CyclophosphamidePotent immunosuppressive agentsCyclosporineCorticosteroidsAzathioprineTacrolimusCorticosteroid therapyGlucocorticoidsKidney TransplantationMalignancyAllograftCytotoxicRemissionImmunosuppressantsInfliximabGraftMycophenolateSurvivalOutcomesDosageImmune systemSirolimusInhibitTherapyToleranceAdministerShort-termCombinationsRegimensEvidenceAutoimmuneSteroidsRenalDrugsNitrogenClinicalAntibodiesTreatmentSafelyAdverseAnti-inflammatoryDegosPatientsImmunomodulatoryTopicalAdministrationDependsLongActivity
Cyclophosphamide6
- Cyclophosphamide is an alkylating agent that prevents cell division by cross-linking DNA strands and thus interfering with DNA replication. (medscape.com)
- The alkylating agents used in immunotherapy are nitrogen mustards (cyclophosphamide), nitrosoureas, platinum compounds, and others. (wikipedia.org)
- Cyclophosphamide (Baxter's Cytoxan) is probably the most potent immunosuppressive compound. (wikipedia.org)
- In terms of treatment for myositis-associated ILD, systemic corticosteroid therapy is usually combined with immunosuppressive agents, such as azathioprine, cyclophosphamide, mycophenolate mofetil, methotrexate, cyclosporine, tacrolimus, and/or rituximab, although there is little evidence to support the efficacy of these individual agents ( 4 ). (frontiersin.org)
- Aim To investigate the efficacy and safety of cyclophosphamide and other immunosuppressive agents (ISAs) in the treatment of necrotising scleritis. (bmj.com)
- Cyclophosphamide (CTX) is an alkylating agent used in the treatment of systemic lupus erythematosus (SLE) for its potent immunosuppression effect. (researchsquare.com)
Potent immunosuppressive agents2
- Owing to use of potent immunosuppressive agents and long-term steroids, post-renal transplant TB can occur in any part(s) of the body and poses high mortality. (jpgmonline.com)
- Many of the medical complications that arise are the direct consequence of the need to administer potent immunosuppressive agents, with their attendant risks of infection, malignancy and drug toxicity. (ersjournals.com)
Cyclosporine4
- Sirolimus-based therapy with or without cyclosporine: long-term follow-up in renal transplant patients. (medigraphic.com)
- Cyclosporine (Atopica) is an oral immunosuppressive agent that can be used to treat the symptoms of atopy. (dupontvet.com)
- Furthermore, over-dosage may manifest itself as cyclosporine toxicity in the long term if over exposure continues. (advfn.com)
- Nonsteroidal immunosuppressive agents that can be used include azathioprine , cyclosporine , mycophenolate mofetil, methotrexate , and tacrolimus . (medscape.com)
Corticosteroids6
- Corticosteroids are immunosuppressive and affect the replication, movement, and activity of virtually all cells involved with inflammation. (medscape.com)
- For people with active ulcerative colitis who do not respond to corticosteroids or immunosuppressive agents, infliximab is effective in inducing clinical remission, inducing clinical response, promoting mucosal healing and reducing the need for colectomy, at least in the short term," said review co-author Dr. Anthony Kwaku Akobeng. (medindia.net)
- The cluster model was further applied to 283 patients who received conventional regimens consisting of corticosteroids with or without a single immunosuppressive agent (dual-combo therapy or monotherapy). (frontiersin.org)
- Corticosteroids or immunosuppressive therapy should be used in all patients who have not met treatment goals after an adequate trial of pyridostigmine. (medscape.com)
- A nonsteroidal immunosuppressive agent should be used alone when corticosteroids are contraindicated or the patient declines them or can be used initially in conjunction with corticosteroids when the risk for steroid side effects is high based on medical comorbidities. (medscape.com)
- A nonsteroidal immunosuppressive agent should be added to corticosteroids when significant steroid side effects develop, response to steroids is inadequate, or the steroid dose cannot be reduced because of symptom relapse. (medscape.com)
Azathioprine3
- Mycophenolate mofetil and azathioprine are the usual agents considered as initial choices. (medscape.com)
- Azathioprine (Prometheus' Imuran), is the main immunosuppressive cytotoxic substance. (wikipedia.org)
- Expert consensus and some clinical trial evidence support the use of azathioprine as a first-line immunosuppressive agent. (medscape.com)
Tacrolimus1
- He received several immunosuppressive agents postoperatively for rejection and maintenance treatment, including mycophenolate sodium, sirolimus, tacrolimus, and methylprednisolone. (jpgmonline.com)
Corticosteroid therapy1
- Rituximab is an anti-CD20 monoclonal antibody indicated for adults with pemphigus vulgaris in combination with short-term corticosteroid therapy. (medscape.com)
Glucocorticoids2
- Immunosuppressive drugs can be classified into five groups:[citation needed] glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs In pharmacologic (supraphysiologic) doses, glucocorticoids, such as prednisone, dexamethasone, and hydrocortisone are used to suppress various allergic, inflammatory, and autoimmune disorders. (wikipedia.org)
- Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents. (medswow.com)
Kidney Transplantation1
- Kidney transplantation--the long term view. (ox.ac.uk)
Malignancy3
- The goal of immunosuppressive therapy is to balance the beneficial effects of reducing acute rejection while minimizing adverse effects from over-immunosuppression such as infections, malignancy, and cardiovascular disease. (benthamscience.com)
- The primary objective of this study was to identify and describe risk factors associated with malignancy or serious infection in patients with IBD, with a specific focus on evaluating the impact of immunosuppressive treatments. (globalrph.com)
- Immunosuppressive agent use was not associated with malignancy. (nature.com)
Allograft2
- Long-term outcomes of keratolimbal allograft for total limbal stem cell deficiency using combined immunosuppressive agents and correction of ocular surface deficits. (springer.com)
- Theoretically, long-term concomitant use might require increased levels of immunosuppression in allograft patients. (interactionsguide.com)
Cytotoxic1
- A small case control trial showed improved laboratory and clinical outcomes in patients with pemphigus vulgaris treated with a combination of cytotoxic agents plus intravenous immunoglobulin (IVIG)compared with those treated with just IVIG. (medscape.com)
Remission1
- Commonly utilized in the maintenance of disease remission are immunosuppressive agents such as thiopurines and a growing range of biological anti-inflammatory drugs. (globalrph.com)
Immunosuppressants3
- Immunosuppressants should be considered early in the course of disease, as steroid-sparing agents. (medscape.com)
- Immunosuppressive drugs, also known as immunosuppressive agents, immunosuppressants and antirejection medications, are drugs that inhibit or prevent the activity of the immune system. (wikipedia.org)
- Due to the chronic and recurring nature of IBD, patients are often exposed to long-term use of immunosuppressants. (globalrph.com)
Infliximab1
- Newer induction immunosuppressive agent combinations [T-cell-depleting antibody (anti-CD3 antibody, alemtuzumab, or antithymocyte globulin) and a tumor necrosis factor alpha (TNF- α ) inhibitor (etanercept or infliximab)] have improved long-term diabetes reversal rates (~50% in 5 years at the most experienced centers) [ 9 ], presumably by preserving transplanted β -cell mass. (hindawi.com)
Graft4
- One-year graft survival of renal grafts increased progressively in the last two decades and can be now considered excellent, but long-term outcomes has not improved proportionally in the last years. (benthamscience.com)
- In summary, the analysis of more than 270,000 kidney transplants recipients who were transplanted between January 1988 and August 2010 showed the following important points: Despite enormous progress in short-term graft survival in the last decades, long-term graft survival remained largely unchanged over the period from 1988 to 2010. (terasaki.org)
- The immunosuppressive agents that were introduced in the past 3 decades have not improved long-term graft survival. (terasaki.org)
- Avoiding and controlling risk factors that are responsible for cardiovascular diseases are the sine qua non for increased long-term graft survival. (terasaki.org)
Mycophenolate2
- [ 72 , 73 , 74 ] Only one placebo-controlled blinded study of mycophenolate has demonstrated more rapid improvement in the short run but no significant steroid-sparing effects in the long term. (medscape.com)
- Inopha is supplier of GMP quality API Mycophenolate Mofetil powder, raw material of immunosuppressive agents medicine mainly used for the prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac or hepatic transplants. (inopha.net)
Survival2
- Surgical advances, in conjunction with more effective immunosuppressive strategies, have propelled the field of lung transplantation forward and have made intermediate-term survival an achievable goal. (ersjournals.com)
- Approximately 15% of Degos' disease exhibit long-term survival with disease often limited to the skin and with no history of catastrophic bowel or central nervous system involvement. (degosdisease.org)
Outcomes1
- Strategies to improve long-term outcomes after renal transplantation. (medigraphic.com)
Dosage3
- However, they are added primarily to other immunosuppressives to diminish their dosage and toxicity. (wikipedia.org)
- A decreased in overall mortality of SLE in low daily dosage of CTX, with adjusted HR (95% CI) of 0.54 (0.36-0.81) and a significant dose-response pattern ( P = 0.004) between overall mortality of SLE and long-term use of CTX with adjusted HR (95% CI) 0.53 (0.35-0.80) were observed. (researchsquare.com)
- Low daily dosage and long-term use of CTX lowers the risk of overall mortality of SLE. (researchsquare.com)
Immune system2
- Immunosuppressive agents are drugs which inhibit the immune system and are used to treat autoimmune diseases including lupus and multiple sclerosis, and to prevent the body's rejection of transplanted organs. (avivadirectory.com)
- However, the same immunosuppressive medications that are required to prevent the child's immune system from attacking and rejecting the transplanted organ can predispose these individuals to developing a very serious cancer that is linked to Epstein-Barr virus (EBV). (stanford.edu)
Sirolimus4
- Experiencia mexicana con el uso de sirolimus en trasplante renal. (medigraphic.com)
- La sobrevida de los receptores de trasplante renal ha mejorado a trav s de los a os, sirolimus (SRL) ha probado ser ben fico en t rminos de funci n renal, histolog a y sobrevida del injerto. (medigraphic.com)
- At the Albany Medical Center, we have a long-term experience, mean follow-up of 75 months, in 50 renal transplant recipients treated with maintenance sirolimus, prednisone and a calcineurin-inhibitor sparing immunosuppressive regimen. (utmb.edu)
- Sirolimus is an effective maintenance immunosuppressive agent that safely allows for a reduction in calcineurin-inhibitor dosing. (utmb.edu)
Inhibit1
- Anti-inflammatory agents inhibit the inflammatory process by inhibiting specific cytokine production. (medscape.com)
Therapy4
- Antibodies are sometimes used as a quick and potent immunosuppressive therapy to prevent the acute rejection reactions as well as a targeted treatment of lymphoproliferative or autoimmune disorders (e.g., anti-CD20 monoclonals). (wikipedia.org)
- Therefore, steroid therapy is reserved for short-term seasonal control or in patients where other therapy is not feasible or effective. (dupontvet.com)
- administer herb short-term only, before recommencing drug therapy. (interactionsguide.com)
- Methylprednisolone may also be used for purposes not listed in this medication guide.Adjunctive therapy for short-term administration in rheumatoid arthritis. (medswow.com)
Tolerance1
- The emergence of new immunosuppressive agents and tolerance protocols appears promising as a means to deliver immunosuppression without long-term toxicity. (benthamscience.com)
Administer1
- For treating pemphigus vulgaris, administer it orally and use alone or in combination with topical or intralesional steroids or in conjunction with other immunosuppressives. (medscape.com)
Short-term3
- Use it for short-term management of ulcers. (medscape.com)
- The mainstay of management of these complications in the short term relies on immunosuppressive drugs. (aamds.org)
- Avoid, except for short-term acute coadministration, with professional monitoring. (interactionsguide.com)
Combinations1
- Current immunosuppressive protocols use combinations of immunosuppressive drugs with different mechanisms of action to maximize efficacy and minimize the toxicity of each drug. (benthamscience.com)
Regimens1
- During the past decade, there has been a increasing interest in identifying regimens that may allow the minimization of immunosuppressive drugs characterized by significant side effects, including nephrotoxicity and metabolic dysregulation. (benthamscience.com)
Evidence1
- Increasing evidence suggests that hypomethylating agents may be effective in treating these complications and reduce steroid dependence. (aamds.org)
Autoimmune2
- These agents are indicated for autoimmune diseases. (medscape.com)
- Most uveitis seen in Western countries is noninfectious and appears to be autoimmune or autoinflammatory in nature, requiring treatment with immunosuppressive and/or anti-inflammatory drugs. (dovepress.com)
Steroids1
- Immunosuppressive agents are useful adjuvants in patients with pemphigus vulgaris with generalized disease unresponsive to steroids and/or other anti-inflammatory agents or in patients unable to tolerate prednisone. (medscape.com)
Renal1
- El uso de SRL en receptores de trasplante renal en M xico arroja una participaci n de colaboradores en manuscritos internacionales en revistas de impacto y la experiencia de centros nicos son en su mayor a res menes de congresos y art culos originales. (medigraphic.com)
Drugs1
- Medical treatment for IBD involves the administration of immunosuppressive drugs to reduce inflammation in the intestines. (globalrph.com)
Nitrogen1
- Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. (nih.gov)
Clinical1
- Anti-GBM disease, a more precise term, should be used to refer to either of the 2 distinct clinical manifestations of this disorder. (medscape.com)
Antibodies1
- Goodpasture disease is a term used to describe glomerulonephritis, with or without pulmonary hemorrhage, and the presence of circulating anti-glomerular basement membrane (anti-GBM) antibodies. (medscape.com)
Treatment2
- These agents are used for topical treatment for aphthae. (medscape.com)
- The drug may also be used in the treatment of chronic rejection in patients previously treated with other immunosuppressive agents. (navitus.com)
Safely1
- Oral antihistamines can safely be given long-term with very few side effects. (dupontvet.com)
Adverse1
- However, long-term steroid use has many potential adverse side effects. (dupontvet.com)
Anti-inflammatory3
- Anti-inflammatory and immunosuppressive agents are used to treat mucocutaneous lesions and arthritis associated with this disease. (medscape.com)
- These agents modify the body's immune response to diverse stimuli and therefore have anti-inflammatory properties. (medscape.com)
- Amlexanox is a topical mucosal anti-inflammatory agent paste at 5% concentration. (medscape.com)
Degos1
- In 1941, in an article entitled "Multiple Hautrekrosen bei Thromboangiitis obliterans," Kohlmeier described a case of a disease that has now been termed malignant atrophic papulosis (MAP) or Degos disease. (medscape.com)
Patients3
- Patients were categorized based on their immunosuppressant exposure history into groups: thiopurines, anti-TNF agents, other biologics, a combination of thiopurines and anti-TNF agents, and non-immunosuppressed patients. (globalrph.com)
- However, the two agents have never been compared head to head, so it is difficult to know how they would compare in similar patients. (medindia.net)
- In this grant we will complete the first three steps toward achieving our goal: 1) we will establish that PTPRS physiologically regulates type 1 interferon production by plasmacytoid dendritic cells of lupus patients, 2) we will show that modulation of the pathway improves the course of lupus in a mouse model if performed alone or 3) in combination with an analog of belimumab, an approved agent for lupus. (lupusresearch.org)
Immunomodulatory1
- These agents may be immunomodulatory. (medscape.com)
Topical1
- Wound care for erosions includes daily gentle cleaning, application of topical agents to promote wound healing, and use of nonadhesive dressings. (medscape.com)
Administration2
- Prior to administration of DTP-Hib, health care personnel should inform the patient or guardian of the patient the benefits and es una suspensión estéril, opaca, uniforme del toxoide diftérico, toxoide tetánico y los bacilos matados de Bordetella Pertussis y adsorbido en gel de aluminio y suspendido en una solución de cloruro sódico isotónico. (who.int)
- Natural killer (NK) cell number and activity increased by long-term administration. (interactionsguide.com)
Depends1
- The long-term success of a PK depends on appropriate postoperative management and conscientious patient adherence. (aao.org)
Long2
- Side effects associated with long-term use are not completely known. (dupontvet.com)
- Hands of a transfusion-dependent patient on long-term hemodialysis. (medscape.com)
Activity1
- It has potent immunosuppressive activity. (medscape.com)