Studies of pH]5 HT release in vitro supports the suggestion the 5 HTib receptor, but not the 5 HTia somatodendritic autoreceptor, regulates evoked 5 HT release in raphe slices. (gabasignaling.com)
Receptor3
It has been shown, employing in vivo voltammetry, that GR127935 enhances although the 5 HTid receptor agonist, sumatriptan, inhibits the electrically evoked release buy Apatinib of 5 HT during the raphe in vitro, steady together with the existence of inhibitory 5 HTid autoreceptors inside of this framework. (gabasignaling.com)
It has been proposed that the inhibitory role of 5-HT 1A and 5-HT 1B serotonergic receptor sub-types that limit somatodendritic and nerve terminal 5-HT release, respectively, plays a key role in the mechanism of action of Selective Serotonin Reuptake Inhibitors (SSRI). (eurekaselect.com)
The serotonin-1A (5-HT1A) receptor is among the most abundant and widely distributed 5-HT receptors in the brain, but is also expressed on serotoninneurons as an autoreceptor where it plays a critical role in regulating the activity of the entire serotonin system. (biomedcentral.com)
Inhibitory1
In vivo recordings, however, suggest that unlike glutamatergic mitral cells, inhibitory granule cells are only weakly activated after sensory stimulation ( Cang and Isaacson, 2003 ). (jneurosci.org)
Raphe2
The 5-HT1A receptors in the raphe nucleus are largely somatodendritic autoreceptors, whereas those in other areas such as the hippocampus are postsynaptic receptors. (wikipedia.org)
The raphe nuclei incorporate 5 HT projections whose terminals impinge on 5 HT together with other cell bodies within the nuclei. (gabasignaling.com)
Neurons2
Proximal synapses arise from piriform cortical neurons and facilitate with paired-pulse stimulation, whereas distal dendrodendritic synapses generate EPSCs with slower kinetics that depress with paired stimulation. (jneurosci.org)
Elevated 5-HT1A autoreceptor expression would tend to reduce the activity of 5-HT neurons, while reduced post-synaptic 5-HT1A receptors would result in a blunted behavioral response to 5-HT. (biomedcentral.com)
Receptors2
Tetanic stimulation of axons in the granule cell layer (GCL) not only activates granule cells but also relieves the Mg blockade of NMDA receptors at distal dendrodendritic synapses ( Halabisky and Strowbridge, 2003 ). (jneurosci.org)
Taken together, these results highlight an integrated regulation of 5-HT1A autoreceptors that differs in several aspects from regulation of post-synaptic 5-HT1A receptors, and could be selectively targeted to enhance serotonergic neurotransmission. (biomedcentral.com)
Slices1
Using two-photon guided minimal stimulation in acute rat brain slices, we found that distal and proximal excitatory synapses onto granule cells are functionally distinct. (jneurosci.org)
Serotonergic2
Over-expression of the 5-HT1A autoreceptor has been implicated in reducing serotonergic neurotransmission, and is associated with major depression and suicide. (biomedcentral.com)
Pet1, an obligatory enhancer for serotonergic differentiation, has been identified as a potent activator of 5-HT1A autoreceptor expression. (biomedcentral.com)
Release1
On the other hand, methiothepin is also unusual in getting able to markedly increase depolarization A 205804 clinical trial evoked pH]5 HT release at concentrations which will not modify basal release and this has been advised to reflect an inverse agonist action with the 5 HT terminal autoreceptor, a property quite possibly not shared by GRl27935. (gabasignaling.com)
Electrical stimulation2
van der Werf JF, Bast A, Bijloo GJ, Van der Vliet A, Timmerman H (1987) HA autoreceptor assay with superfused slices of rat brain cortex and electrical stimulation. (springer.com)
The discovery of extrasynaptic receptors by Miledi (1960) , was followed by observations by Dun and Minota (1982) of peripheral neuronal responses that could be attributed to somatic exocytosis of signaling molecules upon electrical stimulation. (frontiersin.org)
Nerve terminals1
In view of the known loss of nigrostriatal dopamineneurons and decreases in striatal dopamine that occur with ageing, we predicted a decrement in apomorphine-induced yawning and penile grooming , responses that are thought to result from stimulation of autoreceptors located on dopamine nerve terminals. (baillement.com)
Postsynaptic1
On the other hand, the results of receptor binding studies would predict decreased responsiveness to postsynaptic dopamine receptor stimulation in aged rats. (baillement.com)