Polymorphism, GeneticPolymorphism, Single NucleotideTemperatureBody TemperatureProtein ConformationHot TemperatureCold TemperatureModels, MolecularGenetic Predisposition to DiseaseGene FrequencyAllelesMolecular Sequence DataSkin TemperatureBody Temperature RegulationThermodynamicsPolymorphism, Single-Stranded ConformationalHaplotypesAmino Acid SequenceCase-Control StudiesKineticsProtein BindingMutationProtein Structure, SecondaryBinding SitesCircular DichroismPolymerase Chain ReactionGenotypeBase SequenceProtein Structure, TertiaryMolecular ConformationCrystallography, X-RayHydrogen-Ion ConcentrationSpectrometry, FluorescenceGenetic VariationGenetic Association StudiesLinkage DisequilibriumAsian Continental Ancestry GroupProtein FoldingMagnetic Resonance SpectroscopyProtein DenaturationAmino Acid SubstitutionSequence Analysis, DNANucleic Acid ConformationEscherichia coliDNAMolecular Dynamics SimulationModels, ChemicalPhenotypeNuclear Magnetic Resonance, BiomolecularLigandsWaterStructure-Activity RelationshipTransition TemperatureThermometersComputer SimulationGenetic MarkersTime FactorsThermographyHomozygoteBacterial ProteinsRisk FactorsHydrogen BondingDNA PrimersSolutionsRecombinant ProteinsCalorimetry, Differential ScanningChinaPromoter Regions, GeneticMutagenesis, Site-DirectedEnzyme StabilityCattleAmplified Fragment Length Polymorphism AnalysisMethylenetetrahydrofolate Reductase (NADPH2)Protein Structure, QuaternaryDNA Mutational AnalysisEuropean Continental Ancestry GroupProteinsHumiditySpectrophotometry, UltravioletTryptophanModels, BiologicalSolventsHeterozygotePhylogenySpecies SpecificityDimerizationPeptidesPoint MutationCatalysisCalorimetryExonsChromosome MappingAdenosine TriphosphateAllosteric RegulationSpectroscopy, Fourier Transform InfraredSequence AlignmentCatalytic DomainHydrolysisSubstrate SpecificityMolecular Structure