Targets for the development anti bacterial agents. Medical search. Frequent questions

Our target molecules include ficellomycin, pestalone, depsidones, and p-terphenyls, which have all shown promising preliminary activity as antibiotics. (unca.edu)
Our natural product isolation program explores how bacterial competition between diverse natural bacteria influences expression of secondary metabolite antibiotics compared to standard laboratory conditions. (unca.edu)
The stagnation in the development of new antibiotics and the concomitant high increase of resistant bacteria emphasize the urgent need for new therapeutic options. (nature.com)
Owing to the alarming increase in bacterial resistance towards conventional antibiotics and the decrease in the development of new antibiotics at the same time, treatment of bacterial infections has become a major clinical problem 1 . (nature.com)
Traditional antibiotics exert strong selective pressure for resistance development, since they target bacterial processes essential for the growth of the organism. (ispub.com)
Hélène Barreteau is assistant professor at the University Paris-Sud, Orsay, and a member of the Laboratory of Bacterial Envelopes and Antibiotics. (degruyter.com)
She joined the Laboratory of Bacterial Envelopes and Antibiotics as an engineer in 2007. (degruyter.com)
He is director of research at CNRS and, since 2001, is the head of the Laboratory of Bacterial Envelopes and Antibiotics which, for more than 30 years, has been studying the biochemistry, genetics and physiology of the bacterial cell-wall peptidoglycan biosynthesis pathway as a whole. (degruyter.com)
His main research interests concern the identification of genes and enzymes involved in this pathway, the regulation of this metabolism, the mode of action of antibiotics and bacteriocins interfering with this pathway and the corresponding resistance mechanisms, as well as the molecular bases for the recognition of bacterial cell-wall peptidoglycan by host innate immunity mechanisms. (degruyter.com)
Didier Blanot is director of research at CNRS and a member of the Laboratory of Bacterial Envelopes and Antibiotics, University Paris-Sud, Orsay. (degruyter.com)
Third, DXR appears to be a valid target and the results from fosmidomycin (1), the only available DXR inhibitor under clinical trials, suggests synergistic effects with the lincosamide antibiotics, lincomycin and clindamycin. (unboundmedicine.com)
Efflux pumps reduce the accumulation of antibiotics inside of the bacterial cells, and the slow phase in which the process of antibiotic efflux takes place provides sufficient time for the bacterium to adapt to the antibiotics and become resistant through mutations or alteration of antibiotic targets [ 3 ]. (biomedcentral.com)
Due to the development of this resistance in human pathogens against commonly used antibiotics, it has become necessary to search for new antimicrobial substances from other sources including plants [ 6 ]. (biomedcentral.com)
The anti-bacterial effect of different antibiotics and EOs (thyme, oregano, lemongrass, mint, and rosemary) was determined using the standard disc diffusion method. (scielo.br)
Firstline treatment options for moderate to severe acne feature retinoids due to their anti-inflammatory and comedolytic properties, antibiotics which inhibit P. acnes growth and reduce inflammation, or androgen-regulating hormones which target normalization of sebum production. (lavvan.com)
Because of the alarming and rising problems with antibiotic resistance among bacterial pathogens, there is an urgent need to rapidly develop new types of antibiotics and other anti-bacterial agents. (lu.se)
The knowledge about essential cell functions in bacteria and the experimental systems that we develop can be used to find new targets for antibiotics and to screen for molecules that can work as antibiotics. (lu.se)
In an age where the remarkable adaptive and replicative ability of bacteria has lead to the rise of strains resistant to conventional antibiotics, modern medicine is faced with the challenge of discovering and validating new targets for drug development. (bcm.edu)
This approach allows these antibiotics to be delivered into bacterial cells through a pathway that mimics iron uptake. (hku.hk)
These factors collectively impede the accumulation of antibiotics at the bacterial target site. (hku.hk)
For these reasons, there is now an urgent need for both new antibiotic discovery and other modifications or strategies to enhance or prolong the antibacterial activity of existing clinical antibiotics. (hku.hk)
The unabated rise in bacterial resistance to conventional antibiotics, coupled with collateral damage to normal flora incurred by overuse of broad-spectrum antibiotics, necessitates the development of new antimicrobials targeted against pathogenic organisms. (aku.edu)
In an era of emerging bacterial threats where development of new antibiotics is needed, our new therapeutic approach has a novel mechanism of action and molecular target that qualifies it as a truly innovative anti-infective agent," said Robert J. DeLuccia, managing partner of Acurx. (clinicaladvisor.com)
The inhibition of one of these steps by small molecules, such as antimicrobial peptides, or their action on specific targets will leave pathogens armless against classical antibiotics. (intechopen.com)
Subsequent to the discovery of antibiotics during the last century, it was believed that these drugs would allow humans to conquer bacterial disease. (databasefootball.com)
During bacterial infections involving biofilms, most of the existing antibiotics can kill the susceptible, planktonic bacterial population present in various body sites. (databasefootball.com)
This mechanism renders the lysins highly bactericidal, and their rates of bacterial killing are far superior to those of conventional antibiotics. (databasefootball.com)
In addition, because the site of action of lysins is on the external surface of the bacteria, these antibacterial agents do not encounter permeability or efflux issues which are known to affect the potency of conventional antibiotics. (databasefootball.com)

The current study aims at prioritizing broad-spectrum antibacterial targets, present in multiple food and waterborne bacterial pathogens, through a comparative genomics strategy coupled with a protein interaction network analysis. (blogspot.com)
The analyses revealed a set of promising broad-spectrum antibacterial targets, present in multiple food and waterborne pathogens, which are essential for bacterial survival, non-homologous to host and gut flora, and functionally important in the metabolic network. (blogspot.com)
The identified broad-spectrum targets can aid in the design and development of antibacterial agents not only against food and waterborne pathogens but also against other pathogens. (blogspot.com)
Bacterial pathogens must acquire iron in order to grow inside mammalian hosts. (bcm.edu)
Thus, there is a critical need to discover new antibacterial agents which can kill drug-resistant pathogens. (databasefootball.com)
Typical bacterial pathogens that cause CAP include Streptococcus pneumoniae , Haemophilus influenzae , and Moraxella catarrhalis . (medscape.com)
The term "typical" CAP refers to a bacterial pneumonia caused by pathogens such as S pneumoniae , H influenzae , and M catarrhalis . (medscape.com)
Contamination of stream and tank water with en- of resistant pathogens should inform standard treatment teric bacteria, including Salmonella Typhi, is documented guidelines that are developed in the Pacific region. (who.int)

Antimicrobial peptides are promising agents for the treatment of bacterial infections and recent studies indicate that Pep19-2.5, a synthetic anti-lipopolysaccharide (LPS) peptide (SALP), efficiently neutralises pathogenicity factors of Gram-negative (LPS) and Gram-positive (lipoprotein/-peptide, LP) bacteria and protects against sepsis. (nature.com)
Here, we investigated the potential of Pep19-2.5 and the structurally related compound Pep19-4LF for their therapeutic application in bacterial skin infections. (nature.com)
Conclusively, our data suggest a novel therapeutic target for the treatment of patients with acute and chronic skin infections. (nature.com)
This is particularly relevant for bacterial skin and soft-tissue infections (SSTIs) being most commonly caused by multidrug-resistant bacteria with Staphylococcus aureus as predominant causative Gram-positive bacterium and Pseudomonas aeruginosa as most frequent Gram-negative bacterium and having fatal consequences if treated unproperly 2 . (nature.com)
Isoindole antibacterial agents are currently used for treatment of various bacterial infections. (ispub.com)
With its powerful antibacterial properties, Blumont Chloramphenicol Eye Drops are highly effective in treating a wide range of eye infections including conjunctivitis, blepharitis, and keratitis. (villagecountryinn.com)
Blumont Chloramphenicol Eye Drops are a powerful and affordable solution for treating a variety of bacterial eye infections. (villagecountryinn.com)
These drops are effective against a variety of bacterial infections, including conjunctivitis and blepharitis. (villagecountryinn.com)
Differences between fungal cells and bacterial cells account for some of the differences in treatment between fungal and bacterial infections. (ashp.org)
Efflux pump-mediated resistance to single or multiple antimicrobial agents has not only raised serious concerns but also has constricted the treatment options against bacterial infections. (biomedcentral.com)
Faropenem is a late-stage antibiotic product candidate intended to treat adult respiratory tract infections including acute bacterial sinusitis (ABS), community-acquired pneumonia (CAP) and acute exacerbation of chronic bronchitis (AECB). (lumiraventures.com)
This research will lay the groundwork for developing new precision approaches to control bacterial infections such as anti-infective agents or immune-enhancing therapies that target the infection process. (hudson.org.au)
Antimicrobial resistance (AMR) in bacterial infections has emerged as a significant global health concern. (hku.hk)
Gram-negative bacterial infections, such as those caused by Pseudomonas aeruginosa , pose significant challenges in treatment due to their complicated structure. (hku.hk)
Inhibitors of LCP enzymes have the potential to manage a wide range of bacterial infections because the target enzymes are implicated in the assembly of many other bacterial cell wall polymers, including capsular polysaccharide of streptococcal species and arabinogalactan of mycobacterial species. (rcsb.org)
The SCVs too have been implicated in recurrence of various bacterial infections. (databasefootball.com)

Antibacterial and enzyme potency assessments in the presence of an outer membrane-permeabilizing agent or in efflux-compromised strains indicate that penetration and efflux properties of many redesigned BC inhibitors could be improved to various extents. (rcsb.org)
Additionally, increasing the net charge of the peptide by replacing the lone anionic residue with either Gln or Lys dramatically improved efficacy against several bacterial strains without increasing hemolytic activity. (researchwithrowan.com)
Bio-actives that will focus on an as yet unmet need for developing new anti-infective agents (total market size $33 billion) targeted at the increasing number of multi-resistant pathogenic bacterial strains that currently threaten public health. (hw.ac.uk)
The prochelator shows enhanced antibacterial activity against strains expressing β-lactamases, with bactericidal efficacy improved by the presence of low-micromolar copper in the growth medium. (aku.edu)
Any drug impairing crucial processes for bacterial life will inevitably lead to the development of drug-resistant strains, whereas the inhibition of biofilm formation might prevent the onset of bacterial resistance. (intechopen.com)
In this section, we will focus on proteins involved in biofilm formation as useful targets for the development of new drugs that can effectively and specifically impair biofilm formation with slight effects on cell survival, thus avoiding the generation of drug-resistant strains. (intechopen.com)
Thus, an ideal new antibacterial agent, in addition to its activity on drug-resistant strains of bacteria, should also be capable of killing bacteria in biofilms. (databasefootball.com)

Bacterial cell membranes are a possible target for developing new antibacterial drugs since membrane-based efflux pump systems play an important role in bacterial pathogenicity and antimicrobial resistance in bacteria. (biomedcentral.com)
These numbers continue to increase due to development of resistance in microorganisms against the existing first line drugs. (biomedcentral.com)
Whole-genome sequencing of resistant isolates revealed that either BC target mutations or efflux pump overexpression can lead to the development of high-level resistance. (rcsb.org)
Naturally derived antimicrobial peptides have been an area of great interest because of high selectivity against bacterial targets over host cells and the limited development of bacterial resistance to these molecules throughout evolution. (researchwithrowan.com)
The emergence of anti-microbial resistance is fast outpacing the development of effective new antibiotic drugs. (hudson.org.au)
Emerging bacterial antimicrobial (antibiotic) resistance (AMR) is a global threat to human health. (who.int)

She is especially interested in the search for antimicrobial compounds and has been working on peptidoglycan as an antibacterial target for 8 years. (degruyter.com)
Furthermore, CBD was shown to upregulate expression of the antimicrobial peptide LL-37 cathelicidin, suggesting a potential for antibacterial action against Propionibacterium acnes. (lavvan.com)
Here, we explore the antibacterial outcomes and mode of action of a prochelator that exploits the production of β-lactamase enzymes by drug-resistant bacteria to convert a nontoxic compound into a metal-binding antimicrobial agent directly within the microenvironment of pathogenic organisms. (aku.edu)
Examine the lessons learnt from pilot laboratory development programmes in two Pacific island nations that focused on establishing standard procedures for micrological diagnostics and antimicrobial susceptibility testing (AST) and on improving the training of clinicians to increase their use of laboratory services. (who.int)

These include compounds that are antifungal, antibacterial, antibiotic resistant, or can even disable mammalian cells. (wikipedia.org)
Wolfe, A. L. Advances in antibiotic drug discovery: Reducing the barriers for antibiotic development" Future Medicinal Chemistry 2020 , 12(22) , 2067-2087. (unca.edu)
Development of a Robust and Quantitative High Throughput Screening Method for Antibiotic Production in Bacterial Libraries. (unca.edu)
A major challenge for new antibiotic discovery is predicting the physicochemical properties that enable small molecules to permeate Gram-negative bacterial membranes. (rcsb.org)
These priorities include identifying a partner for Replidyne's late-stage antibiotic, faropenem medoxomil (faropenem), advancing and expanding its infectious disease pipeline, and exploring additional corporate development opportunities. (lumiraventures.com)
One of our projects aims at investigating bacterial cell division as an antibiotic target. (lu.se)
This incorporation enables the active transport of the antibiotic into bacterial cell through nutrient pathways. (hku.hk)
ACX-362E is a targeted, narrow spectrum oral antibiotic that blocks the DNA replication process through inhibition of polymerase III, which has been shown to be bactericidal. (clinicaladvisor.com)

At NCSU I worked under Professor Christian Melander on the development of 2-aminoimidazole bacteria biofilm inhibitors. (unca.edu)
EC 1.1.1.23), encoded by the gene hisD in many bacteria , is essential for intramacrophagic replication, providing a novel target for the development of antibacterial agents (1). (ispub.com)
This is different from other infectious agents such as bacteria. (ashp.org)
The identified broad-spectrum candidates, namely, integral membrane protein/virulence factor (MviN), preprotein translocase subunits SecB and SecG, carbon storage regulator (CsrA), and nitrogen regulatory protein P-II 1 (GlnB), contributed by the peptidoglycan pathway, bacterial secretion systems and two-component systems, were also found to be present in a wide range of other disease-causing bacteria. (blogspot.com)
The effects of cannabinoids at non-cytotoxic concentrations on sebum production, gram-positive bacteria, and immune response can direct the development of novel skin therapies with targeted effects for a variety of skin conditions. (lavvan.com)
Cannabinoids have also demonstrated antibacterial activity against other grampositive bacteria, which brings into question the potential activity cannabinoids may have on grampositive P. acnes in the prevention or management of acne vulgaris. (lavvan.com)
Broadly speaking, bacterial pathogenesis refers to the study of the origin and progression of a disease which results from infection by bacteria. (bcm.edu)
Quorum Sensing (QS), a form of bacteria communication mediated through chemical signaling, was investigated in the bacterial pathogen Pseudomonas aeruginosa. (rowan.edu)
However, bacteria present in biofilms can evade the antibacterial effect, forming a reservoir of infection. (databasefootball.com)
Lysins are enzymes derived from bacteriophages (viruses which can kill bacteria) which can cleave bacterial peptidoglycan, a unique covering present in the cell wall of bacteria. (databasefootball.com)
Purpose: To evaluate the antibacterial effect of four oral antiseptics (two solutions of cetylpyridinium chloride, chlorhexidine gluconate and benzalkonium chloride) on facultative bacteria using two methods. (bvsalud.org)

Endotoxin triggers humoral enzymatic mechanisms involving the complement, clotting, fibrinolytic, and kinin pathways and causes much of the morbidity in gram-negative bacterial sepsis. (msdmanuals.com)

Bacterial efflux pump inhibition using both leaf extracts was determined by monitoring the transport of Rhodamine 6 G (R6G) across the cell membrane and IC 50 values were obtained. (biomedcentral.com)
Replidyne will retain key research and development expertise to progress its most promising preclinical programs, including REP3123, its investigational antibacterial for the treatment of C. difficile-associated disease (CDAD), and its DNA replication inhibition program. (lumiraventures.com)
LasR is the main regulator in this system and is also the receptor targeted for inhibition. (rowan.edu)

Her main research interests have been the study of Mur ligases from different bacterial species and the search for inhibitors of these enzymes. (degruyter.com)
For more than 30 years, his main research interests have been the functional and structural study of the enzymes of peptidoglycan biosynthesis, the determination of the structure of peptidoglycan from certain bacterial species, and the search for peptidoglycan biosynthesis inhibitors that could act as antibacterial agents. (degruyter.com)
The synthesis of the peptide stem of bacterial peptidoglycan involves four enzymes, the Mur ligases (MurC, D, E and F). Among them, MurD is responsible for the ATP-dependent addition of d -glutamic acid to UDP-MurNAc- l -Ala, a reaction which involves acyl-phosphate and tetrahedral intermediates. (degruyter.com)
Like most enzymes of peptidoglycan biosynthesis, MurD constitutes an attractive target for the design and synthesis of new antibacterial agents. (degruyter.com)

methane metabolism, d -alanine metabolism, peptidoglycan biosynthesis, bacterial secretion system, two-component system, C5-branched dibasic acid metabolism), identified by comparative metabolic pathway analysis, were considered for the analysis. (blogspot.com)

Morbidity and mortality rates caused by infectious microbial agents have been shown to pose serious public health concerns. (biomedcentral.com)

B. anthracis is an excellent model pathogen to study bacterial pathogenesis. (bcm.edu)
QS has the ability to regulate when a bacterial pathogen is infective or benign. (rowan.edu)
The most common bacterial pathogen overall is S pneumoniae , although, in some settings, including in the United States, its incidence is decreasing, possibly owing to vaccination. (medscape.com)
Historical clues and physical examination findings may suggest a causative pathogen, but the clinical signs and symptoms of CAP are not sufficiently specific to reliably differentiate the exact etiologic agent. (medscape.com)

Soraphen A - An agent highly effective against plant-pathogenic fungi. (wikipedia.org)

For more than 15 years he has been involved in discovery of inhibitors of bacterial cell-wall biosynthesis as potential antibacterial agents. (degruyter.com)

The approach developed by this group was to prepare HDH inhibitors which target the lipophilic binding pocket adjoining the active site of the enzyme. (ispub.com)
This review summarizes the recent and promising developments with respect to the current knowledge of the MEP pathway with emphasis on the understanding of the structure and the catalytic mechanism of the DXR enzyme and the global quest for therapeutically useful inhibitors of DXR. (unboundmedicine.com)
These plant extracts may provide new lead compounds for developing potential efflux pump inhibitors (EPIs) or permeabilising agents that could aid the transport of antibacterial agents into bacterial cells. (biomedcentral.com)
The class of mTOR inhibitors, including sirolimus (rapamycin), temsirolimus, and everolimus, are increasingly being used as anticancer agents and have been associated with the development of oral aphthous-like ulcers, referred to as mTOR inhibitor-associated stomatitis, or mIAS. (medscape.com)

It has an unusually-large genome of 13,033,779 base pairs, making it the largest bacterial genome sequenced to date by roughly 4 Mb. (wikipedia.org)

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. (lu.se)
We are using our global reach and innovation in teaching, research and enterprise to make a significant impact towards the attainment of the UN Sustainable Development Goals. (hw.ac.uk)

Bacterial infectious diseases remain a major threat to human health. (hudson.org.au)

Bismuth and cefiderocol showed synergistic effect both in vitro and in vivo (lung infectious model) against PAO1, a strain of Pseudomonas aeruginosa, as a metallo-sideromycin complex transported actively into bacterial cells. (hku.hk)

Cytoplasmic proteins SecG, CsrA and GlnB were considered as drug targets, while membrane proteins MviN and SecB were classified as vaccine targets. (blogspot.com)
Processes like these have evolved from common ancestors of both eukaryotes and prokaryotes, and it becomes increasingly clear that the bacterial versions of these basic cell functions use similar ancestral molecules, for example cytoskeletal proteins, as those used in animal and plant cells. (lu.se)

Both plant extracts showed some significant effects on permeability of the bacterial membrane when a 24-28% increase of diSC3-5 dye release was observed for S. aureus and 45-53% of dye was released from P. aeruginosa cell membrane after a 60 minute incubation period. (biomedcentral.com)

Some breaks down into microplastics (MPs) that can enter and distribute in living organisms causing effects in multiple target organs. (cdc.gov)

Some of these secondary compounds include: Ambruticin and Jerangolid A - Antifungal agents. (wikipedia.org)
Epothilones - Compounds that target microtubule function leading to apoptosis. (wikipedia.org)
Also provided are methods for utilizing histidinol dehydrogenase polypeptides to screen for antibacterial compounds. (ispub.com)

Our researchers have been awarded six grants totalling more than $9.5 million to improve the understanding, prevention and treatments for preterm and growth restricted babies , endometriosis , bacterial infection. (hudson.org.au)
Further investigation into the mechanisms of prochelators will provide insight for the design of new antibacterial agents that manipulate cellular metallobiology as a strategy against infection. (aku.edu)

Using a combination of spectroscopic and microbiological approaches, the role of cationic residues and net charge on antibacterial activity, lipid bilayer interactions, and bilayer and membrane permeabilization were investigated. (researchwithrowan.com)

Unlike human cells, but similar to bacterial cells, however, a fungal cell also has a cell wall. (ashp.org)

Our medicinal chemistry program involves the development, synthesis, and biological evaluation of antibacterial agents derived from naturally occurring molecules. (unca.edu)

Microorganisms have the extraordinary ability to live in almost all environments and to protect themselves from external agents through sophisticated survival mechanisms. (intechopen.com)
The antibacterial effect of 0.13% benzalkonium chloride against the biological indicators was observed after five minutes in direct exposure, while cetylpyridinium chloride and chlorhexidine gluconate had an antibacterial effect against all the microorganisms after 10 minutes. (bvsalud.org)

Impact of bacterial and somatic cells content on quality fresh milk in small-scale dairy farms in Kosovo. (scielo.br)
For a researcher armed with the powerful tools of genetics and molecular biology, the simple bacterial cells provide great experimental systems for investigating fundamental functions of a living cell. (lu.se)
However, on solid surfaces, bacterial cells tend to grow together in a matrix secreted by the cells. (databasefootball.com)

Consistent with prior guidance, Replidyne will not initiate enrollment in clinical trials for faropenem in acute bacterial sinusitis (ABS) and community-acquired pneumonia (CAP) until a partner is identified. (lumiraventures.com)
Based on currently planned clinical trials and development activities, as well as the restructuring announced today, the Company believes it has internal cash resources to support operations for at least the next two fiscal years. (lumiraventures.com)
In March 2007, Replidyne announced a clinical development program, agreed to by the U.S. Food and Drug Administration (FDA), in which four Phase III clinical trials consisting of one placebo-controlled trial in each of ABS and AECB and two non-inferiority trials in CAP would be adequate to submit a new drug application for faropenem covering the three indications. (lumiraventures.com)
Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. (benthamscience.com)
The diagnosis of chemotherapy-induced oral mucositis is based on clinical findings and the chronology of the development of lesions. (medscape.com)

Most attempts along this path have targeted individual virulence factors, such as pili or toxins, but these approaches have suffered from a limited spectrum of activity. (ispub.com)

The skin comprises various cell types providing the potential to react to bacterial pathogenicity factors and can thus initiate inflammatory responses if exposed to these factors 5 . (nature.com)

This program will extend ongoing studies of several candidate drugs that show promise for developing anti-inflammatory therapies which are both safe and effective in our tiny patients. (hudson.org.au)
Global spending on prescription acne therapies and anti-acne cosmetics respectively exceeded $4.1B USD in 2017 and $2B USD in 2018. (lavvan.com)
Most notably, non-cytotoxic concentrations of CBG and CBGV reportedly increased lipid synthesis and prevented inflammatory cytokine release, which may be beneficial for therapies targeting conditions associated with dry skin and impaired barrier function, such as xerosis, eczema, and anti-aging applications. (lavvan.com)
With the introduction of biologically targeted anticancer therapies, emerging oral toxicities have been identified in cancer patients that appear to be distinct from classic mucositis. (medscape.com)

Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. (benthamscience.com)
The scope of the ebook series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. (benthamscience.com)

One such analog, known as ixabepilone is a U.S. Food and Drug Administration approved chemotherapy agent for the treatment of metastatic breast cancer. (wikipedia.org)
Following the logistic regression analysis of treatment failure, new amikacin target concentrations were estimated and used in development of an alternative dosing strategy. (nih.gov)

and emerging diseases necessitate the ongoing assessment of vaccine development priorities (e.g., pneumococcal disease in children, respiratory syncytial virus [RSV] pneumonia, malaria). (cdc.gov)

Analysed target's ability to act as generalized broad-spectrum drug/vaccine target. (blogspot.com)

Second, there are no functional equivalents to DXR in humans, making it an attractive target for therapeutic intervention. (unboundmedicine.com)

reported that HDH is a suitable target for the development of potential herbicides (3). (ispub.com)
Many venom peptides share the same net cationic, amphiphilic nature as host-defense peptides, making them an attractive target for development as potential antibacterial agents. (researchwithrowan.com)

The findings of the recent study suggest the use of EOs as natural antibacterial agents for food preservation. (scielo.br)
Conclusion: The antiseptic solutions included in this study had an antibacterial effect against S. mutans, E. faecalis, and P. aeruginosa. (bvsalud.org)

The Ebook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. (benthamscience.com)

We will also evaluate our derivatives in house using an antibacterial assay. (unca.edu)
The good interaction of our isoindole derivatives showed that they can be as possible anti bacterial agents. (ispub.com)

Organisms2

Phenomena and Processes1

Antibiotics28

Pathogens8

Infections16

Strains7

Resistance6

Antimicrobial4

Antibiotic8

Bacteria11

Sepsis1

Inhibition3

Enzymes4

Peptidoglycan biosynthesis1

Morbidity1

Pathogen4

Pathogenic1

Biosynthesis1

Inhibitors4

Genome1

Sustainable Development Goals2

Infectious Diseases1

Pseudomonas1

Proteins2

Permeability1

Organisms1

Compounds3

Infection2

Membrane1

Fungal1

Molecules1

Microorganisms2

Cells3

Clinical5

Virulence1

Factors1

Therapies4

Drug targets2

Treatment2

Respiratory1

Vaccine1

Humans1

Potential2

Study2

Essential1

Derivatives2