclude that StAR is localized to normal and neoplastic cells in the gonads and adrenal cortex, which produce large amounts of pregnenolone. (elsevierpure.com)
The critical gene for male sex determination, SRY (sex-determining region Y), which is located on chromosome Yp11.3, initiates gonads to differentiate into testes, induces Leydig cells to secrete testosterone, develops Wolffian ducts, and forms male external genitalia. (e-kjgm.org)
Integration of single-cell transcriptome and chromatin accessibility of early gonads development among goats, pigs, macaques, and humans. (cas.cn)
Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)

A stromal tumor is a rare type of testicular tumor. (medlineplus.gov)
Seminoma - The most common cell type of testicular cancer. (horizonhospital.org)

As with germ cell tumors, the route of spread is hematogenous and lymphatic to the retroperitoneal lymph nodes. (medscape.com)
The cancer is in the testes, but it can spread to the lymph nodes. (medlineplus.gov)
In stage III, the tumour metastasises to the abdominal lymph nodes and abdominal organs such as the intestines and surface of the liver. (cancertame.com)

Lesion of the female vulva characterized by thinning of the epidermis and disappearance of rete pegs, hydropic degeneration of basal cells, superficial hyperkeratosis, dermal fibrosis with scant perivascular, mononuclear inflammatory cell infiltrate. (brainscape.com)

Testis-sparing surgery with enucleation of the mass is increasingly being reported for benign cases, in both the adult and pediatric populations. (medscape.com)
Primordial follicles of adult ovaries did not contain STAR, whereas antral follicles stained intensely in the thecal layer, with occasional staining of granulosa cells. (elsevierpure.com)
Testes are the small organs that are present as a pair and are smaller than the size of golf ballin adult males. (planetayurveda.net)
In our earlier reports, it was demonstrated that experimentally hypothyroidism modulates several oxidative stress and antioxidant defence parameters in mitochondria and postmitochondrial fractions in adult rat testis [ 18 , 19 ]. (hindawi.com)
Fetal type Leydig cells disappear soon after birth (during first 2 weeks after birth) and are replaced by adult type Leydig cells [ 22 , 23 ]. (hindawi.com)
Despite a conserved density of Leydig cells after 30 days of culture (D30), transcript levels of adult Leydig cell and steroidogenic markers were decreased. (elifesciences.org)
Seminiferous tubules constitute of at least75 % testicular mass in adult because of continuous cell multiplication. (superbgrade.com)
Testes mature to perform hormonal functions which involve the production of testosterone and production of spermatozoa in an adult. (superbgrade.com)
The development of adult Leydig cell population was also analyzed 65 days postpartum. (frontiersin.org)
Late-stage pubertal development of Leydig cells is mainly involved in the transition of immature Leydig cells to adult Leydig cells. (frontiersin.org)

Fetal ovaries contained sporadic stromal cells displaying intense StAR staining, particularly in the hilar region. (elsevierpure.com)
In mammals, testosterone is primarily secreted in the testes of males and the ovaries of females, although small amounts are also secreted by the adrenal glands. (absoluteastronomy.com)

Unlike germ cell testicular tumors, Leydig cell neoplasms are not associated with cryptorchidism . (medscape.com)
In the United States, Leydig cell testicular neoplasms are the most common sex cord-stromal tumors and comprise 1-3% of all testicular neoplasms. (medscape.com)
No other organ of the body is victim to such a wide variety of malignant neoplasms as the testis. (planetayurveda.net)

The cancer may look like a painless mass in the testes. (medlineplus.gov)
Once cancer is found, the first step is to determine the type of cancer cell by examining it under a microscope. (medlineplus.gov)
Chemotherapy uses medicines to kill cancer cells. (medlineplus.gov)
In a man, HCG levels may be valuated to help observe whether he has cancer of the testes. (bearcreekbb.net)
Major types of testicular cancer include germ-cell testicular cancer and non-germ-cell testicular cancer. (osmosis.org)
In clinical practice, she concentrates on germ cell tumors, while her epidemiologic research primarily focuses on colorectal cancer screening and prevention. (dana-farber.org)
Testicular cancer also called Germ Cell Tumour most commonly presents with a painless lump/swelling in the testis. (horizonhospital.org)
Chemotherapy is the mainstay of treatment in those cases where cancer has spread beyond the testis. (horizonhospital.org)
Pruefer FG, Lizarraga F, Maldonado V, Melendez-Zajgla J. Participation of Omi Htra2 serine-protease activity in the apoptosis induced by cisplatin on SW480 colon cancer cells. (ijmhr.org)
Pediatric cancer treatments such as chemotherapy have recognized toxicity on germline stem cells, which could lead to infertility at adulthood ( 1 , 2 ). (elifesciences.org)
Tumors or cancer of the LIVER. (lookformedical.com)
Tumors or cancer of the PANCREAS. (lookformedical.com)
Tumors or cancer of the SKIN. (lookformedical.com)

In stage II, the tumour spreads to the uterus, fallopian tubes and other tissues within the pelvis. (cancertame.com)

A seminiferous tubule has a thick wall of epithelial cells that surround a fluid-filled lumen, a bit like a garden hose. (osmosis.org)
It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)

The fetal testis, whose endocrine function orchestrates the masculinization of many distant organs, is particularly sensitive to disruption by xenobiotics. (biomedcentral.com)
In this context, we aimed to determine whether cannabis exposure has the potential to directly impact the human fetal testis. (biomedcentral.com)
We determined the expression of components of the ECS in the human fetal testis from 6 to 17 developmental weeks and assessed the direct effects of phytocannabinoids Δ9-trans-tetrahydrocannabinol (THC) and cannabidiol (CBD) on the testis morphology and cell functions ex vivo. (biomedcentral.com)
We demonstrate the presence in the human fetal testis of two key endocannabinoids, 2-arachidonylglycerol (2-AG) and to a lower level anandamide (AEA), as well as a range of enzymes and receptors for the ECS. (biomedcentral.com)
Transcriptomic analysis on 72 h-exposed fetal testis explants revealed 187 differentially expressed genes (DEGs), including genes involved in steroid synthesis and toxic substance response. (biomedcentral.com)
Our study is the first to evidence the presence of the ECS in the human fetal testis and to highlight the potential adverse effect of cannabis consumption by pregnant women onto the development of the male gonad. (biomedcentral.com)

These tumors can be pure or can be mixed with other sex cord-stromal or germ cell tumors. (medscape.com)
Finally, elevation of serum AMH above normal male prepubertal levels may be indicative of rare cases of sex-cord stromal tumors or Sertoli cell-limited disturbance in the McCune Albright syndrome. (biomedcentral.com)

Evaluation of prevalence and outcomes of serial tyrosine kinase inhibitor use in pediatric patients with advanced solid tumors. (dana-farber.org)
Shah N, Dizon D.S. New-generation platinum agents for solid tumors. (ijmhr.org)

Most malignant post-pubertal GCTs originate from germ cell neoplasia " in situ " (GCNIS). (uroweb.org)

At diagnosis, 1-2% are bilateral and 90-95% of cases are germ cell tumours (GCT) [ 6 ]. (uroweb.org)

Tumor formation generally start in cells in leydig cells in the testis that normally make male sex hormones. (planetayurveda.net)
It is used to produce hormones and cell membranes and is transported in the blood plasma of all mammals. (absoluteastronomy.com)
The process entirely depends on the presence of testosterone hormones in the testis. (superbgrade.com)
Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) stimulate the interstitial cells that are found in the testes to produce testosterone hormones. (superbgrade.com)

These cells are responsible for sperm production. (planetayurveda.net)
It is well established that the formation of normal numbers of Sertoli cells is a key factor in determining testis size, germ cell numbers per testis, and sperm production rate in adulthood in a range of mammals, including humans [ 17 ]. (hindawi.com)

The gene has been found to interact with FAT3, a tumor suppressor gene, as well as INTS2 a gene that is involved in snRNA processing and transcription. (wikipedia.org)
Wilms' tumor suppressor gene 1 (WT1) is the gene responsible for the developmental process of AGP. (biomedcentral.com)

Although these tumors usually secrete testosterone, the production of estrogen, progesterone, and corticosteroids has also been described. (medscape.com)

CIS cells were suggested to arise from primordial germ cells or gonocytes. (ku.dk)

Adults with androgen-secreting tumors are generally asymptomatic. (medscape.com)

[ 9 ] Leydig cells are located within the interstitium of the testis, between the seminiferous tubules, and produce testosterone in response to luteinizing hormone. (medscape.com)
The processes are localized in two major morphological structures, the vascularized Leydig cells of the interstitium and the vascularized seminiferous tubules. (superbgrade.com)

In situ hybridization (ISH) data has found the gene's mRNAs are mostly found in the nucleus of Sertoli cells, with low expression in Leydig cells. (wikipedia.org)

BACKGROUND: It has been hypothesized that poorly functioning Leydig and/or Sertoli cells of the testes, indicated by higher levels of serum gonadotropins and lower levels of androgens, are related to the development of testicular germ cell tumors (TGCT). (bvsalud.org)
Measurement of serum anti-Müllerian hormone (AMH) has become increasingly widespread since it provides information about the activity of the male gonad without the need for dynamic tests, and also reflects the action of FSH and androgens within the testis. (biomedcentral.com)
Consistent with increase in serum T, piperine increased Leydig cell number, cell size, and multiple steroidogenic pathway proteins, including steroidogenic acute regulatory protein, cholesterol side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase 1, 17α-hydroxylase/20-lyase, and steroidogenic factor 1 expression levels. (frontiersin.org)

Ex vivo exposure of first trimester testes to CBD, THC, or CBD/THC [ratio 1:1] at 10 −7 to 10 −5 M altered testosterone secretion by Leydig cells, AMH secretion by Sertoli cells, and impacted testicular cell proliferation and viability as early as 72 h post-exposure. (biomedcentral.com)
2. LH: This stimulates testosterone secretion from the interstitial cells of Leydig (so it is called the interstitial cell-stimulating hormone or ICSH). (online-sciences.com)

Estrogen excess and feminizing syndromes may occur from the peripheral aromatization of testosterone or from the direct production of estradiol by the tumor itself. (medscape.com)
Stromal tumors usually occur during childhood. (medlineplus.gov)
Leydig cell hyperplasia may also occur with aging. (medscape.com)
All these changes occur while spermatids are embedded in the luminal surface of Sertoli cells. (online-sciences.com)

Rupture of a mucinous cystadenoma or cystadenocarcinoma leading to the spread of tumor cells throughout the peritoneum . (amboss.com)
Mucinous cells cause gelatinous ascites and intraabdominal adhesions. (amboss.com)

The report shows squamous cell carcinoma on several biopsies. (pdfcoffee.com)

The Leydig cell cytoplasm contains an abundant supply of smooth endoplasmic reticulum and mitochondria with tubular cristae, both features being characteristic of steroidogenic cells. (ac.ir)
The molecule of MF, a small hydrophilic cation, is transported from the extracellular space to the cytoplasm of the target cell through organic cation transporters-1 and -2 (OCT1, OCT2), multidrug and toxin extrusion transporters (MATE), and ATM (ataxia telangiectasia mutated) transporter, and OCT1 and OCT2 are considered as the main functional units of MF transmembrane transport [ 7 ] . (encyclopedia.pub)

Sertoli cells are supportive cells that provide nutrients to developing sperm cells, and contribute to the blood-testis barrier by only allowing certain molecules, like testosterone , into the seminiferous tubules . (osmosis.org)

Anatomy14

Diseases30

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes3

Disciplines and Occupations1

Information Science1

Spermatogenesis21

Come from the Sertoli cells2

Choriocarcinoma3

Ovarian17

Ovary7

Epididymis4

Tissue15

Alpha-fetoprotein2

Malignant tumors2

Granulosa cell t1

Seminomas2

Cancers9

Maturation2

Puberty4

Gonadal2

Seminoma testis1

Yolk sac2

Histological4

Somatic cells4

Endodermal sinus1

Gonads4

Type of testicular2

Lymph3

Rete1

Adult10

Ovaries2

Neoplasms3

Cancer13

Fallopian tubes1

Epithelial cells2

Fetal testis6

Cord-stromal2

Solid tumors2

GCTs1

Tumours1

Hormones4

Sperm production2

Suppressor gene2

Secrete testosterone1

Primordial1

Asymptomatic1

Interstitium2

Situ1

Serum3

Testosterone secretion2

Occur4

Mucinous2

Squamous1

Cytoplasm2

Blood-testis1