Negative developmental and morphological effects were detected in the experimental groups. (nature.com)
Androgen3
The medication has progonadotropic effects due to its AR antagonist activity and can increase androgen, estrogen, and neurosteroid production and levels. (wikipedia.org)
Also in contrast to SAAs, bicalutamide neither inhibits nor suppresses androgen production in the body (i.e., it does not act as an antigonadotropin or steroidogenesis inhibitor), and instead exclusively mediates its antiandrogen effects by blocking androgen binding and subsequent receptor activation at the level of the AR. (wikipedia.org)
Prostatic carcinoma is known to be androgen-sensitive and responds to treatment that counteracts the effect of androgen and/or removes the source of androgen, e.g., castration. (sdrugs.com)
The mechanism of the antihypertensive effects of beta-blocking agents has not been established, but several mechanisms have been postulated: 1) an effect on the central nervous system resulting in a reduced sympathetic outflow to the periphery, 2) competitive antagonism of catecholamines at peripheral (especially cardiac) adrenergic receptor sites, leading to decreased cardiac output, 3) an inhibition of renin release. (nih.gov)
These mechanisms appear less likely for pindolol than other beta-blockers in view of the modest effect on resting cardiac output and renin. (nih.gov)
In this study, by employing metformin as a comparative group, we evaluated the protective effects of ICA on male reproductive damages caused by DM and explored the possible mechanisms. (biomedcentral.com)
This review sought to report on the selective effects demonstrated by glucose-lowering medications on erectile function and explore the potential mechanisms involved. (encyclopedia.pub)
Tissues2
More than one-third of TBT accumulated in the digestive glands of both males and females, followed by the testis, ctenidium, muscle, and heart tissues in males and in the muscle, ovary, ctenidium, and head tissues (including the central nervous system ganglia) in females. (nih.gov)
Many reports of endocrine disruption describe changes in the normal development of organs and tissues that are consistent with genetic damage, and recent studies confirm that many chemicals classified to have hormone-modulating effects also possess carcinogenic and mutagenic potential. (nih.gov)
Females2
Ovarian spermatogenesis and suppressed ovarian maturation were observed in the females that exhibited imposex, although no histopathological abnormalities were found in males. (nih.gov)
Consistent with this expression pattern, male mice lacking A-Myb are infer-tile because of a block in spermatogenesis, and A-myb null females have underdeveloped breast tissue after pregnancy [19]. (123dok.net)
Adverse effects2
To date, however, there have been no conclusive examples linking genetic damage with perturbation of endocrine function and adverse effects in vivo . (nih.gov)
It includes the physiologic and psychologic beneficial or adverse effects. (nih.gov)
Exerts1
It crosses the blood-brain barrier and exerts effects in the central nervous system. (wikipedia.org)
Reproductive3
however, on the subject of its effects on the reproductive system, few literatures are available. (ijfs.ir)
The present study was carried out for evaluating effects of aspartame on the reproductive system in male mice. (ijfs.ir)
These results suggest that ICA could attenuate male reproductive dysfunction of diabetic rats possibly via increasing cell proliferation and decreasing cell apoptosis of testis. (biomedcentral.com)
Therapeutic1
Beta-blockade therapy is useful when it is necessary to suppress the effects of beta-adrenergic agonists in order to achieve therapeutic goals. (nih.gov)
Temperature3
Development of oxidative stress through methanol oxidation results in structural and functional impairments of proteins responsible for regulating and maintaining the lower temperature of the testes ( 7 ). (ijfs.ir)
Even a slight increase in temperature could lead to rapid disrupts in spermatogenesis due to inducing protein denaturation ( 8 ). (ijfs.ir)
The preservative effects of low temperature on biological materials have been long recognised, and cryopreservation is now widely used in biomedicine, including in organ transplantation, regenerative medicine and drug discovery. (biomedcentral.com)
Rats1
PMID- 5428633 TI - Observations on the effects on rats of compounds related to acrylamide. (nih.gov)
Mechanism2
One of the genes regulated through this mechanism en-codes the B-Myb transcription factor, which has been shown to be critically required for early embryonal de-velopment in the mouse. (123dok.net)
However, substantial differences in the mechanism of action, glucose-lowering efficacy and effects on body weight and other cardiovascular risk factors of each drug may explain a potential variable impact on erectile function. (encyclopedia.pub)
Biological2
Adverse biological effects of naturally high background radiation have been documented 5 , but presently, radiation-based technologies are widespread in society, which leads to the relatively high possibility of radiation exposure, whether intentional or accidental, for anyone. (nature.com)
Whereas Boyle could only speculate on the nature of cold, the intervening centuries have revealed its preservative effect lies in depriving biological systems of the thermal energy required for normal molecular motion and metabolism, in turn slowing cellular processes and decomposition. (biomedcentral.com)
Increase2
Although bicalutamide does not bind to the ERs, it can increase estrogen levels secondarily to blockade of the AR when used as a monotherapy in males, and for this reason, the medication can indirectly activate the ERs to a degree and hence have some indirect estrogenic effects in men. (wikipedia.org)
Allocation of appropriate anti-bacterial agent can increase shelf life by several weeks. (biosensis.com)
Medication1
Our Cialis Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (order-cialis.com)
Preservation1
This results in a variety of differences of bicalutamide monotherapy compared to surgical and medical castration, such as indirect estrogenic effects and associated benefits like preservation of sexual function and drawbacks like gynecomastia. (wikipedia.org)
Contrast1
In contrast, some studies have reported no detectable effects. (nature.com)
Heart1
In standard pharmacologic tests in man and animals, pindolol attenuates increases in heart rate, systolic blood pressure, and cardiac output resulting from exercise and isoproterenol administration, thus confirming its beta-blocking properties. (nih.gov)
tion and a conserved region (CR) which has variously been associated with positive and negative effects on transcriptional activity [5 - 9]. (123dok.net)
These results demonstrated that ingesting low-level radiocesium contaminants in Fukushima (but not natural radiopotassium) imposed biologically negative effects on the cabbage white butterfly, as in the pale grass blue butterfly, at both cellular and organismal levels. (nature.com)
Blood1
The effect on blood pressure is not orthostatic, i.e., pindolol was equally effective in reducing the supine and standing blood pressure. (nih.gov)
Activity3
Pindolol, a synthetic beta-adrenergic receptor blocking agent with intrinsic sympathomimetic activity is 1-(Indol-4-yloxy)-3- (isopropylamino)-2-propanol. (nih.gov)
The ISA or partial agonist activity of pindolol is mediated directly at the adrenergic receptor sites and may be blocked by other beta-blockers. (nih.gov)
Pindolol does not have a consistent effect on plasma renin activity. (nih.gov)
Treatment1
Effects of changing Gonadotropin-releasing hormone pulse frequency and estrogen treatment on levels of estradiol receptor -alpha and induction of Fos and phosphorylated cyclic adenosine monophosphate response element binding protein in pituitary gonadotropes: studies in hypothalamo-pituitary disconnected ewes. (biosensis.com)
Breast1
When used as a monotherapy, bicalutamide can induce breast development in males due to its estrogenic effects. (wikipedia.org)
Effective1
Pindolol has been shown in controlled, double-blind clinical studies to be an effective antihypertensive agent when used as monotherapy, or when added to therapy with thiazide-type diuretics. (nih.gov)
Model1
PMID- 5428643 TI - Behaviour of an iris model and the pupil block hypothesis. (nih.gov)
Animal1
In animal studies, Flutamide demonstrates potent antiandrogenic effects. (sdrugs.com)
Present1
Before discussing the medical applications and opportunities of cryopreservation, we should first consider the physiological effects of low temperatures, and the challenges they present. (biomedcentral.com)