• bind
  • Via Smad3, the MRTF-Smad3 complexes bind to a newly identified cis-element GCCG-like motif in the promoter region of Canis familiaris and the human slug gene, which activates slug transcription and thereby dissociation of cell-cell contacts. (rupress.org)
  • form
  • Binding of TGF-β to its receptor leads to phosphorylation of its downstream targets Smad2 and 3, and then the phosphorylated Smad2 and 3 form complexes with cytoplasmic Smad4 ( Xu, 2006 ). (rupress.org)